Gerhard Sengle

Affiliations

Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany; Department of Pediatrics and Adolescent Medicine, University Hospital Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany; Cologne Center for Musculoskeletal Biomechanics, Cologne, Germany.

Publications (30)

Antimicrobial peptides derived from the cartilage.-specific C-type Lectin Domain Family 3 Member A (CLEC3A) - potential in the prevention and treatment of septic arthritis.

Osteoarthritis and cartilage

Avec: D Elezagic , M Mörgelin , G Hermes , A Hamprecht , G Sengle , D Lau , S Höllriegl , R Wagener , M Paulsson , T Streichert , A R Klatt

Anchoring Cords: A Distinct Suprastructure in the Developing Skin.

The Journal of investigative dermatology

Avec: Temitope Esho , Sara F Tufa , Birgit Kobbe , Alexander P Wohl , Gerhard Sengle , Mats Paulsson , Douglas R Keene , Raimund Wagener

LTBP1 promotes fibrillin incorporation into the extracellular matrix.

Matrix biology : journal of the International Society for Matrix Biology

Avec: Matthias Przyklenk , Veronika S Georgieva , Fabian Metzen , Sebastian Mostert , Birgit Kobbe , Bert Callewaert , Gerhard Sengle , Bent Brachvogel , Robert P Mecham , Mats Paulsson , Raimund Wagener , Manuel Koch , Alvise Schiavinato

Sensitive asprosin detection in clinical samples reveals serum/saliva correlation and indicates cartilage as source for serum asprosin.

Scientific reports

Avec: Yousef A T Morcos , Steffen Lütke , Antje Tenbieg , Franz-Georg Hanisch , Galyna Pryymachuk , Nadin Piekarek , Thorben Hoffmann , Titus Keller , Ruth Janoschek , Anja Niehoff , Frank Zaucke , Jörg Dötsch , Eva Hucklenbruch-Rother , Gerhard Sengle

Hemicentin-1 is an essential extracellular matrix component of the dermal-epidermal and myotendinous junctions.

Scientific reports

Avec: Daniela Welcker , Cornelia Stein , Natalia Martins Feitosa , Joy Armistead , Jin-Li Zhang , Steffen Lütke , Andre Kleinridders , Jens C Brüning , Sabine A Eming , Gerhard Sengle , Anja Niehoff , Wilhelm Bloch , Matthias Hammerschmidt

Targeting of bone morphogenetic protein complexes to heparin/heparan sulfate glycosaminoglycans in bioactive conformation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Chara E S Spanou , Alexander P Wohl , Sandra Doherr , Annkatrin Correns , Niklas Sonntag , Steffen Lütke , Matthias Mörgelin , Thomas Imhof , Jan M Gebauer , Ulrich Baumann , Kay Grobe , Manuel Koch , Gerhard Sengle

ADAMTS12 promotes fibrosis by restructuring extracellular matrix to enable activation of injury-responsive fibroblasts.

The Journal of clinical investigation

Avec: Konrad Hoeft , Lars Koch , Susanne Ziegler , Ling Zhang , Steffen Luetke , Maria C Tanzer , Debashish Mohanta , David Schumacher , Felix Schreibing , Qingqing Long , Hyojin Kim , Barbara M Klinkhammer , Carla Schikarski , Sidrah Maryam , Mathijs Baens , Juliane Hermann , Sarah Krieg , Fabian Peisker , Laura De Laporte , Gideon Jl Schaefer , Sylvia Menzel , Joachim Jankowski , Benjamin D Humphreys , Adam Wahida , Rebekka K Schneider , Matthias Versele , Peter Boor , Matthias Mann , Gerhard Sengle , Sikander Hayat , Rafael Kramann

Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome.

American journal of human genetics

Avec: Lore Pottie , Christin S Adamo , Aude Beyens , Steffen Lütke , Piyanoot Tapaneeyaphan , Adelbert De Clercq , Phil L Salmon , Riet De Rycke , Alper Gezdirici , Elif Yilmaz Gulec , Naz Khan , Jill E Urquhart , William G Newman , Kay Metcalfe , Stephanie Efthymiou , Reza Maroofian , Najwa Anwar , Shazia Maqbool , Fatima Rahman , Ikhlass Altweijri , Monerah Alsaleh , Sawsan Mohamed Abdullah , Mohammad Al-Owain , Mais Hashem , Henry Houlden , Fowzan S Alkuraya , Patrick Sips , Gerhard Sengle , Bert Callewaert

Controlling BMP growth factor bioavailability: The extracellular matrix as multi skilled platform.

