Jared E Toettcher

Affiliations

Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States.

Publications (40)

Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix.

ACS chemical biology

Avec: James N Iuliano , Jinnette Tolentino Collado , Agnieszka A Gil , Pavithran T Ravindran , Andras Lukacs , SeungYoun Shin , Helena A Woroniecka , Katrin Adamczyk , James M Aramini , Uthama R Edupuganti , Christopher R Hall , Gregory M Greetham , Igor V Sazanovich , Ian P Clark , Taraneh Daryaee , Jared E Toettcher , Jarrod B French , Kevin H Gardner , Carlos L Simmerling , Stephen R Meech , Peter J Tonge

Temporal integration of inductive cues on the way to gastrulation.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Sarah McFann , Sayantan Dutta , Jared E Toettcher , Stanislav Y Shvartsman

Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch.

Cell reports

Avec: Elliot Dine , Ellen H Reed , Jared E Toettcher

A self-exciting point process to study multicellular spatial signaling patterns.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Archit Verma , Siddhartha G Jena , Danielle R Isakov , Kazuhiro Aoki , Jared E Toettcher , Barbara E Engelhardt

Stress ball morphogenesis: How the lizard builds its lung.

Science advances

Avec: Michael A Palmer , Bryan A Nerger , Katharine Goodwin , Anvitha Sudhakar , Sandra B Lemke , Pavithran T Ravindran , Jared E Toettcher , Andrej Košmrlj , Celeste M Nelson

Optogenetic control of the Bicoid morphogen reveals fast and slow modes of gap gene regulation.

Cell reports

Avec: Anand P Singh , Ping Wu , Sergey Ryabichko , João Raimundo , Michael Swan , Eric Wieschaus , Thomas Gregor , Jared E Toettcher

pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells.

eLife

Avec: Payam E Farahani , Xiaoyu Yang , Emily V Mesev , Kaylan A Fomby , Ellen H Brumbaugh-Reed , Caleb J Bashor , Celeste M Nelson , Jared E Toettcher

Erratum: Publisher Correction: Deconstructing and repurposing the light-regulated interplay between

Communications biology

Avec: David Golonka , Patrick Fischbach , Siddhartha G Jena , Julius R W Kleeberg , Lars-Oliver Essen , Jared E Toettcher , Matias D Zurbriggen , Andreas Möglich

Engineering combinatorial and dynamic decoders using synthetic immediate-early genes.

Communications biology

Avec: Pavithran T Ravindran , Maxwell Z Wilson , Siddhartha G Jena , Jared E Toettcher

A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control.

Cell systems

Avec: Alexander G Goglia , Maxwell Z Wilson , Siddhartha G Jena , Jillian Silbert , Lena P Basta , Danelle Devenport , Jared E Toettcher

Signaling Dynamics Control Cell Fate in the Early Drosophila Embryo.

Developmental cell

Avec: Heath E Johnson , Jared E Toettcher

Optimizing photoswitchable MEK.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Aleena L Patel , Eyan Yeung , Sarah E McGuire , Andrew Y Wu , Jared E Toettcher , Rebecca D Burdine , Stanislav Y Shvartsman

Design and Characterization of Rapid Optogenetic Circuits for Dynamic Control in Yeast Metabolic Engineering.

ACS synthetic biology

Avec: Evan M Zhao , Makoto A Lalwani , Robert J Lovelett , Sergio A García-Echauri , Shannon M Hoffman , Christopher L Gonzalez , Jared E Toettcher , Ioannis G Kevrekidis , José L Avalos

Rapid and reversible dissolution of biomolecular condensates using light-controlled recruitment of a solubility tag.

bioRxiv : the preprint server for biology

Avec: Ellen H Brumbaugh-Reed , Kazuhiro Aoki , Jared E Toettcher

Development of light-responsive protein binding in the monobody non-immunoglobulin scaffold.

Nature communications

Avec: César Carrasco-López , Evan M Zhao , Agnieszka A Gil , Nathan Alam , Jared E Toettcher , José L Avalos

A bright future: optogenetics to dissect the spatiotemporal control of cell behavior.

Current opinion in chemical biology

Avec: Alexander G Goglia , Jared E Toettcher

Roadmap on biology in time varying environments.

