Alexandra Demcsák

Affiliations

Department of Surgery, University of California Los Angeles, Los Angeles, California, USA.

Publications (16)

Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.

The Journal of biological chemistry

Avec: András Szabó , Vanda Toldi , Lívia Diána Gazda , Alexandra Demcsák , József Tőzsér , Miklós Sahin-Tóth

Evolutionary expansion of polyaspartate motif in the activation peptide of mouse cationic trypsinogen limits autoactivation and protects against pancreatitis.

American journal of physiology. Gastrointestinal and liver physiology

Avec: Anna Orekhova , Balázs Csaba Németh , Zsanett Jancsó , Andrea Geisz , Dóra Mosztbacher , Alexandra Demcsák , Miklós Sahin-Tóth

Measuring digestive protease activation in the mouse pancreas.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Avec: Dóra Mosztbacher , Alexandra Demcsák , Miklós Sahin-Tóth

Preclinical testing of dabigatran in trypsin-dependent pancreatitis.

JCI insight

Avec: Zsófia Gabriella Pesei , Zsanett Jancsó , Alexandra Demcsák , Balázs Csaba Németh , Sandor Vajda , Miklós Sahin-Tóth

Mouse model of PRSS1 p.R122H-related hereditary pancreatitis highlights context-dependent effect of autolysis-site mutation.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Avec: Zsanett Jancsó , Nataly C Morales Granda , Alexandra Demcsák , Miklós Sahin-Tóth

Misfolding-induced chronic pancreatitis in CPA1 N256K mutant mice is unaffected by global deletion of Ddit3/Chop.

Scientific reports

Avec: Balázs Csaba Németh , Alexandra Demcsák , Andrea Geisz , Miklós Sahin-Tóth

Arg236 in human chymotrypsin B2 (CTRB2) is a key determinant of high enzyme activity, trypsinogen degradation capacity, and protection against pancreatitis.

Biochimica et biophysica acta. Proteins and proteomics

Avec: Bálint Zoltán Németh , Alexandra Demcsák , András Micsonai , Bence Kiss , Gitta Schlosser , Andrea Geisz , Eszter Hegyi , Miklós Sahin-Tóth , Gábor Pál

Novel p.G250A Mutation Associated with Chronic Pancreatitis Highlights Misfolding-Prone Region in Carboxypeptidase A1 (CPA1).

International journal of molecular sciences

Avec: Máté Sándor , Franziska G Thiel , Margit Schmid , Alexandra Demcsák , Nataly C Morales Granda , Balázs Csaba Németh , Sandor Vajda , André Hoerning , Miklós Sahin-Tóth

A case study of salivary microbiome in smokers and non-smokers in Hungary: analysis by shotgun metagenome sequencing.

Journal of oral microbiology

Avec: Roland Wirth , Gergely Maróti , Róbert Mihók , Donát Simon-Fiala , Márk Antal , Bernadett Pap , Anett Demcsák , Janos Minarovits , Kornél L Kovács

Substrate specificity of human chymotrypsin-like protease (CTRL) characterized by phage display-selected small-protein inhibitors.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Avec: Bálint Zoltán Németh , Zoltán Attila Nagy , Bence Kiss , Gabriella Gellén , Gitta Schlosser , Alexandra Demcsák , Andrea Geisz , Eszter Hegyi , Miklós Sahin-Tóth , Gábor Pál

Heterozygous Spink1 deficiency promotes trypsin-dependent chronic pancreatitis in mice.

Cellular and molecular gastroenterology and hepatology

Avec: Alexandra Demcsák , Miklós Sahin-Tóth

Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B.