Cellular signalling

Avec: Laura-Marie A Zimmermann , Annkatrin Correns , Ariane G Furlan , Chara E S Spanou , Gerhard Sengle

Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2.

Matrix biology : journal of the International Society for Matrix Biology

Avec: Jin-Li Zhang , Stefania Richetti , Thomas Ramezani , Daniela Welcker , Steffen Lütke , Hans-Martin Pogoda , Julia Hatzold , Frank Zaucke , Douglas R Keene , Wilhelm Bloch , Gerhard Sengle , Matthias Hammerschmidt

Lack of evidence for a role of anthrax toxin receptors as surface receptors for collagen VI and for its cleaved-off C5 domain/endotrophin.

iScience

Avec: Matthias Przyklenk , Stefanie Elisabeth Heumüller , Carolin Freiburg , Steffen Lütke , Gerhard Sengle , Manuel Koch , Mats Paulsson , Alvise Schiavinato , Raimund Wagener

EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis.

American journal of human genetics

Avec: Christin S Adamo , Aude Beyens , Alvise Schiavinato , Douglas R Keene , Sara F Tufa , Matthias Mörgelin , Jürgen Brinckmann , Takako Sasaki , Anja Niehoff , Maren Dreiner , Lore Pottie , Laura Muiño-Mosquera , Elif Yilmaz Gulec , Alper Gezdirici , Paola Braghetta , Paolo Bonaldo , Raimund Wagener , Mats Paulsson , Helen Bornaun , Riet De Rycke , Michiel De Bruyne , Femke Baeke , Walter P Devine , Balram Gangaram , Allison Tam , Meena Balasubramanian , Sian Ellard , Sandra Moore , Sofie Symoens , Joseph Shen , Stacey Cole , Ulrike Schwarze , Kathryn W Holmes , Susan J Hayflick , Wojciech Wiszniewski , Sheela Nampoothiri , Elaine C Davis , Lynn Y Sakai , Gerhard Sengle , Bert Callewaert

Dipeptidyl peptidase-4-mediated fibronectin processing evokes a pro-fibrotic extracellular matrix.

The Journal of investigative dermatology

Avec: Karina A Zeyer , Olivier Bornert , Valentin Nelea , Xinyi Bao , Alexandre Leytens , Svetlana Sharoyan , Gerhard Sengle , Alvard Antonyan , Leena Bruckner-Tuderman , Jörn Dengjel , Dieter P Reinhardt , Alexander Nyström

BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics.

PLoS biology

Avec: Christian Hiepen , Jerome Jatzlau , Susanne Hildebrandt , Branka Kampfrath , Melis Goktas , Arunima Murgai , Jose Luis Cuellar Camacho , Rainer Haag , Clemens Ruppert , Gerhard Sengle , Elisabetta Ada Cavalcanti-Adam , Kerstin G Blank , Petra Knaus

Fibrillin microfibrils and proteases, key integrators of fibrotic pathways.

Advanced drug delivery reviews

Avec: Paola Zigrino , Gerhard Sengle

A new MMP-mediated prodomain cleavage mechanism to activate bone morphogenetic proteins from the extracellular matrix.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Ariane G Furlan , Chara E S Spanou , Alan R F Godwin , Alexander P Wohl , Laura-Marie A Zimmermann , Thomas Imhof , Manuel Koch , Clair Baldock , Gerhard Sengle

Diversity of Mechanisms Underlying Latent TGF-β Activation in Recessive Dystrophic Epidermolysis Bullosa.

The Journal of investigative dermatology

Avec: Eijiro Akasaka , Svenja Kleiser , Gerhard Sengle , Leena Bruckner-Tuderman , Alexander Nyström

The fibrillin microfibril/elastic fibre network: A critical extracellular supramolecular scaffold to balance skin homoeostasis.

Experimental dermatology

Avec: Christin S Adamo , Alexandra V Zuk , Gerhard Sengle

BMP antagonists in tissue development and disease.

Matrix biology plus

Avec: Annkatrin Correns , Laura-Marie A Zimmermann , Clair Baldock , Gerhard Sengle

Correlation of metabolic characteristics with maternal, fetal and placental asprosin in human pregnancy.

