High mitochondrial DNA levels accelerate lung adenocarcinoma progression.

DNA, Mitochondrial / genetics Animals Adenocarcinoma of Lung / genetics Disease Progression Mice Mice, Transgenic Humans Lung Neoplasms / genetics Mitochondria / metabolism DNA Copy Number Variations Disease Models, Animal Proto-Oncogene Proteins p21(ras) / genetics

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
Nov 2024
Historique:
medline: 2 11 2024
pubmed: 2 11 2024
entrez: 1 11 2024
Statut: ppublish

Résumé

Lung adenocarcinoma is a common aggressive cancer and a leading cause of mortality worldwide. Here, we report an important in vivo role for mitochondrial DNA (mtDNA) copy number during lung adenocarcinoma progression in the mouse. We found that lung tumors induced by KRAS

Identifiants

DOI: 10.1126/sciadv.adp3481 PMID: 39485842
pubmed: 39485842
doi: 10.1126/sciadv.adp3481
doi:

Substances chimiques

DNA, Mitochondrial 0
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadp3481

Auteurs

Mara Mennuni (M)

Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0001-6199-6233

Stephen E Wilkie (SE)

Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-1826-7737

Pauline Michon (P)

Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0003-0773-5272

David Alsina (D)

Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0003-0708-7391

Roberta Filograna (R)

Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-6581-9426

Markus Lindberg (M)

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
ORCID: 0000-0001-8984-8064

David E Sanin (DE)

Bloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0003-0188-7267

Florian Rosenberger (F)

Max Planck Institute of Biochemistry, Department of Proteomics and Signal Transduction, Munich, Germany.
ORCID: 0000-0003-4604-6170

Alina Schaaf (A)

Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

Erik Larsson (E)

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
ORCID: 0000-0003-1400-0119

Erika L Pearce (EL)

Bloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0001-5592-5439

Nils-Göran Larsson (NG)

Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0001-5100-996X

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN mitochondrial › High mitochondrial DNA levels accelerate lung...
questionsmedicales.fr › Eucaryotes › Animaux › High mitochondrial DNA levels accelerate lung...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs du thorax › Adénocarcinome pulmonaire › High mitochondrial DNA levels accelerate lung...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › High mitochondrial DNA levels accelerate lung...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › High mitochondrial DNA levels accelerate lung...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › High mitochondrial DNA levels accelerate lung...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › High mitochondrial DNA levels accelerate lung...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › High mitochondrial DNA levels accelerate lung...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › High mitochondrial DNA levels accelerate lung...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Variation structurale du génome › Variations de nombre de copies de segment d'ADN › High mitochondrial DNA levels accelerate lung...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › High mitochondrial DNA levels accelerate lung...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes p21(ras) › High mitochondrial DNA levels accelerate lung...