Eric S Diffenderfer

Affiliations

Department of Radiation Oncology, University of Pennsylvania, Perelman Center for Advanced Medicine, 3400 Civic Center Blvd, Philadelphia, PA 19104, United States.

Publications (20)

Machine learning highlights the deficiency of conventional dosimetric constraints for prevention of high-grade radiation esophagitis in non-small cell lung cancer treated with chemoradiation.

Clinical and translational radiation oncology

Avec: José Marcio Luna , Hann-Hsiang Chao , Russel T Shinohara , Lyle H Ungar , Keith A Cengel , Daniel A Pryma , Chidambaram Chinniah , Abigail T Berman , Sharyn I Katz , Despina Kontos , Charles B Simone , Eric S Diffenderfer

Characterization of a high-resolution 2D transmission ion chamber for independent validation of proton pencil beam scanning of conventional and FLASH dose delivery.

Medical physics

Avec: Wei Zou , Eric S Diffenderfer , Kan Ota , Paul Boisseau , Michele M Kim , Yongliang Cai , Stephen M Avery , David J Carlson , Rodney D Wiersma , Alexander Lin , Constantinos Koumenis , Keith A Cengel , James M Metz , Lei Dong , Boonkeng K Teo

Current delivery limitations of proton PBS for FLASH.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Avec: Wei Zou , Eric S Diffenderfer , Keith A Cengel , Michele M Kim , Steve Avery , Joshua Konzer , Yongliang Cai , Paul Boisseu , Kan Ota , Lingshu Yin , Rodney Wiersma , David J Carlson , Yi Fan , Theresa M Busch , Costas Koumenis , Alexander Lin , James M Metz , BoonKeng K Teo , Lei Dong

FLASH proton radiotherapy mitigates inflammatory and fibrotic pathways and preserves cardiac function in a preclinical mouse model of radiation-induced heart disease.

International journal of radiation oncology, biology, physics

Avec: Kyle Kim , Michele M Kim , Giorgos Skoufos , Eric S Diffenderfer , Seyyedeh Azar Oliaei Motlagh , Michail Kokkorakis , Ilektra Koliaki , George Morcos , Khayrullo Shoniyozov , Joanna Griffin , Artemis G Hatzigeorgiou , James M Metz , Alexander Lin , Steven J Feigenberg , Keith A Cengel , Bonnie Ky , Constantinos Koumenis , Ioannis I Verginadis

FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone.

bioRxiv : the preprint server for biology

Avec: Ioannis I Verginadis , Anastasia Velalopoulou , Michele M Kim , Kyle Kim , Ioannis Paraskevaidis , Brett Bell , Seyyedeh Azar Oliaei Motlagh , Antoneta Karaj , Esha Banerjee , Giovanni Finesso , Charles-Antoine Assenmacher , Enrico Radaelli , Jiawei Lu , Yuewei Lin , Mary E Putt , Eric S Diffenderfer , Chandan Guha , Ling Qin , James M Metz , Amit Maity , Keith A Cengel , Constantinos Koumenis , Theresa M Busch

Building more accurate decision trees with the additive tree.

Proceedings of the National Academy of Sciences of the United States of America

Avec: José Marcio Luna , Efstathios D Gennatas , Lyle H Ungar , Eric Eaton , Eric S Diffenderfer , Shane T Jensen , Charles B Simone , Jerome H Friedman , Timothy D Solberg , Gilmer Valdes

Predicting radiation pneumonitis in locally advanced stage II-III non-small cell lung cancer using machine learning.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Avec: José Marcio Luna , Hann-Hsiang Chao , Eric S Diffenderfer , Gilmer Valdes , Chidambaram Chinniah , Grace Ma , Keith A Cengel , Timothy D Solberg , Abigail T Berman , Charles B Simone

Unedited allogeneic iNKT cells show extended persistence in MHC-mismatched canine recipients.

Cell reports. Medicine

Avec: Antonia Rotolo , Eoin C Whelan , Matthew J Atherton , Irina Kulikovskaya , Danuta Jarocha , Joseph A Fraietta , Michele M Kim , Eric S Diffenderfer , Keith A Cengel , Martina Piviani , Enrico Radaelli , Raimon Duran-Struuck , Nicola J Mason

A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply.

