Jacob Househam

Affiliations

Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

ORCID: http://orcid.org/0000-0003-3199-336X

Publications (11)

Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues.

Nature biotechnology

Avec: Calum Gabbutt , Ryan O Schenck , Daniel J Weisenberger , Christopher Kimberley , Alison Berner , Jacob Househam , Eszter Lakatos , Mark Robertson-Tessi , Isabel Martin , Roshani Patel , Susan K Clark , Andrew Latchford , Chris P Barnes , Simon J Leedham , Alexander R A Anderson , Trevor A Graham , Darryl Shibata

The co-evolution of the genome and epigenome in colorectal cancer.

Nature

Avec: Timon Heide , Jacob Househam , George D Cresswell , Inmaculada Spiteri , Claire Lynn , Maximilian Mossner , Chris Kimberley , Javier Fernandez-Mateos , Bingjie Chen , Luis Zapata , Chela James , Iros Barozzi , Ketevan Chkhaidze , Daniel Nichol , Vinaya Gunasri , Alison Berner , Melissa Schmidt , Eszter Lakatos , Ann-Marie Baker , Helena Costa , Miriam Mitchinson , Rocco Piazza , Marnix Jansen , Giulio Caravagna , Daniele Ramazzotti , Darryl Shibata , John Bridgewater , Manuel Rodriguez-Justo , Luca Magnani , Trevor A Graham , Andrea Sottoriva

Phenotypic noise and plasticity in cancer evolution.

Trends in cell biology

Avec: Frederick J H Whiting , Jacob Househam , Ann-Marie Baker , Andrea Sottoriva , Trevor A Graham

Computational validation of clonal and subclonal copy number alterations from bulk tumor sequencing using CNAqc.

Genome biology

Avec: Alice Antonello , Riccardo Bergamin , Nicola Calonaci , Jacob Househam , Salvatore Milite , Marc J Williams , Fabio Anselmi , Alberto d'Onofrio , Vasavi Sundaram , Alona Sosinsky , William C H Cross , Giulio Caravagna

Profiling of copy number alterations using low-coverage whole-genome sequencing informs differential diagnosis and prognosis in primary cutaneous follicle center lymphoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Avec: Bence Bátai , Laura Kiss , Luca Varga , Ákos Nagy , Jacob Househam , Ann-Marie Baker , Tamás László , Anna Udvari , Róbert Horváth , Tibor Nagy , Judit Csomor , József Szakonyi , Tamás Schneider , Trevor A Graham , Donát Alpár , Jude Fitzgibbon , Ágota Szepesi , Csaba Bödör

Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer.

bioRxiv : the preprint server for biology

Avec: Eszter Lakatos , Vinaya Gunasri , Luis Zapata , Jacob Househam , Timon Heide , Nicholas Trahearn , Ottilie Swinyard , Luis Cisneros , Claire Lynn , Maximilian Mossner , Chris Kimberley , Inmaculada Spiteri , George D Cresswell , Gerard Llibre-Palomar , Miriam Mitchison , Carlo C Maley , Marnix Jansen , Manuel Rodriguez-Justo , John Bridgewater , Ann-Marie Baker , Andrea Sottoriva , Trevor A Graham

The genomic landscape of 2,023 colorectal cancers.

Nature

Avec: Alex J Cornish , Andreas J Gruber , Ben Kinnersley , Daniel Chubb , Anna Frangou , Giulio Caravagna , Boris Noyvert , Eszter Lakatos , Henry M Wood , Steve Thorn , Richard Culliford , Claudia Arnedo-Pac , Jacob Househam , William Cross , Amit Sud , Philip Law , Maire Ni Leathlobhair , Aliah Hawari , Connor Woolley , Kitty Sherwood , Nathalie Feeley , Güler Gül , Juan Fernandez-Tajes , Luis Zapata , Ludmil B Alexandrov , Nirupa Murugaesu , Alona Sosinsky , Jonathan Mitchell , Nuria Lopez-Bigas , Philip Quirke , David N Church , Ian P M Tomlinson , Andrea Sottoriva , Trevor A Graham , David C Wedge , Richard S Houlston

Factor VIII cross-matches to the human proteome reduce the predicted inhibitor risk in missense mutation hemophilia A.

