Frederik Dethloff

Affiliations

Max Planck Institute for Biology of Ageing, Cologne, Germany.

Publications (14)

Time-resolved proteomic analyses of senescence highlight metabolic rewiring of mitochondria.

Life science alliance

Avec: Jun Yong Kim , Ilian Atanassov , Frederik Dethloff , Lara Kroczek , Thomas Langer

Myo-Inositol Levels in the Dorsal Hippocampus Serve as Glial Prognostic Marker of Mild Cognitive Impairment in Mice.

Frontiers in aging neuroscience

Avec: Tim Ebert , Daniel E Heinz , Suellen Almeida-Corrêa , Renata Cruz , Frederik Dethloff , Tibor Stark , Thomas Bajaj , Oriana M Maurel , Fabiola M Ribeiro , Silvio Calcagnini , Kathrin Hafner , Nils C Gassen , Christoph W Turck , Benoit Boulat , Michael Czisch , Carsten T Wotjak

Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice.

Science signaling

Avec: Jens Stepan , Daniel E Heinz , Frederik Dethloff , Svenja Wiechmann , Silvia Martinelli , Kathrin Hafner , Tim Ebert , Ellen Junglas , Alexander S Häusl , Max L Pöhlmann , Mira Jakovcevski , Julius C Pape , Anthony S Zannas , Thomas Bajaj , Anke Hermann , Xiao Ma , Hermann Pavenstädt , Mathias V Schmidt , Alexandra Philipsen , Christoph W Turck , Jan M Deussing , Gerhard Rammes , Andrew C Robinson , Antony Payton , Michael C Wehr , Valentin Stein , Christopher Murgatroyd , Joachim Kremerskothen , Bernhard Kuster , Carsten T Wotjak , Nils C Gassen

Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism.

Science advances

Avec: Alexander S Häusl , Thomas Bajaj , Lea M Brix , Max L Pöhlmann , Kathrin Hafner , Meri De Angelis , Joachim Nagler , Frederik Dethloff , Georgia Balsevich , Karl-Werner Schramm , Patrick Giavalisco , Alon Chen , Mathias V Schmidt , Nils C Gassen

Multiplexed Profiling and Data Processing Methods to Identify Temperature-Regulated Primary Metabolites Using Gas Chromatography Coupled to Mass Spectrometry.

Methods in molecular biology (Clifton, N.J.)

Avec: Alexander Erban , Federico Martinez-Seidel , Yogeswari Rajarathinam , Frederik Dethloff , Isabel Orf , Ines Fehrle , Jessica Alpers , Olga Beine-Golovchuk , Joachim Kopka

Plasma Metabolite Profiles in First Episode Psychosis: Exploring Symptoms Heterogeneity/Severity in Schizophrenia and Bipolar Disorder Cohorts.

Frontiers in psychiatry

Avec: Helena P G Joaquim , Alana C Costa , Leda L Talib , Frederik Dethloff , Mauricio H Serpa , Marcus V Zanetti , Martinus van de Bilt , Christoph W Turck

Paroxetine Administration Affects Microbiota and Bile Acid Levels in Mice.

Frontiers in psychiatry

Avec: Frederik Dethloff , Fernando Vargas , Emmanuel Elijah , Robert Quinn , Dong Ik Park , David P Herzog , Marianne B Müller , Emily C Gentry , Rob Knight , Antonio Gonzalez , Pieter C Dorrestein , Christoph W Turck

Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion.

Nature communications

Avec: Silvia Martinelli , Elmira A Anderzhanova , Thomas Bajaj , Svenja Wiechmann , Frederik Dethloff , Katja Weckmann , Daniel E Heinz , Tim Ebert , Jakob Hartmann , Thomas M Geiger , Michael Döngi , Kathrin Hafner , Max L Pöhlmann , Lee Jollans , Alexandra Philipsen , Susanne V Schmidt , Ulrike Schmidt , Giuseppina Maccarrone , Valentin Stein , Felix Hausch , Christoph W Turck , Mathias V Schmidt , Anne-Kathrin Gellner , Bernhard Kuster , Nils C Gassen

Spermidine is essential for fasting-mediated autophagy and longevity.

