Doug Hoen

Affiliations

Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, New York.
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Publications (8)

Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors.

Nature communications

Avec: Cristina Valero , Mark Lee , Douglas Hoen , Kate Weiss , Daniel W Kelly , Prasad S Adusumilli , Paul K Paik , George Plitas , Marc Ladanyi , Michael A Postow , Charlotte E Ariyan , Alexander N Shoushtari , Vinod P Balachandran , A Ari Hakimi , Aimee M Crago , Kara C Long Roche , J Joshua Smith , Ian Ganly , Richard J Wong , Snehal G Patel , Jatin P Shah , Nancy Y Lee , Nadeem Riaz , Jingming Wang , Ahmet Zehir , Michael F Berger , Timothy A Chan , Venkatraman E Seshan , Luc G T Morris

Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity.

Nature genetics

Avec: Xiaoxiao Ma , Nadeem Riaz , Robert M Samstein , Mark Lee , Vladimir Makarov , Cristina Valero , Diego Chowell , Fengshen Kuo , Douglas Hoen , Conall W R Fitzgerald , Hui Jiang , Jonathan Alektiar , Tyler J Alban , Ivan Juric , Prerana Bangalore Parthasarathy , Yu Zhao , Erich Y Sabio , Richa Verma , Raghvendra M Srivastava , Lynda Vuong , Wei Yang , Xiao Zhang , Jingming Wang , Lawrence K Chu , Stephen L Wang , Daniel W Kelly , Xin Pei , Jiapeng Chen , Rona Yaeger , Dmitriy Zamarin , Ahmet Zehir , Mithat Gönen , Luc G T Morris , Timothy A Chan

A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response.

Nature communications

Avec: A Ari Hakimi , Kyrollis Attalla , Renzo G DiNatale , Irina Ostrovnaya , Jessica Flynn , Kyle A Blum , Yasser Ged , Douglas Hoen , Sviatoslav M Kendall , Ed Reznik , Anita Bowman , Jason Hwee , Christopher J Fong , Fengshen Kuo , Martin H Voss , Timothy A Chan , Robert J Motzer

Immunogenic neoantigens derived from gene fusions stimulate T cell responses.

Nature medicine

Avec: Wei Yang , Ken-Wing Lee , Raghvendra M Srivastava , Fengshen Kuo , Chirag Krishna , Diego Chowell , Vladimir Makarov , Douglas Hoen , Martin G Dalin , Leonard Wexler , Ronald Ghossein , Nora Katabi , Zaineb Nadeem , Marc A Cohen , S Ken Tian , Nicolas Robine , Kanika Arora , Heather Geiger , Phaedra Agius , Nancy Bouvier , Kety Huberman , Katelynd Vanness , Jonathan J Havel , Jennifer S Sims , Robert M Samstein , Rajarsi Mandal , Justin Tepe , Ian Ganly , Alan L Ho , Nadeem Riaz , Richard J Wong , Neerav Shukla , Timothy A Chan , Luc G T Morris

The association between tumor mutational burden and prognosis is dependent on treatment context.

Nature genetics

Avec: Cristina Valero , Mark Lee , Douglas Hoen , Jingming Wang , Zaineb Nadeem , Neal Patel , Michael A Postow , Alexander N Shoushtari , George Plitas , Vinod P Balachandran , J Joshua Smith , Aimee M Crago , Kara C Long Roche , Daniel W Kelly , Robert M Samstein , Satshil Rana , Ian Ganly , Richard J Wong , A Ari Hakimi , Michael F Berger , Ahmet Zehir , David B Solit , Marc Ladanyi , Nadeem Riaz , Timothy A Chan , Venkatraman E Seshan , Luc G T Morris

High Response Rate and Durability Driven by HLA Genetic Diversity in Patients with Kidney Cancer Treated with Lenvatinib and Pembrolizumab.

Molecular cancer research : MCR

Avec: Chung-Han Lee , Renzo G DiNatale , Diego Chowell , Chirag Krishna , Vladimir Makarov , Cristina Valero , Lynda Vuong , Mark Lee , Kate Weiss , Doug Hoen , Luc Morris , Ed Reznik , Samuel Murray , Ritesh Kotecha , Martin H Voss , Maria I Carlo , Darren Feldman , Pallavi Sachdev , Yusuke Adachi , Yukinori Minoshima , Junji Matsui , Yasuhiro Funahashi , Kenichi Nomoto , A Ari Hakimi , Robert J Motzer , Timothy A Chan

Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer.

Immunity

Avec: Maria Tello-Lafoz , Katja Srpan , Elisa E Sanchez , Jing Hu , Jan Remsik , Yevgeniy Romin , Annalisa Calò , Douglas Hoen , Umeshkumar Bhanot , Luc Morris , Adrienne Boire , Katharine C Hsu , Joan Massagué , Morgan Huse , Ekrem Emrah Er

Response Rates to Anti-PD-1 Immunotherapy in Microsatellite-Stable Solid Tumors With 10 or More Mutations per Megabase.

