Factors associated with mortality and functional outcome after decompressive craniectomy in malignant middle cerebral artery infarction.


Journal

BMC neurology
ISSN: 1471-2377
Titre abrégé: BMC Neurol
Pays: England
ID NLM: 100968555

Informations de publication

Date de publication:
01 Nov 2024
Historique:
received: 20 07 2024
accepted: 25 10 2024
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 1 11 2024
Statut: epublish

Résumé

Identifying the predictive factors of mortality and functional outcomes following decompressive craniectomy (DC) surgery in patients with malignant middle cerebral artery infarction (MMCAI) is essential for decision-making regarding conservative versus surgical treatment. This study aimed to assess the mortality and functional outcomes of MMCAI patients after DC surgery and to identify the predictive factors associated with mortality and functional outcomes. A total of 76 patients with MMCAI who underwent surgical DC were included. The mortality rates and functional outcomes were assessed, and factors associated with mortality and functional outcomes were identified through univariate analysis followed by multivariate logistic regression analysis. The mortality rate was 44.8%, while a favorable functional outcome was observed in 28.9% of the patients. modified Glasgow coma scale (GCS) before DC (OR = 0.416, 95% CI = 0.261-0.662, P < 0.001) and infarct volume before DC (OR = 1.000-1.012, 95% CI = 1.000-1.012, P = 0.037) were independent risk factors for death. Age (OR = 0.88, 95% CI = 0.812-0.952, P = 0.002), modified GCS before DC (OR = 2.477, 95% CI = 1.395-4.4, P = 0.002), and infarct volume before DC (OR = 0.987, 95% CI = 0.975-0.999, P = 0.035) were independent factors associated with favorable functional outcomes. Preoperative modified GCS and preoperative infarct volume were independent factors associated with both mortality and functional outcomes. Age was only associated with functional outcomes.

Identifiants

pubmed: 39482588
doi: 10.1186/s12883-024-03937-0
pii: 10.1186/s12883-024-03937-0
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

424

Subventions

Organisme : Natural Science Research Project of Wannan Medical College
ID : WK2021ZF12
Organisme : Wuhu Science and Technology Bureau project
ID : 2022JC85
Organisme : Natural Science Research Project in Higher Education of Anhui Province
ID : No.2022AH040174

Informations de copyright

© 2024. The Author(s).

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Auteurs

Jun Shen (J)

Department of Neurosurgery, The First Affiliated Hospital (YiJiShan Hospital) of Wannan Medical College, Wuhu City, 241001, Anhui, PR China.

Qian An (Q)

Department of Respiratory and Critical Care Medicine, Wuhu Hospital of Traditional Chinese Medicine, Wuhu City, 241001, Anhui, PR China. anqianbb520@163.com.

Shaolin Zhang (S)

Department of Neurosurgery, The First Affiliated Hospital (YiJiShan Hospital) of Wannan Medical College, Wuhu City, 241001, Anhui, PR China.

Ruixiang Ge (R)

Department of Neurosurgery, The First Affiliated Hospital (YiJiShan Hospital) of Wannan Medical College, Wuhu City, 241001, Anhui, PR China.

Dongdong Sun (D)

Department of Neurosurgery, The First Affiliated Hospital (YiJiShan Hospital) of Wannan Medical College, Wuhu City, 241001, Anhui, PR China.

Jun Cao (J)

Department of Neurosurgery, The First Affiliated Hospital (YiJiShan Hospital) of Wannan Medical College, Wuhu City, 241001, Anhui, PR China.

Jingcheng Fang (J)

Department of Neurosurgery, The First Affiliated Hospital (YiJiShan Hospital) of Wannan Medical College, Wuhu City, 241001, Anhui, PR China.

Dayong Xia (D)

Department of Neurosurgery, The First Affiliated Hospital (YiJiShan Hospital) of Wannan Medical College, Wuhu City, 241001, Anhui, PR China.

Xiaochun Jiang (X)

Department of Neurosurgery, The First Affiliated Hospital (YiJiShan Hospital) of Wannan Medical College, Wuhu City, 241001, Anhui, PR China.

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