Exploring the association between lifestyle and cardiovascular health metrics and HPV infection risk: insights from the National Health and Nutrition Examination Survey 2005-2016 data.
Cardiovascular health (CVH)
HPV Infection
Lifestyle Behaviors
Life’s essential 8
NHANES
Public health strategies
Journal
BMC public health
ISSN: 1471-2458
Titre abrégé: BMC Public Health
Pays: England
ID NLM: 100968562
Informations de publication
Date de publication:
31 Oct 2024
31 Oct 2024
Historique:
received:
07
03
2024
accepted:
28
10
2024
medline:
1
11
2024
pubmed:
1
11
2024
entrez:
1
11
2024
Statut:
epublish
Résumé
Human Papillomavirus (HPV) infection has garnered significant attention due to its high prevalence and association with various cancers and other health conditions. Composite lifestyle factors may influence the risk of HPV infection, yet their cumulative impact remains insufficiently explored. This study aims to explore the association between the Life's Essential 8 (LE8) Score and HPV infection status, highlighting the potential role of lifestyle and health behaviors in HPV infection prevention. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005-2016, we analyzed the health and nutritional statuses of 6,773 participants after excluding those with missing HPV infection status, inability to calculate the LE8 Score, and missing covariate data. The LE8 Score was computed based on eight cardiovascular health metrics, encompassing both health factors (BMI, non-HDL cholesterol, blood pressure, and blood glucose) and health behaviors (physical activity, diet, sleep duration, and nicotine exposure). HPV infection status was determined through vaginal swab specimens analyzed using various Roche assays. Multivariate logistic regression, the restricted cubic splines (RCS) analysis and weighted quantile sum (WQS) regression were employed to assess the association between LE8 Score and HPV infection risk. Our findings indicate a significant inverse association between the LE8 Score and HPV infection risk. Participants with medium and high LE8 Scores exhibited a 21% and 31% lower risk of HPV infection, respectively, compared to those with low LE8 Scores in multivariate logistic regression models. The analysis also revealed that lifestyle factors, particularly nicotine exposure and blood pressure, significantly contributed to the observed association. The study underscores the importance of healthy lifestyle behaviors in reducing the risk of HPV infection. Public health strategies promoting such behaviors could complement existing HPV prevention measures, potentially lowering the burden of HPV-related diseases. Future research should further investigate the mechanisms underlying this association and the effectiveness of lifestyle interventions in diverse populations.
Sections du résumé
BACKGROUND
BACKGROUND
Human Papillomavirus (HPV) infection has garnered significant attention due to its high prevalence and association with various cancers and other health conditions. Composite lifestyle factors may influence the risk of HPV infection, yet their cumulative impact remains insufficiently explored. This study aims to explore the association between the Life's Essential 8 (LE8) Score and HPV infection status, highlighting the potential role of lifestyle and health behaviors in HPV infection prevention.
METHODS
METHODS
Utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005-2016, we analyzed the health and nutritional statuses of 6,773 participants after excluding those with missing HPV infection status, inability to calculate the LE8 Score, and missing covariate data. The LE8 Score was computed based on eight cardiovascular health metrics, encompassing both health factors (BMI, non-HDL cholesterol, blood pressure, and blood glucose) and health behaviors (physical activity, diet, sleep duration, and nicotine exposure). HPV infection status was determined through vaginal swab specimens analyzed using various Roche assays. Multivariate logistic regression, the restricted cubic splines (RCS) analysis and weighted quantile sum (WQS) regression were employed to assess the association between LE8 Score and HPV infection risk.
RESULTS
RESULTS
Our findings indicate a significant inverse association between the LE8 Score and HPV infection risk. Participants with medium and high LE8 Scores exhibited a 21% and 31% lower risk of HPV infection, respectively, compared to those with low LE8 Scores in multivariate logistic regression models. The analysis also revealed that lifestyle factors, particularly nicotine exposure and blood pressure, significantly contributed to the observed association.
CONCLUSION
CONCLUSIONS
The study underscores the importance of healthy lifestyle behaviors in reducing the risk of HPV infection. Public health strategies promoting such behaviors could complement existing HPV prevention measures, potentially lowering the burden of HPV-related diseases. Future research should further investigate the mechanisms underlying this association and the effectiveness of lifestyle interventions in diverse populations.