Nature cell biology

Avec: Sebastian J Hofer , Ioanna Daskalaki , Martina Bergmann , Jasna Friščić , Andreas Zimmermann , Melanie I Mueller , Mahmoud Abdellatif , Raffaele Nicastro , Sarah Masser , Sylvère Durand , Alexander Nartey , Mara Waltenstorfer , Sarah Enzenhofer , Isabella Faimann , Verena Gschiel , Thomas Bajaj , Christine Niemeyer , Ilias Gkikas , Lukas Pein , Giulia Cerrato , Hui Pan , YongTian Liang , Jelena Tadic , Andrea Jerkovic , Fanny Aprahamian , Christine E Robbins , Nitharsshini Nirmalathasan , Hansjörg Habisch , Elisabeth Annerer , Frederik Dethloff , Michael Stumpe , Franziska Grundler , Françoise Wilhelmi de Toledo , Daniel E Heinz , Daniela A Koppold , Anika Rajput Khokhar , Andreas Michalsen , Norbert J Tripolt , Harald Sourij , Thomas R Pieber , Rafael de Cabo , Mark A McCormick , Christoph Magnes , Oliver Kepp , Joern Dengjel , Stephan J Sigrist , Nils C Gassen , Simon Sedej , Tobias Madl , Claudio De Virgilio , Ulrich Stelzl , Markus H Hoffmann , Tobias Eisenberg , Nektarios Tavernarakis , Guido Kroemer , Frank Madeo

Exposure-induced changes of plasma metabolome and gene expression in patients with panic disorder.

Depression and anxiety

Avec: Jade Martins , Darina Czamara , Jennifer Lange , Frederik Dethloff , Elisabeth B Binder , Chris W Turck , Angelika Erhardt

Ketamine's Effects on the Glutamatergic and GABAergic Systems: A Proteomics and Metabolomics Study in Mice.

Molecular neuropsychiatry

Avec: Katja Weckmann , Michael J Deery , Julie A Howard , Renata Feret , John M Asara , Frederik Dethloff , Michaela D Filiou , Christiana Labermaier , Giuseppina Maccarrone , Kathryn S Lilley , Marianne Mueller , Christoph W Turck

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.

Nature communications

Avec: Nils C Gassen , Jan Papies , Thomas Bajaj , Jackson Emanuel , Frederik Dethloff , Robert Lorenz Chua , Jakob Trimpert , Nicolas Heinemann , Christine Niemeyer , Friderike Weege , Katja Hönzke , Tom Aschman , Daniel E Heinz , Katja Weckmann , Tim Ebert , Andreas Zellner , Martina Lennarz , Emanuel Wyler , Simon Schroeder , Anja Richter , Daniela Niemeyer , Karen Hoffmann , Thomas F Meyer , Frank L Heppner , Victor M Corman , Markus Landthaler , Andreas C Hocke , Markus Morkel , Nikolaus Osterrieder , Christian Conrad , Roland Eils , Helena Radbruch , Patrick Giavalisco , Christian Drosten , Marcel A Müller

Lipid metabolism is associated with temperament, corticosteroid, and hematological measures in infant rhesus monkeys (

Zoological research

Avec: John P Capitanio , Frederik Dethloff , Christoph W Turck

Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning.

