Amy Goodale

Affiliations

Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Publications (15)

A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering.

Cell

Avec: Tsz-Leung To , Alejandro M Cuadros , Hardik Shah , Wendy H W Hung , Yang Li , Sharon H Kim , Daniel H F Rubin , Ryan H Boe , Sneha Rath , John K Eaton , Federica Piccioni , Amy Goodale , Zohra Kalani , John G Doench , David E Root , Stuart L Schreiber , Scott B Vafai , Vamsi K Mootha

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma.

bioRxiv : the preprint server for biology

Avec: Damon A Hofman , Jorge Ruiz-Orera , Ian Yannuzzi , Rakesh Murugesan , Adam Brown , Karl R Clauser , Alexandra L Condurat , Jip T van Dinter , Sem A G Engels , Amy Goodale , Jasper van der Lugt , Tanaz Abid , Li Wang , Kevin N Zhou , Jayne Vogelzang , Keith L Ligon , Timothy N Phoenix , Jennifer A Roth , David E Root , Norbert Hubner , Todd R Golub , Pratiti Bandopadhayay , Sebastiaan van Heesch , John R Prensner

Optimization of Cas12a for multiplexed genome-scale transcriptional activation.

Cell genomics

Avec: Audrey L Griffith , Fengyi Zheng , Abby V McGee , Nathan W Miller , Zsofia M Szegletes , Ganna Reint , Fabian Gademann , Ifunanya Nwolah , Mudra Hegde , Yanjing V Liu , Amy Goodale , John G Doench

Characterization of permissive and non-permissive peptide insertion sites in chloramphenicol acetyltransferase.

Microbial pathogenesis

Avec: Andrew Goodale , Fanourios Michailidis , Rachel Watts , Shi Chen Chok , Finbarr Hayes

Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer.

Molecular cancer research : MCR

Avec: Elizabeth H Stover , Maria B Baco , Ofir Cohen , Yvonne Y Li , Elizabeth L Christie , Mukta Bagul , Amy Goodale , Yenarae Lee , Sasha Pantel , Matthew G Rees , Guo Wei , Adam G Presser , Maya K Gelbard , Weiqun Zhang , Ioannis K Zervantonakis , Patrick D Bhola , Jeremy Ryan , Jennifer L Guerriero , Joan Montero , Felice J Liang , Andrew D Cherniack , Federica Piccioni , Ursula A Matulonis , David D L Bowtell , Kristopher A Sarosiek , Anthony Letai , Levi A Garraway , Cory M Johannessen , Matthew Meyerson

Genotype-Fitness Maps of EGFR-Mutant Lung Adenocarcinoma Chart the Evolutionary Landscape of Resistance for Combination Therapy Optimization.

Cell systems

Avec: Patrick O Bolan , Asaf Zviran , Lisa Brenan , Joshua S Schiffman , Neville Dusaj , Amy Goodale , Federica Piccioni , Cory M Johannessen , Dan A Landau

A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Lillian M Guenther , Neekesh V Dharia , Linda Ross , Amy Conway , Amanda L Robichaud , Jerrel L Catlett , Caroline S Wechsler , Elizabeth S Frank , Amy Goodale , Alanna J Church , Yuen-Yi Tseng , Rajarshi Guha , Crystal G McKnight , Katherine A Janeway , Jesse S Boehm , Jaume Mora , Mindy I Davis , Gabriela Alexe , Federica Piccioni , Kimberly Stegmaier

Differences in wild-type- and R338L-tenase complex formation are at the root of R338L-factor IX assay discrepancies.

Blood advances

Avec: Jonathan H Foley , Erald Shehu , Anne Riddell , Elaine Gray , Andrew Goodale , I-Mei Yu , Daniël Verhoef , John Little , Diane Shattock , Steve Kitchen , Pratima Chowdary , Romuald Corbau , Amit C Nathwani

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.

