Calcineurin inhibition enhances
Animals
Caenorhabditis elegans
/ physiology
Longevity
Caenorhabditis elegans Proteins
/ metabolism
Calcineurin
/ metabolism
Signal Transduction
Caloric Restriction
Defecation
/ drug effects
Receptors, Cytoplasmic and Nuclear
/ metabolism
Calcineurin Inhibitors
/ pharmacology
Immunity, Innate
Basic Helix-Loop-Helix Transcription Factors
C. elegans
Intestinal bloating
calorie restriction
cell biology
genetics
genomics
hlh-30
longevity
nhr-8
tax-6
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
01 Nov 2024
01 Nov 2024
Historique:
medline:
1
11
2024
pubmed:
1
11
2024
entrez:
1
11
2024
Statut:
epublish
Résumé
Calcineurin is a highly conserved calcium/calmodulin-dependent serine/threonine protein phosphatase with diverse functions. Inhibition of calcineurin is known to enhance the lifespan of Many research efforts currently focus on identifying the dietary, pharmacological or genetic interventions that could help to prolong life. In the process, these investigations often uncover complex or even unexpected relationships between a range of physiological processes
Autres résumés
Type: plain-language-summary
(eng)
Many research efforts currently focus on identifying the dietary, pharmacological or genetic interventions that could help to prolong life. In the process, these investigations often uncover complex or even unexpected relationships between a range of physiological processes
Identifiants
pubmed: 39485281
doi: 10.7554/eLife.89572
pii: 89572
doi:
pii:
Substances chimiques
Caenorhabditis elegans Proteins
0
Calcineurin
EC 3.1.3.16
HLH-30 protein, C elegans
0
Receptors, Cytoplasmic and Nuclear
0
Calcineurin Inhibitors
0
Basic Helix-Loop-Helix Transcription Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Department of Biotechnology, Ministry of Science and Technology, India
ID : HRD-17011/2/2023-HRD-DBT
Organisme : Department of Biotechnology, Ministry of Science and Technology, India
ID : BT/RLF/Re-entry/50/2020
Organisme : Ministry of Education, India
ID : MoE-STARS/STARS-2/2023-0116
Organisme : Council of Scientific and Industrial Research, India
ID : 37/1741/23/EMR-II
Organisme : Science and Engineering Research Board
ID : CRG/2023/001136
Organisme : Science and Engineering Research Board
ID : SRG/2020/000022
Informations de copyright
© 2023, Das et al.
Déclaration de conflit d'intérêts
PD, AA, JS No competing interests declared