Ubiquitination regulates autophagy in cancer: simple modifications, promising targets.
Autophagy
Cancer
E3 ligase
UPS
Ubiquitination
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
31 Oct 2024
31 Oct 2024
Historique:
received:
19
05
2024
accepted:
02
08
2024
medline:
1
11
2024
pubmed:
1
11
2024
entrez:
1
11
2024
Statut:
epublish
Résumé
Autophagy is an important lysosomal degradation process that digests and recycles bio-molecules, protein or lipid aggregates, organelles, and invaded pathogens. Autophagy plays crucial roles in regulation of metabolic and oxidative stress and multiple pathological processes. In cancer, the role of autophagy is dual and paradoxical. Ubiquitination has been identified as a key regulator of autophagy that can influence various steps in the autophagic process, with autophagy-related proteins being targeted for ubiquitination, thus impacting cancer progression and the effectiveness of therapeutic interventions. This review will concentrate on mechanisms underlying autophagy, ubiquitination, and their interactions in cancer, as well as explore the use of drugs that target the ubiquitin-proteasome system (UPS) and ubiquitination process in autophagy as part of cancer therapy.
Identifiants
pubmed: 39482684
doi: 10.1186/s12967-024-05565-1
pii: 10.1186/s12967-024-05565-1
doi:
Substances chimiques
Proteasome Endopeptidase Complex
EC 3.4.25.1
Ubiquitin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
985Subventions
Organisme : National Natural Science Foundation of China
ID : 82002581
Organisme : National Natural Science Foundation of China
ID : 81871888
Organisme : National Natural Science Foundation of China
ID : 82172942
Organisme : China Postdoctoral Science Foundation
ID : 2020M671375
Organisme : Postdoctoral Science Foundation of Jiangsu Province
ID : 2020Z261
Informations de copyright
© 2024. The Author(s).
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