Nature communications

Avec: Pratiti Bandopadhayay , Federica Piccioni , Ryan O'Rourke , Patricia Ho , Elizabeth M Gonzalez , Graham Buchan , Kenin Qian , Gabrielle Gionet , Emily Girard , Margo Coxon , Matthew G Rees , Lisa Brenan , Frank Dubois , Ofer Shapira , Noah F Greenwald , Melanie Pages , Amanda Balboni Iniguez , Brenton R Paolella , Alice Meng , Claire Sinai , Giovanni Roti , Neekesh V Dharia , Amanda Creech , Benjamin Tanenbaum , Prasidda Khadka , Adam Tracy , Hong L Tiv , Andrew L Hong , Shannon Coy , Rumana Rashid , Jia-Ren Lin , Glenn S Cowley , Fred C Lam , Amy Goodale , Yenarae Lee , Kathleen Schoolcraft , Francisca Vazquez , William C Hahn , Aviad Tsherniak , James E Bradner , Michael B Yaffe , Till Milde , Stefan M Pfister , Jun Qi , Monica Schenone , Steven A Carr , Keith L Ligon , Mark W Kieran , Sandro Santagata , James M Olson , Prafulla C Gokhale , Jacob D Jaffe , David E Root , Kimberly Stegmaier , Cory M Johannessen , Rameen Beroukhim

Noncanonical open reading frames encode functional proteins essential for cancer cell survival.

Nature biotechnology

Avec: John R Prensner , Oana M Enache , Victor Luria , Karsten Krug , Karl R Clauser , Joshua M Dempster , Amir Karger , Li Wang , Karolina Stumbraite , Vickie M Wang , Ginevra Botta , Nicholas J Lyons , Amy Goodale , Zohra Kalani , Briana Fritchman , Adam Brown , Douglas Alan , Thomas Green , Xiaoping Yang , Jacob D Jaffe , Jennifer A Roth , Federica Piccioni , Marc W Kirschner , Zhe Ji , David E Root , Todd R Golub

Mapping the landscape of genetic dependencies in chordoma.

Nature communications

Avec: Tanaz Sharifnia , Mathias J Wawer , Amy Goodale , Yenarae Lee , Mariya Kazachkova , Joshua M Dempster , Sandrine Muller , Joan Levy , Daniel M Freed , Josh Sommer , Jérémie Kalfon , Francisca Vazquez , William C Hahn , David E Root , Paul A Clemons , Stuart L Schreiber

Modular vector assembly enables rapid assessment of emerging CRISPR technologies.

Cell genomics

Avec: Abby V McGee , Yanjing V Liu , Audrey L Griffith , Zsofia M Szegletes , Bronte Wen , Carolyn Kraus , Nathan W Miller , Ryan J Steger , Berta Escude Velasco , Justin A Bosch , Jonathan D Zirin , Raghuvir Viswanatha , Erik J Sontheimer , Amy Goodale , Matthew A Greene , Thomas M Green , John G Doench

Small-molecule targeting of brachyury transcription factor addiction in chordoma.

Nature medicine

Avec: Tanaz Sharifnia , Mathias J Wawer , Ting Chen , Qing-Yuan Huang , Barbara A Weir , Ann Sizemore , Matthew A Lawlor , Amy Goodale , Glenn S Cowley , Francisca Vazquez , Christopher J Ott , Joshua M Francis , Slim Sassi , Patricia Cogswell , Hadley E Sheppard , Tinghu Zhang , Nathanael S Gray , Paul A Clarke , Julian Blagg , Paul Workman , Josh Sommer , Francis Hornicek , David E Root , William C Hahn , James E Bradner , Kwok K Wong , Paul A Clemons , Charles Y Lin , Joanne D Kotz , Stuart L Schreiber

Subjective morbidity following radial free flap reconstruction in head and neck tumour patients.

The Journal of laryngology and otology

Avec: A Minkara , M R Simmons , A Goodale , Y J Patil

Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia.

Cancer discovery

Avec: Anjali Cremer , Jana M Ellegast , Gabriela Alexe , Elizabeth S Frank , Linda Ross , S Haihua Chu , Yana Pikman , Amanda Robichaud , Amy Goodale , Björn Häupl , Sebastian Mohr , Arati V Rao , Alison R Walker , James S Blachly , Federica Piccioni , Scott A Armstrong , John C Byrd , Thomas Oellerich , Kimberly Stegmaier

