A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia.

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism Animals Mice Humans Cell Line, Tumor Cell Proliferation Adaptor Proteins, Signal Transducing / metabolism Mitochondria / metabolism Gene Expression Regulation, Leukemic Electron Transport Complex IV / metabolism

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
Nov 2024
Historique:
medline: 2 11 2024
pubmed: 2 11 2024
entrez: 1 11 2024
Statut: ppublish

Résumé

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy. Current intensified therapeutic protocols coincide with severe side effects, and no salvage therapy is available for primary therapy-resistant or relapsed patients. This highlights the need to identify new therapeutic targets in T-ALL. PSIP1, dispensable for normal hematopoiesis, is a dependency factor in

Identifiants

DOI: 10.1126/sciadv.ado6765 PMID: 39485844
pubmed: 39485844
doi: 10.1126/sciadv.ado6765
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
Electron Transport Complex IV EC 1.9.3.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eado6765

Auteurs

Lisa Demoen (L)

Lab of Normal and Malignant Hematopoiesis, Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
Cancer Research Institute Ghent (CRIG), Ghent University, 9000 Ghent, Belgium.
ORCID: 0000-0001-7035-0266

Filip Matthijssens (F)

Lab of Normal and Malignant Hematopoiesis, Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
Cancer Research Institute Ghent (CRIG), Ghent University, 9000 Ghent, Belgium.

Lindy Reunes (L)

Lab of Normal and Malignant Hematopoiesis, Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
Cancer Research Institute Ghent (CRIG), Ghent University, 9000 Ghent, Belgium.

Bruno Palhais (B)

Lab of Normal and Malignant Hematopoiesis, Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
Cancer Research Institute Ghent (CRIG), Ghent University, 9000 Ghent, Belgium.
ORCID: 0000-0003-3733-6256

Béatrice Lintermans (B)

Lab of Normal and Malignant Hematopoiesis, Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
Cancer Research Institute Ghent (CRIG), Ghent University, 9000 Ghent, Belgium.
ORCID: 0000-0003-4842-944X

Sara T'Sas (S)

Cancer Research Institute Ghent (CRIG), Ghent University, 9000 Ghent, Belgium.
Unit for Translational Research in Oncology, Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium.
ORCID: 0000-0003-4256-9775

Igor Fijalkowski (I)

Cancer Research Institute Ghent (CRIG), Ghent University, 9000 Ghent, Belgium.
Leukemia Therapy Resistance Laboratory, Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
ORCID: 0000-0002-3212-5516

Joachim Taminau (J)

Cancer Research Institute Ghent (CRIG), Ghent University, 9000 Ghent, Belgium.
Department Biomedical Molecular Biology, 9000 Ghent University, Ghent, Belgium.

Muluembet Z Akele (MZ)

Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit (KU) Leuven, 3000 Leuven, Belgium.

Siska Van Belle (S)

Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit (KU) Leuven, 3000 Leuven, Belgium.
ORCID: 0000-0002-1179-3064

Tom Taghon (T)

Cancer Research Institute Ghent (CRIG), Ghent University, 9000 Ghent, Belgium.
T Cell Team Taghon, Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium.
ORCID: 0000-0002-5781-0288

Dieter Deforce (D)

Laboratory of Pharmaceutical Biotechnology, Ghent University, 9000 Ghent, Belgium.
ORCID: 0000-0002-0635-661X

Filip Van Nieuwerburgh (F)

Laboratory of Pharmaceutical Biotechnology, Ghent University, 9000 Ghent, Belgium.
ORCID: 0000-0001-8815-5485

Geert Berx (G)

Cancer Research Institute Ghent (CRIG), Ghent University, 9000 Ghent, Belgium.
Department Biomedical Molecular Biology, 9000 Ghent University, Ghent, Belgium.
ORCID: 0000-0001-5770-2458

Panagiotis Ntziachristos (P)

Cancer Research Institute Ghent (CRIG), Ghent University, 9000 Ghent, Belgium.
Leukemia Therapy Resistance Laboratory, Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.

Zeger Debyser (Z)

Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit (KU) Leuven, 3000 Leuven, Belgium.
ORCID: 0000-0002-3982-1565

Kaat Durinck (K)

Cancer Research Institute Ghent (CRIG), Ghent University, 9000 Ghent, Belgium.
Pediatric Precision Oncology Lab, Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
ORCID: 0000-0003-1762-5739

Tim Pieters (T)

Lab of Normal and Malignant Hematopoiesis, Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
Cancer Research Institute Ghent (CRIG), Ghent University, 9000 Ghent, Belgium.
Unit for Translational Research in Oncology, Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium.
Leukemia Therapy Resistance Laboratory, Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
ORCID: 0000-0002-2958-0104

Steven Goossens (S)

Cancer Research Institute Ghent (CRIG), Ghent University, 9000 Ghent, Belgium.
Unit for Translational Research in Oncology, Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium.
ORCID: 0000-0002-5693-8570

Pieter Van Vlierberghe (P)

Lab of Normal and Malignant Hematopoiesis, Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
Cancer Research Institute Ghent (CRIG), Ghent University, 9000 Ghent, Belgium.
ORCID: 0000-0001-9063-7205

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Leucémie lymphoïde › Leucémie-lymphome lymphoblastique à précurseurs B et T › Leucémie-lymphome lymphoblastique à précurseurs T › A dual role for PSIP1/LEDGF in T cell acute...
questionsmedicales.fr › Eucaryotes › Animaux › A dual role for PSIP1/LEDGF in T cell acute...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A dual role for PSIP1/LEDGF in T cell acute...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A dual role for PSIP1/LEDGF in T cell acute...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › A dual role for PSIP1/LEDGF in T cell acute...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › A dual role for PSIP1/LEDGF in T cell acute...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › A dual role for PSIP1/LEDGF in T cell acute...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › A dual role for PSIP1/LEDGF in T cell acute...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Régulation de l'expression des gènes dans la leucémie › A dual role for PSIP1/LEDGF in T cell acute...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs de cations › Pompes à protons › Complexe IV de la chaîne respiratoire › A dual role for PSIP1/LEDGF in T cell acute...