Edith M Hessel

Publications (12)

Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target.

Journal of medicinal chemistry

Avec: Zoë A Henley , Augustin Amour , Nick Barton , Marcus Bantscheff , Giovanna Bergamini , Sophie M Bertrand , Máire Convery , Kenneth Down , Birgit Dümpelfeld , Chris D Edwards , Paola Grandi , Paul M Gore , Steve Keeling , Stefano Livia , David Mallett , Aoife Maxwell , Mark Price , Christina Rau , Friedrich B M Reinhard , James Rowedder , Paul Rowland , Jonathan A Taylor , Daniel A Thomas , Edith M Hessel , J Nicole Hamblin

Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode.

Journal of medicinal chemistry

Avec: Kenneth Down , Augustin Amour , Niall A Anderson , Nick Barton , Sebastien Campos , Edward P Cannons , Cole Clissold , Maire A Convery , John J Coward , Kevin Doyle , Birgit Duempelfeld , Christopher D Edwards , Michael D Goldsmith , Jana Krause , David N Mallett , Grant A McGonagle , Vipulkumar K Patel , James Rowedder , Paul Rowland , Andrew Sharpe , Srividya Sriskantharajah , Daniel A Thomas , Douglas W Thomson , Sorif Uddin , J Nicole Hamblin , Edith M Hessel

Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical Investigations.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Aarti Patel , Robert Wilson , Andrew W Harrell , Kunal S Taskar , Maxine Taylor , Helen Tracey , Kylie Riddell , Alex Georgiou , Anthony P Cahn , Miriam Marotti , Edith M Hessel

Airway host-microbiome interactions in chronic obstructive pulmonary disease.

Respiratory research

Avec: Zhang Wang , Barbara Maschera , Simon Lea , Umme Kolsum , David Michalovich , Stephanie Van Horn , Christopher Traini , James R Brown , Edith M Hessel , Dave Singh

Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study.

International journal of chronic obstructive pulmonary disease

Avec: William A Fahy , Farshid Homayoun-Valiani , Anthony Cahn , Jon Robertson , Alison Templeton , Wilhelmine H Meeraus , Robert Wilson , Mike Lowings , Miriam Marotti , Sarah L West , Maggie Tabberer , Edith M Hessel

Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures.

American journal of respiratory cell and molecular biology

Avec: Sabine Wronski , Soren Beinke , Helena Obernolte , Nikolai N Belyaev , Ken A Saunders , Mark G Lennon , Dirk Schaudien , Peter Braubach , Danny Jonigk , Gregor Warnecke , Patrick Zardo , Hans-Gerd Fieguth , Ludwig Wilkens , Armin Braun , Edith M Hessel , Katherina Sewald

The FAM13A Long Isoform Regulates Cilia Movement and Co-ordination in Airway Mucociliary Transport.

American journal of respiratory cell and molecular biology

Avec: Ashleigh Howes , Clare Rogerson , Nikolai Belyaev , Tina Karagyozova , Radu Rapiteanu , Ricardo Fradique , Nicola Pellicciotta , David Mayhew , Catherine Hurd , Stefania Crotta , Tanya Singh , Kevin Dingwell , Anniek Myatt , Navot Arad , Hikmatyar Hasan , Hielke Bijlsma , Aliza Panjwani , Vinaya Vijayan , George Young , Angela Bridges , Sebastien Petit-Frere , Joanna Betts , Chris Larminie , James C Smith , Edith M Hessel , David Michalovich , Louise Walport , Pietro Cicuta , Andrew J Powell , Soren Beinke , Andreas Wack

Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage.

