Nicholas D Huntington

Affiliations

Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australia. davis.m@wehi.edu.au nicholas.huntington@monash.edu.
Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Biomedicine Discovery Institute and the Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.

ORCID: 0000-0002-5267-7211

Publications (16)

A Gene Signature Predicting Natural Killer Cell Infiltration and Improved Survival in Melanoma Patients.

Cancer immunology research

Avec: Joseph Cursons , Fernando Souza-Fonseca-Guimaraes , Momeneh Foroutan , Ashley Anderson , Frédéric Hollande , Soroor Hediyeh-Zadeh , Andreas Behren , Nicholas D Huntington , Melissa J Davis

The cancer-natural killer cell immunity cycle.

Nature reviews. Cancer

Avec: Nicholas D Huntington , Joseph Cursons , Jai Rautela

NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS.

Frontiers in immunology

Avec: Rebecca B Delconte , Geoffrey Guittard , Wilford Goh , Soroor Hediyeh-Zadeh , Robert J Hennessy , Jai Rautela , Melissa J Davis , Fernando Souza-Fonseca-Guimaraes , Jacques A Nunès , Nicholas D Huntington

BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia.

Blood advances

Avec: Emma M Carrington , Cynthia Louis , Tobias Kratina , Manuela Hancock , Christine R Keenan , Nadia Iannarella , Rhys S Allan , Ahmad Z Wardak , Peter E Czabotar , Marco J Herold , Robyn L Schenk , Christine A White , Damian D'Silva , Yuyan Yang , Wesley Wong , Huon Wong , Vanessa L Bryant , Nicholas D Huntington , Jai Rautela , Robyn M Sutherland , Yifan Zhan , Jacinta Hansen , Duong Nhu , Guillaume Lessene , Ian P Wicks , Andrew M Lew

Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity.

Journal for immunotherapy of cancer

Avec: Pierre-Louis Bernard , Rebecca Delconte , Sonia Pastor , Vladimir Laletin , Cathy Costa Da Silva , Armelle Goubard , Emmanuelle Josselin , Rémy Castellano , Adrien Krug , Julien Vernerey , Raynier Devillier , Daniel Olive , Els Verhoeyen , Eric Vivier , Nicholas D Huntington , Jacques Nunes , Geoffrey Guittard

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity.

Nature communications

Avec: Shuwei Liang , Eric Tran , Xin Du , Jiajun Dong , Harrison Sudholz , Hao Chen , Zihan Qu , Nicholas D Huntington , Jeffrey J Babon , Nadia J Kershaw , Zhong-Yin Zhang , Jonathan B Baell , Florian Wiede , Tony Tiganis

CD45 limits early Natural Killer cell development.

Immunology and cell biology

Avec: Lizeth G Meza Guzman , Craig D Hyland , Grace M Bidgood , Evelyn Leong , Zihan Shen , Wilford Goh , Jai Rautela , James E Vince , Sandra E Nicholson , Nicholas D Huntington

The Antitumor Effect of Heparin is not Mediated by Direct NK Cell Activation.

Journal of clinical medicine

Avec: Gustavo R Rossi , Jenifer P Gonçalves , Timothy McCulloch , Rebecca B Delconte , Robert J Hennessy , Nicholas D Huntington , Edvaldo S Trindade , Fernando Souza-Fonseca-Guimaraes

Tissue-resident memory CD8

Nature

Avec: Simone L Park , Anthony Buzzai , Jai Rautela , Jyh Liang Hor , Katharina Hochheiser , Maike Effern , Nathan McBain , Teagan Wagner , Jarem Edwards , Robyn McConville , James S Wilmott , Richard A Scolyer , Thomas Tüting , Umaimainthan Palendira , David Gyorki , Scott N Mueller , Nicholas D Huntington , Sammy Bedoui , Michael Hölzel , Laura K Mackay , Jason Waithman , Thomas Gebhardt

Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells.

Molecular immunology

Avec: Jai Rautela , Laura F Dagley , Tobias Kratina , Angaleena Anthony , Wilford Goh , Elliot Surgenor , Rebecca B Delconte , Andrew I Webb , Ngaire Elwood , Joanna R Groom , Fernando Souza-Fonseca-Guimaraes , Lynn Corcoran , Nicholas D Huntington

Drug target validation in primary human natural killer cells using CRISPR RNP.

Journal of leukocyte biology

Avec: Jai Rautela , Elliot Surgenor , Nicholas D Huntington

Single-cell analyses reveal the clonal and molecular aetiology of Flt3L-induced emergency dendritic cell development.