Réseau de co-auteurs

Federica Piccioni 7 collaborations

David E Root 6 collaborations

John G Doench 3 collaborations

Stuart L Schreiber 3 collaborations

Yenarae Lee 3 collaborations

Cory M Johannessen 3 collaborations

Kimberly Stegmaier 3 collaborations

Francisca Vazquez 3 collaborations

William C Hahn 3 collaborations

Zohra Kalani 2 collaborations

Adam Brown 2 collaborations

Karl R Clauser 2 collaborations

Li Wang 2 collaborations

Keith L Ligon 2 collaborations

Jennifer A Roth 2 collaborations

Todd R Golub 2 collaborations

Pratiti Bandopadhayay 2 collaborations

John R Prensner 2 collaborations

Audrey L Griffith 2 collaborations

Abby V McGee 2 collaborations

Nathan W Miller 2 collaborations

Zsofia M Szegletes 2 collaborations

Yanjing V Liu 2 collaborations

Andrew Goodale 2 collaborations

Matthew G Rees 2 collaborations

Lisa Brenan 2 collaborations

Neekesh V Dharia 2 collaborations

Linda Ross 2 collaborations

Elizabeth S Frank 2 collaborations

Gabriela Alexe 2 collaborations

Glenn S Cowley 2 collaborations

James E Bradner 2 collaborations

Jacob D Jaffe 2 collaborations

Joshua M Dempster 2 collaborations

Tanaz Sharifnia 2 collaborations

Mathias J Wawer 2 collaborations

Josh Sommer 2 collaborations

Paul A Clemons 2 collaborations

Tsz-Leung To 1 collaboration

Alejandro M Cuadros 1 collaboration

Hardik Shah 1 collaboration

Wendy H W Hung 1 collaboration

Yang Li 1 collaboration

Sharon H Kim 1 collaboration

Daniel H F Rubin 1 collaboration

Ryan H Boe 1 collaboration

Sneha Rath 1 collaboration

John K Eaton 1 collaboration

Scott B Vafai 1 collaboration

Vamsi K Mootha 1 collaboration

Damon A Hofman 1 collaboration

Jorge Ruiz-Orera 1 collaboration

Ian Yannuzzi 1 collaboration

Rakesh Murugesan 1 collaboration

Alexandra L Condurat 1 collaboration

Jip T van Dinter 1 collaboration

Sem A G Engels 1 collaboration

Jasper van der Lugt 1 collaboration

Tanaz Abid 1 collaboration

Kevin N Zhou 1 collaboration

Jayne Vogelzang 1 collaboration

Timothy N Phoenix 1 collaboration

Norbert Hubner 1 collaboration

Sebastiaan van Heesch 1 collaboration

Fengyi Zheng 1 collaboration

Ganna Reint 1 collaboration

Fabian Gademann 1 collaboration

Ifunanya Nwolah 1 collaboration

Mudra Hegde 1 collaboration

Fanourios Michailidis 1 collaboration

Rachel Watts 1 collaboration

Shi Chen Chok 1 collaboration

Finbarr Hayes 1 collaboration

Elizabeth H Stover 1 collaboration

Maria B Baco 1 collaboration

Ofir Cohen 1 collaboration

Yvonne Y Li 1 collaboration

Elizabeth L Christie 1 collaboration

Mukta Bagul 1 collaboration

Sasha Pantel 1 collaboration

Guo Wei 1 collaboration

Adam G Presser 1 collaboration

Maya K Gelbard 1 collaboration

Weiqun Zhang 1 collaboration

Ioannis K Zervantonakis 1 collaboration

Patrick D Bhola 1 collaboration

Jeremy Ryan 1 collaboration

Jennifer L Guerriero 1 collaboration

Joan Montero 1 collaboration

Felice J Liang 1 collaboration

Andrew D Cherniack 1 collaboration

Ursula A Matulonis 1 collaboration

David D L Bowtell 1 collaboration

Kristopher A Sarosiek 1 collaboration

Anthony Letai 1 collaboration

Levi A Garraway 1 collaboration

Matthew Meyerson 1 collaboration

Patrick O Bolan 1 collaboration

Asaf Zviran 1 collaboration

Joshua S Schiffman 1 collaboration

Neville Dusaj 1 collaboration

Dan A Landau 1 collaboration

Lillian M Guenther 1 collaboration

Amy Conway 1 collaboration

Amanda L Robichaud 1 collaboration

Jerrel L Catlett 1 collaboration

Caroline S Wechsler 1 collaboration

Alanna J Church 1 collaboration

Yuen-Yi Tseng 1 collaboration

Rajarshi Guha 1 collaboration

Crystal G McKnight 1 collaboration

Katherine A Janeway 1 collaboration

Jesse S Boehm 1 collaboration