Endocrine connections

Avec: Thorben Hoffmann , Yousef Ashraf Tawfik Morcos , Ruth Janoschek , Eva-Maria Turnwald , Antje Gerken , Annette Müller , Gerhard Sengle , Jörg Dötsch , Sarah Appel , Eva Hucklenbruch-Rother

BMPER Improves Vascular Remodeling and the Contractile Vascular SMC Phenotype.

International journal of molecular sciences

Avec: Franziska Pankratz , Aziza Maksudova , Roman Goesele , Lena Meier , Kora Proelss , Katia Marenne , Ann-Kathrin Thut , Gerhard Sengle , Annkatrin Correns , Jeanina Begelspacher , Deniz Alkis , Patrick M Siegel , Christian Smolka , Sebastian Grundmann , Martin Moser , Qian Zhou , Jennifer S Esser

New specific HSP47 functions in collagen subfamily chaperoning.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Anna Köhler , Matthias Mörgelin , Jan M Gebauer , Sinan Öcal , Thomas Imhof , Manuel Koch , Kazuhiro Nagata , Mats Paulsson , Monique Aumailley , Ulrich Baumann , Frank Zaucke , Gerhard Sengle

Author Correction: Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D.

Nature protocols

Avec: Alejandro E Mayorca-Guiliani , Oliver Willacy , Chris D Madsen , Maria Rafaeva , Stefanie Elisabeth Heumüller , Felix Bock , Gerhard Sengle , Manuel Koch , Thomas Imhof , Frank Zaucke , Raimund Wagener , Takako Sasaki , Janine T Erler , Raphael Reuten

Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D.

Nature protocols

C-terminal proteolysis of the collagen VI α3 chain by BMP-1 and proprotein convertase(s) releases endotrophin in fragments of different sizes.

The Journal of biological chemistry

Avec: Stefanie Elisabeth Heumüller , Maya Talantikite , Manon Napoli , Jean Armengaud , Matthias Mörgelin , Ursula Hartmann , Gerhard Sengle , Mats Paulsson , Catherine Moali , Raimund Wagener

Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis.

The European respiratory journal

Avec: Wenguang Yin , Hyun-Taek Kim , ShengPeng Wang , Felix Gunawan , Rui Li , Carmen Buettner , Beate Grohmann , Gerhard Sengle , Debora Sinner , Stefan Offermanns , Didier Y R Stainier

Internal cleavage and synergy with twisted gastrulation enhance BMP inhibition by BMPER.

Matrix biology : journal of the International Society for Matrix Biology

Avec: Michael P Lockhart-Cairns , Karen Tzia Wei Lim , Alexandra Zuk , Alan R F Godwin , Stuart A Cain , Gerhard Sengle , Clair Baldock

Signaling pathways affected by mutations causing osteogenesis imperfecta.

Cellular signalling

Avec: Julia Etich , Mirko Rehberg , Beate Eckes , Gerhard Sengle , Oliver Semler , Frank Zaucke

EMILIN proteins are novel extracellular constituents of the dentin-pulp complex.

Scientific reports

Avec: Thomas Imhof , Yüksel Korkmaz , Manuel Koch , Gerhard Sengle , Alvise Schiavinato

Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGFβ-binding site.

Nature structural & molecular biology

Avec: Alan R F Godwin , Rana Dajani , Xinyang Zhang , Jennifer Thomson , David F Holmes , Christin S Adamo , Gerhard Sengle , Michael J Sherratt , Alan M Roseman , Clair Baldock

