K Kluck

Affiliations

Institute of Pathology, Heidelberg University Hospital, 69120, Heidelberg, Germany.

Publications (19)

Deciphering the immunosuppressive tumor microenvironment in ALK- and EGFR-positive lung adenocarcinoma.

Cancer immunology, immunotherapy : CII

Avec: Jan Budczies , Martina Kirchner , Klaus Kluck , Daniel Kazdal , Julia Glade , Michael Allgäuer , Mark Kriegsmann , Claus-Peter Heußel , Felix J Herth , Hauke Winter , Michael Meister , Thomas Muley , Torsten Goldmann , Stefan Fröhling , Martin Wermke , Cornelius F Waller , Amanda Tufman , Martin Reck , Solange Peters , Peter Schirmacher , Michael Thomas , Petros Christopoulos , Albrecht Stenzinger

The Different Immune Profiles of Normal Colonic Mucosa in Cancer-Free Lynch Syndrome Carriers and Lynch Syndrome Colorectal Cancer Patients.

Gastroenterology

Avec: Lena Bohaumilitzky , Klaus Kluck , Robert Hüneburg , Richard Gallon , Jacob Nattermann , Martina Kirchner , Glen Kristiansen , Oliver Hommerding , Pauline L Pfuderer , Lelia Wagner , Fabian Echterdiek , Svenja Kösegi , Nico Müller , Konstantin Fischer , Nina Nelius , Ben Hartog , Gillian Borthwick , Elena Busch , Georg Martin Haag , Hendrik Bläker , Gabriela Möslein , Magnus von Knebel Doeberitz , Toni T Seppälä , Maarit Ahtiainen , Jukka-Pekka Mecklin , D Timothy Bishop , John Burn , Albrecht Stenzinger , Jan Budczies , Matthias Kloor , Aysel Ahadova

Homogenous TP53mut-associated tumor biology across mutation and cancer types revealed by transcriptome analysis.

Cell death discovery

Avec: Eva Romanovsky , Klaus Kluck , Iordanis Ourailidis , Michael Menzel , Susanne Beck , Markus Ball , Daniel Kazdal , Petros Christopoulos , Peter Schirmacher , Thorsten Stiewe , Albrecht Stenzinger , Jan Budczies

Multicentric pilot study to standardize clinical whole exome sequencing (WES) for cancer patients.

NPJ precision oncology

Avec: Michael Menzel , Stephan Ossowski , Sebastian Kral , Patrick Metzger , Peter Horak , Ralf Marienfeld , Melanie Boerries , Steffen Wolter , Markus Ball , Olaf Neumann , Sorin Armeanu-Ebinger , Christopher Schroeder , Uta Matysiak , Hannah Goldschmid , Vincent Schipperges , Axel Fürstberger , Michael Allgäuer , Timo Eberhardt , Jakob Niewöhner , Andreas Blaumeiser , Carolin Ploeger , Tobias Bernd Haack , Timothy Kwang Yong Tay , Olga Kelemen , Thomas Pauli , Martina Kirchner , Klaus Kluck , Alexander Ott , Marcus Renner , Jakob Admard , Axel Gschwind , Silke Lassmann , Hans Kestler , Falko Fend , Anna Lena Illert , Martin Werner , Peter Möller , Thomas Theodor Werner Seufferlein , Nisar Malek , Peter Schirmacher , Stefan Fröhling , Daniel Kazdal , Jan Budczies , Albrecht Stenzinger

Genomic heterogeneity at baseline is associated with T790M resistance mutations in EGFR-mutated lung cancer treated with the first-/second-generation tyrosine kinase inhibitors.

