Adam Skarka

Affiliations

Department of Chemistry, Faculty of Sciences, University of Hradec Kralove, Hradecká 1285, 500 03 Hradec Kralove, Czech Republic.

Publications (15)

Role of N-Cadherin in Epithelial-to-Mesenchymal Transition and Chemosensitivity of Colon Carcinoma Cells.

Cancers

Avec: Veronika Skarkova , Barbora Vitovcova , Petra Matouskova , Monika Manethova , Petra Kazimirova , Adam Skarka , Veronika Brynychova , Pavel Soucek , Hana Vosmikova , Emil Rudolf

The Evaluation of Glioblastoma Cell Dissociation and Its Influence on Its Behavior.

International journal of molecular sciences

Avec: Veronika Skarkova , Marketa Krupova , Barbora Vitovcova , Adam Skarka , Petra Kasparova , Petr Krupa , Vera Kralova , Emil Rudolf

Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents.

Archives of toxicology

Avec: Eliska Prchalova , Rudolf Andrys , Jaroslav Pejchal , Zuzana Kohoutova , Karolina Knittelova , Tereza Hofmanova , Adam Skarka , Alzbeta Dlabkova , Miroslav Psotka , Lukas Prchal , Kamil Musilek , Jana Zdarova Karasova , David Malinak

Tepotinib Inhibits Several Drug Efflux Transporters and Biotransformation Enzymes: The Role in Drug-Drug Interactions and Targeting Cytostatic Resistance In Vitro and Ex Vivo.

International journal of molecular sciences

Avec: Dimitrios Vagiannis , Youssif Budagaga , Anselm Morell , Yu Zhang , Eva Novotná , Adam Skarka , Sarah Kammerer , Jan-Heiner Küpper , Ivo Hanke , Tomáš Rozkoš , Jakub Hofman

Alisertib shows negligible potential for perpetrating pharmacokinetic drug-drug interactions on ABCB1, ABCG2 and cytochromes P450, but acts as dual-activity resistance modulator through the inhibition of ABCC1 transporter.

Toxicology and applied pharmacology

Avec: Dimitrios Vagiannis , Yu Zhang , Youssif Budagaga , Eva Novotna , Adam Skarka , Sarah Kammerer , Jan-Heiner Küpper , Jakub Hofman

Frentizole derivatives with mTOR inhibiting and senomorphic properties.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Avec: Zofia Chrienova , David Rysanek , Josef Novak , Pavla Vasicova , Patrik Oleksak , Rudolf Andrys , Adam Skarka , Jelena Dumanovic , Zoran Milovanovic , Vesna Jacevic , Marketa Chvojkova , Kristina Holubova , Karel Vales , Veronika Skoupilova , Marian Valko , Klaudia Jomova , Suliman Y Alomar , Fernanda D Botelho , Tanos C C Franca , Kamil Kuca , Zdenek Hodny , Eugenie Nepovimova

Carbonyl Reduction of Flubendazole in the Human Liver: Strict Stereospecificity, Sex Difference, Low Risk of Drug Interactions.

Frontiers in pharmacology

Avec: Vladimír Kubíček , Lenka Skálová , Adam Skarka , Věra Králová , Jana Holubová , Jana Štěpánková , Zdeněk Šubrt , Barbora Szotáková

Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme.

Cancers

Avec: Dimitrios Vagiannis , Eva Novotna , Adam Skarka , Sarah Kammerer , Jan-Heiner Küpper , Si Chen , Lei Guo , Frantisek Staud , Jakub Hofman

Silencing of E-cadherin expression leads to increased chemosensitivity to irinotecan and oxaliplatin in colorectal cancer cell lines.

Human & experimental toxicology

Avec: Veronika Skarkova , Adam Skarka , Monika Manethova , Afroditi A Stefanidi , Emil Rudolf

Expression of STAT3 and hypoxia markers in long-term surviving malignant glioma patients.

BMC cancer

Avec: Katerina Dvorakova , Veronika Skarkova , Barbora Vitovcova , Jiri Soukup , Hana Vosmikova , Zuzana Pleskacova , Adam Skarka , Michael Christian Bartos , Petr Krupa , Petra Kasparova , Jiri Petera , Emil Rudolf

Development of submicromolar 17β-HSD10 inhibitors and their in vitro and in vivo evaluation.

European journal of medicinal chemistry

Avec: Ondrej Benek , Michaela Vaskova , Marketa Miskerikova , Monika Schmidt , Rudolf Andrys , Aneta Rotterova , Adam Skarka , Jana Hatlapatkova , Jana Zdarova Karasova , Matej Medvecky , Lukas Hroch , Lucie Vinklarova , Zdenek Fisar , Jana Hroudova , Jiri Handl , Jan Capek , Tomas Rousar , Tereza Kobrlova , Rafael Dolezal , Ondrej Soukup , Laura Aitken , Frank Gunn-Moore , Kamil Musilek

Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates.

Journal of enzyme inhibition and medicinal chemistry

Avec: Hyun Myung Lee , Rudolf Andrys , Jakub Jonczyk , Kyuneun Kim , Avinash G Vishakantegowda , David Malinak , Adam Skarka , Monika Schmidt , Michaela Vaskova , Kamil Latka , Marek Bajda , Young-Sik Jung , Barbara Malawska , Kamil Musilek

Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics.

