Katja Conrath

Affiliations

Galapagos NV, Mechelen, Belgium.

Publications (12)

GLPG2737 in lumacaftor/ivacaftor-treated CF subjects homozygous for the F508del mutation: A randomized phase 2A trial (PELICAN).

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Avec: Silke van Koningsbruggen-Rietschel , Katja Conrath , Rainald Fischer , Sivagurunathan Sutharsan , Axel Kempa , Wolfgang Gleiber , Carsten Schwarz , Andreas Hector , Nancy Van Osselaer , Arian Pano , Sam Corveleyn , Dieudonné Bwirire , Eva Santermans , Karine Muller , Susan Bellaire , Olivier Van de Steen

GLPG1837, a CFTR potentiator, in p.Gly551Asp (G551D)-CF patients: An open-label, single-arm, phase 2a study (SAPHIRA1).

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Avec: Jane C Davies , Olivier Van de Steen , Silke van Koningsbruggen-Rietschel , Pavel Drevinek , Nico Derichs , Edward F McKone , Desirée Kanters , Lisa Allamassey , Florence Namour , Herman de Kock , Katja Conrath

Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770.

The Journal of general physiology

Avec: Han-I Yeh , Liming Qiu , Yoshiro Sohma , Katja Conrath , Xiaoqin Zou , Tzyh-Chang Hwang

Evaluation of a novel CFTR potentiator in COPD ferrets with acquired CFTR dysfunction.

The European respiratory journal

Avec: Niroop Kaza , Vivian Y Lin , Denise Stanford , Shah S Hussain , Emily Falk Libby , Harrison Kim , Monica Borgonovi , Katja Conrath , Venkateshwar Mutyam , Stephen A Byzek , Li Ping Tang , John E Trombley , Lawrence Rasmussen , Trenton Schoeb , Hui Min Leung , Guillermo J Tearney , S Vamsee Raju , Steven M Rowe

CFTR Rescue in Intestinal Organoids with GLPG/ABBV-2737, ABBV/GLPG-2222 and ABBV/GLPG-2451 Triple Therapy.

Frontiers in molecular biosciences

Avec: Eyleen de Poel , Sacha Spelier , Ricardo Korporaal , Ka Wai Lai , Sylvia F Boj , Katja Conrath , Cornelis K van der Ent , Jeffrey M Beekman

Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222.

The Journal of pharmacology and experimental therapeutics

Avec: Ashvani K Singh , Yihong Fan , Corina Balut , Sara Alani , Arlene M Manelli , Andrew M Swensen , Ying Jia , Torben R Neelands , Timothy A Vortherms , Bo Liu , Xenia B Searle , Xueqing Wang , Wenqing Gao , Tzyh-Chang Hwang , Hong Y Ren , Douglas Cyr , Philip R Kym , Katja Conrath , Chris Tse

CFTR activity is enhanced by the novel corrector GLPG2222, given with and without ivacaftor in two randomized trials.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Avec: Scott C Bell , Peter J Barry , Kris De Boeck , Pavel Drevinek , J Stuart Elborn , Barry J Plant , Predag Minić , Eva Van Braeckel , Stijn Verhulst , Karine Muller , Desirée Kanters , Susan Bellaire , Herman de Kock , David E Geller , Katja Conrath , Olivier Van de Steen , Kors van der Ent

Novel Correctors and Potentiators Enhance Translational Readthrough in CFTR Nonsense Mutations.

American journal of respiratory cell and molecular biology

Avec: Venkateshwar Mutyam , Jyoti Sharma , Yao Li , Ning Peng , Jianguo Chen , Li Ping Tang , Emily Falk Libby , Ashvani K Singh , Katja Conrath , Steven M Rowe

Identification of GLPG/ABBV-2737, a Novel Class of Corrector, Which Exerts Functional Synergy With Other CFTR Modulators.