Scientific reports

Avec: Braulio Henrique Freire Lima , Pedro Elias Marques , Lindisley Ferreira Gomides , Matheus Silvério Mattos , Lucas Kraemer , Celso M Queiroz-Junior , Mark Lennon , Emilio Hirsch , Remo Castro Russo , Gustavo Batista Menezes , Edith M Hessel , Augustin Amour , Mauro Martins Teixeira

An Innovative Approach to Characterize Clinical ADME and Pharmacokinetics of the Inhaled Drug Nemiralisib Using an Intravenous Microtracer Combined with an Inhaled Dose and an Oral Radiolabel Dose in Healthy Male Subjects.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Andrew W Harrell , Robert Wilson , Yau Lun Man , Kylie Riddell , Emily Jarvis , Graeme Young , Robert Chambers , Lee Crossman , Alex Georgiou , Adrian Pereira , David Kenworthy , Claire Beaumont , Miriam Marotti , Denisa Wilkes , Edith M Hessel , William A Fahy

Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily Dosing Regimen for Nemiralisib.

The Journal of pharmacology and experimental therapeutics

Avec: M Begg , R Wilson , J N Hamblin , M Montembault , J Green , A Deans , A Amour , S Worsley , K Fantom , Y Cui , G Dear , S Ahmad , A Kielkowska , J Clark , M Boyce , A Cahn , E M Hessel

Predicting Re-Exacerbation Timing and Understanding Prolonged Exacerbations: An Analysis of Patients with COPD in the ECLIPSE Cohort.

International journal of chronic obstructive pulmonary disease

Avec: Wilhelmine H Meeraus , Hana Mullerova , Céline El Baou , Marion Fahey , Edith M Hessel , William A Fahy

Corrected Super-Resolution Microscopy Enables Nanoscale Imaging of Autofluorescent Lung Macrophages.

Biophysical journal

Avec: Ashley R Ambrose , Susanne Dechantsreiter , Rajesh Shah , M Angeles Montero , Anne Marie Quinn , Edith M Hessel , Soren Beinke , Gillian M Tannahill , Daniel M Davis