Physical biology

Avec: Arvind Murugan , Kabir Husain , Michael J Rust , Chelsea Hepler , Joseph Bass , Julian M J Pietsch , Peter S Swain , Siddhartha G Jena , Jared E Toettcher , Arup K Chakraborty , Kayla G Sprenger , T Mora , A M Walczak , O Rivoire , Shenshen Wang , Kevin B Wood , Antun Skanata , Edo Kussell , Rama Ranganathan , Hong-Yan Shih , Nigel Goldenfeld

Light-switchable transcription factors obtained by direct screening in mammalian cells.

Nature communications

Avec: Liyuan Zhu , Harold M McNamara , Jared E Toettcher

Rapid and reversible dissolution of biomolecular condensates using light-controlled recruitment of a solubility tag.

Nature communications

Avec: Ellen H Brumbaugh-Reed , Yang Gao , Kazuhiro Aoki , Jared E Toettcher

Engineered chimeric receptors for dissecting interferon signaling.

Journal of virology

Avec: Aaron E Lin , Emily V Mesev , Jared E Toettcher , Alexander Ploss

Deconstructing and repurposing the light-regulated interplay between

Communications biology

Avec: David Golonka , Patrick Fischbach , Siddhartha G Jena , Julius R W Kleeberg , Lars-Oliver Essen , Jared E Toettcher , Matias D Zurbriggen , Andreas Möglich

Light-based control of metabolic flux through assembly of synthetic organelles.

Nature chemical biology

Avec: Evan M Zhao , Nathan Suek , Maxwell Z Wilson , Elliot Dine , Nicole L Pannucci , Zemer Gitai , José L Avalos , Jared E Toettcher

A synthetic gene circuit for imaging-free detection of signaling pulses.

Cell systems

Avec: Pavithran T Ravindran , Sarah McFann , Richard H Thornton , Jared E Toettcher

Signaling, Deconstructed: Using Optogenetics to Dissect and Direct Information Flow in Biological Systems.

Annual review of biomedical engineering

Avec: Payam E Farahani , Ellen H Reed , Evan J Underhill , Kazuhiro Aoki , Jared E Toettcher

Substratum stiffness regulates Erk signaling dynamics through receptor-level control.

Cell reports

Avec: Payam E Farahani , Sandra B Lemke , Elliot Dine , Giselle Uribe , Jared E Toettcher , Celeste M Nelson

Synthetic developmental biology: New tools to deconstruct and rebuild developmental systems.

Seminars in cell & developmental biology

Avec: Harold M McNamara , Beatrice Ramm , Jared E Toettcher

Dynamics of an incoherent feedforward loop drive ERK-dependent pattern formation in the early Drosophila embryo.

Development (Cambridge, England)

Avec: Emily K Ho , Harrison R Oatman , Sarah E McFann , Liu Yang , Heath E Johnson , Stanislav Y Shvartsman , Jared E Toettcher

Efficient prime editing in two-cell mouse embryos using PEmbryo.

Nature biotechnology

Avec: Rebecca P Kim-Yip , Ryan McNulty , Bradley Joyce , Antonio Mollica , Peter J Chen , Purnima Ravisankar , Benjamin K Law , David R Liu , Jared E Toettcher , Evgueni A Ivakine , Eszter Posfai , Britt Adamson

Recording morphogen signals reveals mechanisms underlying gastruloid symmetry breaking.

Nature cell biology

Avec: Harold M McNamara , Sabrina C Solley , Britt Adamson , Michelle M Chan , Jared E Toettcher

Optogenetic Amplification Circuits for Light-Induced Metabolic Control.

ACS synthetic biology

Avec: Evan M Zhao , Makoto A Lalwani , Jhong-Min Chen , Paulina Orillac , Jared E Toettcher , José L Avalos

Dynamical Modeling of Optogenetic Circuits in Yeast for Metabolic Engineering Applications.

ACS synthetic biology

Avec: Robert J Lovelett , Evan M Zhao , Makoto A Lalwani , Jared E Toettcher , Ioannis G Kevrekidis , José L Avalos

Optogenetic control of protein binding using light-switchable nanobodies.

