LINC01320 facilitates cell proliferation and migration of ovarian cancer via regulating PURB/DDB2/NEDD4L/TGF-β axis.

Humans Female Ovarian Neoplasms / pathology Cell Proliferation RNA, Long Noncoding / genetics Cell Movement / genetics Transforming Growth Factor beta / metabolism Gene Expression Regulation, Neoplastic DNA-Binding Proteins / metabolism Cell Line, Tumor Nedd4 Ubiquitin Protein Ligases / metabolism Signal Transduction Animals Mice Mice, Nude
DDB2 LINC01320 Ovarian cancer PURB TGF-β signaling pathway

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
31 Oct 2024
Historique:
received: 27 07 2024
accepted: 29 10 2024
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 1 11 2024
Statut: epublish

Résumé

Ovarian cancer (OC) is one of the most prevalent and lethal malignancies affecting the female reproductive system, due to its tendency for metastasis and recurrence. This study identified the overexpression of LINC01320 (or long intergenic nonprotein coding RNA 1320) in tissues of ovarian cancer through the analysis of patient samples and online datasets. In vitro and in vivo experiments demonstrate that silencing of LINC01320 expression led to inhibition of proliferation and metastasis of OC cells. RNA pull-down followed by liquid chromatography tandem mass spectrometry (RNA pull-down-LC-MS/MS) revealed that LINC01320 interacted with purine-rich element binding protein B (PURB), a transcriptional repressor. Furthermore, the RNA-seq analysis identified damage-specific DNA binding protein 2 (DDB2) as a major common target of LINC01320 and PURB. Mechanistically, LINC01320 could recruit PURB to the promoter region of DDB2 to repress DDB2 transcription; thus, promoting the expression of NEDD4L and impeding the TGF-β/SMAD signaling pathway, and ultimately facilitating the progression of OC. Finally, rescue experiments confirmed the involvement of the DDB2/NEDD4L/TGF-β axis in LINC01320-mediated OC progression. In conclusion, this study unveils for the first time the pivotal function of the LINC01320/PURB/DDB2/NEDD4L/TGF-β axis and explores its prospective clinical implications in OC.

Identifiants

DOI: 10.1038/s41598-024-78255-z PMID: 39482389
pubmed: 39482389
doi: 10.1038/s41598-024-78255-z
pii: 10.1038/s41598-024-78255-z
doi:

Substances chimiques

RNA, Long Noncoding 0
Transforming Growth Factor beta 0
DNA-Binding Proteins 0
Nedd4 Ubiquitin Protein Ligases EC 2.3.2.26

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

26233

Subventions

Organisme : Suzhou Gu Su Health Talent Research Project
ID : GSWS2023056

Informations de copyright

© 2024. The Author(s).

Références

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Auteurs

Gaigai Wang (G)

State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University, Suzhou, 215002, China.

Bingya Xu (B)

Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, 214062, China.

Xiangling Yu (X)

Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, 214062, China.

Meng Liu (M)

Department of Gynaecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University, Suzhou, 215002, China.

Tiantian Wu (T)

State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University, Suzhou, 215002, China.

Wenxin Gao (W)

State Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.

Haoyue Hu (H)

Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, 214062, China.

Bing Jiang (B)

Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, 214062, China.

Yibo Wu (Y)

Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, 214062, China.

Tao Zhou (T)

Research Institute for Reproductive Medicine and Genetic Diseases, Wuxi Maternity and Child Health Care Hospital, Wuxi, 214002, China. zhoutao@njmu.edu.cn.

Xia Chen (X)

Department of Obstetrics and Gynecology, Nantong First People's Hospital, Affiliated Hospital 2 of Nantong University, Nantong University, Nantong, 226001, China. chenxia_0511@126.com.

Cong Shen (C)

State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University, Suzhou, 215002, China. congshen@njmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › LINC01320 facilitates cell proliferation and...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › LINC01320 facilitates cell proliferation and...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › LINC01320 facilitates cell proliferation and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › LINC01320 facilitates cell proliferation and...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › LINC01320 facilitates cell proliferation and...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › LINC01320 facilitates cell proliferation and...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › LINC01320 facilitates cell proliferation and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › LINC01320 facilitates cell proliferation and...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › LINC01320 facilitates cell proliferation and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Complexes de tri endosomique requis pour le transport › Ubiquitine protéine ligases NEDD4 › LINC01320 facilitates cell proliferation and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › LINC01320 facilitates cell proliferation and...
questionsmedicales.fr › Eucaryotes › Animaux › LINC01320 facilitates cell proliferation and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › LINC01320 facilitates cell proliferation and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › LINC01320 facilitates cell proliferation and...