Haematologica

Avec: Daniel P Hart , Nazmiye Uzun , Stuart Skelton , Alison Kakoschke , Jacob Househam , David S Moss , Adrian J Shepherd

Evolutionary dynamics of neoantigens in growing tumors.

Nature genetics

Avec: Eszter Lakatos , Marc J Williams , Ryan O Schenck , William C H Cross , Jacob Househam , Luis Zapata , Benjamin Werner , Chandler Gatenbee , Mark Robertson-Tessi , Chris P Barnes , Alexander R A Anderson , Andrea Sottoriva , Trevor A Graham

Phenotypic plasticity and genetic control in colorectal cancer evolution.

Nature

Avec: Jacob Househam , Timon Heide , George D Cresswell , Inmaculada Spiteri , Chris Kimberley , Luis Zapata , Claire Lynn , Chela James , Maximilian Mossner , Javier Fernandez-Mateos , Alessandro Vinceti , Ann-Marie Baker , Calum Gabbutt , Alison Berner , Melissa Schmidt , Bingjie Chen , Eszter Lakatos , Vinaya Gunasri , Daniel Nichol , Helena Costa , Miriam Mitchinson , Daniele Ramazzotti , Benjamin Werner , Francesco Iorio , Marnix Jansen , Giulio Caravagna , Chris P Barnes , Darryl Shibata , John Bridgewater , Manuel Rodriguez-Justo , Luca Magnani , Andrea Sottoriva , Trevor A Graham

Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of oesophagael adenocarcinoma.

Research square

Avec: Melissa Barroux , Jacob Househam , Eszter Lakatos , Tahel Ronel , Ann-Marie Baker , Henrike Salié , Max Mossner , Kane Smith , Chris Kimberley , Salpie Nowinski , Alison Berner , Vinaya Gunasri , Mamix Jansen , Giulio Caravagna , Katja Steiger , Julia Slotta-Huspenina , Wilko Weichert , Markus Alberstmeier , Benny Chain , Helmut Friess , Bertram Bengsch , Roland Schmid , Jens Siveke , Michael Quante , Trevor Graham

