Intraarticular gold microparticles using hyaluronic acid as the carrier for hip osteoarthritis. A 2-year follow-up pilot study.
Gold microparticles
Hip
Hyaluronic acid
Osteoarthritis
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 Nov 2024
01 Nov 2024
Historique:
received:
14
04
2024
accepted:
24
10
2024
medline:
1
11
2024
pubmed:
1
11
2024
entrez:
1
11
2024
Statut:
epublish
Résumé
We recently conducted a pilot study in which we discovered that introducing metallic gold microparticles into the knee joint can help reduce pain caused by osteoarthritis for up to two years. Additionally, we identified significant proteomic changes in the synovial fluid and serum within eight weeks of the procedure. In this study, we aimed to evaluate whether there may be a clinical relevant effect of intra-articular injection of gold microparticles on hip osteoarthritis. A cohort of 22 patients, aged ≥ 18 years, with pain ≥ 3 months, and Kellgren-Lawrence OA grade 2-4, were included. Metallic gold 20 mg, 72.000 pieces, 20-40 µ-meter BerlockMicroImplants (BMI) were injected into the hip joint using hyaluronic acid as the carrier. In total, we treated 26 hip joints. The primary outcome was the Western Ontario and McMaster Universities Arthritis Index (WOMAC). WOMAC pain decreased from 11 (2-20 to 3 (0-8), stiffness from 6 (0-8) to 1 (0-4), and activity from 43 (18-68) to 11 (0-27), all P = 0.0001. When adjusting for the minimally relevant differences, the P-values were 0.0015 for WOMAC pain, 0.26 for stiffness, and 0.011 for activity. Combined intraarticular treatment with metallic gold microparticles and hyaluronic acid may improve hip joint pain and function. Joint stiffness did not improve when assessed against the minimal clinically relevant difference. This study suggests a basis for a future placebo-controlled randomized trial of gold microparticles and hyaluronic acid in hip osteoarthritic patients.
Identifiants
pubmed: 39482349
doi: 10.1038/s41598-024-77760-5
pii: 10.1038/s41598-024-77760-5
doi:
Substances chimiques
Hyaluronic Acid
9004-61-9
Gold
7440-57-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
26249Informations de copyright
© 2024. The Author(s).
Références
Murphy, N. J., Eyles, J. P. & Hunter, D. J. Hip osteoarthritis: Etiopathogenesis and implications for management. Adv. Ther. 33(11), 1921–1946. https://doi.org/10.1007/s12325-016-0409-3 (2016).
doi: 10.1007/s12325-016-0409-3
pubmed: 27671326
pmcid: 5083776
Wehling, P., Evans, C., Wehling, J. & Maixner, W. Effectiveness of intra-articular therapies in osteoarthritis: A literature review. Therapeutic Advances in Musculoskeletal Disease 9(8), 183–196. https://doi.org/10.1177/1759720X17712695 (2017).
doi: 10.1177/1759720X17712695
pubmed: 28835778
pmcid: 5557186
Uson, J. et al. EULAR recommendations for intra-articular therapies. Ann. Rheum. Dis. 80(10), 1299–1305. https://doi.org/10.1136/annrheumdis-2021-220266 (2021).
doi: 10.1136/annrheumdis-2021-220266
pubmed: 34035002
Rampal, S. et al. A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?. Joint Diseases and Related Surgery 33(1), 255–262. https://doi.org/10.52312/jdrs.2022.402 (2022).
doi: 10.52312/jdrs.2022.402
pubmed: 35361105
pmcid: 9057559
Choueiri, M., Chevalier, X. & Eymard, F. Intraarticular corticosteroids for hip osteoarthritis: A review. Cartilage 13(1_suppl), 122S-131S. https://doi.org/10.1177/1947603520951634 (2021).
doi: 10.1177/1947603520951634
pubmed: 32815375
Zhong, H. M. et al. Intra-articular steroid injection for patients with hip osteoarthritis: A systematic review and meta-analysis. Biomed. Res. Int. 2020, 6320154. https://doi.org/10.1155/2020/6320154 (2020).
doi: 10.1155/2020/6320154
pubmed: 32185212
pmcid: 7060863
Acuña, A. J., Samuel, L. T., Jeong, S. H., Emara, A. K. & Kamath, A. F. Viscosupplementation for hip osteoarthritis: Does systematic review of patient-reported outcome measures support use?. Journal of Orthopaedics 21, 137–149. https://doi.org/10.1016/j.jor.2020.03.016 (2020).