Cell reports

Avec: Jens Stepan , Daniel E Heinz , Frederik Dethloff , Thomas Bajaj , Andreas Zellner , Kathrin Hafner , Svenja Wiechmann , Sarah Mackert , Yara Mecdad , Michael Rabenstein , Tim Ebert , Silvia Martinelli , Alexander S Häusl , Maximilian L Pöhlmann , Anke Hermann , Xiao Ma , Hermann Pavenstädt , Mathias V Schmidt , Alexandra Philipsen , Chris W Turck , Jan M Deussing , Bernhard Kuster , Michael C Wehr , Valentin Stein , Joachim Kremerskothen , Carsten T Wotjak , Nils C Gassen

Réseau de co-auteurs

Thomas Bajaj 7 collaborations

Nils C Gassen 7 collaborations

Christoph W Turck 7 collaborations

Daniel E Heinz 6 collaborations

Tim Ebert 5 collaborations

Kathrin Hafner 5 collaborations

Mathias V Schmidt 4 collaborations

Carsten T Wotjak 3 collaborations

Svenja Wiechmann 3 collaborations

Silvia Martinelli 3 collaborations

Alexander S Häusl 3 collaborations

Max L Pöhlmann 3 collaborations

Alexandra Philipsen 3 collaborations

Valentin Stein 3 collaborations

Bernhard Kuster 3 collaborations

Katja Weckmann 3 collaborations

Jens Stepan 2 collaborations

Anke Hermann 2 collaborations

Xiao Ma 2 collaborations

Hermann Pavenstädt 2 collaborations

Jan M Deussing 2 collaborations

Michael C Wehr 2 collaborations

Joachim Kremerskothen 2 collaborations

Patrick Giavalisco 2 collaborations

Giuseppina Maccarrone 2 collaborations

Christine Niemeyer 2 collaborations

Chris W Turck 2 collaborations

Andreas Zellner 2 collaborations

Jun Yong Kim 1 collaboration

Ilian Atanassov 1 collaboration

Lara Kroczek 1 collaboration

Thomas Langer 1 collaboration

Suellen Almeida-Corrêa 1 collaboration

Renata Cruz 1 collaboration

Tibor Stark 1 collaboration

Oriana M Maurel 1 collaboration

Fabiola M Ribeiro 1 collaboration

Silvio Calcagnini 1 collaboration

Benoit Boulat 1 collaboration

Michael Czisch 1 collaboration

Ellen Junglas 1 collaboration

Mira Jakovcevski 1 collaboration

Julius C Pape 1 collaboration

Anthony S Zannas 1 collaboration

Gerhard Rammes 1 collaboration

Andrew C Robinson 1 collaboration

Antony Payton 1 collaboration

Christopher Murgatroyd 1 collaboration

Lea M Brix 1 collaboration

Meri De Angelis 1 collaboration

Joachim Nagler 1 collaboration

Georgia Balsevich 1 collaboration

Karl-Werner Schramm 1 collaboration

Alon Chen 1 collaboration

Alexander Erban 1 collaboration

Federico Martinez-Seidel 1 collaboration

Yogeswari Rajarathinam 1 collaboration

Isabel Orf 1 collaboration

Ines Fehrle 1 collaboration

Jessica Alpers 1 collaboration

Olga Beine-Golovchuk 1 collaboration

Joachim Kopka 1 collaboration

Helena P G Joaquim 1 collaboration

Alana C Costa 1 collaboration

Leda L Talib 1 collaboration

Mauricio H Serpa 1 collaboration

Marcus V Zanetti 1 collaboration

Martinus van de Bilt 1 collaboration

Fernando Vargas 1 collaboration

Emmanuel Elijah 1 collaboration

Robert Quinn 1 collaboration

Dong Ik Park 1 collaboration

David P Herzog 1 collaboration

Marianne B Müller 1 collaboration

Emily C Gentry 1 collaboration

Rob Knight 1 collaboration

Antonio Gonzalez 1 collaboration

Pieter C Dorrestein 1 collaboration

Elmira A Anderzhanova 1 collaboration

Jakob Hartmann 1 collaboration

Thomas M Geiger 1 collaboration

Michael Döngi 1 collaboration

Lee Jollans 1 collaboration

