Lotta Happonen

Affiliations

Division of Infection Medicine, Department of Clinical Sciences, Faculty of Medicine, Lund Universitygrid.4514.4, Lund, Sweden.

Publications (29)

Streptococcus pyogenes Forms Serotype- and Local Environment-Dependent Interspecies Protein Complexes.

mSystems

Avec: Sounak Chowdhury , Hamed Khakzad , Gizem Ertürk Bergdahl , Rolf Lood , Simon Ekstrom , Dirk Linke , Lars Malmström , Lotta Happonen , Johan Malmström

Multimodal Mass Spectrometry Identifies a Conserved Protective Epitope in

Analytical chemistry

Avec: Di Tang , Carlos Gueto-Tettay , Elisabeth Hjortswang , Joel Ströbaek , Simon Ekström , Lotta Happonen , Lars Malmström , Johan Malmström

Proteomic Characterization of Plasma in Lemierre's Syndrome.

Thrombosis and haemostasis

Avec: David Nygren , Gustav Torisson , Lotta Happonen , Lisa Mellhammar , Adam Linder , Johan Elf , Hong Yan , Charlotte Welinder , Karin Holm

Frontiers in genetics

Avec: Hamed Khakzad , Lotta Happonen , Guy Tran Van Nhieu , Johan Malmström , Lars Malmström

Snapshots of actin and tubulin folding inside the TRiC chaperonin.

Nature structural & molecular biology

Avec: John J Kelly , Dale Tranter , Els Pardon , Gamma Chi , Holger Kramer , Lotta Happonen , Kelly M Knee , Jay M Janz , Jan Steyaert , Christine Bulawa , Ville O Paavilainen , Juha T Huiskonen , Wyatt W Yue

IdeS, a secreted proteinase of Streptococcus pyogenes, is bound to a nuclease at the bacterial surface where it inactivates opsonizing IgG antibodies.

The Journal of biological chemistry

Avec: Inga-Maria Frick , Lotta Happonen , Sebastian Wrighton , Pontus Nordenfelt , Lars Björck

Thiourea-Based Tritopic Halogen-Bonding Acceptors.

Chemistry, an Asian journal

Avec: Lauri Happonen , Milla Mattila , Ivan Peshev , Arttu Lehikoinen , Arto Valkonen

Structural proteomics, electron cryo-microscopy and structural modeling approaches in bacteria-human protein interactions.

Medical microbiology and immunology

Avec: Sounak Chowdhury , Lotta Happonen , Hamed Khakzad , Lars Malmström , Johan Malmström

Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology.

PLoS computational biology

Avec: Hamed Khakzad , Lotta Happonen , Yasaman Karami , Sounak Chowdhury , Gizem Ertürk Bergdahl , Michael Nilges , Guy Tran Van Nhieu , Johan Malmström , Lars Malmström

Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2.

Frontiers in immunology

Avec: Wael Bahnan , Sebastian Wrighton , Martin Sundwall , Anna Bläckberg , Olivia Larsson , Urban Höglund , Hamed Khakzad , Magdalena Godzwon , Maria Walle , Elisabeth Elder , Anna Söderlund Strand , Lotta Happonen , Oscar André , Johannes Kumra Ahnlide , Thomas Hellmark , Vidar Wendel-Hansen , Robert Pa Wallin , Johan Malmstöm , Lars Malmström , Mats Ohlin , Magnus Rasmussen , Pontus Nordenfelt

Molecular view of ER membrane remodeling by the Sec61/TRAP translocon.

EMBO reports

Avec: Sudeep Karki , Matti Javanainen , Shahid Rehan , Dale Tranter , Juho Kellosalo , Juha T Huiskonen , Lotta Happonen , Ville Paavilainen

The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms.

Chemical science

Avec: Mahmudul Hasan , Hamed Khakzad , Lotta Happonen , Anders Sundin , Johan Unge , Uwe Mueller , Johan Malmström , Gunilla Westergren-Thorsson , Lars Malmström , Ulf Ellervik , Anders Malmström , Emil Tykesson

A quantitative Streptococcus pyogenes-human protein-protein interaction map reveals localization of opsonizing antibodies.

Nature communications

Avec: Lotta Happonen , Simon Hauri , Gabriel Svensson Birkedal , Christofer Karlsson , Therese de Neergaard , Hamed Khakzad , Pontus Nordenfelt , Mats Wikström , Magdalena Wisniewska , Lars Björck , Lars Malmström , Johan Malmström

Interaction with the host: the role of fibronectin and extracellular matrix proteins in the adhesion of Gram-negative bacteria.

Medical microbiology and immunology

Avec: Diana J Vaca , Arno Thibau , Monika Schütz , Peter Kraiczy , Lotta Happonen , Johan Malmström , Volkhard A J Kempf

Cheetah-MS: a web server to model protein complexes using tandem cross-linking mass spectrometry data.

