Andrea Schmidts

Affiliations

Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts.
Department of Medicine, Harvard Medical School, Boston, Massachusetts.

Publications (17)

Blockade or Deletion of IFNγ Reduces Macrophage Activation without Compromising CAR T-cell Function in Hematologic Malignancies.

Blood cancer discovery

Avec: Stefanie R Bailey , Sonika Vatsa , Rebecca C Larson , Amanda A Bouffard , Irene Scarfò , Michael C Kann , Trisha R Berger , Mark B Leick , Marc Wehrli , Andrea Schmidts , Harrison Silva , Kevin A Lindell , Ashley Demato , Kathleen M E Gallagher , Matthew J Frigault , Marcela V Maus

Toward Better Understanding and Management of CAR-T Cell-Associated Toxicity.

Annual review of medicine

Avec: Andrea Schmidts , Marc Wehrli , Marcela V Maus

Dynamic Profiling of Antitumor Activity of CAR T Cells Using Micropatterned Tumor Arrays.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Avec: Xiao Wang , Irene Scarfò , Andrea Schmidts , Mehmet Toner , Marcela V Maus , Daniel Irimia

Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Maria Ormhøj , Irene Scarfò , Maria L Cabral , Stefanie R Bailey , Selena J Lorrey , Amanda A Bouffard , Ana P Castano , Rebecca C Larson , Lauren S Riley , Andrea Schmidts , Bryan D Choi , Rikke S Andersen , Oriane Cédile , Charlotte G Nyvold , Jacob H Christensen , Morten F Gjerstorff , Henrik J Ditzel , David M Weinstock , Torben Barington , Matthew J Frigault , Marcela V Maus

Anti-TACI single and dual-targeting CAR T cells overcome BCMA antigen loss in multiple myeloma.

Nature communications

Avec: Rebecca C Larson , Michael C Kann , Charlotte Graham , Christopher W Mount , Ana P Castano , Won-Ho Lee , Amanda A Bouffard , Hana N Takei , Antonio J Almazan , Irene Scarfó , Trisha R Berger , Andrea Schmidts , Matthew J Frigault , Kathleen M E Gallagher , Marcela V Maus

Mesothelin CAR T-cells secreting anti-FAP/anti-CD3 molecules efficiently target pancreatic adenocarcinoma and its stroma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Marc Wehrli , Samantha Guinn , Filippo Birocchi , Adam Kuo , Yi Sun , Rebecca C Larson , Antonio J Almazan , Irene Scarfò , Amanda A Bouffard , Stefanie R Bailey , Praju Vikas Anekal , Paula Montero Lopis , Linda T Nieman , Yuhui Song , Katherine H Xu , Trisha R Berger , Michael C Kann , Mark B Leick , Harrison Silva , Diego Salas-Benito , Tamina Kienka , Korneel Grauwet , Todd D Armstrong , Rui Zhang , Qingfeng Zhu , Juan Fu , Andrea Schmidts , Felix Korell , Max Jan , Bryan D Choi , Andrew S Liss , Genevieve M Boland , David T Ting , Richard A Burkhart , Russell W Jenkins , Lei Zheng , Elizabeth M Jaffee , Jacquelyn W Zimmerman , Marcela V Maus

Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia.

Cancer cell

Avec: Mark B Leick , Harrison Silva , Irene Scarfò , Rebecca Larson , Bryan D Choi , Amanda A Bouffard , Kathleen Gallagher , Andrea Schmidts , Stefanie R Bailey , Michael C Kann , Max Jan , Marc Wehrli , Korneel Grauwet , Nora Horick , Matthew J Frigault , Marcela V Maus

CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours.

Nature

Avec: Rebecca C Larson , Michael C Kann , Stefanie R Bailey , Nicholas J Haradhvala , Paula Montero Llopis , Amanda A Bouffard , Irene Scarfó , Mark B Leick , Korneel Grauwet , Trisha R Berger , Kai Stewart , Praju Vikas Anekal , Max Jan , Julia Joung , Andrea Schmidts , Tamara Ouspenskaia , Travis Law , Aviv Regev , Gad Getz , Marcela V Maus

GFR estimation in lenalidomide treatment of multiple myeloma patients: a prospective cohort study.

Clinical and experimental nephrology

Avec: Andrea Schmidts , Julian Grünewald , Martina Kleber , Evangelos Terpos , Gabriele Ihorst , Heike Reinhardt , Gerd Walz , Ralph Wäsch , Monika Engelhardt , Stefan Zschiedrich

APC/C

Cellular and molecular life sciences : CMLS

Avec: Daniel Ewerth , Stefanie Kreutmair , Andrea Schmidts , Gabriele Ihorst , Marie Follo , Dagmar Wider , Julia Felthaus , Julia Schüler , Justus Duyster , Anna Lena Illert , Monika Engelhardt , Ralph Wäsch

Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources.

Journal for immunotherapy of cancer

Avec: Andrea Schmidts , Leah C Marsh , Ambike A Srivastava , Amanda A Bouffard , Angela C Boroughs , Irene Scarfò , Rebecca C Larson , Felipe Bedoya , Bryan D Choi , Matthew J Frigault , Stefanie R Bailey , Mark B Leick , Sonika Vatsa , Michael C Kann , Michelle S Prew , Benjamin P Kleinstiver , J Keith Joung , Marcela V Maus

CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells.