JAMA oncology

Avec: Cristina Valero , Mark Lee , Douglas Hoen , Ahmet Zehir , Michael F Berger , Venkatraman E Seshan , Timothy A Chan , Luc G T Morris

Réseau de co-auteurs

Douglas Hoen 7 collaborations

Timothy A Chan 7 collaborations

Cristina Valero 5 collaborations

Mark Lee 5 collaborations

Luc G T Morris 5 collaborations

A Ari Hakimi 4 collaborations

Nadeem Riaz 4 collaborations

Ahmet Zehir 4 collaborations

Daniel W Kelly 3 collaborations

Ian Ganly 3 collaborations

Richard J Wong 3 collaborations

Jingming Wang 3 collaborations

Michael F Berger 3 collaborations

Venkatraman E Seshan 3 collaborations

Robert M Samstein 3 collaborations

Vladimir Makarov 3 collaborations

Diego Chowell 3 collaborations

Fengshen Kuo 3 collaborations

Kate Weiss 2 collaborations

George Plitas 2 collaborations

Marc Ladanyi 2 collaborations

Michael A Postow 2 collaborations

Alexander N Shoushtari 2 collaborations

Vinod P Balachandran 2 collaborations

Aimee M Crago 2 collaborations

Kara C Long Roche 2 collaborations

J Joshua Smith 2 collaborations

Raghvendra M Srivastava 2 collaborations

Lynda Vuong 2 collaborations

Wei Yang 2 collaborations

Renzo G DiNatale 2 collaborations

Ed Reznik 2 collaborations

Martin H Voss 2 collaborations

Robert J Motzer 2 collaborations

Chirag Krishna 2 collaborations

Zaineb Nadeem 2 collaborations

Luc Morris 2 collaborations

Prasad S Adusumilli 1 collaboration

Paul K Paik 1 collaboration

Charlotte E Ariyan 1 collaboration

Snehal G Patel 1 collaboration

Jatin P Shah 1 collaboration

Nancy Y Lee 1 collaboration

Xiaoxiao Ma 1 collaboration

Conall W R Fitzgerald 1 collaboration

Hui Jiang 1 collaboration

Jonathan Alektiar 1 collaboration

Tyler J Alban 1 collaboration

Ivan Juric 1 collaboration

Prerana Bangalore Parthasarathy 1 collaboration

Yu Zhao 1 collaboration

Erich Y Sabio 1 collaboration

Richa Verma 1 collaboration

Xiao Zhang 1 collaboration

Lawrence K Chu 1 collaboration

Stephen L Wang 1 collaboration

Xin Pei 1 collaboration

Jiapeng Chen 1 collaboration

Rona Yaeger 1 collaboration

Dmitriy Zamarin 1 collaboration

Mithat Gönen 1 collaboration

Kyrollis Attalla 1 collaboration

Irina Ostrovnaya 1 collaboration

Jessica Flynn 1 collaboration

Kyle A Blum 1 collaboration

Yasser Ged 1 collaboration

Sviatoslav M Kendall 1 collaboration

Anita Bowman 1 collaboration

Jason Hwee 1 collaboration

Christopher J Fong 1 collaboration

Ken-Wing Lee 1 collaboration

Martin G Dalin 1 collaboration

Leonard Wexler 1 collaboration

Ronald Ghossein 1 collaboration

Nora Katabi 1 collaboration

Marc A Cohen 1 collaboration

S Ken Tian 1 collaboration

Nicolas Robine 1 collaboration

Kanika Arora 1 collaboration

Heather Geiger 1 collaboration

Phaedra Agius 1 collaboration

Nancy Bouvier 1 collaboration

Kety Huberman 1 collaboration

Katelynd Vanness 1 collaboration

Jonathan J Havel 1 collaboration

Jennifer S Sims 1 collaboration

Rajarsi Mandal 1 collaboration

Justin Tepe 1 collaboration

Alan L Ho 1 collaboration

Neerav Shukla 1 collaboration

Neal Patel 1 collaboration

Satshil Rana 1 collaboration

David B Solit 1 collaboration

Chung-Han Lee 1 collaboration

Samuel Murray 1 collaboration

Ritesh Kotecha 1 collaboration

Maria I Carlo 1 collaboration

Darren Feldman 1 collaboration

Pallavi Sachdev 1 collaboration

Yusuke Adachi 1 collaboration

Yukinori Minoshima 1 collaboration

Junji Matsui 1 collaboration

Yasuhiro Funahashi 1 collaboration

Kenichi Nomoto 1 collaboration

Maria Tello-Lafoz 1 collaboration

Katja Srpan 1 collaboration

Elisa E Sanchez 1 collaboration

Jing Hu 1 collaboration

Jan Remsik 1 collaboration

Yevgeniy Romin 1 collaboration

Annalisa Calò 1 collaboration

Umeshkumar Bhanot 1 collaboration

Adrienne Boire 1 collaboration

Katharine C Hsu 1 collaboration

Joan Massagué 1 collaboration

Morgan Huse 1 collaboration

Ekrem Emrah Er 1 collaboration