Frontiers in oncology

Avec: Wei Zou , Haram Kim , Eric S Diffenderfer , David J Carlson , Cameron J Koch , Ying Xiao , BoonKeng K Teo , Michele M Kim , James M Metz , Yi Fan , Amit Maity , Costas Koumenis , Theresa M Busch , Rodney Wiersma , Keith A Cengel , Lei Dong

Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System.

International journal of radiation oncology, biology, physics

Avec: Eric S Diffenderfer , Ioannis I Verginadis , Michele M Kim , Khayrullo Shoniyozov , Anastasia Velalopoulou , Denisa Goia , Mary Putt , Sarah Hagan , Stephen Avery , Kevin Teo , Wei Zou , Alexander Lin , Samuel Swisher-McClure , Cameron Koch , Ann R Kennedy , Andy Minn , Amit Maity , Theresa M Busch , Lei Dong , Costas Koumenis , James Metz , Keith A Cengel

The current status of preclinical proton FLASH radiation and future directions.

Medical physics

Avec: Eric S Diffenderfer , Brita S Sørensen , Alejandro Mazal , David J Carlson

Comparison of FLASH Proton Entrance and the Spread-Out Bragg Peak Dose Regions in the Sparing of Mouse Intestinal Crypts and in a Pancreatic Tumor Model.

Cancers

Avec: Michele M Kim , Ioannis I Verginadis , Denisa Goia , Allison Haertter , Khayrullo Shoniyozov , Wei Zou , Amit Maity , Theresa M Busch , James M Metz , Keith A Cengel , Lei Dong , Costas Koumenis , Eric S Diffenderfer

Secondary neutron dosimetry for conformal FLASH proton therapy.

Medical physics

Avec: Dixin Chen , Seyyedeh Azar Oliaei Motlagh , François Vander Stappen , Rudi Labarbe , Beryl Bell , Michele Kim , Boon-Keng Kevin Teo , Lei Dong , Wei Zou , Eric Stanton Diffenderfer

Proton radiation boosts the efficacy of mesothelin-targeting chimeric antigen receptor T cell therapy in pancreatic cancer.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Uri Amit , Ugur Uslu , Ioannis I Verginadis , Michele M Kim , Seyyedeh Azar Oliaei Motlagh , Eric S Diffenderfer , Charles-Antoine Assenmacher , Sandra Bicher , Sebastian J Atoche , Edgar Ben-Josef , Regina M Young , Carl H June , Constantinos Koumenis

Design and commissioning of an image-guided small animal radiation platform and quality assurance protocol for integrated proton and x-ray radiobiology research.

Physics in medicine and biology

Avec: Michele M Kim , Peyton Irmen , Khayrullo Shoniyozov , Ioannis I Verginadis , Keith A Cengel , Costantinos Koumenis , James M Metz , Lei Dong , Eric S Diffenderfer

Patient-derived organoids as a platform for modeling a patient's response to chemoradiotherapy in esophageal cancer.

Scientific reports

Avec: Tatiana A Karakasheva , Joel T Gabre , Uma M Sachdeva , Ricardo Cruz-Acuña , Eric W Lin , Maureen DeMarshall , Gary W Falk , Gregory G Ginsberg , Zhaohai Yang , Michele M Kim , Eric S Diffenderfer , Jason R Pitarresi , Jinyang Li , Amanda B Muir , Kathryn E Hamilton , Hiroshi Nakagawa , Adam J Bass , Anil K Rustgi

Radiomic Phenotypes for Improving Early Prediction of Survival in Stage III Non-Small Cell Lung Cancer Adenocarcinoma after Chemoradiation.

Cancers

Avec: José Marcio Luna , Andrew R Barsky , Russell T Shinohara , Leonid Roshkovan , Michelle Hershman , Alexandra D Dreyfuss , Hannah Horng , Carolyn Lou , Peter B Noël , Keith A Cengel , Sharyn Katz , Eric S Diffenderfer , Despina Kontos

Framework for Quality Assurance of Ultrahigh Dose Rate Clinical Trials Investigating FLASH Effects and Current Technology Gaps.