doi: 10.1016/j.jor.2020.03.016
pubmed: 32255995
pmcid: 7114596
Lim, A., Zhu, J. B. & Khanduja, V. The use of intra-articular platelet-rich plasma as a therapeutic intervention for hip osteoarthritis: A systematic review and meta-analysis. The American Journal of Sports Medicine 51(9), 2487–2497. https://doi.org/10.1177/03635465221095563 (2023).
doi: 10.1177/03635465221095563
pubmed: 35971803
Schmitz, C. et al. Methodological flaws in meta-analyses of clinical studies on the management of knee osteoarthritis with stem cells: A systematic review. Cells 11(6), 965. https://doi.org/10.3390/cells11060965 (2022).
doi: 10.3390/cells11060965
pubmed: 35326416
pmcid: 8946093
Entessari, M. & Oliveira, L. P. Current evidence on mesenchymal stem cells for hip osteoarthritis: A narrative review. Regenerative Medicine 18(9), 749–758. https://doi.org/10.2217/rme-2023-0071 (2023).
doi: 10.2217/rme-2023-0071
pubmed: 37496424
Ferrara, P. E. et al. State of art in intra-articular hip injections of different medications for osteoarthritis: A systematic review. BMC Musculoskeletal Disorders 22(Suppl 2), 997. https://doi.org/10.1186/s12891-021-04866-6 (2021).
doi: 10.1186/s12891-021-04866-6
pubmed: 34844603
pmcid: 8630838
Gazendam, A., Ekhtiari, S., Bozzo, A., Phillips, M. & Bhandari, M. Intra-articular saline injection is as effective as corticosteroids, platelet-rich plasma and hyaluronic acid for hip osteoarthritis pain: A systematic review and network meta-analysis of randomised controlled trials. British Journal of Sports Medicine 55(5), 256–261. https://doi.org/10.1136/bjsports-2020-102179 (2021).
doi: 10.1136/bjsports-2020-102179
pubmed: 32829298
Rasmussen, S. et al. Gold micro-particles for knee osteoarthritis. European Journal of Pain (London, England) 26(4), 811–824. https://doi.org/10.1002/ejp.1909 (2022).
doi: 10.1002/ejp.1909
pubmed: 35076138
Katz, J. N., Arant, K. R. & Loeser, R. F. Diagnosis and treatment of hip and knee osteoarthritis: A review. JAMA 325(6), 568–578. https://doi.org/10.1001/jama.2020.22171 (2021).
doi: 10.1001/jama.2020.22171
pubmed: 33560326
pmcid: 8225295
Grässel, S. & Muschter, D. Recent advances in the treatment of osteoarthritis. F1000Res https://doi.org/10.12688/f1000research.22115.1 (2020).
doi: 10.12688/f1000research.22115.1
pubmed: 32419923
pmcid: 7199286
Zhang, W. et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 16(2), 137–162. https://doi.org/10.1016/j.joca.2007.12.013 (2008).
doi: 10.1016/j.joca.2007.12.013
pubmed: 18279766
Danscher, G. & Rasmussen, S. nanoGold and µGold inhibit autoimmune inflammation: A review. Histochemistry and Cell Biology 159(3), 225–232. https://doi.org/10.1007/s00418-023-02182-9 (2023).
doi: 10.1007/s00418-023-02182-9
pubmed: 36864314
pmcid: 10006034
Rasmussen, S., Frederickson, C. & Danscher, G. Inhibition of local inflammation by implanted gold: A narrative review of the history and use of gold. The Journal of Rheumatology 50(5), 704–705. https://doi.org/10.3899/jrheum.221150 (2023).
doi: 10.3899/jrheum.221150
pubmed: 36921973
Märki, N. et al. Safety of intra-articular gold microimplants in horses–A randomized, blinded, controlled experimental study. J. Equine Vet. Sci. 60, 59–66 (2018).
doi: 10.1016/j.jevs.2017.03.005
Bellamy, N., Buchanan, W. W., Goldsmith, C. H., Campbell, J. & Stitt, L. W. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. The Journal of Rheumatology 15(12), 1833–1840 (1988).
pubmed: 3068365
Deckey, D. G. et al. Discordance Abounds in Minimum Clinically Important Differences in THA: A Systematic Review. Clinical Orthopaedics and Related Research 481(4), 702–714. https://doi.org/10.1097/CORR.0000000000002434 (2023).
