Manja Friese-Hamim

Affiliations

Translational Innovation Platform, Oncology & Immuno-Oncology, Merck Healthcare KGaA, Darmstadt, Germany.

Publications (14)

Brain penetration and efficacy of tepotinib in orthotopic patient-derived xenograft models of MET-driven non-small cell lung cancer brain metastases.

Lung cancer (Amsterdam, Netherlands)

Avec: Manja Friese-Hamim , Anderson Clark , Dominique Perrin , Lindsey Crowley , Christof Reusch , Olga Bogatyrova , Hong Zhang , Timothy Crandall , Jing Lin , Jianguo Ma , David Bachner , Jürgen Schmidt , Martin Schaefer , Christopher Stroh

Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i).

Journal of medicinal chemistry

Avec: Markus Klein , Michael Busch , Manja Friese-Hamim , Stefano Crosignani , Thomas Fuchss , Djordje Musil , Felix Rohdich , Michael P Sanderson , Jeyaprakashnarayanan Seenisamy , Gina Walter-Bausch , Ugo Zanelli , Philip Hewitt , Christina Esdar , Oliver Schadt

Translational PK/PD Modeling of Tumor Growth Inhibition and Target Inhibition to Support Dose Range Selection of the LMP7 Inhibitor M3258 in Relapsed/Refractory Multiple Myeloma.

The Journal of pharmacology and experimental therapeutics

Avec: Floriane Lignet , Christina Esdar , Gina Walter-Bausch , Manja Friese-Hamim , Sofia Stinchi , Elise Drouin , Samer El Bawab , Andreas D Becker , Claude Gimmi , Michael P Sanderson , Felix Rohdich

Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors.

Journal of medicinal chemistry

Avec: Timo Heinrich , Jeyaprakashnarayanan Seenisamy , Beatrix Blume , Jörg Bomke , Michel Calderini , Uwe Eckert , Manja Friese-Hamim , Rainer Kohl , Martin Lehmann , Birgitta Leuthner , Djordje Musil , Felix Rohdich , Frank T Zenke

The Preclinical Pharmacology of Tepotinib-A Highly Selective MET Inhibitor with Activity in Tumors Harboring MET Alterations.

Molecular cancer therapeutics

Avec: Joachim Albers , Manja Friese-Hamim , Anderson Clark , Oliver Schadt , Gina Walter-Bausch , Christopher Stroh , Andreas Johne , Niki Karachaliou , Andree Blaukat

M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (β5i) Delivering Efficacy in Multiple Myeloma Models.

Molecular cancer therapeutics

Avec: Michael P Sanderson , Manja Friese-Hamim , Gina Walter-Bausch , Michael Busch , Stefanie Gaus , Djordje Musil , Felix Rohdich , Ugo Zanelli , Sondra L Downey-Kopyscinski , Constantine S Mitsiades , Oliver Schadt , Markus Klein , Christina Esdar

Preclinical Pharmacokinetics and Translational Pharmacokinetic/Pharmacodynamic Modeling of M8891, a Potent and Reversible Inhibitor of Methionine Aminopeptidase 2.

Pharmaceutical research

Avec: Floriane Lignet , Manja Friese-Hamim , Frank Jaehrling , Samer El Bawab , Felix Rohdich

Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models.

Molecular cancer therapeutics

Avec: Manja Friese-Hamim , Maria J Ortiz-Ruiz , Olga Bogatyrova , Marina Keil , Felix Rohdich , Beatrix Blume , Birgitta Leuthner , Frank Czauderna , Diane Hahn , Julia Jabs , Frank Jaehrling , Timo Heinrich , Roland Kellner , Katherine Chan , Amy H Y Tong , Dirk Wienke , Jason Moffat , Andree Blaukat , Frank T Zenke

E2F1-associated purine synthesis pathway is a major component of the MET-DNA damage response network.

Cancer research communications

Avec: Michaela Poliaková Turan , Rahel Riedo , Matúš Medo , Chiara Pozzato , Manja Friese-Hamim , Jonas Paul Koch , Si'Ana A Coggins , Qun Li , Baek Kim , Joachim Albers , Daniel M Aebersold , Nicola Zamboni , Yitzhak Zimmer , Michaela Medová

Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor

Journal of medicinal chemistry

Avec: Timo Heinrich , Jeyaprakashnarayanan Seenisamy , Frank Becker , Beatrix Blume , Jörg Bomke , Melanie Dietz , Uwe Eckert , Manja Friese-Hamim , Jakub Gunera , Kerrin Hansen , Birgitta Leuthner , Djordje Musil , Jens Pfalzgraf , Felix Rohdich , Christian Siegl , Dieter Spuck , Ansgar Wegener , Frank T Zenke

Targeting the MET Receptor Tyrosine Kinase as a Strategy for Radiosensitization in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma.

Molecular cancer therapeutics

Avec: Lluís Nisa , Paola Francica , Roland Giger , Matúš Medo , Olgun Elicin , Manja Friese-Hamim , Claudia Wilm , Christopher Stroh , Beat Bojaxhiu , Aurélie Quintin , Marco D Caversaccio , Matthias S Dettmer , Mélanie Buchwalder , Tess M Brodie , Daniel M Aebersold , Yitzhak Zimmer , Thomas E Carey , Michaela Medová

First-in-Man Phase I Trial of the Selective MET Inhibitor Tepotinib in Patients with Advanced Solid Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Gerald S Falchook , Razelle Kurzrock , Hesham M Amin , Wenyuan Xiong , Siqing Fu , Sarina A Piha-Paul , Filip Janku , Ghazaleh Eskandari , Daniel V Catenacci , Manfred Klevesath , Rolf Bruns , Uz Stammberger , Andreas Johne , Friedhelm Bladt , Manja Friese-Hamim , Pascal Girard , Samer El Bawab , David S Hong

Translational pharmacokinetic-pharmacodynamic modeling of preclinical and clinical data of the oral MET inhibitor tepotinib to determine the recommended phase II dose.