Réseau de co-auteurs

Manuel Koch 8 collaborations

Raimund Wagener 7 collaborations

Mats Paulsson 6 collaborations

Steffen Lütke 6 collaborations

Frank Zaucke 6 collaborations

Thomas Imhof 6 collaborations

Alvise Schiavinato 4 collaborations

Annkatrin Correns 4 collaborations

Matthias Mörgelin 4 collaborations

Christin S Adamo 4 collaborations

Stefanie Elisabeth Heumüller 4 collaborations

Clair Baldock 4 collaborations

Alexander P Wohl 3 collaborations

Douglas R Keene 3 collaborations

Bert Callewaert 3 collaborations

Anja Niehoff 3 collaborations

Chara E S Spanou 3 collaborations

Laura-Marie A Zimmermann 3 collaborations

Takako Sasaki 3 collaborations

Alan R F Godwin 3 collaborations

Sara F Tufa 2 collaborations

Birgit Kobbe 2 collaborations

Matthias Przyklenk 2 collaborations

Thorben Hoffmann 2 collaborations

Ruth Janoschek 2 collaborations

Jörg Dötsch 2 collaborations

Eva Hucklenbruch-Rother 2 collaborations

Daniela Welcker 2 collaborations

Jin-Li Zhang 2 collaborations

Wilhelm Bloch 2 collaborations

Matthias Hammerschmidt 2 collaborations

Jan M Gebauer 2 collaborations

Ulrich Baumann 2 collaborations

Lore Pottie 2 collaborations

Aude Beyens 2 collaborations

Riet De Rycke 2 collaborations

Alper Gezdirici 2 collaborations

Elif Yilmaz Gulec 2 collaborations

Ariane G Furlan 2 collaborations

Leena Bruckner-Tuderman 2 collaborations

Alexander Nyström 2 collaborations

Alejandro E Mayorca-Guiliani 2 collaborations

Oliver Willacy 2 collaborations

Chris D Madsen 2 collaborations

Maria Rafaeva 2 collaborations

Felix Bock 2 collaborations

Janine T Erler 2 collaborations

Raphael Reuten 2 collaborations

D Elezagic 1 collaboration

M Mörgelin 1 collaboration

G Hermes 1 collaboration

A Hamprecht 1 collaboration

G Sengle 1 collaboration

D Lau 1 collaboration

S Höllriegl 1 collaboration

R Wagener 1 collaboration

M Paulsson 1 collaboration

T Streichert 1 collaboration

A R Klatt 1 collaboration

Temitope Esho 1 collaboration

Veronika S Georgieva 1 collaboration

Fabian Metzen 1 collaboration

Sebastian Mostert 1 collaboration

Bent Brachvogel 1 collaboration

Robert P Mecham 1 collaboration

Yousef A T Morcos 1 collaboration

Antje Tenbieg 1 collaboration

Franz-Georg Hanisch 1 collaboration

Galyna Pryymachuk 1 collaboration

Nadin Piekarek 1 collaboration

Titus Keller 1 collaboration

Cornelia Stein 1 collaboration

Natalia Martins Feitosa 1 collaboration

Joy Armistead 1 collaboration

Andre Kleinridders 1 collaboration

Jens C Brüning 1 collaboration

Sabine A Eming 1 collaboration

Sandra Doherr 1 collaboration

Niklas Sonntag 1 collaboration

Kay Grobe 1 collaboration

Konrad Hoeft 1 collaboration

Lars Koch 1 collaboration

Susanne Ziegler 1 collaboration

Ling Zhang 1 collaboration

Steffen Luetke 1 collaboration

Maria C Tanzer 1 collaboration

Debashish Mohanta 1 collaboration

David Schumacher 1 collaboration

Felix Schreibing 1 collaboration

Qingqing Long 1 collaboration

Hyojin Kim 1 collaboration

Barbara M Klinkhammer 1 collaboration

Carla Schikarski 1 collaboration

Sidrah Maryam 1 collaboration

Mathijs Baens 1 collaboration

Juliane Hermann 1 collaboration

Sarah Krieg 1 collaboration

Fabian Peisker 1 collaboration

Laura De Laporte 1 collaboration

Gideon Jl Schaefer 1 collaboration

Sylvia Menzel 1 collaboration

Joachim Jankowski 1 collaboration

Benjamin D Humphreys 1 collaboration

Adam Wahida 1 collaboration

Rebekka K Schneider 1 collaboration

Matthias Versele 1 collaboration

Peter Boor 1 collaboration

Matthias Mann 1 collaboration

Sikander Hayat 1 collaboration

Rafael Kramann 1 collaboration

Piyanoot Tapaneeyaphan 1 collaboration

Adelbert De Clercq 1 collaboration

Phil L Salmon 1 collaboration

Naz Khan 1 collaboration

Jill E Urquhart 1 collaboration

William G Newman 1 collaboration

Kay Metcalfe 1 collaboration

Stephanie Efthymiou 1 collaboration

