Irina Goptar

Affiliations

Viral Hepatitis Laboratory, Central Research Institute of Epidemiology, 3A Novogireevskaya Street, Moscow, 111123, Russian Federation.
Izmerov Research Institute of Occupational Health, Moscow, 105275, Russian Federation.

Publications (7)

Orthologous CRISPR/Cas9 systems for specific and efficient degradation of covalently closed circular DNA of hepatitis B virus.

Cellular and molecular life sciences : CMLS

Avec: Dmitry Kostyushev , Sergey Brezgin , Anastasiya Kostyusheva , Dmitry Zarifyan , Irina Goptar , Vladimir Chulanov

Replenishment of Hepatitis B Virus cccDNA Pool Is Restricted by Baseline Expression of Host Restriction Factors In Vitro.

Microorganisms

Avec: Sergey Brezgin , Anastasiia Kostyusheva , Ekaterina Bayurova , Ilya Gordeychuk , Maria Isaguliants , Irina Goptar , Anastasiia Nikiforova , Valery Smirnov , Elena Volchkova , Dieter Glebe , Dmitry Kostyushev , Vladimir Chulanov

Transient and tunable CRISPRa regulation of APOBEC/AID genes for targeting hepatitis B virus.

Molecular therapy. Nucleic acids

Avec: Dmitry Kostyushev , Sergey Brezgin , Anastasiya Kostyusheva , Natalia Ponomareva , Ekaterina Bayurova , Natalia Zakirova , Alla Kondrashova , Irina Goptar , Anastasiya Nikiforova , Anna Sudina , Yurii Babin , Ilya Gordeychuk , Alexander Lukashev , Andrey A Zamyatnin , Alexander Ivanov , Vladimir Chulanov

Suppressing the NHEJ pathway by DNA-PKcs inhibitor NU7026 prevents degradation of HBV cccDNA cleaved by CRISPR/Cas9.

Scientific reports

Avec: Dmitry Kostyushev , Anastasiya Kostyusheva , Sergey Brezgin , Dmitry Zarifyan , Anastasiya Utkina , Irina Goptar , Vladimir Chulanov

ATM and ATR Expression Potentiates HBV Replication and Contributes to Reactivation of HBV Infection upon DNA Damage.

Viruses

Avec: Anastasiya Kostyusheva , Sergey Brezgin , Ekaterina Bayurova , Ilya Gordeychuk , Maria Isaguliants , Irina Goptar , Felix Urusov , Anastasiya Nikiforova , Elena Volchkova , Dmitry Kostyushev , Vladimir Chulanov

Depleting hepatitis B virus relaxed circular DNA is necessary for resolution of infection by CRISPR-Cas9.

Molecular therapy. Nucleic acids

Avec: Dmitry Kostyushev , Anastasiya Kostyusheva , Sergey Brezgin , Natalia Ponomareva , Natalia F Zakirova , Aleksandra Egorshina , Dmitry V Yanvarev , Ekaterina Bayurova , Anna Sudina , Irina Goptar , Anastasiya Nikiforova , Elena Dunaeva , Tatiana Lisitsa , Ivan Abramov , Anastasiia Frolova , Alexander Lukashev , Ilya Gordeychuk , Andrey A Zamyatnin , Alexander Ivanov , Vladimir Chulanov

Clearing of Foreign Episomal DNA from Human Cells by CRISPRa-Mediated Activation of Cytidine Deaminases.

International journal of molecular sciences

Avec: Sergey Brezgin , Anastasiya Kostyusheva , Natalia Ponomareva , Viktoriia Volia , Irina Goptar , Anastasiya Nikiforova , Igor Shilovskiy , Valery Smirnov , Dmitry Kostyushev , Vladimir Chulanov

Réseau de co-auteurs

Dmitry Kostyushev 7 collaborations

Sergey Brezgin 7 collaborations

Vladimir Chulanov 7 collaborations

Anastasiya Kostyusheva 6 collaborations

Ekaterina Bayurova 4 collaborations

Ilya Gordeychuk 4 collaborations

Anastasiya Nikiforova 4 collaborations

Natalia Ponomareva 3 collaborations

Dmitry Zarifyan 2 collaborations

Maria Isaguliants 2 collaborations

Valery Smirnov 2 collaborations

Elena Volchkova 2 collaborations

Anna Sudina 2 collaborations

Alexander Lukashev 2 collaborations

Andrey A Zamyatnin 2 collaborations

Alexander Ivanov 2 collaborations

Anastasiia Kostyusheva 1 collaboration

Anastasiia Nikiforova 1 collaboration

Dieter Glebe 1 collaboration

Natalia Zakirova 1 collaboration

Alla Kondrashova 1 collaboration

Yurii Babin 1 collaboration

Anastasiya Utkina 1 collaboration

Felix Urusov 1 collaboration

Natalia F Zakirova 1 collaboration

Aleksandra Egorshina 1 collaboration

Dmitry V Yanvarev 1 collaboration

Elena Dunaeva 1 collaboration

Tatiana Lisitsa 1 collaboration

Ivan Abramov 1 collaboration

Anastasiia Frolova 1 collaboration

Viktoriia Volia 1 collaboration

Igor Shilovskiy 1 collaboration