CPT: pharmacometrics & systems pharmacology

Avec: Wenyuan Xiong , Manja Friese-Hamim , Andreas Johne , Christopher Stroh , Manfred Klevesath , Gerald S Falchook , David S Hong , Pascal Girard , Samer El Bawab

Activity of Tepotinib in Hepatocellular Carcinoma With High-Level

JCO precision oncology

Avec: Shukui Qin , Hongming Pan , Jean Frédéric Blanc , Véronique Grando , Ho Yeong Lim , Xin Ying Chang , Aurora O'Brate , Christopher Stroh , Manja Friese-Hamim , Joachim Albers , Andreas Johne , Sandrine Faivre

Réseau de co-auteurs

Felix Rohdich 7 collaborations

Christopher Stroh 5 collaborations

Djordje Musil 4 collaborations

Gina Walter-Bausch 4 collaborations

Samer El Bawab 4 collaborations

Andreas Johne 4 collaborations

Michael P Sanderson 3 collaborations

Jeyaprakashnarayanan Seenisamy 3 collaborations

Christina Esdar 3 collaborations

Oliver Schadt 3 collaborations

Timo Heinrich 3 collaborations

Beatrix Blume 3 collaborations

Birgitta Leuthner 3 collaborations

Frank T Zenke 3 collaborations

Joachim Albers 3 collaborations

Anderson Clark 2 collaborations

Olga Bogatyrova 2 collaborations

Markus Klein 2 collaborations

Michael Busch 2 collaborations

Ugo Zanelli 2 collaborations

Floriane Lignet 2 collaborations

Jörg Bomke 2 collaborations

Uwe Eckert 2 collaborations

Andree Blaukat 2 collaborations

Frank Jaehrling 2 collaborations

Matúš Medo 2 collaborations

Daniel M Aebersold 2 collaborations

Yitzhak Zimmer 2 collaborations

Michaela Medová 2 collaborations

Gerald S Falchook 2 collaborations

Wenyuan Xiong 2 collaborations

Manfred Klevesath 2 collaborations

Pascal Girard 2 collaborations

David S Hong 2 collaborations

Dominique Perrin 1 collaboration

Lindsey Crowley 1 collaboration

Christof Reusch 1 collaboration

Hong Zhang 1 collaboration

Timothy Crandall 1 collaboration

Jing Lin 1 collaboration

Jianguo Ma 1 collaboration

David Bachner 1 collaboration

Jürgen Schmidt 1 collaboration

Martin Schaefer 1 collaboration

Stefano Crosignani 1 collaboration

Thomas Fuchss 1 collaboration

Philip Hewitt 1 collaboration

Sofia Stinchi 1 collaboration

Elise Drouin 1 collaboration

Andreas D Becker 1 collaboration

Claude Gimmi 1 collaboration

Michel Calderini 1 collaboration

Rainer Kohl 1 collaboration

Martin Lehmann 1 collaboration

Niki Karachaliou 1 collaboration

Stefanie Gaus 1 collaboration

Sondra L Downey-Kopyscinski 1 collaboration

Constantine S Mitsiades 1 collaboration

Maria J Ortiz-Ruiz 1 collaboration

Marina Keil 1 collaboration

Frank Czauderna 1 collaboration

Diane Hahn 1 collaboration

Julia Jabs 1 collaboration

Roland Kellner 1 collaboration

Katherine Chan 1 collaboration

Amy H Y Tong 1 collaboration

Dirk Wienke 1 collaboration

Jason Moffat 1 collaboration

Michaela Poliaková Turan 1 collaboration

Rahel Riedo 1 collaboration

Chiara Pozzato 1 collaboration

Jonas Paul Koch 1 collaboration

Si'Ana A Coggins 1 collaboration

Qun Li 1 collaboration

Baek Kim 1 collaboration

Nicola Zamboni 1 collaboration

Frank Becker 1 collaboration

Melanie Dietz 1 collaboration

Jakub Gunera 1 collaboration

Kerrin Hansen 1 collaboration

Jens Pfalzgraf 1 collaboration

Christian Siegl 1 collaboration

Dieter Spuck 1 collaboration

Ansgar Wegener 1 collaboration

Lluís Nisa 1 collaboration

Paola Francica 1 collaboration

Roland Giger 1 collaboration

Olgun Elicin 1 collaboration

Claudia Wilm 1 collaboration

Beat Bojaxhiu 1 collaboration

Aurélie Quintin 1 collaboration

Marco D Caversaccio 1 collaboration

Matthias S Dettmer 1 collaboration

Mélanie Buchwalder 1 collaboration

Tess M Brodie 1 collaboration

Thomas E Carey 1 collaboration

Razelle Kurzrock 1 collaboration

Hesham M Amin 1 collaboration

Siqing Fu 1 collaboration

Sarina A Piha-Paul 1 collaboration

Filip Janku 1 collaboration

Ghazaleh Eskandari 1 collaboration

Daniel V Catenacci 1 collaboration

Rolf Bruns 1 collaboration

Uz Stammberger 1 collaboration

Friedhelm Bladt 1 collaboration

Shukui Qin 1 collaboration

Hongming Pan 1 collaboration

Jean Frédéric Blanc 1 collaboration

Véronique Grando 1 collaboration

Ho Yeong Lim 1 collaboration

Xin Ying Chang 1 collaboration

Aurora O'Brate 1 collaboration

Sandrine Faivre 1 collaboration