Nature cell biology

Avec: Dawn S Lin , Luyi Tian , Sara Tomei , Daniela Amann-Zalcenstein , Tracey M Baldwin , Tom S Weber , Jaring Schreuder , Olivia J Stonehouse , Jai Rautela , Nicholas D Huntington , Samir Taoudi , Matthew E Ritchie , Philip D Hodgkin , Ashley P Ng , Stephen L Nutt , Shalin H Naik

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity.

Nature immunology

Avec: Susan N Christo , Maximilien Evrard , Simone L Park , Luke C Gandolfo , Thomas N Burn , Raissa Fonseca , Dane M Newman , Yannick O Alexandre , Nicholas Collins , Natasha M Zamudio , Fernando Souza-Fonseca-Guimaraes , Daniel G Pellicci , David Chisanga , Wei Shi , Laurent Bartholin , Gabrielle T Belz , Nicholas D Huntington , Andrew Lucas , Michaela Lucas , Scott N Mueller , William R Heath , Florent Ginhoux , Terence P Speed , Francis R Carbone , Axel Kallies , Laura K Mackay

The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome.

Cancer immunology research

Avec: Momeneh Foroutan , Ramyar Molania , Aline Pfefferle , Corina Behrenbruch , Sebastian Scheer , Axel Kallies , Terence P Speed , Joseph Cursons , Nicholas D Huntington

Targeting WEE1/AKT Restores p53-Dependent Natural Killer-Cell Activation to Induce Immune Checkpoint Blockade Responses in "Cold" Melanoma.

Cancer immunology research

Avec: Saketh S Dinavahi , Yu-Chi Chen , Kishore Punnath , Arthur Berg , Meenhard Herlyn , Momeneh Foroutan , Nicholas D Huntington , Gavin P Robertson

Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.

Science advances

Avec: Ashleigh R Poh , Christopher G Love , David Chisanga , James H Steer , David Baloyan , Michaël Chopin , Stephen Nutt , Jai Rautela , Nicholas D Huntington , Nima Etemadi , Megan O'Brien , Ryan O'Keefe , Lesley G Ellies , Christophe Macri , Justine D Mintern , Lachlan Whitehead , Gangadhara Gangadhara , Louis Boon , Ashwini L Chand , Clifford A Lowell , Wei Shi , Fiona J Pixley , Matthias Ernst