International journal of radiation oncology, biology, physics

Avec: Wei Zou , Rongxiao Zhang , Emil Schüler , Paige A Taylor , Anthony E Mascia , Eric S Diffenderfer , Tianyu Zhao , Ahmet S Ayan , Manju Sharma , Shu-Jung Yu , Weiguo Lu , Walter R Bosch , Christina Tsien , Murat Surucu , Julianne M Pollard-Larkin , Jan Schuemann , Eduardo G Moros , Magdalena Bazalova-Carter , David J Gladstone , Heng Li , Charles B Simone , Kristoffer Petersson , Stephen F Kry , Amit Maity , Billy W Loo , Lei Dong , Peter G Maxim , Ying Xiao , Jeffrey C Buchsbaum

FLASH Radiotherapy: What Can FLASH's Ultra High Dose Rate Offer to the Treatment of Patients With Sarcoma?

Seminars in radiation oncology

Avec: Keith A Cengel , Michele M Kim , Eric S Diffenderfer , Theresa M Busch

Proton FLASH radiotherapy ameliorates radiation-induced salivary gland dysfunction and oral mucositis and increases survival in a mouse model of head and neck cancer.

Molecular cancer therapeutics

Avec: Priyanka Chowdhury , Anastasia Velalopoulou , Ioannis I Verginadis , George Morcos , Phoebe E Loo , Michele M Kim , Seyyedeh Azar Oliaei Motlagh , Khayrullo Shoniyozov , Eric S Diffenderfer , Emilio A Ocampo , Mary Putt , Charles-Antoine Assenmacher , Enrico Radaelli , Jiawei Lu , Ling Qin , Hengxi Liu , Nektaria Maria Leli , Swati Girdhani , Nicolas Denef , Francois Vander Stappen , Keith A Cengel , Theresa M Busch , James M Metz , Lei Dong , Alexander Lin , Constantinos Koumenis