Jaume Mora 1 collaboration

Mindy I Davis 1 collaboration

Jonathan H Foley 1 collaboration

Erald Shehu 1 collaboration

Anne Riddell 1 collaboration

Elaine Gray 1 collaboration

I-Mei Yu 1 collaboration

Daniël Verhoef 1 collaboration

John Little 1 collaboration

Diane Shattock 1 collaboration

Steve Kitchen 1 collaboration

Pratima Chowdary 1 collaboration

Romuald Corbau 1 collaboration

Amit C Nathwani 1 collaboration

Ryan O'Rourke 1 collaboration

Patricia Ho 1 collaboration

Elizabeth M Gonzalez 1 collaboration

Graham Buchan 1 collaboration

Kenin Qian 1 collaboration

Gabrielle Gionet 1 collaboration

Emily Girard 1 collaboration

Margo Coxon 1 collaboration

Frank Dubois 1 collaboration

Ofer Shapira 1 collaboration

Noah F Greenwald 1 collaboration

Melanie Pages 1 collaboration

Amanda Balboni Iniguez 1 collaboration

Brenton R Paolella 1 collaboration

Alice Meng 1 collaboration

Claire Sinai 1 collaboration

Giovanni Roti 1 collaboration

Amanda Creech 1 collaboration

Benjamin Tanenbaum 1 collaboration

Prasidda Khadka 1 collaboration

Adam Tracy 1 collaboration

Hong L Tiv 1 collaboration

Andrew L Hong 1 collaboration

Shannon Coy 1 collaboration

Rumana Rashid 1 collaboration

Jia-Ren Lin 1 collaboration

Fred C Lam 1 collaboration

Kathleen Schoolcraft 1 collaboration

Aviad Tsherniak 1 collaboration

Michael B Yaffe 1 collaboration

Till Milde 1 collaboration

Stefan M Pfister 1 collaboration

Jun Qi 1 collaboration

Monica Schenone 1 collaboration

Steven A Carr 1 collaboration

Mark W Kieran 1 collaboration

Sandro Santagata 1 collaboration

James M Olson 1 collaboration

Prafulla C Gokhale 1 collaboration

Rameen Beroukhim 1 collaboration

Oana M Enache 1 collaboration

Victor Luria 1 collaboration

Karsten Krug 1 collaboration

Amir Karger 1 collaboration

Karolina Stumbraite 1 collaboration

Vickie M Wang 1 collaboration

Ginevra Botta 1 collaboration

Nicholas J Lyons 1 collaboration

Briana Fritchman 1 collaboration

Douglas Alan 1 collaboration

Thomas Green 1 collaboration

Xiaoping Yang 1 collaboration

Marc W Kirschner 1 collaboration

Zhe Ji 1 collaboration

Mariya Kazachkova 1 collaboration

Sandrine Muller 1 collaboration

Joan Levy 1 collaboration

Daniel M Freed 1 collaboration

Jérémie Kalfon 1 collaboration

Bronte Wen 1 collaboration

Carolyn Kraus 1 collaboration

Ryan J Steger 1 collaboration

Berta Escude Velasco 1 collaboration

Justin A Bosch 1 collaboration

Jonathan D Zirin 1 collaboration

Raghuvir Viswanatha 1 collaboration

Erik J Sontheimer 1 collaboration

Matthew A Greene 1 collaboration

Thomas M Green 1 collaboration

Ting Chen 1 collaboration

Qing-Yuan Huang 1 collaboration

Barbara A Weir 1 collaboration

Ann Sizemore 1 collaboration

Matthew A Lawlor 1 collaboration

Christopher J Ott 1 collaboration

Joshua M Francis 1 collaboration

Slim Sassi 1 collaboration

Patricia Cogswell 1 collaboration

Hadley E Sheppard 1 collaboration

Tinghu Zhang 1 collaboration

Nathanael S Gray 1 collaboration

Paul A Clarke 1 collaboration

Julian Blagg 1 collaboration

Paul Workman 1 collaboration

Francis Hornicek 1 collaboration

Kwok K Wong 1 collaboration

Charles Y Lin 1 collaboration

Joanne D Kotz 1 collaboration

A Minkara 1 collaboration

M R Simmons 1 collaboration

A Goodale 1 collaboration

Y J Patil 1 collaboration

Anjali Cremer 1 collaboration

Jana M Ellegast 1 collaboration

S Haihua Chu 1 collaboration

Yana Pikman 1 collaboration

Amanda Robichaud 1 collaboration

Björn Häupl 1 collaboration

Sebastian Mohr 1 collaboration

Arati V Rao 1 collaboration

Alison R Walker 1 collaboration

James S Blachly 1 collaboration

Scott A Armstrong 1 collaboration

John C Byrd 1 collaboration

Thomas Oellerich 1 collaboration