Nature biotechnology

Avec: Karl Petri , Weiting Zhang , Junyan Ma , Andrea Schmidts , Hyunho Lee , Joy E Horng , Daniel Y Kim , Ibrahim C Kurt , Kendell Clement , Jonathan Y Hsu , Luca Pinello , Marcela V Maus , J Keith Joung , Jing-Ruey Joanna Yeh

Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide.

Science translational medicine

Avec: Max Jan , Irene Scarfò , Rebecca C Larson , Amanda Walker , Andrea Schmidts , Andrew A Guirguis , Jessica A Gasser , Mikołaj Słabicki , Amanda A Bouffard , Ana P Castano , Michael C Kann , Maria L Cabral , Alexander Tepper , Daniel E Grinshpun , Adam S Sperling , Taeyoon Kyung , Quinlan L Sievers , Michael E Birnbaum , Marcela V Maus , Benjamin L Ebert

Phase 1 study of CAR-37 T cells in patients with relapsed or refractory CD37+ lymphoid malignancies.

Blood

Avec: Matthew J Frigault , Charlotte E Graham , Trisha R Berger , Julie K Ritchey , Nora Horick , Areej El-Jawahri , Irene Scarfò , Andrea Schmidts , Nicholas Haradhvala , Marc Wehrli , Won-Ho Lee , Aiyana Parker , Hadley R Wiggin , Amanda A Bouffard , Aonkon Dey , Mark B Leick , Katelin Katsis , Eva L Elder , Maria Dolaher , Daniella Cook , Alena A Chekmasova , Lu Huang , Sarah Nikiforow , Heather Daley , Jerome Ritz , Myriam Armant , Fred Preffer , John F DiPersio , Valentina Nardi , Yi-Bin Chen , Kathleen M E Gallagher , Marcela V Maus

CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity.

Nature biotechnology

Avec: Bryan D Choi , Xiaoling Yu , Ana P Castano , Amanda A Bouffard , Andrea Schmidts , Rebecca C Larson , Stefanie R Bailey , Angela C Boroughs , Matthew J Frigault , Mark B Leick , Irene Scarfò , Curtis L Cetrulo , Shadmehr Demehri , Brian V Nahed , Daniel P Cahill , Hiroaki Wakimoto , William T Curry , Bob S Carter , Marcela V Maus

Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma.

Blood advances

Avec: Andrea Schmidts , Maria Ormhøj , Bryan D Choi , Allison O Taylor , Amanda A Bouffard , Irene Scarfò , Rebecca C Larson , Matthew J Frigault , Kathleen Gallagher , Ana P Castano , Lauren S Riley , Maria L Cabral , Angela C Boroughs , Rubí M-H Velasco Cárdenas , Wolfgang Schamel , Jing Zhou , Sean Mackay , Yu-Tzu Tai , Kenneth C Anderson , Marcela V Maus

CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma.

Journal for immunotherapy of cancer

Avec: Bryan D Choi , Xiaoling Yu , Ana P Castano , Henia Darr , Daniel B Henderson , Amanda A Bouffard , Rebecca C Larson , Irene Scarfò , Stefanie R Bailey , Genevieve M Gerhard , Matthew J Frigault , Mark B Leick , Andrea Schmidts , Jason G Sagert , William T Curry , Bob S Carter , Marcela V Maus