Susanne V Schmidt 1 collaboration

Ulrike Schmidt 1 collaboration

Felix Hausch 1 collaboration

Anne-Kathrin Gellner 1 collaboration

Sebastian J Hofer 1 collaboration

Ioanna Daskalaki 1 collaboration

Martina Bergmann 1 collaboration

Jasna Friščić 1 collaboration

Andreas Zimmermann 1 collaboration

Melanie I Mueller 1 collaboration

Mahmoud Abdellatif 1 collaboration

Raffaele Nicastro 1 collaboration

Sarah Masser 1 collaboration

Sylvère Durand 1 collaboration

Alexander Nartey 1 collaboration

Mara Waltenstorfer 1 collaboration

Sarah Enzenhofer 1 collaboration

Isabella Faimann 1 collaboration

Verena Gschiel 1 collaboration

Ilias Gkikas 1 collaboration

Lukas Pein 1 collaboration

Giulia Cerrato 1 collaboration

Hui Pan 1 collaboration

YongTian Liang 1 collaboration

Jelena Tadic 1 collaboration

Andrea Jerkovic 1 collaboration

Fanny Aprahamian 1 collaboration

Christine E Robbins 1 collaboration

Nitharsshini Nirmalathasan 1 collaboration

Hansjörg Habisch 1 collaboration

Elisabeth Annerer 1 collaboration

Michael Stumpe 1 collaboration

Franziska Grundler 1 collaboration

Françoise Wilhelmi de Toledo 1 collaboration

Daniela A Koppold 1 collaboration

Anika Rajput Khokhar 1 collaboration

Andreas Michalsen 1 collaboration

Norbert J Tripolt 1 collaboration

Harald Sourij 1 collaboration

Thomas R Pieber 1 collaboration

Rafael de Cabo 1 collaboration

Mark A McCormick 1 collaboration

Christoph Magnes 1 collaboration

Oliver Kepp 1 collaboration

Joern Dengjel 1 collaboration

Stephan J Sigrist 1 collaboration

Simon Sedej 1 collaboration

Tobias Madl 1 collaboration

Claudio De Virgilio 1 collaboration

Ulrich Stelzl 1 collaboration

Markus H Hoffmann 1 collaboration

Tobias Eisenberg 1 collaboration

Nektarios Tavernarakis 1 collaboration

Guido Kroemer 1 collaboration

Frank Madeo 1 collaboration

Jade Martins 1 collaboration

Darina Czamara 1 collaboration

Jennifer Lange 1 collaboration

Elisabeth B Binder 1 collaboration

Angelika Erhardt 1 collaboration

Michael J Deery 1 collaboration

Julie A Howard 1 collaboration

Renata Feret 1 collaboration

John M Asara 1 collaboration

Michaela D Filiou 1 collaboration

Christiana Labermaier 1 collaboration

Kathryn S Lilley 1 collaboration

Marianne Mueller 1 collaboration

Jan Papies 1 collaboration

Jackson Emanuel 1 collaboration

Robert Lorenz Chua 1 collaboration

Jakob Trimpert 1 collaboration

Nicolas Heinemann 1 collaboration

Friderike Weege 1 collaboration

Katja Hönzke 1 collaboration

Tom Aschman 1 collaboration

Martina Lennarz 1 collaboration

Emanuel Wyler 1 collaboration

Simon Schroeder 1 collaboration

Anja Richter 1 collaboration

Daniela Niemeyer 1 collaboration

Karen Hoffmann 1 collaboration

Thomas F Meyer 1 collaboration

Frank L Heppner 1 collaboration

Victor M Corman 1 collaboration

Markus Landthaler 1 collaboration

Andreas C Hocke 1 collaboration

Markus Morkel 1 collaboration

Nikolaus Osterrieder 1 collaboration

Christian Conrad 1 collaboration

Roland Eils 1 collaboration

Helena Radbruch 1 collaboration

Christian Drosten 1 collaboration

Marcel A Müller 1 collaboration

John P Capitanio 1 collaboration

Sarah Mackert 1 collaboration

Yara Mecdad 1 collaboration

Michael Rabenstein 1 collaboration

Maximilian L Pöhlmann 1 collaboration