Frontiers in aging neuroscience

Avec: Zofia Chrienova , David Rysanek , Patrik Oleksak , Dorota Stary , Marek Bajda , Milan Reinis , Romana Mikyskova , Ondrej Novotny , Rudolf Andrys , Adam Skarka , Pavla Vasicova , Josef Novak , Martin Valis , Kamil Kuca , Zdenek Hodny , Eugenie Nepovimova

BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Avec: Eliska Prchalova , Martina Sukupova , David Malinak , Rudolf Andrys , Ladislav Sivak , Vladimir Pekarik , Adam Skarka , Jana Svobodova , Lukas Prchal , Lukas Fresser , Zbynek Heger , Kamil Musilek

7-Amino-3-phenyl-2-methyl-pyrazolopyrimidine derivatives inhibit human rhinovirus replication.

European journal of medicinal chemistry

Avec: Prashant Chakrasali , Dasom Hwang , Joo-Youn Lee , Eunhye Jung , Hye Lim Lee , Alba Reneesh , Adam Skarka , Kamil Musilek , Nhung Hong Nguyen , Jin Soo Shin , Young-Sik Jung

Réseau de co-auteurs

Rudolf Andrys 6 collaborations

Kamil Musilek 5 collaborations

Veronika Skarkova 4 collaborations

Emil Rudolf 4 collaborations

Barbora Vitovcova 3 collaborations

David Malinak 3 collaborations

Dimitrios Vagiannis 3 collaborations

Sarah Kammerer 3 collaborations

Jan-Heiner Küpper 3 collaborations

Jakub Hofman 3 collaborations

Monika Manethova 2 collaborations

Hana Vosmikova 2 collaborations

Petra Kasparova 2 collaborations

Petr Krupa 2 collaborations

Eliska Prchalova 2 collaborations

Lukas Prchal 2 collaborations

Jana Zdarova Karasova 2 collaborations

Youssif Budagaga 2 collaborations

Yu Zhang 2 collaborations

Eva Novotna 2 collaborations

Zofia Chrienova 2 collaborations

David Rysanek 2 collaborations

Josef Novak 2 collaborations

Pavla Vasicova 2 collaborations

Patrik Oleksak 2 collaborations

Kamil Kuca 2 collaborations

Zdenek Hodny 2 collaborations

Eugenie Nepovimova 2 collaborations

Michaela Vaskova 2 collaborations

Monika Schmidt 2 collaborations

Marek Bajda 2 collaborations

Young-Sik Jung 2 collaborations

Petra Matouskova 1 collaboration

Petra Kazimirova 1 collaboration

Veronika Brynychova 1 collaboration

Pavel Soucek 1 collaboration

Marketa Krupova 1 collaboration

Vera Kralova 1 collaboration

Jaroslav Pejchal 1 collaboration

Zuzana Kohoutova 1 collaboration

Karolina Knittelova 1 collaboration

Tereza Hofmanova 1 collaboration

Alzbeta Dlabkova 1 collaboration

Miroslav Psotka 1 collaboration

Anselm Morell 1 collaboration

Eva Novotná 1 collaboration

Ivo Hanke 1 collaboration

Tomáš Rozkoš 1 collaboration

Jelena Dumanovic 1 collaboration

Zoran Milovanovic 1 collaboration

Vesna Jacevic 1 collaboration

Marketa Chvojkova 1 collaboration

Kristina Holubova 1 collaboration

Karel Vales 1 collaboration

Veronika Skoupilova 1 collaboration

Marian Valko 1 collaboration

Klaudia Jomova 1 collaboration

Suliman Y Alomar 1 collaboration

Fernanda D Botelho 1 collaboration

Tanos C C Franca 1 collaboration

Vladimír Kubíček 1 collaboration

Lenka Skálová 1 collaboration

Věra Králová 1 collaboration

Jana Holubová 1 collaboration

Jana Štěpánková 1 collaboration

Zdeněk Šubrt 1 collaboration

Barbora Szotáková 1 collaboration

Si Chen 1 collaboration

Lei Guo 1 collaboration

Frantisek Staud 1 collaboration

Afroditi A Stefanidi 1 collaboration

Katerina Dvorakova 1 collaboration

Jiri Soukup 1 collaboration

Zuzana Pleskacova 1 collaboration

Michael Christian Bartos 1 collaboration

Jiri Petera 1 collaboration

Ondrej Benek 1 collaboration

Marketa Miskerikova 1 collaboration

Aneta Rotterova 1 collaboration

Jana Hatlapatkova 1 collaboration

Matej Medvecky 1 collaboration

Lukas Hroch 1 collaboration

Lucie Vinklarova 1 collaboration

Zdenek Fisar 1 collaboration

Jana Hroudova 1 collaboration

Jiri Handl 1 collaboration

Jan Capek 1 collaboration

Tomas Rousar 1 collaboration

Tereza Kobrlova 1 collaboration

Rafael Dolezal 1 collaboration

Ondrej Soukup 1 collaboration

Laura Aitken 1 collaboration

Frank Gunn-Moore 1 collaboration

Hyun Myung Lee 1 collaboration

Jakub Jonczyk 1 collaboration

Kyuneun Kim 1 collaboration

Avinash G Vishakantegowda 1 collaboration

Kamil Latka 1 collaboration

Barbara Malawska 1 collaboration

Dorota Stary 1 collaboration

Milan Reinis 1 collaboration

Romana Mikyskova 1 collaboration

Ondrej Novotny 1 collaboration

Martin Valis 1 collaboration

Martina Sukupova 1 collaboration

Ladislav Sivak 1 collaboration

Vladimir Pekarik 1 collaboration

Jana Svobodova 1 collaboration

Lukas Fresser 1 collaboration

Zbynek Heger 1 collaboration

Prashant Chakrasali 1 collaboration

Dasom Hwang 1 collaboration

Joo-Youn Lee 1 collaboration

Eunhye Jung 1 collaboration

Hye Lim Lee 1 collaboration

Alba Reneesh 1 collaboration

Nhung Hong Nguyen 1 collaboration

Jin Soo Shin 1 collaboration