Identifiants
pubmed: 39482693
doi: 10.1186/s12889-024-20546-1
pii: 10.1186/s12889-024-20546-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3028Informations de copyright
© 2024. The Author(s).
Références
Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, Vignat J, Ferlay J, Bray F, Plummer M, et al. Global burden of human papillomavirus and related diseases. Vaccine. 2012;30(Suppl 5):F12–23.
doi: 10.1016/j.vaccine.2012.07.055
pubmed: 23199955
Fu L, Tian T, Wang B, Lu Z, Bian J, Zhang W, Wu X, Li X, Siow RC, Fang EF, et al. Global, regional, and national burden of HIV and other sexually transmitted infections in older adults aged 60–89 years from 1990 to 2019: results from the global burden of Disease Study 2019. Lancet Healthy Longev. 2024;5(1):e17–30.
doi: 10.1016/S2666-7568(23)00214-3
pubmed: 38183996
de Martel C, Plummer M, Vignat J, Franceschi S. Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int J Cancer. 2017;141(4):664–70.
doi: 10.1002/ijc.30716
pubmed: 28369882
pmcid: 5520228
Oshman LD, Davis AM. Human papillomavirus vaccination for adults: updated recommendations of the Advisory Committee on Immunization Practices (ACIP). JAMA. 2020;323(5):468–9.
doi: 10.1001/jama.2019.18411
pubmed: 31930397
Moscicki AB, Schiffman M, Burchell A, Albero G, Giuliano AR, Goodman MT, Kjaer SK, Palefsky J. Updating the natural history of human papillomavirus and anogenital cancers. Vaccine. 2012;30(0 5):F24–33.
doi: 10.1016/j.vaccine.2012.05.089
pubmed: 23199964
pmcid: 3700362
Giuliano AR, Sedjo RL, Roe DJ, Harri R, Baldwi S, Papenfuss MR, Abrahamsen M, Inserra P. Clearance of oncogenic human papillomavirus (HPV) infection: effect of smoking (United States). Cancer Causes Control: CCC. 2002;13(9):839–46.
doi: 10.1023/A:1020668232219
pubmed: 12462549
Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Das SR, et al. Heart Disease and Stroke Statistics-2019 update: a Report from the American Heart Association. Circulation. 2019;139(10):e56–528.
doi: 10.1161/CIR.0000000000000659
pubmed: 30700139
Lloyd-Jones DM, Hong Y, Labarthe D, Mozaffarian D, Appel LJ, Van Horn L, Greenlund K, Daniels S, Nichol G, Tomaselli GF, et al. Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association’s strategic impact goal through 2020 and beyond. Circulation. 2010;121(4):586–613.
doi: 10.1161/CIRCULATIONAHA.109.192703
pubmed: 20089546
Nieman DC, Wentz LM. The compelling link between physical activity and the body’s defense system. J Sport Health Sci. 2019;8(3):201–17.
doi: 10.1016/j.jshs.2018.09.009
pubmed: 31193280
Christ A, Lauterbach M, Latz E. Western Diet and the Immune System: an inflammatory connection. Immunity. 2019;51(5):794–811.
doi: 10.1016/j.immuni.2019.09.020
pubmed: 31747581
Simpson RJ, Kunz H, Agha N, Graff R. Exercise and the regulation of Immune functions. Prog Mol Biol Transl Sci. 2015;135:355–80.
doi: 10.1016/bs.pmbts.2015.08.001
pubmed: 26477922
Wintergerst ES, Maggini S, Hornig DH. Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab. 2007;51(4):301–23.
doi: 10.1159/000107673
pubmed: 17726308
Moscicki AB, Ma Y, Farhat S, Jay J, Hanson E, Benningfield S, Jonte J, Godwin-Medina C, Wilson R, Shiboski S. Natural history of anal human papillomavirus infection in heterosexual women and risks associated with persistence. Clin Infect Dis. 2014;58(6):804–11.
doi: 10.1093/cid/cit947
pubmed: 24368624
Ford ES, Ajani UA, Croft JB, Critchley JA, Labarthe DR, Kottke TE, Giles WH, Capewell S. Explaining the decrease in U.S. deaths from coronary disease, 1980–2000. N Engl J Med. 2007;356(23):2388–98.