Réseau de co-auteurs

Augustin Amour 3 collaborations

Robert Wilson 3 collaborations

Miriam Marotti 3 collaborations

William A Fahy 3 collaborations

Soren Beinke 3 collaborations

Nick Barton 2 collaborations

Kenneth Down 2 collaborations

James Rowedder 2 collaborations

Paul Rowland 2 collaborations

Daniel A Thomas 2 collaborations

J Nicole Hamblin 2 collaborations

Andrew W Harrell 2 collaborations

Kylie Riddell 2 collaborations

Alex Georgiou 2 collaborations

David Michalovich 2 collaborations

Wilhelmine H Meeraus 2 collaborations

Zoë A Henley 1 collaboration

Marcus Bantscheff 1 collaboration

Giovanna Bergamini 1 collaboration

Sophie M Bertrand 1 collaboration

Máire Convery 1 collaboration

Birgit Dümpelfeld 1 collaboration

Chris D Edwards 1 collaboration

Paola Grandi 1 collaboration

Paul M Gore 1 collaboration

Steve Keeling 1 collaboration

Stefano Livia 1 collaboration

David Mallett 1 collaboration

Aoife Maxwell 1 collaboration

Mark Price 1 collaboration

Christina Rau 1 collaboration

Friedrich B M Reinhard 1 collaboration

Jonathan A Taylor 1 collaboration

Niall A Anderson 1 collaboration

Sebastien Campos 1 collaboration

Edward P Cannons 1 collaboration

Cole Clissold 1 collaboration

Maire A Convery 1 collaboration

John J Coward 1 collaboration

Kevin Doyle 1 collaboration

Birgit Duempelfeld 1 collaboration

Christopher D Edwards 1 collaboration

Michael D Goldsmith 1 collaboration

Jana Krause 1 collaboration

David N Mallett 1 collaboration

Grant A McGonagle 1 collaboration

Vipulkumar K Patel 1 collaboration

Andrew Sharpe 1 collaboration

Srividya Sriskantharajah 1 collaboration

Douglas W Thomson 1 collaboration

Sorif Uddin 1 collaboration

Aarti Patel 1 collaboration

Kunal S Taskar 1 collaboration

Maxine Taylor 1 collaboration

Helen Tracey 1 collaboration

Anthony P Cahn 1 collaboration

Zhang Wang 1 collaboration

Barbara Maschera 1 collaboration

Simon Lea 1 collaboration

Umme Kolsum 1 collaboration

Stephanie Van Horn 1 collaboration

Christopher Traini 1 collaboration

James R Brown 1 collaboration

Dave Singh 1 collaboration

Farshid Homayoun-Valiani 1 collaboration

Anthony Cahn 1 collaboration

Jon Robertson 1 collaboration

Alison Templeton 1 collaboration

Mike Lowings 1 collaboration

Sarah L West 1 collaboration

Maggie Tabberer 1 collaboration

Sabine Wronski 1 collaboration

Helena Obernolte 1 collaboration

Nikolai N Belyaev 1 collaboration

Ken A Saunders 1 collaboration

Mark G Lennon 1 collaboration

Dirk Schaudien 1 collaboration

Peter Braubach 1 collaboration

Danny Jonigk 1 collaboration

Gregor Warnecke 1 collaboration

Patrick Zardo 1 collaboration

Hans-Gerd Fieguth 1 collaboration

Ludwig Wilkens 1 collaboration

Armin Braun 1 collaboration

Katherina Sewald 1 collaboration

Ashleigh Howes 1 collaboration

Clare Rogerson 1 collaboration

Nikolai Belyaev 1 collaboration

Tina Karagyozova 1 collaboration

Radu Rapiteanu 1 collaboration

Ricardo Fradique 1 collaboration

Nicola Pellicciotta 1 collaboration

David Mayhew 1 collaboration

Catherine Hurd 1 collaboration

Stefania Crotta 1 collaboration

Tanya Singh 1 collaboration

Kevin Dingwell 1 collaboration

Anniek Myatt 1 collaboration

Navot Arad 1 collaboration

Hikmatyar Hasan 1 collaboration

Hielke Bijlsma 1 collaboration

Aliza Panjwani 1 collaboration

Vinaya Vijayan 1 collaboration

George Young 1 collaboration

Angela Bridges 1 collaboration

Sebastien Petit-Frere 1 collaboration

Joanna Betts 1 collaboration

Chris Larminie 1 collaboration

James C Smith 1 collaboration

Louise Walport 1 collaboration

Pietro Cicuta 1 collaboration

Andrew J Powell 1 collaboration

Andreas Wack 1 collaboration

Braulio Henrique Freire Lima 1 collaboration

Pedro Elias Marques 1 collaboration

Lindisley Ferreira Gomides 1 collaboration

Matheus Silvério Mattos 1 collaboration

Lucas Kraemer 1 collaboration

Celso M Queiroz-Junior 1 collaboration

Mark Lennon 1 collaboration

Emilio Hirsch 1 collaboration

Remo Castro Russo 1 collaboration

Gustavo Batista Menezes 1 collaboration

Mauro Martins Teixeira 1 collaboration

Yau Lun Man 1 collaboration

Emily Jarvis 1 collaboration

Graeme Young 1 collaboration

Robert Chambers 1 collaboration

Lee Crossman 1 collaboration

Adrian Pereira 1 collaboration

David Kenworthy 1 collaboration

Claire Beaumont 1 collaboration

Denisa Wilkes 1 collaboration

M Begg 1 collaboration

R Wilson 1 collaboration

J N Hamblin 1 collaboration

M Montembault 1 collaboration

J Green 1 collaboration

A Deans 1 collaboration

A Amour 1 collaboration

S Worsley 1 collaboration

K Fantom 1 collaboration

Y Cui 1 collaboration

G Dear 1 collaboration

S Ahmad 1 collaboration

A Kielkowska 1 collaboration

J Clark 1 collaboration

M Boyce 1 collaboration

A Cahn 1 collaboration

E M Hessel 1 collaboration

Hana Mullerova 1 collaboration

Céline El Baou 1 collaboration

Marion Fahey 1 collaboration

Ashley R Ambrose 1 collaboration

Susanne Dechantsreiter 1 collaboration

Rajesh Shah 1 collaboration

M Angeles Montero 1 collaboration

Anne Marie Quinn 1 collaboration

Gillian M Tannahill 1 collaboration

Daniel M Davis 1 collaboration