Dimitrios Arkilo

Affiliations

Global Drug Metabolism and Pharmacokinetics, Takeda California Inc., San Diego, California (A.K., S.B., N.H.) and Clinical and Neuroscience Therapeutic Area, Takeda Boston Inc., Boston, Massachusetts (D.A., A.L.).

Publications (8)

In Vitro Metabolism of Slowly Cleared G Protein-Coupled Receptor 139 Agonist TAK-041 Using Rat, Dog, Monkey, and Human Hepatocyte Models (HepatoPac): Correlation with In Vivo Metabolism.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Amin Kamel , Steve Bowlin , Natalie Hosea , Dimitrios Arkilo , Antonio Laurenza

Safety, pharmacokinetics and pharmacodynamics of TAK-418, a novel inhibitor of the epigenetic modulator lysine-specific demethylase 1A.

British journal of clinical pharmacology

Avec: Wei Yin , Dimitrios Arkilo , Polyna Khudyakov , Jim Hazel , Saurabh Gupta , Maria S Quinton , Jie Lin , Deborah S Hartman , Martin M Bednar , Laura Rosen , Jens R Wendland

A phase 1b/2a study of soticlestat as adjunctive therapy in participants with developmental and/or epileptic encephalopathies.

Epilepsy research

Avec: Jonathan J Halford , Michael R Sperling , Dimitrios Arkilo , Mahnaz Asgharnejad , Celia Zinger , Rengyi Xu , Matthew During , Jacqueline A French

A phase 2, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in pediatric patients with Dravet syndrome or Lennox-Gastaut syndrome (ELEKTRA).

Epilepsia

Avec: Cecil D Hahn , Yuwu Jiang , Vicente Villanueva , Marta Zolnowska , Dimitrios Arkilo , Samuel Hsiao , Mahnaz Asgharnejad , Dennis Dlugos

A Randomized Phase 2 KINETIC Trial Evaluating SAGE-324/BIIB124 in Individuals with Essential Tremor.

Movement disorders : official journal of the Movement Disorder Society

Avec: Rodger J Elble , William G Ondo , Kelly E Lyons , Min Qin , Svetlana Garafola , Bonnie Hersh , TinaMarie Lieu , Dimitrios Arkilo , Rosalind Chuang , Kemi Bankole , Rajesh Pahwa

A phase 1 study to evaluate the safety, tolerability and pharmacokinetics of TAK-041 in healthy participants and patients with stable schizophrenia.

British journal of clinical pharmacology

Avec: Wei Yin , David Han , Polyna Khudyakov , Rhett Behrje , Joel Posener , Antonio Laurenza , Dimitrios Arkilo

Randomized controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in adults with complex regional pain syndrome.

Pain medicine (Malden, Mass.)

Avec: Stuart Ratcliffe , Dimitrios Arkilo , Mahnaz Asgharnejad , Sudipta Bhattacharya , R Norman Harden

Efficacy, safety, and tolerability of soticlestat as adjunctive therapy for the treatment of seizures in patients with Dup15q syndrome or CDKL5 deficiency disorder in an open-label signal-finding phase II study (ARCADE).

Epilepsy & behavior : E&B

Avec: Scott Demarest , Shafali Jeste , Nitin Agarwal , Dimitrios Arkilo , Mahnaz Asgharnejad , Samuel Hsiao , Ronald Thibert

Réseau de co-auteurs

Mahnaz Asgharnejad 4 collaborations

Antonio Laurenza 2 collaborations

Wei Yin 2 collaborations

Polyna Khudyakov 2 collaborations

Samuel Hsiao 2 collaborations

Amin Kamel 1 collaboration

Steve Bowlin 1 collaboration

Natalie Hosea 1 collaboration

Jim Hazel 1 collaboration

Saurabh Gupta 1 collaboration

Maria S Quinton 1 collaboration

Jie Lin 1 collaboration

Deborah S Hartman 1 collaboration

Martin M Bednar 1 collaboration

Laura Rosen 1 collaboration

Jens R Wendland 1 collaboration

Jonathan J Halford 1 collaboration

Michael R Sperling 1 collaboration

Celia Zinger 1 collaboration

Rengyi Xu 1 collaboration

Matthew During 1 collaboration

Jacqueline A French 1 collaboration

Cecil D Hahn 1 collaboration

Yuwu Jiang 1 collaboration

Vicente Villanueva 1 collaboration

Marta Zolnowska 1 collaboration

Dennis Dlugos 1 collaboration

Rodger J Elble 1 collaboration

William G Ondo 1 collaboration

Kelly E Lyons 1 collaboration

Min Qin 1 collaboration

Svetlana Garafola 1 collaboration

Bonnie Hersh 1 collaboration

TinaMarie Lieu 1 collaboration

Rosalind Chuang 1 collaboration

Kemi Bankole 1 collaboration

Rajesh Pahwa 1 collaboration

David Han 1 collaboration

Rhett Behrje 1 collaboration

Joel Posener 1 collaboration

Stuart Ratcliffe 1 collaboration

Sudipta Bhattacharya 1 collaboration

R Norman Harden 1 collaboration

Scott Demarest 1 collaboration

Shafali Jeste 1 collaboration

Nitin Agarwal 1 collaboration

Ronald Thibert 1 collaboration