Bioinformatics (Oxford, England)

Avec: Hamed Khakzad , Lotta Happonen , Johan Malmström , Lars Malmström

Multinodal Acoustic Trapping Enables High Capacity and High Throughput Enrichment of Extracellular Vesicles and Microparticles in miRNA and MS Proteomics Studies.

Analytical chemistry

Avec: Axel Broman , Andreas Lenshof , Mikael Evander , Lotta Happonen , Anson Ku , Johan Malmström , Thomas Laurell

Host Defense Peptides LL-37 and Lactoferrin Trigger ET Release from Blood-Derived Circulating Monocytes.

Biomedicines

Avec: Frederic V Schwäbe , Lotta Happonen , Sofie Ekestubbe , Ariane Neumann

Reduced binding of apoE4 to complement factor H promotes amyloid-β oligomerization and neuroinflammation.

EMBO reports

Avec: Larisa Chernyaeva , Giorgio Ratti , Laura Teirilä , Satoshi Fudo , Uni Rankka , Anssi Pelkonen , Paula Korhonen , Katarzyna Leskinen , Salla Keskitalo , Kari Salokas , Christina Gkolfinopoulou , Katrina E Crompton , Matti Javanainen , Lotta Happonen , Markku Varjosalo , Tarja Malm , Ville Leinonen , Angeliki Chroni , Päivi Saavalainen , Seppo Meri , Tommi Kajander , Adam Jm Wollman , Eija Nissilä , Karita Haapasalo

The intracellular helical bundle of human glucose transporter GLUT4 is important for complex formation with ASPL.

FEBS open bio

Avec: Peng Huang , Hannah Åbacka , Daniel Varela , Raminta Venskutonytė , Lotta Happonen , Jonathan S Bogan , Pontus Gourdon , Mahmood R Amiry-Moghaddam , Ingmar André , Karin Lindkvist-Petersson

The twin-arginine translocation system is vital for cell adhesion and uptake of iron in the cystic fibrosis pathogen

Virulence

Avec: S M Hossein Khademi , Cecilia Sahl , Lotta Happonen , Åke Forsberg , Lisa I Påhlman

Rapid determination of quaternary protein structures in complex biological samples.

Nature communications

Avec: Simon Hauri , Hamed Khakzad , Lotta Happonen , Johan Teleman , Johan Malmström , Lars Malmström

Distinct Serotypes of Streptococcal M Proteins Mediate Fibrinogen-Dependent Platelet Activation and Proinflammatory Effects.

Infection and immunity

Avec: Frida Palm , Sounak Chowdhury , Sara Wettemark , Johan Malmström , Lotta Happonen , Oonagh Shannon

Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens.

Diagnostics (Basel, Switzerland)

Avec: Alex van Belkum , Carina Almeida , Benjamin Bardiaux , Sarah V Barrass , Sarah J Butcher , Tuğçe Çaykara , Sounak Chowdhury , Rucha Datar , Ian Eastwood , Adrian Goldman , Manisha Goyal , Lotta Happonen , Nadia Izadi-Pruneyre , Theis Jacobsen , Pirjo H Johnson , Volkhard A J Kempf , Andreas Kiessling , Juan Leva Bueno , Anchal Malik , Johan Malmström , Ina Meuskens , Paul A Milner , Michael Nilges , Nicole Pamme , Sally A Peyman , Ligia R Rodrigues , Pablo Rodriguez-Mateos , Maria G Sande , Carla Joana Silva , Aleksandra Cecylia Stasiak , Thilo Stehle , Arno Thibau , Diana J Vaca , Dirk Linke

Interaction of Bartonella henselae with Fibronectin Represents the Molecular Basis for Adhesion to Host Cells.

Microbiology spectrum

Avec: Diana J Vaca , Arno Thibau , Matthias S Leisegang , Johan Malmström , Dirk Linke , Johannes A Eble , Wibke Ballhorn , Martin Schaller , Lotta Happonen , Volkhard A J Kempf

Quantification of adaptive immune responses against protein binding interfaces in the streptococcal M1 protein.

Molecular & cellular proteomics : MCP

Avec: E Torres-Sangiao , L Happonen , M Heusel , F Palm , C Gueto-Tettay , L Malmström , O Shannon , J Malmström

The hinge-engineered IgG1-IgG3 hybrid subclass IgGh

Nature communications

Avec: Arman Izadi , Yasaman Karami , Eleni Bratanis , Sebastian Wrighton , Hamed Khakzad , Maria Nyblom , Berit Olofsson , Lotta Happonen , Di Tang , Martin Sundwall , Magdalena Godzwon , Yashuan Chao , Alejandro Gomez Toledo , Tobias Schmidt , Mats Ohlin , Michael Nilges , Johan Malmström , Wael Bahnan , Oonagh Shannon , Lars Malmström , Pontus Nordenfelt

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function.