Scientific reports

Avec: Alexandra Demcsák , Andrea Geisz , Miklós Sahin-Tóth

Acid suppression therapy, gastrointestinal bleeding and infection in acute pancreatitis - An international cohort study.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Avec: Alexandra Demcsák , Alexandra Soós , Lilla Kincses , Ines Capunge , Georgi Minkov , Mila Kovacheva-Slavova , Radislav Nakov , Dong Wu , Wei Huang , Qing Xia , Lihui Deng , Marcus Hollenbach , Alexander Schneider , Michael Hirth , Orestis Ioannidis , Áron Vincze , Judit Bajor , Patrícia Sarlós , László Czakó , Dóra Illés , Ferenc Izbéki , László Gajdán , Mária Papp , József Hamvas , Márta Varga , Péter Kanizsai , Ernő Bóna , Alexandra Mikó , Szilárd Váncsa , Márk Félix Juhász , Klementina Ocskay , Erika Darvasi , Emőke Miklós , Bálint Erőss , Andrea Szentesi , Andrea Párniczky , Riccardo Casadei , Claudio Ricci , Carlo Ingaldi , Laura Mastrangelo , Elio Jovine , Vincenzo Cennamo , Marco V Marino , Giedrius Barauskas , Povilas Ignatavicius , Mario Pelaez-Luna , Andrea Soriano Rios , Svetlana Turcan , Eugen Tcaciuc , Ewa Małecka-Panas , Hubert Zatorski , Vitor Nunes , Antonio Gomes , Tiago Cúrdia Gonçalves , Marta Freitas , Júlio Constantino , Milene Sá , Jorge Pereira , Bogdan Mateescu , Gabriel Constantinescu , Vasile Sandru , Ionut Negoi , Cezar Ciubotaru , Valentina Negoita , Stefania Bunduc , Cristian Gheorghe , Sorin Barbu , Alina Tantau , Marcel Tantau , Eugen Dumitru , Andra Iulia Suceveanu , Cristina Tocia , Adriana Gherbon , Andrey Litvin , Natalia Shirinskaya , Yliya Rabotyagova , Mihailo Bezmarevic , Péter Jenő Hegyi , Jimin Han , Juan Armando Rodriguez-Oballe , Isabel Miguel Salas , Eva Pijoan Comas , Daniel de la Iglesia Garcia , Andrea Jardi Cuadrado , Adriano Quiroga Castiñeira , Yu-Ting Chang , Ming-Chu Chang , Ali Kchaou , Ahmed Tlili , Sabite Kacar , Volkan Gökbulut , Deniz Duman , Haluk Tarik Kani , Engin Altintas , Serge Chooklin , Serhii Chuklin , Amir Gougol , George Papachristou , Péter Hegyi

Loss-of-function variant in chymotrypsin like elastase 3B (CELA3B) is associated with non-alcoholic chronic pancreatitis.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Avec: Andrea Tóth , Alexandra Demcsák , Florence Zankl , Grzegorz Oracz , Lara Sophie Unger , Peter Bugert , Helmut Laumen , Andrea Párniczky , Péter Hegyi , Jonas Rosendahl , Tomasz Gambin , Rafał Płoski , Dorota Koziel , Stanisław Gluszek , Fredrik Lindgren , J Matthias Löhr , Miklós Sahin-Tóth , Heiko Witt , Agnieszka Magdalena Rygiel , Maren Ewers , Eszter Hegyi

No evidence for the benefit of PPIs in the treatment of acute pancreatitis: a systematic review and meta-analysis.

Scientific reports

Avec: István László Horváth , Stefania Bunduc , Balázs Hankó , Dénes Kleiner , Alexandra Demcsák , Bence Szabó , Péter Hegyi , Dezső Csupor

Novel chymotrypsin C (CTRC) variants from real-world genetic testing of pediatric chronic pancreatitis cases.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Avec: Regina Stefanovics , Máté Sándor , Alexandra Demcsák , Gergő Berke , Balázs Csaba Németh , Wenying Zhang , Maisam Abu-El-Haija , Miklós Sahin-Tóth