Réseau de co-auteurs

Trevor A Graham 8 collaborations

Eszter Lakatos 7 collaborations

Ann-Marie Baker 6 collaborations

Andrea Sottoriva 6 collaborations

Luis Zapata 5 collaborations

Giulio Caravagna 5 collaborations

Alison Berner 4 collaborations

Chris Kimberley 4 collaborations

Vinaya Gunasri 4 collaborations

Chris P Barnes 3 collaborations

Darryl Shibata 3 collaborations

Timon Heide 3 collaborations

George D Cresswell 3 collaborations

Inmaculada Spiteri 3 collaborations

Claire Lynn 3 collaborations

Maximilian Mossner 3 collaborations

Marnix Jansen 3 collaborations

John Bridgewater 3 collaborations

Manuel Rodriguez-Justo 3 collaborations

Calum Gabbutt 2 collaborations

Ryan O Schenck 2 collaborations

Mark Robertson-Tessi 2 collaborations

Alexander R A Anderson 2 collaborations

Javier Fernandez-Mateos 2 collaborations

Bingjie Chen 2 collaborations

Chela James 2 collaborations

Daniel Nichol 2 collaborations

Melissa Schmidt 2 collaborations

Helena Costa 2 collaborations

Miriam Mitchinson 2 collaborations

Daniele Ramazzotti 2 collaborations

Luca Magnani 2 collaborations

Marc J Williams 2 collaborations

Alona Sosinsky 2 collaborations

William C H Cross 2 collaborations

Benjamin Werner 2 collaborations

Daniel J Weisenberger 1 collaboration

Christopher Kimberley 1 collaboration

Isabel Martin 1 collaboration

Roshani Patel 1 collaboration

Susan K Clark 1 collaboration

Andrew Latchford 1 collaboration

Simon J Leedham 1 collaboration

Iros Barozzi 1 collaboration

Ketevan Chkhaidze 1 collaboration

Rocco Piazza 1 collaboration

Frederick J H Whiting 1 collaboration

Alice Antonello 1 collaboration

Riccardo Bergamin 1 collaboration

Nicola Calonaci 1 collaboration

Salvatore Milite 1 collaboration

Fabio Anselmi 1 collaboration

Alberto d'Onofrio 1 collaboration

Vasavi Sundaram 1 collaboration

Bence Bátai 1 collaboration

Laura Kiss 1 collaboration

Luca Varga 1 collaboration

Ákos Nagy 1 collaboration

Tamás László 1 collaboration

Anna Udvari 1 collaboration

Róbert Horváth 1 collaboration

Tibor Nagy 1 collaboration

Judit Csomor 1 collaboration

József Szakonyi 1 collaboration

Tamás Schneider 1 collaboration

Donát Alpár 1 collaboration

Jude Fitzgibbon 1 collaboration

Ágota Szepesi 1 collaboration

Csaba Bödör 1 collaboration

Nicholas Trahearn 1 collaboration

Ottilie Swinyard 1 collaboration

Luis Cisneros 1 collaboration

Gerard Llibre-Palomar 1 collaboration

Miriam Mitchison 1 collaboration

Carlo C Maley 1 collaboration

Alex J Cornish 1 collaboration

Andreas J Gruber 1 collaboration

Ben Kinnersley 1 collaboration

Daniel Chubb 1 collaboration

Anna Frangou 1 collaboration

Boris Noyvert 1 collaboration

Henry M Wood 1 collaboration

Steve Thorn 1 collaboration

Richard Culliford 1 collaboration

Claudia Arnedo-Pac 1 collaboration

William Cross 1 collaboration

Amit Sud 1 collaboration

Philip Law 1 collaboration

Maire Ni Leathlobhair 1 collaboration

Aliah Hawari 1 collaboration

Connor Woolley 1 collaboration

Kitty Sherwood 1 collaboration

Nathalie Feeley 1 collaboration

Güler Gül 1 collaboration

Juan Fernandez-Tajes 1 collaboration

Ludmil B Alexandrov 1 collaboration

Nirupa Murugaesu 1 collaboration

Jonathan Mitchell 1 collaboration

Nuria Lopez-Bigas 1 collaboration

Philip Quirke 1 collaboration

David N Church 1 collaboration

Ian P M Tomlinson 1 collaboration

David C Wedge 1 collaboration

Richard S Houlston 1 collaboration

Daniel P Hart 1 collaboration

Nazmiye Uzun 1 collaboration

Stuart Skelton 1 collaboration

Alison Kakoschke 1 collaboration

David S Moss 1 collaboration

Adrian J Shepherd 1 collaboration

Chandler Gatenbee 1 collaboration

Alessandro Vinceti 1 collaboration

Francesco Iorio 1 collaboration

Melissa Barroux 1 collaboration

Tahel Ronel 1 collaboration

Henrike Salié 1 collaboration

Max Mossner 1 collaboration

Kane Smith 1 collaboration

Salpie Nowinski 1 collaboration

Mamix Jansen 1 collaboration

Katja Steiger 1 collaboration

Julia Slotta-Huspenina 1 collaboration

Wilko Weichert 1 collaboration

Markus Alberstmeier 1 collaboration

Benny Chain 1 collaboration

Helmut Friess 1 collaboration

Bertram Bengsch 1 collaboration

Roland Schmid 1 collaboration

Jens Siveke 1 collaboration

Michael Quante 1 collaboration

Trevor Graham 1 collaboration