The journal of pathology. Clinical research

Avec: Michael Menzel , Martina Kirchner , Klaus Kluck , Markus Ball , Susanne Beck , Michael Allgäuer , Christin Assmann , Johannes Schnorbach , Anna-Lena Volckmar , Timothy Kwang Yong Tay , Hannah Goldschmid , Daniel Sw Tan , Michael Thomas , Daniel Kazdal , Jan Budczies , Albrecht Stenzinger , Petros Christopoulos

Decoding and targeting the molecular basis of MACC1-driven metastatic spread: Lessons from big data mining and clinical-experimental approaches.

Seminars in cancer biology

Avec: Jan Budczies , Klaus Kluck , Wolfgang Walther , Ulrike Stein

Influence of a 12-month supervised, intensive resistance, aerobic and impact exercise intervention on muscle strength in prostate cancer patients undergoing anti-hormone therapy: Study protocol for the randomized, controlled Burgdorf study.

Contemporary clinical trials

Avec: N Reimer , R Hafke , M Wrensch , P Horst , W Bloch , T Hahn , A Kirchhoff , K-L Kluck , J Stein , F T Baumann

Homologous recombination deficiency is inversely correlated with microsatellite instability and identifies immunologically cold tumors in most cancer types.

The journal of pathology. Clinical research

Avec: Jan Budczies , Klaus Kluck , Susanne Beck , Iordanis Ourailidis , Michael Allgäuer , Michael Menzel , Daniel Kazdal , Lukas Perkhofer , Alexander Kleger , Peter Schirmacher , Thomas Seufferlein , Albrecht Stenzinger

Nivolumab and ipilimumab in recurrent or refractory cancer of unknown primary: a phase II trial.

Nature communications

Avec: Maria Pouyiourou , Bianca N Kraft , Timothy Wohlfromm , Michael Stahl , Boris Kubuschok , Harald Löffler , Ulrich T Hacker , Gerdt Hübner , Lena Weiss , Michael Bitzer , Thomas Ernst , Philipp Schütt , Thomas Hielscher , Stefan Delorme , Martina Kirchner , Daniel Kazdal , Markus Ball , Klaus Kluck , Albrecht Stenzinger , Tilmann Bochtler , Alwin Krämer

Tumor Mutational Burden as a Predictive Biomarker in Solid Tumors.

Cancer discovery

Avec: Dan Sha , Zhaohui Jin , Jan Budczies , Klaus Kluck , Albrecht Stenzinger , Frank A Sinicrope

A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma.

Oncoimmunology

Avec: Jan Budczies , Martina Kirchner , Klaus Kluck , Daniel Kazdal , Julia Glade , Michael Allgäuer , Mark Kriegsmann , Claus-Peter Heußel , Felix J Herth , Hauke Winter , Michael Meister , Thomas Muley , Stefan Fröhling , Solange Peters , Barbara Seliger , Peter Schirmacher , Michael Thomas , Petros Christopoulos , Albrecht Stenzinger

Pan-cancer analysis of genomic scar patterns caused by homologous repair deficiency (HRD).

NPJ precision oncology

Avec: E Rempel , K Kluck , S Beck , I Ourailidis , D Kazdal , O Neumann , A L Volckmar , M Kirchner , H Goldschmid , N Pfarr , W Weichert , D Hübschmann , S Fröhling , C Sutter , C P Schaaf , P Schirmacher , V Endris , A Stenzinger , J Budczies

Accurate tumor purity determination is critical for the analysis of homologous recombination deficiency (HRD).

Translational oncology

Avec: Michael Menzel , Volker Endris , Constantin Schwab , Klaus Kluck , Olaf Neumann , Susanne Beck , Markus Ball , Christian Schaaf , Stefan Fröhling , Peter Lichtner , Peter Schirmacher , Daniel Kazdal , Albrecht Stenzinger , Jan Budczies

Spatial profiling of the microenvironment reveals low intratumoral heterogeneity and STK11-associated immune evasion in therapy-naïve lung adenocarcinomas.