Reza Maroofian 1 collaboration

Najwa Anwar 1 collaboration

Shazia Maqbool 1 collaboration

Fatima Rahman 1 collaboration

Ikhlass Altweijri 1 collaboration

Monerah Alsaleh 1 collaboration

Sawsan Mohamed Abdullah 1 collaboration

Mohammad Al-Owain 1 collaboration

Mais Hashem 1 collaboration

Henry Houlden 1 collaboration

Fowzan S Alkuraya 1 collaboration

Patrick Sips 1 collaboration

Stefania Richetti 1 collaboration

Thomas Ramezani 1 collaboration

Hans-Martin Pogoda 1 collaboration

Julia Hatzold 1 collaboration

Carolin Freiburg 1 collaboration

Jürgen Brinckmann 1 collaboration

Maren Dreiner 1 collaboration

Laura Muiño-Mosquera 1 collaboration

Paola Braghetta 1 collaboration

Paolo Bonaldo 1 collaboration

Helen Bornaun 1 collaboration

Michiel De Bruyne 1 collaboration

Femke Baeke 1 collaboration

Walter P Devine 1 collaboration

Balram Gangaram 1 collaboration

Allison Tam 1 collaboration

Meena Balasubramanian 1 collaboration

Sian Ellard 1 collaboration

Sandra Moore 1 collaboration

Sofie Symoens 1 collaboration

Joseph Shen 1 collaboration

Stacey Cole 1 collaboration

Ulrike Schwarze 1 collaboration

Kathryn W Holmes 1 collaboration

Susan J Hayflick 1 collaboration

Wojciech Wiszniewski 1 collaboration

Sheela Nampoothiri 1 collaboration

Elaine C Davis 1 collaboration

Lynn Y Sakai 1 collaboration

Karina A Zeyer 1 collaboration

Olivier Bornert 1 collaboration

Valentin Nelea 1 collaboration

Xinyi Bao 1 collaboration

Alexandre Leytens 1 collaboration

Svetlana Sharoyan 1 collaboration

Alvard Antonyan 1 collaboration

Jörn Dengjel 1 collaboration

Dieter P Reinhardt 1 collaboration

Christian Hiepen 1 collaboration

Jerome Jatzlau 1 collaboration

Susanne Hildebrandt 1 collaboration

Branka Kampfrath 1 collaboration

Melis Goktas 1 collaboration

Arunima Murgai 1 collaboration

Jose Luis Cuellar Camacho 1 collaboration

Rainer Haag 1 collaboration

Clemens Ruppert 1 collaboration

Elisabetta Ada Cavalcanti-Adam 1 collaboration

Kerstin G Blank 1 collaboration

Petra Knaus 1 collaboration

Paola Zigrino 1 collaboration

Eijiro Akasaka 1 collaboration

Svenja Kleiser 1 collaboration

Alexandra V Zuk 1 collaboration

Yousef Ashraf Tawfik Morcos 1 collaboration

Eva-Maria Turnwald 1 collaboration

Antje Gerken 1 collaboration

Annette Müller 1 collaboration

Sarah Appel 1 collaboration

Franziska Pankratz 1 collaboration

Aziza Maksudova 1 collaboration

Roman Goesele 1 collaboration

Lena Meier 1 collaboration

Kora Proelss 1 collaboration

Katia Marenne 1 collaboration

Ann-Kathrin Thut 1 collaboration

Jeanina Begelspacher 1 collaboration

Deniz Alkis 1 collaboration

Patrick M Siegel 1 collaboration

Christian Smolka 1 collaboration

Sebastian Grundmann 1 collaboration

Martin Moser 1 collaboration

Qian Zhou 1 collaboration

Jennifer S Esser 1 collaboration

Anna Köhler 1 collaboration

Sinan Öcal 1 collaboration

Kazuhiro Nagata 1 collaboration

Monique Aumailley 1 collaboration

Maya Talantikite 1 collaboration

Manon Napoli 1 collaboration

Jean Armengaud 1 collaboration

Ursula Hartmann 1 collaboration

Catherine Moali 1 collaboration

Wenguang Yin 1 collaboration

Hyun-Taek Kim 1 collaboration

ShengPeng Wang 1 collaboration

Felix Gunawan 1 collaboration

Rui Li 1 collaboration

Carmen Buettner 1 collaboration

Beate Grohmann 1 collaboration

Debora Sinner 1 collaboration

Stefan Offermanns 1 collaboration

Didier Y R Stainier 1 collaboration

Michael P Lockhart-Cairns 1 collaboration

Karen Tzia Wei Lim 1 collaboration

Alexandra Zuk 1 collaboration

Stuart A Cain 1 collaboration

Julia Etich 1 collaboration

Mirko Rehberg 1 collaboration

Beate Eckes 1 collaboration

Oliver Semler 1 collaboration

Yüksel Korkmaz 1 collaboration

Rana Dajani 1 collaboration

Xinyang Zhang 1 collaboration

Jennifer Thomson 1 collaboration

David F Holmes 1 collaboration

Michael J Sherratt 1 collaboration

Alan M Roseman 1 collaboration