Réseau de co-auteurs

Marcela V Maus 15 collaborations

Amanda A Bouffard 12 collaborations

Irene Scarfò 11 collaborations

Rebecca C Larson 10 collaborations

Matthew J Frigault 9 collaborations

Stefanie R Bailey 8 collaborations

Mark B Leick 8 collaborations

Michael C Kann 7 collaborations

Bryan D Choi 7 collaborations

Ana P Castano 6 collaborations

Trisha R Berger 5 collaborations

Marc Wehrli 5 collaborations

Max Jan 4 collaborations

Harrison Silva 3 collaborations

Kathleen M E Gallagher 3 collaborations

Maria L Cabral 3 collaborations

Korneel Grauwet 3 collaborations

Angela C Boroughs 3 collaborations

Sonika Vatsa 2 collaborations

Maria Ormhøj 2 collaborations

Lauren S Riley 2 collaborations

Won-Ho Lee 2 collaborations

Antonio J Almazan 2 collaborations

Irene Scarfó 2 collaborations

Praju Vikas Anekal 2 collaborations

Kathleen Gallagher 2 collaborations

Nora Horick 2 collaborations

Gabriele Ihorst 2 collaborations

Ralph Wäsch 2 collaborations

Monika Engelhardt 2 collaborations

J Keith Joung 2 collaborations

Xiaoling Yu 2 collaborations

William T Curry 2 collaborations

Bob S Carter 2 collaborations

Kevin A Lindell 1 collaboration

Ashley Demato 1 collaboration

Xiao Wang 1 collaboration

Mehmet Toner 1 collaboration

Daniel Irimia 1 collaboration

Selena J Lorrey 1 collaboration

Rikke S Andersen 1 collaboration

Oriane Cédile 1 collaboration

Charlotte G Nyvold 1 collaboration

Jacob H Christensen 1 collaboration

Morten F Gjerstorff 1 collaboration

Henrik J Ditzel 1 collaboration

David M Weinstock 1 collaboration

Torben Barington 1 collaboration

Charlotte Graham 1 collaboration

Christopher W Mount 1 collaboration

Hana N Takei 1 collaboration

Samantha Guinn 1 collaboration

Filippo Birocchi 1 collaboration

Adam Kuo 1 collaboration

Yi Sun 1 collaboration

Paula Montero Lopis 1 collaboration

Linda T Nieman 1 collaboration

Yuhui Song 1 collaboration

Katherine H Xu 1 collaboration

Diego Salas-Benito 1 collaboration

Tamina Kienka 1 collaboration

Todd D Armstrong 1 collaboration

Rui Zhang 1 collaboration

Qingfeng Zhu 1 collaboration

Juan Fu 1 collaboration

Felix Korell 1 collaboration

Andrew S Liss 1 collaboration

Genevieve M Boland 1 collaboration

David T Ting 1 collaboration

Richard A Burkhart 1 collaboration

Russell W Jenkins 1 collaboration

Lei Zheng 1 collaboration

Elizabeth M Jaffee 1 collaboration

Jacquelyn W Zimmerman 1 collaboration

Rebecca Larson 1 collaboration

Nicholas J Haradhvala 1 collaboration

Paula Montero Llopis 1 collaboration

Kai Stewart 1 collaboration

Julia Joung 1 collaboration

Tamara Ouspenskaia 1 collaboration

Travis Law 1 collaboration

Aviv Regev 1 collaboration

Gad Getz 1 collaboration

Julian Grünewald 1 collaboration

Martina Kleber 1 collaboration

Evangelos Terpos 1 collaboration

Heike Reinhardt 1 collaboration

Gerd Walz 1 collaboration

Stefan Zschiedrich 1 collaboration

Daniel Ewerth 1 collaboration

Stefanie Kreutmair 1 collaboration

Marie Follo 1 collaboration

Dagmar Wider 1 collaboration

Julia Felthaus 1 collaboration

Julia Schüler 1 collaboration

Justus Duyster 1 collaboration

Anna Lena Illert 1 collaboration

Leah C Marsh 1 collaboration

Ambike A Srivastava 1 collaboration

Felipe Bedoya 1 collaboration

Michelle S Prew 1 collaboration

Benjamin P Kleinstiver 1 collaboration

Karl Petri 1 collaboration

Weiting Zhang 1 collaboration

Junyan Ma 1 collaboration

Hyunho Lee 1 collaboration

Joy E Horng 1 collaboration

Daniel Y Kim 1 collaboration

Ibrahim C Kurt 1 collaboration

Kendell Clement 1 collaboration

Jonathan Y Hsu 1 collaboration

Luca Pinello 1 collaboration

Jing-Ruey Joanna Yeh 1 collaboration

Amanda Walker 1 collaboration

Andrew A Guirguis 1 collaboration

Jessica A Gasser 1 collaboration

Mikołaj Słabicki 1 collaboration

Alexander Tepper 1 collaboration

Daniel E Grinshpun 1 collaboration

Adam S Sperling 1 collaboration

Taeyoon Kyung 1 collaboration

Quinlan L Sievers 1 collaboration

Michael E Birnbaum 1 collaboration

Benjamin L Ebert 1 collaboration

Charlotte E Graham 1 collaboration

Julie K Ritchey 1 collaboration

Areej El-Jawahri 1 collaboration

Nicholas Haradhvala 1 collaboration

Aiyana Parker 1 collaboration

Hadley R Wiggin 1 collaboration

Aonkon Dey 1 collaboration

Katelin Katsis 1 collaboration

Eva L Elder 1 collaboration

Maria Dolaher 1 collaboration

Daniella Cook 1 collaboration

Alena A Chekmasova 1 collaboration

Lu Huang 1 collaboration

Sarah Nikiforow 1 collaboration

Heather Daley 1 collaboration

Jerome Ritz 1 collaboration

Myriam Armant 1 collaboration

Fred Preffer 1 collaboration

John F DiPersio 1 collaboration

Valentina Nardi 1 collaboration

Yi-Bin Chen 1 collaboration

Curtis L Cetrulo 1 collaboration

Shadmehr Demehri 1 collaboration

Brian V Nahed 1 collaboration

Daniel P Cahill 1 collaboration

Hiroaki Wakimoto 1 collaboration

Allison O Taylor 1 collaboration

Rubí M-H Velasco Cárdenas 1 collaboration

Wolfgang Schamel 1 collaboration

Jing Zhou 1 collaboration

Sean Mackay 1 collaboration

Yu-Tzu Tai 1 collaboration

Kenneth C Anderson 1 collaboration

Henia Darr 1 collaboration

Daniel B Henderson 1 collaboration

Genevieve M Gerhard 1 collaboration

Jason G Sagert 1 collaboration