doi: 10.1056/NEJMsa053935
pubmed: 17554120
Lloyd-Jones DM, Allen NB, Anderson CAM, Black T, Brewer LC, Foraker RE, Grandner MA, Lavretsky H, Perak AM, Sharma G, et al. Life’s essential 8: updating and enhancing the American Heart Association’s construct of Cardiovascular Health: a Presidential Advisory from the American Heart Association. Circulation. 2022;146(5):e18–43.
doi: 10.1161/CIR.0000000000001078
pubmed: 35766027
pmcid: 10503546
Zhang J, Chen G, Habudele Z, Wang X, Cai M, Li H, Gao Y, Lip GYH, Lin H. Relation of Life’s essential 8 to the genetic predisposition for cardiovascular outcomes and all-cause mortality: results from a national prospective cohort. Eur J Prev Cardiol. 2023;30(15):1676–85.
doi: 10.1093/eurjpc/zwad179
pubmed: 37228091
Lloyd-Jones DM, Ning H, Labarthe D, Brewer L, Sharma G, Rosamond W, Foraker RE, Black T, Grandner MA, Allen NB, et al. Status of Cardiovascular Health in US adults and Children Using the American Heart Association’s New Life’s essential 8 Metrics: Prevalence Estimates from the National Health and Nutrition Examination Survey (NHANES), 2013 through 2018. Circulation. 2022;146(11):822–35.
doi: 10.1161/CIRCULATIONAHA.122.060911
pubmed: 35766033
Krebs-Smith SM, Pannucci TE, Subar AF, Kirkpatrick SI, Lerman JL, Tooze JA, Wilson MM, Reedy J. Update of the healthy eating index: HEI-2015. J Acad Nutr Dietetics. 2018;118(9):1591–602.
doi: 10.1016/j.jand.2018.05.021
Rao JNK, Scott AJ. On Chi-Squared tests for Multiway Contingency Tables with cell proportions estimated from Survey Data. Annals Stat. 1984;12(1):46–60.
doi: 10.1214/aos/1176346391
Stapleton JH. Linear statistical models. Volume 719. Wiley; 2009.
Frank EH. Regression modeling strategies with applications to linear models, logistic and ordinal regression, and survival analysis. In.: Spinger; 2015.
Carrico C, Gennings C, Wheeler DC, Factor-Litvak P. Characterization of weighted quantile sum regression for highly correlated data in a risk analysis setting. J Agricultural Biol Environ Stat. 2015;20:100–20.
doi: 10.1007/s13253-014-0180-3
Yorita Christensen KL, Carrico CK, Sanyal AJ, Gennings C. Multiple classes of environmental chemicals are associated with liver disease: NHANES 2003–2004. Int J Hyg Environ Health. 2013;216(6):703–9.
doi: 10.1016/j.ijheh.2013.01.005
pubmed: 23491026
pmcid: 3713174
Allen NB, Siddique J, Wilkins JT, Shay C, Lewis CE, Goff DC, Jacobs DR Jr., Liu K, Lloyd-Jones D. Blood pressure trajectories in early adulthood and subclinical atherosclerosis in middle age. JAMA. 2014;311(5):490–7.
doi: 10.1001/jama.2013.285122
pubmed: 24496536
pmcid: 4122296
Gravitt PE. The known unknowns of HPV natural history. J Clin Investig. 2011;121(12):4593–9.
doi: 10.1172/JCI57149
pubmed: 22133884
pmcid: 3225991
Calder PC, Carr AC, Gombart AF, Eggersdorfer M. Optimal nutritional status for a well-functioning Immune System is an important factor to protect against viral infections. Nutrients 2020, 12(4).
