David Smil

Affiliations

Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada.

ORCID: http://orcid.org/0000-0002-6232-6087

Publications (11)

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.

Nature communications

Avec: Sebastian Scheer , Suzanne Ackloo , Tiago S Medina , Matthieu Schapira , Fengling Li , Jennifer A Ward , Andrew M Lewis , Jeffrey P Northrop , Paul L Richardson , H Ümit Kaniskan , Yudao Shen , Jing Liu , David Smil , David McLeod , Carlos A Zepeda-Velazquez , Minkui Luo , Jian Jin , Dalia Barsyte-Lovejoy , Kilian V M Huber , Daniel D De Carvalho , Masoud Vedadi , Colby Zaph , Peter J Brown , Cheryl H Arrowsmith

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.

Journal of medicinal chemistry

Avec: Deeba Ensan , David Smil , Carlos A Zepeda-Velázquez , Dimitrios Panagopoulos , Jong Fu Wong , Eleanor P Williams , Roslin Adamson , Alex N Bullock , Taira Kiyota , Ahmed Aman , Owen G Roberts , Aled M Edwards , Jeff A O'Meara , Methvin B Isaac , Rima Al-Awar

Discovery of Conformationally Constrained ALK2 Inhibitors.

Journal of medicinal chemistry

Avec: Héctor González-Álvarez , Deeba Ensan , Tao Xin , Jong Fu Wong , Carlos A Zepeda-Velázquez , Julien Cros , Laurent Hoffer , Taira Kiyota , Brian J Wilson , Ahmed Aman , Owen Roberts , Methvin B Isaac , Alex N Bullock , David Smil , Rima Al-Awar

Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics*.

ChemMedChem

Avec: Mathew Sutherland , Alice Li , Anissa Kaghad , Dimitrios Panagopoulos , Fengling Li , Magdalena Szewczyk , David Smil , Cora Scholten , Léa Bouché , Timo Stellfeld , Cheryl H Arrowsmith , Dalia Barsyte , Masoud Vedadi , Ingo V Hartung , Holger Steuber , Robert Britton , Vijayaratnam Santhakumar

Leveraging Open Science Drug Development for PET: Preliminary Neuroimaging of

ACS medicinal chemistry letters

Avec: Emily Murrell , Junchao Tong , David Smil , Taira Kiyota , Ahmed M Aman , Methvin B Isaac , Iain D G Watson , Neil Vasdev

Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors.

SLAS discovery : advancing life sciences R & D

Avec: Kanchan Devkota , Matthieu Schapira , Sumera Perveen , Aliakbar Khalili Yazdi , Fengling Li , Irene Chau , Pegah Ghiabi , Taraneh Hajian , Peter Loppnau , Albina Bolotokova , Karla J F Satchell , Ke Wang , Deyao Li , Jing Liu , David Smil , Minkui Luo , Jian Jin , Paul V Fish , Peter J Brown , Masoud Vedadi

Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2.

Journal of medicinal chemistry

Avec: Václav Němec , Marek Remeš , Petr Beňovský , Michael C Böck , Eliška Šranková , Jong Fu Wong , Julien Cros , Eleanor Williams , Lap Hang Tse , David Smil , Deeba Ensan , Methvin B Isaac , Rima Al-Awar , Regina Gomolková , Vlad-Constantin Ursachi , Bohumil Fafílek , Zuzana Kahounová , Ráchel Víchová , Ondřej Vacek , Benedict-Tilman Berger , Carrow I Wells , Cesear R Corona , James D Vasta , Matthew B Robers , Pavel Krejci , Karel Souček , Alex N Bullock , Stefan Knapp , Kamil Paruch

Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma.

Journal of medicinal chemistry

Avec: David Smil , Jong Fu Wong , Eleanor P Williams , Roslin J Adamson , Alison Howarth , David A McLeod , Ahmed Mamai , Soyoung Kim , Brian J Wilson , Taira Kiyota , Ahmed Aman , Julie Owen , Gennady Poda , Kurumi Y Horiuchi , Ekaterina Kuznetsova , Haiching Ma , J Nicole Hamblin , Sue Cramp , Owen G Roberts , Aled M Edwards , David Uehling , Rima Al-Awar , Alex N Bullock , Jeff A O'Meara , Methvin B Isaac

Identification and characterization of the first fragment hits for SETDB1 Tudor domain.

Bioorganic & medicinal chemistry

Avec: Pavel Mader , Rodrigo Mendoza-Sanchez , Aman Iqbal , Aiping Dong , Elena Dobrovetsky , Victoria B Corless , Sean K Liew , Scott R Houliston , Renato Ferreira De Freitas , David Smil , Carlo C Dela Sena , Steven Kennedy , Diego B Diaz , Hong Wu , Ludmila Dombrovski , Abdellah Allali-Hassani , Jinrong Min , Matthieu Schapira , Masoud Vedadi , Peter J Brown , Vijayaratnam Santhakumar , Andrei K Yudin , Cheryl H Arrowsmith

Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors.

bioRxiv : the preprint server for biology

Avec: Kanchan Devkota , Matthieu Schapira , Sumera Perveen , Aliakbar Khalili Yazdi , Fengling Li , Irene Chau , Pegah Ghiabi , Taraneh Hajian , Peter Loppnau , Albina Bolotokova , Karla J F Satchell , Ke Wang , Deyao Li , Jing Liu , David Smil , Minkui Luo , Jian Jin , Paul V Fish , Peter J Brown , Masoud Vedadi

A non-traditional crystal-based compound screening method targeting the ATP binding site of

