Anne M Filppula

Affiliations

Department of Clinical Pharmacology, Faculty of Medicine (F.D., S.-K.T., M.Ne, P.H., S.K., A.M.F., M.Ni.), and Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland (F.D., S.-K.T., M.Ne, P.H., S.K., A.M.F., M.Ni.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medicine Greifswald, Greifswald, Germany (C.W., S.O.); Institute of Pharmacology and Toxicology, Rostock University Medical Center, Rostock, Germany (S.O.); and Department of Clinical Pharmacology, HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland (M.Ni.).

Publications (15)

Comparative Hepatic and Intestinal Efflux Transport of Statins.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Feng Deng , Suvi-Kukka Tuomi , Mikko Neuvonen , Päivi Hirvensalo , Sami Kulju , Christoph Wenzel , Stefan Oswald , Anne M Filppula , Mikko Niemi

Rhabdomyolysis during concomitant ticagrelor and rosuvastatin: A breast cancer resistance protein-mediated drug interaction?

British journal of clinical pharmacology

Avec: Minna Lehtisalo , Wilma Kiander , Anne M Filppula , Feng Deng , Heidi Kidron , Mari Korhonen , Johanna Sinkko , Kimmo Koivula , Mikko Niemi

Translational aspects of cytochrome P450-mediated drug-drug interactions: A case study with clopidogrel.

Basic & clinical pharmacology & toxicology

Avec: Aleksi Tornio , Anne M Filppula , Janne T Backman

Ticagrelor Increases Exposure to the Breast Cancer Resistance Protein Substrate Rosuvastatin.

Clinical pharmacology and therapeutics

Avec: Minna Lehtisalo , E Katriina Tarkiainen , Mikko Neuvonen , Mikko Holmberg , Johanna I Kiiski , Outi Lapatto-Reiniluoto , Anne M Filppula , Mika Kurkela , Janne T Backman , Mikko Niemi

Clinical Studies on Drug-Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation.

Clinical pharmacology and therapeutics

Avec: Aleksi Tornio , Anne M Filppula , Mikko Niemi , Janne T Backman

Screening of 16 major drug glucuronides for time-dependent inhibition of nine drug-metabolizing CYP enzymes - detailed studies on CYP3A inhibitors.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Helinä Kahma , Marie-Noëlle Paludetto , Mikko Neuvonen , Mika Kurkela , Anne M Filppula , Mikko Niemi , Janne T Backman

Solanidine is a sensitive and specific dietary biomarker for CYP2D6 activity.

Human genomics

Avec: Johanna I Kiiski , Mikko Neuvonen , Mika Kurkela , Päivi Hirvensalo , Kreetta Hämäläinen , E Katriina Tarkiainen , Johanna Sistonen , Mari Korhonen , Sofia Khan , Arto Orpana , Anne M Filppula , Marko Lehtonen , Mikko Niemi

Real-world pharmacogenetics of statin intolerance: effects of SLCO1B1, ABCG2 , and CYP2C9 variants.

Pharmacogenetics and genomics

Avec: K Ivar Lönnberg , Aleksi Tornio , Päivi Hirvensalo , Jenni Keskitalo , Anna-Liina Mustaniemi , Johanna I Kiiski , Anne M Filppula , Mikko Niemi

Comparative Hepatic and Intestinal Metabolism and Pharmacodynamics of Statins.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Anne M Filppula , Päivi Hirvensalo , Heli Parviainen , Vilma E Ivaska , K Ivar Lönnberg , Feng Deng , Jenni Viinamäki , Mika Kurkela , Mikko Neuvonen , Mikko Niemi

An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes - application to establishing CYP2C8 inhibitor selectivity.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Helinä Kahma , Laura Aurinsalo , Mikko Neuvonen , Jani Katajamäki , Marie-Noëlle Paludetto , Jenni Viinamäki , Terhi Launiainen , Anne M Filppula , Aleksi Tornio , Mikko Niemi , Janne T Backman

Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Helinä Kahma , Anne M Filppula , Terhi Launiainen , Jenni Viinamäki , Mikko Neuvonen , Eric A Evangelista , Rheem A Totah , Janne T Backman

Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations.

Scientific reports

Avec: Anne M Filppula , Rezvan Parvizi , André Mateus , Pawel Baranczewski , Per Artursson

Self-Healing Dynamic Hydrogel Microparticles with Structural Color for Wound Management.

Nano-micro letters

Avec: Li Wang , Xiaoya Ding , Lu Fan , Anne M Filppula , Qinyu Li , Hongbo Zhang , Yuanjin Zhao , Luoran Shang

Fabricating biomimetic materials with ice-templating for biomedical applications.

Smart medicine

Avec: Xiang Lin , Lu Fan , Li Wang , Anne M Filppula , Yunru Yu , Hongbo Zhang

Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4, and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A

Drug metabolism and disposition: the biological fate of chemicals

Avec: Marie-Noëlle Paludetto , Mika Kurkela , Helinä Kahma , Janne T Backman , Mikko Niemi , Anne M Filppula

Réseau de co-auteurs

Mikko Niemi 10 collaborations

Mikko Neuvonen 7 collaborations

Janne T Backman 7 collaborations

Mika Kurkela 5 collaborations

Päivi Hirvensalo 4 collaborations

Aleksi Tornio 4 collaborations

Helinä Kahma 4 collaborations

Feng Deng 3 collaborations

Johanna I Kiiski 3 collaborations

Marie-Noëlle Paludetto 3 collaborations

Jenni Viinamäki 3 collaborations

Minna Lehtisalo 2 collaborations

Mari Korhonen 2 collaborations

E Katriina Tarkiainen 2 collaborations

K Ivar Lönnberg 2 collaborations

Terhi Launiainen 2 collaborations

Li Wang 2 collaborations

Lu Fan 2 collaborations

Hongbo Zhang 2 collaborations

Suvi-Kukka Tuomi 1 collaboration

Sami Kulju 1 collaboration

Christoph Wenzel 1 collaboration

Stefan Oswald 1 collaboration

Wilma Kiander 1 collaboration

Heidi Kidron 1 collaboration

Johanna Sinkko 1 collaboration

Kimmo Koivula 1 collaboration

Mikko Holmberg 1 collaboration

Outi Lapatto-Reiniluoto 1 collaboration

Kreetta Hämäläinen 1 collaboration

Johanna Sistonen 1 collaboration

Sofia Khan 1 collaboration

Arto Orpana 1 collaboration

Marko Lehtonen 1 collaboration

Jenni Keskitalo 1 collaboration

Anna-Liina Mustaniemi 1 collaboration

Heli Parviainen 1 collaboration

Vilma E Ivaska 1 collaboration

Laura Aurinsalo 1 collaboration

Jani Katajamäki 1 collaboration

Eric A Evangelista 1 collaboration

Rheem A Totah 1 collaboration

Rezvan Parvizi 1 collaboration

André Mateus 1 collaboration

Pawel Baranczewski 1 collaboration

Per Artursson 1 collaboration

Xiaoya Ding 1 collaboration

Qinyu Li 1 collaboration

Yuanjin Zhao 1 collaboration

Luoran Shang 1 collaboration

Xiang Lin 1 collaboration

Yunru Yu 1 collaboration