Ye X, Wang Y, Zou Y, Tu J, Tang W, Yu R, Yang S, Huang P. Associations of socioeconomic status with infectious diseases mediated by lifestyle, environmental pollution and chronic comorbidities: a comprehensive evaluation based on UK Biobank. Infect Dis Poverty. 2023;12(1):5.
doi: 10.1186/s40249-023-01056-5
pubmed: 36717939
pmcid: 9885698
Li Y, Pan A, Wang DD, Liu X, Dhana K, Franco OH, Kaptoge S, Di Angelantonio E, Stampfer M, Willett WC, et al. Impact of healthy lifestyle factors on life expectancies in the US Population. Circulation. 2018;138(4):345–55.
doi: 10.1161/CIRCULATIONAHA.117.032047
pubmed: 29712712
pmcid: 6207481
Shane AL, Sánchez PJ, Stoll BJ. Neonatal sepsis. Lancet (London England). 2017;390(10104):1770–80.
doi: 10.1016/S0140-6736(17)31002-4
pubmed: 28434651
He CS, Handzlik M, Fraser WD, Muhamad A, Preston H, Richardson A, Gleeson M. Influence of vitamin D status on respiratory infection incidence and immune function during 4 months of winter training in endurance sport athletes. Exerc Immunol Rev. 2013;19:86–101.
pubmed: 23977722
Zhao X, Wu Y, Hu H. Healthy lifestyle and HPV infection risk: results from a cross-sectional study. Front Public Health. 2024;12:1421636.
doi: 10.3389/fpubh.2024.1421636
pubmed: 39416948
pmcid: 11479906
Koshiol J, Schroeder J, Jamieson DJ, Marshall SW, Duerr A, Heilig CM, Shah KV, Klein RS, Cu-Uvin S, Schuman P. Smoking and time to clearance of human papillomavirus infection in HIV-seropositive and HIV-seronegative women. Am J Epidemiol. 2006;164(2):176–83.
doi: 10.1093/aje/kwj165
pubmed: 16775041
Campbell JP, Turner JE. Debunking the myth of Exercise-Induced Immune suppression: redefining the Impact of Exercise on Immunological Health across the Lifespan. Front Immunol. 2018;9:648.
doi: 10.3389/fimmu.2018.00648
pubmed: 29713319
pmcid: 5911985
Ghosh TS, Rampelli S, Jeffery IB, Santoro A, Neto M, Capri M, Giampieri E, Jennings A, Candela M, Turroni S, et al. Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries. Gut. 2020;69(7):1218–28.
doi: 10.1136/gutjnl-2019-319654
pubmed: 32066625
Nosalski R, McGinnigle E, Siedlinski M, Guzik TJ. Novel Immune mechanisms in Hypertension and Cardiovascular Risk. Curr Cardiovasc Risk Rep. 2017;11(4):12.
doi: 10.1007/s12170-017-0537-6
pubmed: 28360962
pmcid: 5339316
Goldin A, Beckman JA, Schmidt AM, Creager MA. Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation. 2006;114(6):597–605.
doi: 10.1161/CIRCULATIONAHA.106.621854
pubmed: 16894049
Colsoul ML, Goderniaux N, Onorati S, Dupuis S, Jamart J, Vanpee D, Berlin I, Galanti L. Changes in biomarkers of endothelial function, oxidative stress, inflammation and lipids after smoking cessation: a cohort study. Eur J Clin Invest. 2023;53(8):e13996.
doi: 10.1111/eci.13996
pubmed: 37000021
Dharmashankar K, Widlansky ME. Vascular endothelial function and hypertension: insights and directions. Curr Hypertens Rep. 2010;12(6):448–55.
doi: 10.1007/s11906-010-0150-2
pubmed: 20857237
pmcid: 2982873
Thomson NC, Polosa R, Sin DD. Cigarette smoking and asthma. J Allergy Clin Immunol Pract. 2022;10(11):2783–97.
Virdis A, Duranti E, Taddei S. Oxidative stress and vascular damage in hypertension: role of angiotensin II. Int J Hypertens. 2011;2011:916310.
doi: 10.4061/2011/916310
pubmed: 21747985
pmcid: 3124711
Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Delling FN, et al. Heart Disease and Stroke Statistics-2020 update: a Report from the American Heart Association. Circulation. 2020;141(9):e139–596.
doi: 10.1161/CIR.0000000000000757
pubmed: 31992061
Nasreddine L, Tamim H, Itani L, Nasrallah MP, Isma’eel H, Nakhoul NF, Abou-Rizk J, Naja F. A minimally processed dietary pattern is associated with lower odds of metabolic syndrome among Lebanese adults. Public Health Nutr. 2018;21(1):160–71.
doi: 10.1017/S1368980017002130
pubmed: 28965534