Réseau de co-auteurs

Miklós Sahin-Tóth 13 collaborations

Balázs Csaba Németh 5 collaborations

Andrea Geisz 5 collaborations

Zsanett Jancsó 3 collaborations

Eszter Hegyi 3 collaborations

Péter Hegyi 3 collaborations

Dóra Mosztbacher 2 collaborations

Sandor Vajda 2 collaborations

Nataly C Morales Granda 2 collaborations

Bálint Zoltán Németh 2 collaborations

Bence Kiss 2 collaborations

Gitta Schlosser 2 collaborations

Gábor Pál 2 collaborations

Máté Sándor 2 collaborations

Andrea Párniczky 2 collaborations

Stefania Bunduc 2 collaborations

András Szabó 1 collaboration

Vanda Toldi 1 collaboration

Lívia Diána Gazda 1 collaboration

József Tőzsér 1 collaboration

Anna Orekhova 1 collaboration

Zsófia Gabriella Pesei 1 collaboration

András Micsonai 1 collaboration

Franziska G Thiel 1 collaboration

Margit Schmid 1 collaboration

André Hoerning 1 collaboration

Roland Wirth 1 collaboration

Gergely Maróti 1 collaboration

Róbert Mihók 1 collaboration

Donát Simon-Fiala 1 collaboration

Márk Antal 1 collaboration

Bernadett Pap 1 collaboration

Anett Demcsák 1 collaboration

Janos Minarovits 1 collaboration

Kornél L Kovács 1 collaboration

Zoltán Attila Nagy 1 collaboration

Gabriella Gellén 1 collaboration

Alexandra Soós 1 collaboration

Lilla Kincses 1 collaboration

Ines Capunge 1 collaboration

Georgi Minkov 1 collaboration

Mila Kovacheva-Slavova 1 collaboration

Radislav Nakov 1 collaboration

Dong Wu 1 collaboration

Wei Huang 1 collaboration

Qing Xia 1 collaboration

Lihui Deng 1 collaboration

Marcus Hollenbach 1 collaboration

Alexander Schneider 1 collaboration

Michael Hirth 1 collaboration

Orestis Ioannidis 1 collaboration

Áron Vincze 1 collaboration

Judit Bajor 1 collaboration

Patrícia Sarlós 1 collaboration

László Czakó 1 collaboration

Dóra Illés 1 collaboration

Ferenc Izbéki 1 collaboration

László Gajdán 1 collaboration

Mária Papp 1 collaboration

József Hamvas 1 collaboration

Márta Varga 1 collaboration

Péter Kanizsai 1 collaboration

Ernő Bóna 1 collaboration

Alexandra Mikó 1 collaboration

Szilárd Váncsa 1 collaboration

Márk Félix Juhász 1 collaboration

Klementina Ocskay 1 collaboration

Erika Darvasi 1 collaboration

Emőke Miklós 1 collaboration

Bálint Erőss 1 collaboration

Andrea Szentesi 1 collaboration

Riccardo Casadei 1 collaboration

Claudio Ricci 1 collaboration

Carlo Ingaldi 1 collaboration

Laura Mastrangelo 1 collaboration

Elio Jovine 1 collaboration

Vincenzo Cennamo 1 collaboration

Marco V Marino 1 collaboration

Giedrius Barauskas 1 collaboration

Povilas Ignatavicius 1 collaboration

Mario Pelaez-Luna 1 collaboration

Andrea Soriano Rios 1 collaboration

Svetlana Turcan 1 collaboration

Eugen Tcaciuc 1 collaboration

Ewa Małecka-Panas 1 collaboration

Hubert Zatorski 1 collaboration

Vitor Nunes 1 collaboration

Antonio Gomes 1 collaboration

Tiago Cúrdia Gonçalves 1 collaboration

Marta Freitas 1 collaboration

Júlio Constantino 1 collaboration

Milene Sá 1 collaboration

Jorge Pereira 1 collaboration

Bogdan Mateescu 1 collaboration

Gabriel Constantinescu 1 collaboration

Vasile Sandru 1 collaboration

Ionut Negoi 1 collaboration

Cezar Ciubotaru 1 collaboration

Valentina Negoita 1 collaboration

Cristian Gheorghe 1 collaboration

Sorin Barbu 1 collaboration

Alina Tantau 1 collaboration

Marcel Tantau 1 collaboration

Eugen Dumitru 1 collaboration

Andra Iulia Suceveanu 1 collaboration

Cristina Tocia 1 collaboration

Adriana Gherbon 1 collaboration

Andrey Litvin 1 collaboration

Natalia Shirinskaya 1 collaboration

Yliya Rabotyagova 1 collaboration

Mihailo Bezmarevic 1 collaboration

Péter Jenő Hegyi 1 collaboration

Jimin Han 1 collaboration

Juan Armando Rodriguez-Oballe 1 collaboration

Isabel Miguel Salas 1 collaboration

Eva Pijoan Comas 1 collaboration

Daniel de la Iglesia Garcia 1 collaboration

Andrea Jardi Cuadrado 1 collaboration

Adriano Quiroga Castiñeira 1 collaboration

Yu-Ting Chang 1 collaboration

Ming-Chu Chang 1 collaboration

Ali Kchaou 1 collaboration

Ahmed Tlili 1 collaboration

Sabite Kacar 1 collaboration

Volkan Gökbulut 1 collaboration

Deniz Duman 1 collaboration

Haluk Tarik Kani 1 collaboration

Engin Altintas 1 collaboration

Serge Chooklin 1 collaboration

Serhii Chuklin 1 collaboration

Amir Gougol 1 collaboration

George Papachristou 1 collaboration

Andrea Tóth 1 collaboration

Florence Zankl 1 collaboration

Grzegorz Oracz 1 collaboration

Lara Sophie Unger 1 collaboration

Peter Bugert 1 collaboration

Helmut Laumen 1 collaboration

Jonas Rosendahl 1 collaboration

Tomasz Gambin 1 collaboration

Rafał Płoski 1 collaboration

Dorota Koziel 1 collaboration

Stanisław Gluszek 1 collaboration

Fredrik Lindgren 1 collaboration

J Matthias Löhr 1 collaboration

Heiko Witt 1 collaboration

Agnieszka Magdalena Rygiel 1 collaboration

Maren Ewers 1 collaboration

István László Horváth 1 collaboration

Balázs Hankó 1 collaboration

Dénes Kleiner 1 collaboration

Bence Szabó 1 collaboration

Dezső Csupor 1 collaboration

Regina Stefanovics 1 collaboration

Gergő Berke 1 collaboration

Wenying Zhang 1 collaboration

Maisam Abu-El-Haija 1 collaboration