doi: 10.1097/CORR.0000000000002434
pubmed: 36398323
Kim, M. S. et al. The minimal clinically important difference (MCID) for the WOMAC and factors related to achievement of the MCID after medial opening wedge high tibial osteotomy for knee osteoarthritis. The American Journal of Sports Medicine 49(9), 2406–2415. https://doi.org/10.1177/03635465211016853 (2021).
doi: 10.1177/03635465211016853
pubmed: 34115533
Freynhagen, R., Baron, R., Gockel, U. & Tölle, T. R. painDETECT: A new screening questionnaire to identify neuropathic components in patients with back pain. Curr. Med. Res. Opin. 22, 1911–1920. https://doi.org/10.1185/030079906X132488 (2006).
doi: 10.1185/030079906X132488
pubmed: 17022849
Kamper, S. J., Maher, C. G. & Mackay, G. Global rating of change scales: A review of strengths and weaknesses and considerations for design. The Journal of Manual & Manipulative Therapy 17(3), 163–170. https://doi.org/10.1179/jmt.2009.17.3.163 (2009).
doi: 10.1179/jmt.2009.17.3.163
Lancaster, G. A. & Thabane, L. Guidelines for reporting non-randomised pilot and feasibility studies. Pilot Feasibility Studies 5, 114. https://doi.org/10.1186/s40814-019-0499-1 (2019).
doi: 10.1186/s40814-019-0499-1
pubmed: 31608150
pmcid: 6778655
Schiavi, P. et al. Efficacy and safety of viscosupplementation with hyaluronic acid for hip osteoarthritis: Results from a cross-sectional study with a minimum follow-up of 4 years. Acta Bio-medica Atenei Parmensis 91(14-S), e2020032. https://doi.org/10.23750/abm.v91i14-S.11110 (2020).
doi: 10.23750/abm.v91i14-S.11110
pubmed: 33559627
pmcid: 7944698
GBD 2021 Osteoarthritis Collaborators. Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: A systematic analysis for the Global Burden of Disease Study 2021. The Lancet Rheumatology 5(9), e508–e522. https://doi.org/10.1016/S2665-9913(23)00163-7 (2023).
doi: 10.1016/S2665-9913(23)00163-7
Gibbs, A. J. et al. Recommendations for the management of hip and knee osteoarthritis: A systematic review of clinical practice guidelines. Osteoarthritis and Cartilage 31(10), 1280–1292. https://doi.org/10.1016/j.joca.2023.05.015 (2023).
doi: 10.1016/j.joca.2023.05.015
pubmed: 37394226
Richard, M. J., Driban, J. B. & McAlindon, T. E. Pharmaceutical treatment of osteoarthritis. Osteoarthritis and Cartilage 31(4), 458–466. https://doi.org/10.1016/j.joca.2022.11.005 (2023).
doi: 10.1016/j.joca.2022.11.005
pubmed: 36414224
Batushansky, A. et al. Fundamentals of OA. An initiative of Osteoarthritis and Cartilage. Obesity and metabolic factors in OA. Osteoarthritis and Cartilage 30(4), 501–515. https://doi.org/10.1016/j.joca.2021.06.013 (2022).
doi: 10.1016/j.joca.2021.06.013
pubmed: 34537381
Zhao, K., Ruan, J., Nie, L., Ye, X. & Li, J. Effects of synovial macrophages in osteoarthritis. Frontiers in Immunology 14, 1164137. https://doi.org/10.3389/fimmu.2023.1164137 (2023).
doi: 10.3389/fimmu.2023.1164137
pubmed: 37492583
pmcid: 10364050
Wood, M. J., Miller, R. E. & Malfait, A. M. The genesis of pain in osteoarthritis: Inflammation as a mediator of osteoarthritis pain. Clinics in Geriatric Medicine 38(2), 221–238. https://doi.org/10.1016/j.cger.2021.11.013 (2022).
doi: 10.1016/j.cger.2021.11.013
pubmed: 35410677
pmcid: 9053380
Saltzman, B. M. et al. The therapeutic effect of intra-articular normal saline injections for knee osteoarthritis: A meta-analysis of evidence level 1 studies. The American Journal of Sports Medicine 45(11), 2647–2653. https://doi.org/10.1177/0363546516680607 (2017).
doi: 10.1177/0363546516680607
pubmed: 28027657