Synergistic effects of curcumin and stem cells on spinal cord injury: a comprehensive review.
Combination therapy
Curcumin
Spinal cord injury
Stem cells
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
01 Nov 2024
01 Nov 2024
Historique:
received:
30
07
2024
accepted:
24
10
2024
medline:
1
11
2024
pubmed:
1
11
2024
entrez:
1
11
2024
Statut:
epublish
Résumé
Spinal cord injury (SCI) is damage to the spinal cord that permanently or temporarily disrupts its function, causing considerable autonomic, sensory, and motor disorders, and involves between 10 and 83 cases per million yearly. Traumatic SCI happens following primary acute mechanical damage, leading to injury to the spinal cord tissue and worsening clinical outcomes. The present therapeutic strategies for this complex disease fundamentally rely on surgical approaches and conservative remedies. However, these modalities are not effective enough for neurological recovery. Therefore, it is necessary to discover more efficient methods to treat patients with SCI. Today, considerable attention has been drawn to bioactive compounds-based remedies and stem cell therapy for curing various ailments and disorders, such as neurological diseases. Some researchers have recommended that harnessing curcumin, a polyphenol obtained from turmeric, in combination with stem cells, like mesenchymal stem cells, neural stem cells, and ependymal stem cells, can remarkably improve neurological recovery-related parameters more effective than the treatment with these two methods separately in experimental models. Hereby, this literature review delves into the functionality of curcumin combined with stem cells in treating SCI with a focus on cellular and molecular mechanisms.
Identifiants
pubmed: 39485550
doi: 10.1007/s11033-024-10057-y
pii: 10.1007/s11033-024-10057-y
doi:
Substances chimiques
Curcumin
IT942ZTH98
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1113Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
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