Réseau de co-auteurs

Keith A Cengel 14 collaborations

Michele M Kim 13 collaborations

Lei Dong 9 collaborations

James M Metz 8 collaborations

Wei Zou 7 collaborations

Theresa M Busch 7 collaborations

Ioannis I Verginadis 7 collaborations

Alexander Lin 5 collaborations

Constantinos Koumenis 5 collaborations

Seyyedeh Azar Oliaei Motlagh 5 collaborations

Khayrullo Shoniyozov 5 collaborations

Amit Maity 5 collaborations

José Marcio Luna 4 collaborations

Charles B Simone 4 collaborations

David J Carlson 4 collaborations

Costas Koumenis 4 collaborations

Anastasia Velalopoulou 3 collaborations

Charles-Antoine Assenmacher 3 collaborations

Enrico Radaelli 3 collaborations

Hann-Hsiang Chao 2 collaborations

Lyle H Ungar 2 collaborations

Chidambaram Chinniah 2 collaborations

Abigail T Berman 2 collaborations

Despina Kontos 2 collaborations

Kan Ota 2 collaborations

Yongliang Cai 2 collaborations

Rodney Wiersma 2 collaborations

Yi Fan 2 collaborations

BoonKeng K Teo 2 collaborations

Kyle Kim 2 collaborations

George Morcos 2 collaborations

Jiawei Lu 2 collaborations

Ling Qin 2 collaborations

Timothy D Solberg 2 collaborations

Gilmer Valdes 2 collaborations

Ying Xiao 2 collaborations

Denisa Goia 2 collaborations

Mary Putt 2 collaborations

Russel T Shinohara 1 collaboration

Daniel A Pryma 1 collaboration

Sharyn I Katz 1 collaboration

Paul Boisseau 1 collaboration

Stephen M Avery 1 collaboration

Rodney D Wiersma 1 collaboration

Boonkeng K Teo 1 collaboration

Steve Avery 1 collaboration

Joshua Konzer 1 collaboration

Paul Boisseu 1 collaboration

Lingshu Yin 1 collaboration

Giorgos Skoufos 1 collaboration

Michail Kokkorakis 1 collaboration

Ilektra Koliaki 1 collaboration

Joanna Griffin 1 collaboration

Artemis G Hatzigeorgiou 1 collaboration

Steven J Feigenberg 1 collaboration

Bonnie Ky 1 collaboration

Ioannis Paraskevaidis 1 collaboration

Brett Bell 1 collaboration

Antoneta Karaj 1 collaboration

Esha Banerjee 1 collaboration

Giovanni Finesso 1 collaboration

Yuewei Lin 1 collaboration

Mary E Putt 1 collaboration

Chandan Guha 1 collaboration

Efstathios D Gennatas 1 collaboration

Eric Eaton 1 collaboration

Shane T Jensen 1 collaboration

Jerome H Friedman 1 collaboration

Grace Ma 1 collaboration

Antonia Rotolo 1 collaboration

Eoin C Whelan 1 collaboration

Matthew J Atherton 1 collaboration

Irina Kulikovskaya 1 collaboration

Danuta Jarocha 1 collaboration

Joseph A Fraietta 1 collaboration

Martina Piviani 1 collaboration

Raimon Duran-Struuck 1 collaboration

Nicola J Mason 1 collaboration

Haram Kim 1 collaboration

Cameron J Koch 1 collaboration

Sarah Hagan 1 collaboration

Stephen Avery 1 collaboration

Kevin Teo 1 collaboration

Samuel Swisher-McClure 1 collaboration

Cameron Koch 1 collaboration

Ann R Kennedy 1 collaboration

Andy Minn 1 collaboration

James Metz 1 collaboration

Brita S Sørensen 1 collaboration

Alejandro Mazal 1 collaboration

Allison Haertter 1 collaboration

Dixin Chen 1 collaboration

François Vander Stappen 1 collaboration

Rudi Labarbe 1 collaboration

Beryl Bell 1 collaboration

Michele Kim 1 collaboration

Boon-Keng Kevin Teo 1 collaboration

Eric Stanton Diffenderfer 1 collaboration

Uri Amit 1 collaboration

Ugur Uslu 1 collaboration

Sandra Bicher 1 collaboration

Sebastian J Atoche 1 collaboration

Edgar Ben-Josef 1 collaboration

Regina M Young 1 collaboration

Carl H June 1 collaboration

Peyton Irmen 1 collaboration

Costantinos Koumenis 1 collaboration

Tatiana A Karakasheva 1 collaboration

Joel T Gabre 1 collaboration

Uma M Sachdeva 1 collaboration

Ricardo Cruz-Acuña 1 collaboration

Eric W Lin 1 collaboration

Maureen DeMarshall 1 collaboration

Gary W Falk 1 collaboration

Gregory G Ginsberg 1 collaboration

Zhaohai Yang 1 collaboration

Jason R Pitarresi 1 collaboration

Jinyang Li 1 collaboration

Amanda B Muir 1 collaboration

Kathryn E Hamilton 1 collaboration

Hiroshi Nakagawa 1 collaboration

Adam J Bass 1 collaboration

Anil K Rustgi 1 collaboration

Andrew R Barsky 1 collaboration

Russell T Shinohara 1 collaboration

Leonid Roshkovan 1 collaboration

Michelle Hershman 1 collaboration

Alexandra D Dreyfuss 1 collaboration

Hannah Horng 1 collaboration

Carolyn Lou 1 collaboration

Peter B Noël 1 collaboration

Sharyn Katz 1 collaboration

Rongxiao Zhang 1 collaboration

Emil Schüler 1 collaboration

Paige A Taylor 1 collaboration

Anthony E Mascia 1 collaboration

Tianyu Zhao 1 collaboration

Ahmet S Ayan 1 collaboration

Manju Sharma 1 collaboration

Shu-Jung Yu 1 collaboration

Weiguo Lu 1 collaboration

Walter R Bosch 1 collaboration

Christina Tsien 1 collaboration

Murat Surucu 1 collaboration

Julianne M Pollard-Larkin 1 collaboration

Jan Schuemann 1 collaboration

Eduardo G Moros 1 collaboration

Magdalena Bazalova-Carter 1 collaboration

David J Gladstone 1 collaboration

Heng Li 1 collaboration

Kristoffer Petersson 1 collaboration

Stephen F Kry 1 collaboration

Billy W Loo 1 collaboration

Peter G Maxim 1 collaboration

Jeffrey C Buchsbaum 1 collaboration

Priyanka Chowdhury 1 collaboration

Phoebe E Loo 1 collaboration

Emilio A Ocampo 1 collaboration

Hengxi Liu 1 collaboration

Nektaria Maria Leli 1 collaboration

Swati Girdhani 1 collaboration

Nicolas Denef 1 collaboration

Francois Vander Stappen 1 collaboration