Isabelle Krimm

Affiliations

a Université de Lyon, CNRS, Université Claude Bernard Lyon 1, ENS Lyon, CRMN FRE 2034 , Villeurbanne , France.

ORCID: http://orcid.org/0000-0002-5981-109X

Publications (15)

1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery.

Journal of enzyme inhibition and medicinal chemistry

Avec: Claire Raingeval , Olivier Cala , Béatrice Brion , Marc Le Borgne , Roderick Eliot Hubbard , Isabelle Krimm

Combining nano-differential scanning fluorimetry and microscale thermophoresis to investigate VDAC1 interaction with small molecules.

Journal of enzyme inhibition and medicinal chemistry

Avec: Hubert Gorny , Angélique Mularoni , Jean-Guy Delcros , Céline Freton , Jordane Preto , Isabelle Krimm

Miniaturized weak affinity chromatography for ligand identification of nanodiscs-embedded G-protein coupled receptors.

Analytica chimica acta

Avec: Lucile Lecas , Lucie Hartmann , Lydia Caro , Sarah Mohamed-Bouteben , Claire Raingeval , Isabelle Krimm , Renaud Wagner , Vincent Dugas , Claire Demesmay

A fragment-based drug discovery strategy applied to the identification of NDM-1 β-lactamase inhibitors.

European journal of medicinal chemistry

Avec: Jérémy Caburet , Benjamin Boucherle , Sofiane Bourdillon , Giorgia Simoncelli , Federica Verdirosa , Jean-Denis Docquier , Yohann Moreau , Isabelle Krimm , Serge Crouzy , Marine Peuchmaur

Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket.

iScience

Avec: Alexandre Bancet , Rita Frem , Florian Jeanneret , Angélique Mularoni , Pauline Bazelle , Caroline Roelants , Jean-Guy Delcros , Jean-François Guichou , Catherine Pillet , Isabelle Coste , Toufic Renno , Christophe Battail , Claude Cochet , Thierry Lomberget , Odile Filhol , Isabelle Krimm

Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin.

Journal of medicinal chemistry

Avec: Yunqi Li , Yuan He , Ting Shao , Haixiang Pei , Weikai Guo , Dazhao Mi , Isabelle Krimm , Yuanjin Zhang , Peili Wang , Xin Wang , Mingyao Liu , Zhengfang Yi , Yihua Chen

Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity.

Journal of medicinal chemistry

Avec: Sebastian Mielniczuk , Katharina Hoff , Fady Baselious , Yunqi Li , Jörg Haupenthal , Andreas M Kany , Maria Riedner , Holger Rohde , Katharina Rox , Anna K H Hirsch , Isabelle Krimm , Wolfgang Sippl , Ralph Holl

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site.

Journal of medicinal chemistry

Avec: Benoît Bestgen , Isabelle Krimm , Irina Kufareva , Ahmed Ashraf Moustafa Kamal , Wei-Guang Seetoh , Chris Abell , Rolf W Hartmann , Ruben Abagyan , Claude Cochet , Marc Le Borgne , Matthias Engel , Thierry Lomberget

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.

Scientific reports

Avec: Irina Kufareva , Benoit Bestgen , Paul Brear , Renaud Prudent , Béatrice Laudet , Virginie Moucadel , Mohamed Ettaoussi , Celine F Sautel , Isabelle Krimm , Matthias Engel , Odile Filhol , Marc Le Borgne , Thierry Lomberget , Claude Cochet , Ruben Abagyan

The intrinsically disordered N-terminus of the voltage-dependent anion channel.

PLoS computational biology

Avec: Jordane Preto , Isabelle Krimm

A Deep Dive into VDAC1 Conformational Diversity Using All-Atom Simulations Provides New Insights into the Structural Origin of the Closed States.

International journal of molecular sciences

Avec: Jordane Preto , Hubert Gorny , Isabelle Krimm

Preparation of miniaturized hydrophilic affinity monoliths: Towards a reduction of non-specific interactions and an increased target protein density.

Journal of chromatography. A

Avec: Julie Gil , Isabelle Krimm , Vincent Dugas , Claire Demesmay

NMR investigation of protein-ligand interactions for G-protein coupled receptors.

Future medicinal chemistry

Avec: Claire Raingeval , Isabelle Krimm

Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols.