Nature communications

Avec: Agnieszka A Gil , César Carrasco-López , Liyuan Zhu , Evan M Zhao , Pavithran T Ravindran , Maxwell Z Wilson , Alexander G Goglia , José L Avalos , Jared E Toettcher

Optogenetic Rescue of a Patterning Mutant.

Current biology : CB

Avec: Heath E Johnson , Nareg J V Djabrayan , Stanislav Y Shvartsman , Jared E Toettcher

Putting in the Erk: Growth factor signaling and mesoderm morphogenesis.

Current topics in developmental biology

Avec: Sarah E McFann , Stanislav Y Shvartsman , Jared E Toettcher

Efficient Genome Editing with Chimeric Oligonucleotide-Directed Editing.

bioRxiv : the preprint server for biology

Avec: Long T Nguyen , Noah R Rakestraw , Brianna L M Pizzano , Cullen B Young , Yujia Huang , Kate T Beerensson , Anne Fang , Sydney G Antal , Katerina V Anamisis , Coleen M D Peggs , Jun Yan , Yangwode Jing , Rebecca D Burdine , Britt Adamson , Jared E Toettcher , Cameron Myhrvold , Piyush K Jain

Dynamics of an incoherent feedforward loop drive ERK-dependent pattern formation in the early

bioRxiv : the preprint server for biology

Avec: Emily K Ho , Harrison R Oatman , Sarah E McFann , Liu Yang , Heath E Johnson , Stanislav Y Shvartsman , Jared E Toettcher

Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways.

Development (Cambridge, England)

Avec: Evan J Underhill , Jared E Toettcher

Synthetic Heterodimers of Type III Interferon Receptors Require TYK2 for STAT Activation.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Avec: Emily V Mesev , Emma G Guare , Alexander Ploss , Jared E Toettcher

Membrane-proximal motifs encode differences in signaling strength between type I and III interferon receptors.

Science signaling

Avec: Emily V Mesev , Aaron E Lin , Emma G Guare , Brigitte L Heller , Florian Douam , Britt Adamson , Jared E Toettcher , Alexander Ploss

Recording morphogen signals reveals origins of gastruloid symmetry breaking.

bioRxiv : the preprint server for biology

Avec: Harold M McNamara , Sabrina C Solley , Britt Adamson , Michelle M Chan , Jared E Toettcher