EMBO molecular medicine

Avec: Wael Bahnan , Lotta Happonen , Hamed Khakzad , Vibha Kumra Ahnlide , Therese de Neergaard , Sebastian Wrighton , Oscar André , Eleni Bratanis , Di Tang , Thomas Hellmark , Lars Björck , Oonagh Shannon , Lars Malmström , Johan Malmström , Pontus Nordenfelt

Multienzyme deep learning models improve peptide de novo sequencing by mass spectrometry proteomics.

PLoS computational biology

Avec: Carlos Gueto-Tettay , Di Tang , Lotta Happonen , Moritz Heusel , Hamed Khakzad , Johan Malmström , Lars Malmström

Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence.

Cell reports

Avec: Aida Rodríguez López , Maria H Jørgensen , Jesper F Havelund , Frederic S Arendrup , Srinivasa Prasad Kolapalli , Thorbjørn M Nielsen , Eva Pais , Carsten Jörn Beese , Ahmad Abdul-Al , Anna Constance Vind , Jiri Bartek , Simon Bekker-Jensen , Marta Montes , Panagiotis Galanos , Nils Faergeman , Lotta Happonen , Lisa B Frankel

Réseau de co-auteurs

Johan Malmström 17 collaborations

Lars Malmström 13 collaborations

Hamed Khakzad 12 collaborations

Sounak Chowdhury 5 collaborations

Pontus Nordenfelt 5 collaborations

Di Tang 4 collaborations

Sebastian Wrighton 4 collaborations

Dirk Linke 3 collaborations

Lars Björck 3 collaborations

Michael Nilges 3 collaborations

Wael Bahnan 3 collaborations

Diana J Vaca 3 collaborations

Arno Thibau 3 collaborations

Volkhard A J Kempf 3 collaborations

Oonagh Shannon 3 collaborations

Gizem Ertürk Bergdahl 2 collaborations

Carlos Gueto-Tettay 2 collaborations

Guy Tran Van Nhieu 2 collaborations

Dale Tranter 2 collaborations

Juha T Huiskonen 2 collaborations

Yasaman Karami 2 collaborations

Martin Sundwall 2 collaborations

Magdalena Godzwon 2 collaborations

Oscar André 2 collaborations

Thomas Hellmark 2 collaborations

Mats Ohlin 2 collaborations

Matti Javanainen 2 collaborations

Simon Hauri 2 collaborations

Therese de Neergaard 2 collaborations

Eleni Bratanis 2 collaborations

Rolf Lood 1 collaboration

Simon Ekstrom 1 collaboration

Elisabeth Hjortswang 1 collaboration

Joel Ströbaek 1 collaboration

Simon Ekström 1 collaboration

David Nygren 1 collaboration

Gustav Torisson 1 collaboration

Lisa Mellhammar 1 collaboration

Adam Linder 1 collaboration

Johan Elf 1 collaboration

Hong Yan 1 collaboration

Charlotte Welinder 1 collaboration

Karin Holm 1 collaboration

John J Kelly 1 collaboration

Els Pardon 1 collaboration

Gamma Chi 1 collaboration

Holger Kramer 1 collaboration

Kelly M Knee 1 collaboration

Jay M Janz 1 collaboration

Jan Steyaert 1 collaboration

Christine Bulawa 1 collaboration

Ville O Paavilainen 1 collaboration

Wyatt W Yue 1 collaboration

Inga-Maria Frick 1 collaboration

Lauri Happonen 1 collaboration

Milla Mattila 1 collaboration

Ivan Peshev 1 collaboration

Arttu Lehikoinen 1 collaboration

Arto Valkonen 1 collaboration

Anna Bläckberg 1 collaboration

Olivia Larsson 1 collaboration

Urban Höglund 1 collaboration

Maria Walle 1 collaboration

Elisabeth Elder 1 collaboration

Anna Söderlund Strand 1 collaboration

Johannes Kumra Ahnlide 1 collaboration

Vidar Wendel-Hansen 1 collaboration

Robert Pa Wallin 1 collaboration

Johan Malmstöm 1 collaboration

Magnus Rasmussen 1 collaboration

Sudeep Karki 1 collaboration

Shahid Rehan 1 collaboration

Juho Kellosalo 1 collaboration

Ville Paavilainen 1 collaboration

Mahmudul Hasan 1 collaboration

Anders Sundin 1 collaboration

Johan Unge 1 collaboration

Uwe Mueller 1 collaboration

Gunilla Westergren-Thorsson 1 collaboration

Ulf Ellervik 1 collaboration

Anders Malmström 1 collaboration

Emil Tykesson 1 collaboration

Gabriel Svensson Birkedal 1 collaboration