Frontiers in pharmacology

Avec: Gert de Wilde , Maarten Gees , Sara Musch , Katleen Verdonck , Mia Jans , Anne-Sophie Wesse , Ashvani K Singh , Tzyh-Chang Hwang , Thierry Christophe , Mathieu Pizzonero , Steven Van der Plas , Nicolas Desroy , Marlon Cowart , Pieter Stouten , Luc Nelles , Katja Conrath

Discovery of 9-Cyclopropylethynyl-2-((

Journal of medicinal chemistry

Avec: Frédéric Labéguère , Sonia Dupont , Luke Alvey , Florilène Soulas , Gregory Newsome , Amynata Tirera , Vanessa Quenehen , Thi Thu Trang Mai , Pierre Deprez , Roland Blanqué , Line Oste , Sandrine Le Tallec , Steve De Vos , Annick Hagers , Ann Vandevelde , Luc Nelles , Nele Vandervoort , Katja Conrath , Thierry Christophe , Ellen van der Aar , Emanuelle Wakselman , Didier Merciris , Céline Cottereaux , Cécile da Costa , Laurent Saniere , Philippe Clement-Lacroix , Laura Jenkins , Graeme Milligan , Stephen Fletcher , Reginald Brys , Romain Gosmini

Discovery of GLPG2451, a Novel Once Daily Potentiator for the Treatment of Cystic Fibrosis.

Journal of medicinal chemistry

Avec: Steven E Van der Plas , Hans Kelgtermans , Oscar Mammoliti , Christel Menet , Giovanni Tricarico , Ann De Blieck , Caroline Joannesse , Tom De Munck , Dominique Lambin , Marlon Cowart , Sebastien Dropsit , Sebastien L X Martina , Maarten Gees , Anne-Sophie Wesse , Katja Conrath , Martin Andrews

Discovery of GLPG2737, a Potent Type 2 Corrector of CFTR for the Treatment of Cystic Fibrosis in Combination with a Potentiator and a Type 1 Co-corrector.

Journal of medicinal chemistry

Avec: Mathieu Pizzonero , Rhalid Akkari , Xavier Bock , Romain Gosmini , Elsa De Lemos , Béranger Duthion , Gregory Newsome , Thi-Thu-Trang Mai , Virginie Roques , Hélène Jary , Jean-Michel Lefrancois , Laetitia Cherel , Vanessa Quenehen , Marielle Babel , Nuria Merayo , Natacha Bienvenu , Oscar Mammoliti , Ghjuvanni Coti , Adeline Palisse , Marlon Cowart , Anurupa Shrestha , Stephen Greszler , Steven Van Der Plas , Koen Jansen , Pieter Claes , Mia Jans , Maarten Gees , Monica Borgonovi , Gert De Wilde , Katja Conrath