Réseau de co-auteurs

Stanislav Y Shvartsman 6 collaborations

Siddhartha G Jena 6 collaborations

Evan M Zhao 6 collaborations

José L Avalos 6 collaborations

Pavithran T Ravindran 5 collaborations

Britt Adamson 5 collaborations

Kazuhiro Aoki 4 collaborations

Emily V Mesev 4 collaborations

Maxwell Z Wilson 4 collaborations

Heath E Johnson 4 collaborations

Harold M McNamara 4 collaborations

Agnieszka A Gil 3 collaborations

Elliot Dine 3 collaborations

Celeste M Nelson 3 collaborations

Payam E Farahani 3 collaborations

Ellen H Brumbaugh-Reed 3 collaborations

Alexander G Goglia 3 collaborations

Makoto A Lalwani 3 collaborations

Alexander Ploss 3 collaborations

Sarah E McFann 3 collaborations

Sarah McFann 2 collaborations

Ellen H Reed 2 collaborations

Sandra B Lemke 2 collaborations

David Golonka 2 collaborations

Patrick Fischbach 2 collaborations

Julius R W Kleeberg 2 collaborations

Lars-Oliver Essen 2 collaborations

Matias D Zurbriggen 2 collaborations

Andreas Möglich 2 collaborations

Rebecca D Burdine 2 collaborations

Robert J Lovelett 2 collaborations

Ioannis G Kevrekidis 2 collaborations

César Carrasco-López 2 collaborations

Liyuan Zhu 2 collaborations

Aaron E Lin 2 collaborations

Evan J Underhill 2 collaborations

Emily K Ho 2 collaborations

Harrison R Oatman 2 collaborations

Liu Yang 2 collaborations

Sabrina C Solley 2 collaborations

Michelle M Chan 2 collaborations

Emma G Guare 2 collaborations

James N Iuliano 1 collaboration

Jinnette Tolentino Collado 1 collaboration

Andras Lukacs 1 collaboration

SeungYoun Shin 1 collaboration

Helena A Woroniecka 1 collaboration

Katrin Adamczyk 1 collaboration

James M Aramini 1 collaboration

Uthama R Edupuganti 1 collaboration

Christopher R Hall 1 collaboration

Gregory M Greetham 1 collaboration

Igor V Sazanovich 1 collaboration

Ian P Clark 1 collaboration

Taraneh Daryaee 1 collaboration

Jarrod B French 1 collaboration

Kevin H Gardner 1 collaboration

Carlos L Simmerling 1 collaboration

Stephen R Meech 1 collaboration

Peter J Tonge 1 collaboration

Sayantan Dutta 1 collaboration

Archit Verma 1 collaboration

Danielle R Isakov 1 collaboration

Barbara E Engelhardt 1 collaboration

Michael A Palmer 1 collaboration

Bryan A Nerger 1 collaboration

Katharine Goodwin 1 collaboration

Anvitha Sudhakar 1 collaboration

Andrej Košmrlj 1 collaboration

Anand P Singh 1 collaboration

Ping Wu 1 collaboration

Sergey Ryabichko 1 collaboration

João Raimundo 1 collaboration

Michael Swan 1 collaboration

Eric Wieschaus 1 collaboration

Thomas Gregor 1 collaboration

Xiaoyu Yang 1 collaboration

Kaylan A Fomby 1 collaboration

Caleb J Bashor 1 collaboration

Jillian Silbert 1 collaboration

Lena P Basta 1 collaboration

Danelle Devenport 1 collaboration

Aleena L Patel 1 collaboration

Eyan Yeung 1 collaboration

Sarah E McGuire 1 collaboration

Andrew Y Wu 1 collaboration

Sergio A García-Echauri 1 collaboration

Shannon M Hoffman 1 collaboration

Christopher L Gonzalez 1 collaboration

Nathan Alam 1 collaboration

Arvind Murugan 1 collaboration

Kabir Husain 1 collaboration

Michael J Rust 1 collaboration

Chelsea Hepler 1 collaboration

Joseph Bass 1 collaboration

Julian M J Pietsch 1 collaboration

Peter S Swain 1 collaboration

Arup K Chakraborty 1 collaboration

Kayla G Sprenger 1 collaboration

T Mora 1 collaboration

A M Walczak 1 collaboration

O Rivoire 1 collaboration

Shenshen Wang 1 collaboration

Kevin B Wood 1 collaboration

Antun Skanata 1 collaboration

Edo Kussell 1 collaboration

Rama Ranganathan 1 collaboration

Hong-Yan Shih 1 collaboration

Nigel Goldenfeld 1 collaboration

Yang Gao 1 collaboration

Nathan Suek 1 collaboration

Nicole L Pannucci 1 collaboration

Zemer Gitai 1 collaboration

Richard H Thornton 1 collaboration

Giselle Uribe 1 collaboration

Beatrice Ramm 1 collaboration

Rebecca P Kim-Yip 1 collaboration

Ryan McNulty 1 collaboration

Bradley Joyce 1 collaboration

Antonio Mollica 1 collaboration

Peter J Chen 1 collaboration

Purnima Ravisankar 1 collaboration

Benjamin K Law 1 collaboration

David R Liu 1 collaboration

Evgueni A Ivakine 1 collaboration

Eszter Posfai 1 collaboration

Jhong-Min Chen 1 collaboration

Paulina Orillac 1 collaboration

Nareg J V Djabrayan 1 collaboration

Long T Nguyen 1 collaboration

Noah R Rakestraw 1 collaboration

Brianna L M Pizzano 1 collaboration

Cullen B Young 1 collaboration

Yujia Huang 1 collaboration

Kate T Beerensson 1 collaboration

Anne Fang 1 collaboration

Sydney G Antal 1 collaboration

Katerina V Anamisis 1 collaboration

Coleen M D Peggs 1 collaboration

Jun Yan 1 collaboration

Yangwode Jing 1 collaboration

Cameron Myhrvold 1 collaboration

Piyush K Jain 1 collaboration

Brigitte L Heller 1 collaboration

Florian Douam 1 collaboration