Lung cancer (Amsterdam, Netherlands)

Avec: Hannah Goldschmid , Klaus Kluck , Markus Ball , Martina Kirchner , Michael Allgäuer , Hauke Winter , Felix Herth , Claus-Peter Heußel , Soni Savai Pullamsetti , Rajkumar Savai , Timothy Tay Kwang Yong , Peter Schirmacher , Solange Peters , Michael Thomas , Petros Christopoulos , Jan Budczies , Albrecht Stenzinger , Daniel Kazdal

Leveraging off-target reads in panel sequencing for homologous recombination repair deficiency screening in tumor.

The Journal of molecular diagnostics : JMD

Avec: Markus Ball , Iordanis Ourailidis , Klaus Kluck , Michael Menzel , Martina Kirchner , Michael Allgäuer , Timothy Kwang Yong Tay , Fabian Schnecko , Anna-Lena Volckmar , Hannah Goldschmid , Olaf Neuman , Stefan Fröhling , Peter Schirmacher , Jan Budczies , Albrecht Stenzinger , Daniel Kazdal

Tumour mutational burden: clinical utility, challenges and emerging improvements.

Nature reviews. Clinical oncology

Avec: Jan Budczies , Daniel Kazdal , Michael Menzel , Susanne Beck , Klaus Kluck , Christian Altbürger , Constantin Schwab , Michael Allgäuer , Aysel Ahadova , Matthias Kloor , Peter Schirmacher , Solange Peters , Alwin Krämer , Petros Christopoulos , Albrecht Stenzinger

The immune microenvironment in EGFR- and ERBB2-mutated lung adenocarcinoma.

ESMO open

Avec: M Kirchner , K Kluck , R Brandt , A-L Volckmar , R Penzel , D Kazdal , V Endris , O Neumann , H Seker-Cin , H Goldschmid , J Glade , M Allgäuer , M Kriegsmann , H Winter , T Muley , S Perner , N Frost , M Reck , S Fröhling , P Schirmacher , M Thomas , J Budczies , P Christopoulos , A Stenzinger

The impact of TP53 co-mutations and immunologic microenvironment on outcome of lung cancer with EGFR exon 20 insertions.

European journal of cancer (Oxford, England : 1990)

Avec: Petros Christopoulos , Klaus Kluck , Martina Kirchner , Heike Lüders , Julia Roeper , Roger-Fei Falkenstern-Ge , Marlen Szewczyk , Florian Sticht , Felix C Saalfeld , Claas Wesseler , Björn Hackanson , Sebastian Dintner , Martin Faehling , Jonas Kuon , Melanie Janning , Diego Kauffmann-Guerrero , Daniel Kazdal , Sylke Kurz , Florian Eichhorn , Farastuk Bozorgmehr , Rajiv Shah , Amanda Tufman , Martin Wermke , Sonja Loges , Wolfgang M Brueckl , Christian Schulz , Daniel Misch , Nikolaj Frost , Jens Kollmeier , Martin Reck , Frank Griesinger , Christian Grohé , Jin-Liern Hong , Huamao M Lin , Jan Budczies , Albrecht Stenzinger , Michael Thomas

Analysis of rare fusions in NSCLC: Genomic architecture and clinical implications.

Lung cancer (Amsterdam, Netherlands)

Avec: Huriye Seker-Cin , Timothy Kwang Yong Tay , Daniel Kazdal , Klaus Kluck , Markus Ball , Olaf Neumann , Hauke Winter , Felix Herth , Claus-Peter Heußel , Rajkumar Savai , Peter Schirmacher , Michael Thomas , Jan Budczies , Michael Allgäuer , Petros Christopoulos , Albrecht Stenzinger , Anna-Lena Volckmar