Pharmaceuticals (Basel, Switzerland)

Avec: Nicolas Lebouvier , Fabrice Pagniez , Young Min Na , Da Shi , Patricia Pinson , Mathieu Marchivie , Jean Guillon , Tarek Hakki , Rita Bernhardt , Sook Wah Yee , Claire Simons , Marie-Pierre Lézé , Rolf W Hartmann , Angélique Mularoni , Guillaume Le Baut , Isabelle Krimm , Ruben Abagyan , Patrice Le Pape , Marc Le Borgne

Fragment Linking Strategies for Structure-Based Drug Design.

Journal of medicinal chemistry

Avec: Alexandre Bancet , Claire Raingeval , Thierry Lomberget , Marc Le Borgne , Jean-François Guichou , Isabelle Krimm

Réseau de co-auteurs

Marc Le Borgne 5 collaborations

Claire Raingeval 4 collaborations

Thierry Lomberget 4 collaborations

Angélique Mularoni 3 collaborations

Jordane Preto 3 collaborations

Claude Cochet 3 collaborations

Ruben Abagyan 3 collaborations

Hubert Gorny 2 collaborations

Jean-Guy Delcros 2 collaborations

Vincent Dugas 2 collaborations

Claire Demesmay 2 collaborations

Alexandre Bancet 2 collaborations

Jean-François Guichou 2 collaborations

Odile Filhol 2 collaborations

Yunqi Li 2 collaborations

Irina Kufareva 2 collaborations

Rolf W Hartmann 2 collaborations

Matthias Engel 2 collaborations

Olivier Cala 1 collaboration

Béatrice Brion 1 collaboration

Roderick Eliot Hubbard 1 collaboration

Céline Freton 1 collaboration

Lucile Lecas 1 collaboration

Lucie Hartmann 1 collaboration

Lydia Caro 1 collaboration

Sarah Mohamed-Bouteben 1 collaboration

Renaud Wagner 1 collaboration

Jérémy Caburet 1 collaboration

Benjamin Boucherle 1 collaboration

Sofiane Bourdillon 1 collaboration

Giorgia Simoncelli 1 collaboration

Federica Verdirosa 1 collaboration

Jean-Denis Docquier 1 collaboration

Yohann Moreau 1 collaboration

Serge Crouzy 1 collaboration

Marine Peuchmaur 1 collaboration

Rita Frem 1 collaboration

Florian Jeanneret 1 collaboration

Pauline Bazelle 1 collaboration

Caroline Roelants 1 collaboration

Catherine Pillet 1 collaboration

Isabelle Coste 1 collaboration

Toufic Renno 1 collaboration

Christophe Battail 1 collaboration

Yuan He 1 collaboration

Ting Shao 1 collaboration

Haixiang Pei 1 collaboration

Weikai Guo 1 collaboration

Dazhao Mi 1 collaboration

Yuanjin Zhang 1 collaboration

Peili Wang 1 collaboration

Xin Wang 1 collaboration

Mingyao Liu 1 collaboration

Zhengfang Yi 1 collaboration

Yihua Chen 1 collaboration

Sebastian Mielniczuk 1 collaboration

Katharina Hoff 1 collaboration

Fady Baselious 1 collaboration

Jörg Haupenthal 1 collaboration

Andreas M Kany 1 collaboration

Maria Riedner 1 collaboration

Holger Rohde 1 collaboration

Katharina Rox 1 collaboration

Anna K H Hirsch 1 collaboration

Wolfgang Sippl 1 collaboration

Ralph Holl 1 collaboration

Benoît Bestgen 1 collaboration

Ahmed Ashraf Moustafa Kamal 1 collaboration

Wei-Guang Seetoh 1 collaboration

Chris Abell 1 collaboration

Benoit Bestgen 1 collaboration

Paul Brear 1 collaboration

Renaud Prudent 1 collaboration

Béatrice Laudet 1 collaboration

Virginie Moucadel 1 collaboration

Mohamed Ettaoussi 1 collaboration

Celine F Sautel 1 collaboration

Julie Gil 1 collaboration

Nicolas Lebouvier 1 collaboration

Fabrice Pagniez 1 collaboration

Young Min Na 1 collaboration

Da Shi 1 collaboration

Patricia Pinson 1 collaboration

Mathieu Marchivie 1 collaboration

Jean Guillon 1 collaboration

Tarek Hakki 1 collaboration

Rita Bernhardt 1 collaboration

Sook Wah Yee 1 collaboration

Claire Simons 1 collaboration

Marie-Pierre Lézé 1 collaboration

Guillaume Le Baut 1 collaboration

Patrice Le Pape 1 collaboration