Conservation of the cooling agent binding pocket within the TRPM subfamily.

TRPM Cation Channels / metabolism Animals Binding Sites Mice Pyrimidinones / pharmacology Humans HEK293 Cells Calcium / metabolism Protein Binding
TRPM channels cool agents intracellular calcium molecular biophysics mouse structural biology voltage

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
01 Nov 2024
Historique:
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 1 11 2024
Statut: epublish

Résumé

Transient receptor potential (TRP) channels are a large and diverse family of tetrameric cation-selective channels that are activated by many different types of stimuli, including noxious heat or cold, organic ligands such as vanilloids or cooling agents, or intracellular Ca

Identifiants

DOI: 10.7554/eLife.99643 PMID: 39485376
pubmed: 39485376
doi: 10.7554/eLife.99643
pii: 99643
doi:
pii:

Substances chimiques

TRPM Cation Channels 0
Pyrimidinones 0
icilin CS70PZQ4QJ
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NINDS NIH HHS
ID : NS002945-28
Pays : United States

Déclaration de conflit d'intérêts

KH, MD, EO No competing interests declared, KS Reviewing editor, eLife

Auteurs

Kate Huffer (K)

Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.
ORCID: 0000-0001-5003-3140

Matthew C S Denley (MCS)

Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.
ORCID: 0000-0003-2798-9448

Elisabeth V Oskoui (EV)

Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.
ORCID: 0009-0002-5714-5991

Kenton J Swartz (KJ)

Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.
ORCID: 0000-0003-3419-0765

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux cationiques TRP › Canaux cationiques TRPM › Conservation of the cooling agent binding...
questionsmedicales.fr › Eucaryotes › Animaux › Conservation of the cooling agent binding...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Conservation of the cooling agent binding...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Conservation of the cooling agent binding...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Conservation of the cooling agent binding...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Conservation of the cooling agent binding...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Conservation of the cooling agent binding...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Conservation of the cooling agent binding...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Conservation of the cooling agent binding...