Réseau de co-auteurs

Klaus Kluck 16 collaborations

Jan Budczies 15 collaborations

Albrecht Stenzinger 15 collaborations

Daniel Kazdal 13 collaborations

Peter Schirmacher 10 collaborations

Martina Kirchner 9 collaborations

Michael Allgäuer 9 collaborations

Petros Christopoulos 8 collaborations

Markus Ball 8 collaborations

Michael Menzel 7 collaborations

Michael Thomas 6 collaborations

Stefan Fröhling 5 collaborations

Susanne Beck 5 collaborations

Claus-Peter Heußel 4 collaborations

Hauke Winter 4 collaborations

Solange Peters 4 collaborations

Hannah Goldschmid 4 collaborations

Timothy Kwang Yong Tay 4 collaborations

Iordanis Ourailidis 3 collaborations

Olaf Neumann 3 collaborations

Anna-Lena Volckmar 3 collaborations

Julia Glade 2 collaborations

Mark Kriegsmann 2 collaborations

Felix J Herth 2 collaborations

Michael Meister 2 collaborations

Thomas Muley 2 collaborations

Martin Wermke 2 collaborations

Amanda Tufman 2 collaborations

Martin Reck 2 collaborations

Matthias Kloor 2 collaborations

Aysel Ahadova 2 collaborations

Alwin Krämer 2 collaborations

D Kazdal 2 collaborations

O Neumann 2 collaborations

M Kirchner 2 collaborations

H Goldschmid 2 collaborations

S Fröhling 2 collaborations

P Schirmacher 2 collaborations

V Endris 2 collaborations

A Stenzinger 2 collaborations

J Budczies 2 collaborations

Constantin Schwab 2 collaborations

Felix Herth 2 collaborations

Rajkumar Savai 2 collaborations

Torsten Goldmann 1 collaboration

Cornelius F Waller 1 collaboration

Lena Bohaumilitzky 1 collaboration

Robert Hüneburg 1 collaboration

Richard Gallon 1 collaboration

Jacob Nattermann 1 collaboration

Glen Kristiansen 1 collaboration

Oliver Hommerding 1 collaboration

Pauline L Pfuderer 1 collaboration

Lelia Wagner 1 collaboration

Fabian Echterdiek 1 collaboration

Svenja Kösegi 1 collaboration

Nico Müller 1 collaboration

Konstantin Fischer 1 collaboration

Nina Nelius 1 collaboration

Ben Hartog 1 collaboration

Gillian Borthwick 1 collaboration

Elena Busch 1 collaboration

Georg Martin Haag 1 collaboration

Hendrik Bläker 1 collaboration

Gabriela Möslein 1 collaboration

Magnus von Knebel Doeberitz 1 collaboration

Toni T Seppälä 1 collaboration

Maarit Ahtiainen 1 collaboration

Jukka-Pekka Mecklin 1 collaboration

D Timothy Bishop 1 collaboration

John Burn 1 collaboration

Eva Romanovsky 1 collaboration

Thorsten Stiewe 1 collaboration

Stephan Ossowski 1 collaboration

Sebastian Kral 1 collaboration

Patrick Metzger 1 collaboration

Peter Horak 1 collaboration

Ralf Marienfeld 1 collaboration

Melanie Boerries 1 collaboration

Steffen Wolter 1 collaboration

Sorin Armeanu-Ebinger 1 collaboration

Christopher Schroeder 1 collaboration

Uta Matysiak 1 collaboration

Vincent Schipperges 1 collaboration

Axel Fürstberger 1 collaboration

Timo Eberhardt 1 collaboration

Jakob Niewöhner 1 collaboration

Andreas Blaumeiser 1 collaboration

Carolin Ploeger 1 collaboration

Tobias Bernd Haack 1 collaboration

Olga Kelemen 1 collaboration

Thomas Pauli 1 collaboration

Alexander Ott 1 collaboration

Marcus Renner 1 collaboration

Jakob Admard 1 collaboration

Axel Gschwind 1 collaboration