Frontiers in molecular biosciences

Avec: Alexander Mrozek , Tetyana Antoshchenko , Yun Chen , Carlos Zepeda-Velázquez , David Smil , Nirbhay Kumar , Hua Lu , Hee-Won Park

Réseau de co-auteurs

Masoud Vedadi 5 collaborations

Methvin B Isaac 5 collaborations

Matthieu Schapira 4 collaborations

Fengling Li 4 collaborations

Peter J Brown 4 collaborations

Jong Fu Wong 4 collaborations

Alex N Bullock 4 collaborations

Taira Kiyota 4 collaborations

Rima Al-Awar 4 collaborations

Jing Liu 3 collaborations

Minkui Luo 3 collaborations

Jian Jin 3 collaborations

Cheryl H Arrowsmith 3 collaborations

Deeba Ensan 3 collaborations

Ahmed Aman 3 collaborations

Carlos A Zepeda-Velázquez 2 collaborations

Dimitrios Panagopoulos 2 collaborations

Eleanor P Williams 2 collaborations

Owen G Roberts 2 collaborations

Aled M Edwards 2 collaborations

Jeff A O'Meara 2 collaborations

Julien Cros 2 collaborations

Brian J Wilson 2 collaborations

Vijayaratnam Santhakumar 2 collaborations

Kanchan Devkota 2 collaborations

Sumera Perveen 2 collaborations

Aliakbar Khalili Yazdi 2 collaborations

Irene Chau 2 collaborations

Pegah Ghiabi 2 collaborations

Taraneh Hajian 2 collaborations

Peter Loppnau 2 collaborations

Albina Bolotokova 2 collaborations

Karla J F Satchell 2 collaborations

Ke Wang 2 collaborations

Deyao Li 2 collaborations

Paul V Fish 2 collaborations

Sebastian Scheer 1 collaboration

Suzanne Ackloo 1 collaboration

Tiago S Medina 1 collaboration

Jennifer A Ward 1 collaboration

Andrew M Lewis 1 collaboration

Jeffrey P Northrop 1 collaboration

Paul L Richardson 1 collaboration

H Ümit Kaniskan 1 collaboration

Yudao Shen 1 collaboration

David McLeod 1 collaboration

Carlos A Zepeda-Velazquez 1 collaboration

Dalia Barsyte-Lovejoy 1 collaboration

Kilian V M Huber 1 collaboration

Daniel D De Carvalho 1 collaboration

Colby Zaph 1 collaboration

Roslin Adamson 1 collaboration

Héctor González-Álvarez 1 collaboration

Tao Xin 1 collaboration

Laurent Hoffer 1 collaboration

Owen Roberts 1 collaboration

Mathew Sutherland 1 collaboration

Alice Li 1 collaboration

Anissa Kaghad 1 collaboration

Magdalena Szewczyk 1 collaboration

Cora Scholten 1 collaboration

Léa Bouché 1 collaboration

Timo Stellfeld 1 collaboration

Dalia Barsyte 1 collaboration

Ingo V Hartung 1 collaboration

Holger Steuber 1 collaboration

Robert Britton 1 collaboration

Emily Murrell 1 collaboration

Junchao Tong 1 collaboration

Ahmed M Aman 1 collaboration

Iain D G Watson 1 collaboration

Neil Vasdev 1 collaboration

Václav Němec 1 collaboration

Marek Remeš 1 collaboration

Petr Beňovský 1 collaboration

Michael C Böck 1 collaboration

Eliška Šranková 1 collaboration

Eleanor Williams 1 collaboration

Lap Hang Tse 1 collaboration

Regina Gomolková 1 collaboration

Vlad-Constantin Ursachi 1 collaboration

Bohumil Fafílek 1 collaboration

Zuzana Kahounová 1 collaboration

Ráchel Víchová 1 collaboration

Ondřej Vacek 1 collaboration

Benedict-Tilman Berger 1 collaboration

Carrow I Wells 1 collaboration

Cesear R Corona 1 collaboration

James D Vasta 1 collaboration

Matthew B Robers 1 collaboration

Pavel Krejci 1 collaboration

Karel Souček 1 collaboration

Stefan Knapp 1 collaboration

Kamil Paruch 1 collaboration

Roslin J Adamson 1 collaboration

Alison Howarth 1 collaboration

David A McLeod 1 collaboration

Ahmed Mamai 1 collaboration

Soyoung Kim 1 collaboration

Julie Owen 1 collaboration

Gennady Poda 1 collaboration

Kurumi Y Horiuchi 1 collaboration

Ekaterina Kuznetsova 1 collaboration

Haiching Ma 1 collaboration

J Nicole Hamblin 1 collaboration

Sue Cramp 1 collaboration

David Uehling 1 collaboration

Pavel Mader 1 collaboration

Rodrigo Mendoza-Sanchez 1 collaboration

Aman Iqbal 1 collaboration

Aiping Dong 1 collaboration

Elena Dobrovetsky 1 collaboration

Victoria B Corless 1 collaboration

Sean K Liew 1 collaboration

Scott R Houliston 1 collaboration

Renato Ferreira De Freitas 1 collaboration

Carlo C Dela Sena 1 collaboration

Steven Kennedy 1 collaboration

Diego B Diaz 1 collaboration

Hong Wu 1 collaboration

Ludmila Dombrovski 1 collaboration

Abdellah Allali-Hassani 1 collaboration

Jinrong Min 1 collaboration

Andrei K Yudin 1 collaboration

Alexander Mrozek 1 collaboration

Tetyana Antoshchenko 1 collaboration

Yun Chen 1 collaboration

Carlos Zepeda-Velázquez 1 collaboration

Nirbhay Kumar 1 collaboration

Hua Lu 1 collaboration

Hee-Won Park 1 collaboration