Réseau de co-auteurs

Jai Rautela 9 collaborations

Fernando Souza-Fonseca-Guimaraes 5 collaborations

Joseph Cursons 3 collaborations

Momeneh Foroutan 3 collaborations

Rebecca B Delconte 3 collaborations

Wilford Goh 3 collaborations

Soroor Hediyeh-Zadeh 2 collaborations

Melissa J Davis 2 collaborations

Geoffrey Guittard 2 collaborations

Robert J Hennessy 2 collaborations

Tobias Kratina 2 collaborations

Simone L Park 2 collaborations

Scott N Mueller 2 collaborations

Laura K Mackay 2 collaborations

Elliot Surgenor 2 collaborations

David Chisanga 2 collaborations

Wei Shi 2 collaborations

Terence P Speed 2 collaborations

Axel Kallies 2 collaborations

Ashley Anderson 1 collaboration

Frédéric Hollande 1 collaboration

Andreas Behren 1 collaboration

Jacques A Nunès 1 collaboration

Emma M Carrington 1 collaboration

Cynthia Louis 1 collaboration

Manuela Hancock 1 collaboration

Christine R Keenan 1 collaboration

Nadia Iannarella 1 collaboration

Rhys S Allan 1 collaboration

Ahmad Z Wardak 1 collaboration

Peter E Czabotar 1 collaboration

Marco J Herold 1 collaboration

Robyn L Schenk 1 collaboration

Christine A White 1 collaboration

Damian D'Silva 1 collaboration

Yuyan Yang 1 collaboration

Wesley Wong 1 collaboration

Huon Wong 1 collaboration

Vanessa L Bryant 1 collaboration

Robyn M Sutherland 1 collaboration

Yifan Zhan 1 collaboration

Jacinta Hansen 1 collaboration

Duong Nhu 1 collaboration

Guillaume Lessene 1 collaboration

Ian P Wicks 1 collaboration

Andrew M Lew 1 collaboration

Pierre-Louis Bernard 1 collaboration

Rebecca Delconte 1 collaboration

Sonia Pastor 1 collaboration

Vladimir Laletin 1 collaboration

Cathy Costa Da Silva 1 collaboration

Armelle Goubard 1 collaboration

Emmanuelle Josselin 1 collaboration

Rémy Castellano 1 collaboration

Adrien Krug 1 collaboration

Julien Vernerey 1 collaboration

Raynier Devillier 1 collaboration

Daniel Olive 1 collaboration

Els Verhoeyen 1 collaboration

Eric Vivier 1 collaboration

Jacques Nunes 1 collaboration

Shuwei Liang 1 collaboration

Eric Tran 1 collaboration

Xin Du 1 collaboration

Jiajun Dong 1 collaboration

Harrison Sudholz 1 collaboration

Hao Chen 1 collaboration

Zihan Qu 1 collaboration

Jeffrey J Babon 1 collaboration

Nadia J Kershaw 1 collaboration

Zhong-Yin Zhang 1 collaboration

Jonathan B Baell 1 collaboration

Florian Wiede 1 collaboration

Tony Tiganis 1 collaboration

Lizeth G Meza Guzman 1 collaboration

Craig D Hyland 1 collaboration

Grace M Bidgood 1 collaboration

Evelyn Leong 1 collaboration

Zihan Shen 1 collaboration

James E Vince 1 collaboration

Sandra E Nicholson 1 collaboration

Gustavo R Rossi 1 collaboration

Jenifer P Gonçalves 1 collaboration

Timothy McCulloch 1 collaboration

Edvaldo S Trindade 1 collaboration

Anthony Buzzai 1 collaboration

Jyh Liang Hor 1 collaboration

Katharina Hochheiser 1 collaboration

Maike Effern 1 collaboration

Nathan McBain 1 collaboration

Teagan Wagner 1 collaboration

Jarem Edwards 1 collaboration

Robyn McConville 1 collaboration

James S Wilmott 1 collaboration

Richard A Scolyer 1 collaboration

Thomas Tüting 1 collaboration

Umaimainthan Palendira 1 collaboration

David Gyorki 1 collaboration

Sammy Bedoui 1 collaboration

Michael Hölzel 1 collaboration

Jason Waithman 1 collaboration

Thomas Gebhardt 1 collaboration

Laura F Dagley 1 collaboration

Angaleena Anthony 1 collaboration

Andrew I Webb 1 collaboration

Ngaire Elwood 1 collaboration

Joanna R Groom 1 collaboration

Lynn Corcoran 1 collaboration

Dawn S Lin 1 collaboration

Luyi Tian 1 collaboration

Sara Tomei 1 collaboration

Daniela Amann-Zalcenstein 1 collaboration

Tracey M Baldwin 1 collaboration

Tom S Weber 1 collaboration

Jaring Schreuder 1 collaboration

Olivia J Stonehouse 1 collaboration

Samir Taoudi 1 collaboration

Matthew E Ritchie 1 collaboration

Philip D Hodgkin 1 collaboration

Ashley P Ng 1 collaboration

Stephen L Nutt 1 collaboration

Shalin H Naik 1 collaboration

Susan N Christo 1 collaboration

Maximilien Evrard 1 collaboration

Luke C Gandolfo 1 collaboration

Thomas N Burn 1 collaboration

Raissa Fonseca 1 collaboration

Dane M Newman 1 collaboration

Yannick O Alexandre 1 collaboration

Nicholas Collins 1 collaboration

Natasha M Zamudio 1 collaboration

Daniel G Pellicci 1 collaboration

Laurent Bartholin 1 collaboration

Gabrielle T Belz 1 collaboration

Andrew Lucas 1 collaboration

Michaela Lucas 1 collaboration

William R Heath 1 collaboration

Florent Ginhoux 1 collaboration

Francis R Carbone 1 collaboration

Ramyar Molania 1 collaboration

Aline Pfefferle 1 collaboration

Corina Behrenbruch 1 collaboration

Sebastian Scheer 1 collaboration

Saketh S Dinavahi 1 collaboration

Yu-Chi Chen 1 collaboration

Kishore Punnath 1 collaboration

Arthur Berg 1 collaboration

Meenhard Herlyn 1 collaboration

Gavin P Robertson 1 collaboration

Ashleigh R Poh 1 collaboration

Christopher G Love 1 collaboration

James H Steer 1 collaboration

David Baloyan 1 collaboration

Michaël Chopin 1 collaboration

Stephen Nutt 1 collaboration

Nima Etemadi 1 collaboration

Megan O'Brien 1 collaboration

Ryan O'Keefe 1 collaboration

Lesley G Ellies 1 collaboration

Christophe Macri 1 collaboration

Justine D Mintern 1 collaboration

Lachlan Whitehead 1 collaboration

Gangadhara Gangadhara 1 collaboration

Louis Boon 1 collaboration

Ashwini L Chand 1 collaboration

Clifford A Lowell 1 collaboration

Fiona J Pixley 1 collaboration

Matthias Ernst 1 collaboration