Christofer Karlsson 1 collaboration

Mats Wikström 1 collaboration

Magdalena Wisniewska 1 collaboration

Monika Schütz 1 collaboration

Peter Kraiczy 1 collaboration

Axel Broman 1 collaboration

Andreas Lenshof 1 collaboration

Mikael Evander 1 collaboration

Anson Ku 1 collaboration

Thomas Laurell 1 collaboration

Frederic V Schwäbe 1 collaboration

Sofie Ekestubbe 1 collaboration

Ariane Neumann 1 collaboration

Larisa Chernyaeva 1 collaboration

Giorgio Ratti 1 collaboration

Laura Teirilä 1 collaboration

Satoshi Fudo 1 collaboration

Uni Rankka 1 collaboration

Anssi Pelkonen 1 collaboration

Paula Korhonen 1 collaboration

Katarzyna Leskinen 1 collaboration

Salla Keskitalo 1 collaboration

Kari Salokas 1 collaboration

Christina Gkolfinopoulou 1 collaboration

Katrina E Crompton 1 collaboration

Markku Varjosalo 1 collaboration

Tarja Malm 1 collaboration

Ville Leinonen 1 collaboration

Angeliki Chroni 1 collaboration

Päivi Saavalainen 1 collaboration

Seppo Meri 1 collaboration

Tommi Kajander 1 collaboration

Adam Jm Wollman 1 collaboration

Eija Nissilä 1 collaboration

Karita Haapasalo 1 collaboration

Peng Huang 1 collaboration

Hannah Åbacka 1 collaboration

Daniel Varela 1 collaboration

Raminta Venskutonytė 1 collaboration

Jonathan S Bogan 1 collaboration

Pontus Gourdon 1 collaboration

Mahmood R Amiry-Moghaddam 1 collaboration

Ingmar André 1 collaboration

Karin Lindkvist-Petersson 1 collaboration

S M Hossein Khademi 1 collaboration

Cecilia Sahl 1 collaboration

Åke Forsberg 1 collaboration

Lisa I Påhlman 1 collaboration

Johan Teleman 1 collaboration

Frida Palm 1 collaboration

Sara Wettemark 1 collaboration

Alex van Belkum 1 collaboration

Carina Almeida 1 collaboration

Benjamin Bardiaux 1 collaboration

Sarah V Barrass 1 collaboration

Sarah J Butcher 1 collaboration

Tuğçe Çaykara 1 collaboration

Rucha Datar 1 collaboration

Ian Eastwood 1 collaboration

Adrian Goldman 1 collaboration

Manisha Goyal 1 collaboration

Nadia Izadi-Pruneyre 1 collaboration

Theis Jacobsen 1 collaboration

Pirjo H Johnson 1 collaboration

Andreas Kiessling 1 collaboration

Juan Leva Bueno 1 collaboration

Anchal Malik 1 collaboration

Ina Meuskens 1 collaboration

Paul A Milner 1 collaboration

Nicole Pamme 1 collaboration

Sally A Peyman 1 collaboration

Ligia R Rodrigues 1 collaboration

Pablo Rodriguez-Mateos 1 collaboration

Maria G Sande 1 collaboration

Carla Joana Silva 1 collaboration

Aleksandra Cecylia Stasiak 1 collaboration

Thilo Stehle 1 collaboration

Matthias S Leisegang 1 collaboration

Johannes A Eble 1 collaboration

Wibke Ballhorn 1 collaboration

Martin Schaller 1 collaboration

E Torres-Sangiao 1 collaboration

L Happonen 1 collaboration

M Heusel 1 collaboration

F Palm 1 collaboration

C Gueto-Tettay 1 collaboration

L Malmström 1 collaboration

O Shannon 1 collaboration

J Malmström 1 collaboration

Arman Izadi 1 collaboration

Maria Nyblom 1 collaboration

Berit Olofsson 1 collaboration

Yashuan Chao 1 collaboration

Alejandro Gomez Toledo 1 collaboration

Tobias Schmidt 1 collaboration

Vibha Kumra Ahnlide 1 collaboration

Moritz Heusel 1 collaboration

Aida Rodríguez López 1 collaboration

Maria H Jørgensen 1 collaboration

Jesper F Havelund 1 collaboration

Frederic S Arendrup 1 collaboration

Srinivasa Prasad Kolapalli 1 collaboration

Thorbjørn M Nielsen 1 collaboration

Eva Pais 1 collaboration

Carsten Jörn Beese 1 collaboration

Ahmad Abdul-Al 1 collaboration

Anna Constance Vind 1 collaboration

Jiri Bartek 1 collaboration

Simon Bekker-Jensen 1 collaboration

Marta Montes 1 collaboration

Panagiotis Galanos 1 collaboration

Nils Faergeman 1 collaboration

Lisa B Frankel 1 collaboration