Silke Lassmann 1 collaboration

Hans Kestler 1 collaboration

Falko Fend 1 collaboration

Anna Lena Illert 1 collaboration

Martin Werner 1 collaboration

Peter Möller 1 collaboration

Thomas Theodor Werner Seufferlein 1 collaboration

Nisar Malek 1 collaboration

Christin Assmann 1 collaboration

Johannes Schnorbach 1 collaboration

Daniel Sw Tan 1 collaboration

Wolfgang Walther 1 collaboration

Ulrike Stein 1 collaboration

N Reimer 1 collaboration

R Hafke 1 collaboration

M Wrensch 1 collaboration

P Horst 1 collaboration

W Bloch 1 collaboration

T Hahn 1 collaboration

A Kirchhoff 1 collaboration

K-L Kluck 1 collaboration

J Stein 1 collaboration

F T Baumann 1 collaboration

Lukas Perkhofer 1 collaboration

Alexander Kleger 1 collaboration

Thomas Seufferlein 1 collaboration

Maria Pouyiourou 1 collaboration

Bianca N Kraft 1 collaboration

Timothy Wohlfromm 1 collaboration

Michael Stahl 1 collaboration

Boris Kubuschok 1 collaboration

Harald Löffler 1 collaboration

Ulrich T Hacker 1 collaboration

Gerdt Hübner 1 collaboration

Lena Weiss 1 collaboration

Michael Bitzer 1 collaboration

Thomas Ernst 1 collaboration

Philipp Schütt 1 collaboration

Thomas Hielscher 1 collaboration

Stefan Delorme 1 collaboration

Tilmann Bochtler 1 collaboration

Dan Sha 1 collaboration

Zhaohui Jin 1 collaboration

Frank A Sinicrope 1 collaboration

Barbara Seliger 1 collaboration

E Rempel 1 collaboration

S Beck 1 collaboration

I Ourailidis 1 collaboration

A L Volckmar 1 collaboration

N Pfarr 1 collaboration

W Weichert 1 collaboration

D Hübschmann 1 collaboration

C Sutter 1 collaboration

C P Schaaf 1 collaboration

Volker Endris 1 collaboration

Christian Schaaf 1 collaboration

Peter Lichtner 1 collaboration

Soni Savai Pullamsetti 1 collaboration

Timothy Tay Kwang Yong 1 collaboration

Fabian Schnecko 1 collaboration

Olaf Neuman 1 collaboration

Christian Altbürger 1 collaboration

R Brandt 1 collaboration

A-L Volckmar 1 collaboration

R Penzel 1 collaboration

H Seker-Cin 1 collaboration

J Glade 1 collaboration

M Allgäuer 1 collaboration

M Kriegsmann 1 collaboration

H Winter 1 collaboration

T Muley 1 collaboration

S Perner 1 collaboration

N Frost 1 collaboration

M Reck 1 collaboration

M Thomas 1 collaboration

P Christopoulos 1 collaboration

Heike Lüders 1 collaboration

Julia Roeper 1 collaboration

Roger-Fei Falkenstern-Ge 1 collaboration

Marlen Szewczyk 1 collaboration

Florian Sticht 1 collaboration

Felix C Saalfeld 1 collaboration

Claas Wesseler 1 collaboration

Björn Hackanson 1 collaboration

Sebastian Dintner 1 collaboration

Martin Faehling 1 collaboration

Jonas Kuon 1 collaboration

Melanie Janning 1 collaboration

Diego Kauffmann-Guerrero 1 collaboration

Sylke Kurz 1 collaboration

Florian Eichhorn 1 collaboration

Farastuk Bozorgmehr 1 collaboration

Rajiv Shah 1 collaboration

Sonja Loges 1 collaboration

Wolfgang M Brueckl 1 collaboration

Christian Schulz 1 collaboration

Daniel Misch 1 collaboration

Nikolaj Frost 1 collaboration

Jens Kollmeier 1 collaboration

Frank Griesinger 1 collaboration

Christian Grohé 1 collaboration

Jin-Liern Hong 1 collaboration

Huamao M Lin 1 collaboration

Huriye Seker-Cin 1 collaboration