Réseau de co-auteurs

Olivier Van de Steen 3 collaborations

Tzyh-Chang Hwang 3 collaborations

Ashvani K Singh 3 collaborations

Maarten Gees 3 collaborations

Marlon Cowart 3 collaborations

Silke van Koningsbruggen-Rietschel 2 collaborations

Karine Muller 2 collaborations

Susan Bellaire 2 collaborations

Pavel Drevinek 2 collaborations

Desirée Kanters 2 collaborations

Herman de Kock 2 collaborations

Emily Falk Libby 2 collaborations

Monica Borgonovi 2 collaborations

Venkateshwar Mutyam 2 collaborations

Li Ping Tang 2 collaborations

Steven M Rowe 2 collaborations

Mia Jans 2 collaborations

Anne-Sophie Wesse 2 collaborations

Thierry Christophe 2 collaborations

Mathieu Pizzonero 2 collaborations

Luc Nelles 2 collaborations

Gregory Newsome 2 collaborations

Vanessa Quenehen 2 collaborations

Romain Gosmini 2 collaborations

Oscar Mammoliti 2 collaborations

Rainald Fischer 1 collaboration

Sivagurunathan Sutharsan 1 collaboration

Axel Kempa 1 collaboration

Wolfgang Gleiber 1 collaboration

Carsten Schwarz 1 collaboration

Andreas Hector 1 collaboration

Nancy Van Osselaer 1 collaboration

Arian Pano 1 collaboration

Sam Corveleyn 1 collaboration

Dieudonné Bwirire 1 collaboration

Eva Santermans 1 collaboration

Jane C Davies 1 collaboration

Nico Derichs 1 collaboration

Edward F McKone 1 collaboration

Lisa Allamassey 1 collaboration

Florence Namour 1 collaboration

Han-I Yeh 1 collaboration

Liming Qiu 1 collaboration

Yoshiro Sohma 1 collaboration

Xiaoqin Zou 1 collaboration

Niroop Kaza 1 collaboration

Vivian Y Lin 1 collaboration

Denise Stanford 1 collaboration

Shah S Hussain 1 collaboration

Harrison Kim 1 collaboration

Stephen A Byzek 1 collaboration

John E Trombley 1 collaboration

Lawrence Rasmussen 1 collaboration

Trenton Schoeb 1 collaboration

Hui Min Leung 1 collaboration

Guillermo J Tearney 1 collaboration

S Vamsee Raju 1 collaboration

Eyleen de Poel 1 collaboration

Sacha Spelier 1 collaboration

Ricardo Korporaal 1 collaboration

Ka Wai Lai 1 collaboration

Sylvia F Boj 1 collaboration

Cornelis K van der Ent 1 collaboration

Jeffrey M Beekman 1 collaboration

Yihong Fan 1 collaboration

Corina Balut 1 collaboration

Sara Alani 1 collaboration

Arlene M Manelli 1 collaboration

Andrew M Swensen 1 collaboration

Ying Jia 1 collaboration

Torben R Neelands 1 collaboration

Timothy A Vortherms 1 collaboration

Bo Liu 1 collaboration

Xenia B Searle 1 collaboration

Xueqing Wang 1 collaboration

Wenqing Gao 1 collaboration

Hong Y Ren 1 collaboration

Douglas Cyr 1 collaboration

Philip R Kym 1 collaboration

Chris Tse 1 collaboration

Scott C Bell 1 collaboration

Peter J Barry 1 collaboration

Kris De Boeck 1 collaboration

J Stuart Elborn 1 collaboration

Barry J Plant 1 collaboration

Predag Minić 1 collaboration

Eva Van Braeckel 1 collaboration

Stijn Verhulst 1 collaboration

David E Geller 1 collaboration

Kors van der Ent 1 collaboration

Jyoti Sharma 1 collaboration

Yao Li 1 collaboration

Ning Peng 1 collaboration

Jianguo Chen 1 collaboration

Gert de Wilde 1 collaboration

Sara Musch 1 collaboration

Katleen Verdonck 1 collaboration

Steven Van der Plas 1 collaboration

Nicolas Desroy 1 collaboration

Pieter Stouten 1 collaboration

Frédéric Labéguère 1 collaboration

Sonia Dupont 1 collaboration

Luke Alvey 1 collaboration

Florilène Soulas 1 collaboration

Amynata Tirera 1 collaboration

Thi Thu Trang Mai 1 collaboration

Pierre Deprez 1 collaboration

Roland Blanqué 1 collaboration

Line Oste 1 collaboration

Sandrine Le Tallec 1 collaboration

Steve De Vos 1 collaboration

Annick Hagers 1 collaboration

Ann Vandevelde 1 collaboration

Nele Vandervoort 1 collaboration

Ellen van der Aar 1 collaboration

Emanuelle Wakselman 1 collaboration

Didier Merciris 1 collaboration

Céline Cottereaux 1 collaboration

Cécile da Costa 1 collaboration

Laurent Saniere 1 collaboration

Philippe Clement-Lacroix 1 collaboration

Laura Jenkins 1 collaboration

Graeme Milligan 1 collaboration

Stephen Fletcher 1 collaboration

Reginald Brys 1 collaboration

Steven E Van der Plas 1 collaboration

Hans Kelgtermans 1 collaboration

Christel Menet 1 collaboration

Giovanni Tricarico 1 collaboration

Ann De Blieck 1 collaboration

Caroline Joannesse 1 collaboration

Tom De Munck 1 collaboration

Dominique Lambin 1 collaboration

Sebastien Dropsit 1 collaboration

Sebastien L X Martina 1 collaboration

Martin Andrews 1 collaboration

Rhalid Akkari 1 collaboration

Xavier Bock 1 collaboration

Elsa De Lemos 1 collaboration

Béranger Duthion 1 collaboration

Thi-Thu-Trang Mai 1 collaboration

Virginie Roques 1 collaboration

Hélène Jary 1 collaboration

Jean-Michel Lefrancois 1 collaboration

Laetitia Cherel 1 collaboration

Marielle Babel 1 collaboration

Nuria Merayo 1 collaboration

Natacha Bienvenu 1 collaboration

Ghjuvanni Coti 1 collaboration

Adeline Palisse 1 collaboration

Anurupa Shrestha 1 collaboration

Stephen Greszler 1 collaboration

Steven Van Der Plas 1 collaboration

Koen Jansen 1 collaboration

Pieter Claes 1 collaboration

Gert De Wilde 1 collaboration