Pascal Chanu

Affiliations

Clinical Pharmacology, Genentech/Roche, Lyon, France.

Publications (17)

A modeling and simulation-based assessment of the impact of confounding factors on the readout of a sildenafil survival trial in pulmonary arterial hypertension.

Journal of pharmacokinetics and pharmacodynamics

Avec: Pascal Chanu , Xiang Gao , Rene Bruno , Laurent Claret , Lutz Harnisch

Population Pharmacokinetics of Ipatasertib and Its Metabolite in Cancer Patients.

Journal of clinical pharmacology

Avec: Kenta Yoshida , Justin Wilkins , Julia Winkler , Janet R Wade , Naoki Kotani , Nina Wang , Rucha Sane , Pascal Chanu

Model-based approach for methoxy polyethylene glycol-epoetin beta drug development in paediatric patients with anaemia of chronic kidney disease.

British journal of clinical pharmacology

Avec: Pascal Chanu , Franz Schaefer , Bradley A Warady , Claus Peter Schmitt , Bruno Reigner , Gabriel Schnetzler , Sylvie Meyer Reigner , Mark Eisner , Arlette Weichert , Nicolas Frey

Integrated Two-Analyte Population Pharmacokinetic Model of Polatuzumab Vedotin in Patients With Non-Hodgkin Lymphoma.

CPT: pharmacometrics & systems pharmacology

Avec: Dan Lu , Tong Lu , Leonid Gibiansky , Xiaobin Li , Chunze Li , Priya Agarwal , Colby S Shemesh , Rong Shi , Randall C Dere , Jamie Hirata , Dale Miles , Pascal Chanu , Sandhya Girish , Jin Yan Jin

Population pharmacokinetics, exposure-safety, and immunogenicity of atezolizumab in pediatric and young adult patients with cancer.

Journal for immunotherapy of cancer

Avec: Colby S Shemesh , Pascal Chanu , Kris Jamsen , Russ Wada , Gianluca Rossato , Francis Donaldson , Amit Garg , Helen Winter , Jane Ruppel , Xin Wang , Rene Bruno , Jin Jin , Sandhya Girish

Application of a Two-Analyte Integrated Population Pharmacokinetic Model to Evaluate the Impact of Intrinsic and Extrinsic Factors on the Pharmacokinetics of Polatuzumab Vedotin in Patients with Non-Hodgkin Lymphoma.

Pharmaceutical research

Avec: Dan Lu , Tong Lu , Rong Shi , Leonid Gibiansky , Priya Agarwal , Colby S Shemesh , Randall C Dere , Uzor Ogbu , Jamie Hirata , Pascal Chanu , Sandhya Girish , Jin Yan Jin , Chunze Li , Dale Miles

Clinical Pharmacology Applications of Real-World Data and Real-World Evidence in Drug Development and Approval-An Industry Perspective.

Clinical pharmacology and therapeutics

Avec: Rui Zhu , Bianca Vora , Sujatha Menon , Islam Younis , Gaurav Dwivedi , Zhaoling Meng , Amita Datta-Mannan , Pooja Manchandani , Satyaprakash Nayak , Brinda K Tammara , Parag Garhyan , Shahed Iqbal , Simon Dagenais , Pascal Chanu , Arnab Mukherjee , Cyrus Ghobadi , Auteur inconnu

Modeling Alzheimer's disease progression utilizing clinical trial and ADNI data to predict longitudinal trajectory of CDR-SB.

CPT: pharmacometrics & systems pharmacology

Avec: Samira Jamalian , Michael Dolton , Pascal Chanu , Vidya Ramakrishnan , Yesenia Franco , Kristin Wildsmith , Paul Manser , Edmond Teng , Jin Y Jin , Angelica Quartino , Joy C Hsu , Auteur inconnu

A Novel Step-Up Dosage Regimen for Enhancing the Benefit-to-Risk Ratio of Mosunetuzumab in Relapsed or Refractory Follicular Lymphoma.

Clinical pharmacology and therapeutics

Avec: Chi-Chung Li , Brendan Bender , Justin Wilkins , Feifei Li , David C Turner , Bei Wang , Rong Deng , Shweta Vadhavkar , Zao Li , Antonia Kwan , Huang Huang , Kun Peng , Elicia Penuel , Ling-Yuh Huw , Pascal Chanu , Chunze Li , Shen Yin , Michael C Wei

Results of a Dose-Finding Phase 1b Study of Subcutaneous Atezolizumab in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer.

Clinical pharmacology in drug development

Avec: Enriqueta Felip , Mauricio Burotto , Zanete Zvirbule , Luis A Herraez-Baranda , Pascal Chanu , Smita Kshirsagar , Vidya Maiya , Phyllis Chan , Emanuela Pozzi , Mathilde Marchand , Marion Monchalin , Kunihiko Tanaka , Nadia Tosti , Bei Wang , Eleonora Restuccia

Real-world data prognostic model of overall survival in patients with advanced NSCLC receiving anti-PD-1/PD-L1 immune checkpoint inhibitors as second-line monotherapy.

Cancer reports (Hoboken, N.J.)

Avec: Cristina Julian , Robson J M Machado , Sandhya Girish , Pascal Chanu , Dominik Heinzmann , Chris Harbron , Anda Gershon , Shannon M Pfeiffer , Wei Zou , Valerie Quarmby , Qing Zhang , Yachi Chen

Population pharmacokinetics and CD20 binding dynamics for mosunetuzumab in relapsed/refractory B-cell non-Hodgkin lymphoma.

Clinical and translational science

Avec: Brendan Bender , Chi-Chung Li , Mathilde Marchand , David C Turner , Feifei Li , Shweta Vadhavkar , Bei Wang , Rong Deng , James Lu , Jin Jin , Chunze Li , Shen Yin , Michael Wei , Pascal Chanu

Exposure-safety and exposure-efficacy analyses of polatuzumab vedotin in patients with relapsed or refractory diffuse large B-cell lymphoma.

Leukemia & lymphoma

Avec: Tong Lu , Leonid Gibiansky , Xiaobin Li , Chunze Li , Rong Shi , Priya Agarwal , Jamie Hirata , Dale Miles , Pascal Chanu , Sandhya Girish , Jin Yan Jin , Dan Lu

Characterization of exposure-response relationships of ipatasertib in patients with metastatic castration-resistant prostate cancer in the IPATential150 study.

Cancer chemotherapy and pharmacology

Avec: Naoki Kotani , Justin J Wilkins , Janet R Wade , Steve Dang , Dhruvitkumar S Sutaria , Kenta Yoshida , Sameer Sundrani , Hao Ding , Josep Garcia , Heather Hinton , Rucha Sane , Pascal Chanu

Tumor Dynamic Model-Based Decision Support for Phase Ib/II Combination Studies: A Retrospective Assessment Based on Resampling of the Phase III Study IMpower150.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: René Bruno , Mathilde Marchand , Kenta Yoshida , Phyllis Chan , Haocheng Li , Wei Zou , Francois Mercier , Pascal Chanu , Benjamin Wu , Anthony Lee , Chunze Li , Jin Y Jin , Michael L Maitland , Martin Reck , Mark A Socinski

Support to early clinical decisions in drug development and personalised medicine with checkpoint inhibitors using dynamic biomarker-overall survival models.

British journal of cancer

Avec: René Bruno , Pascal Chanu , Matts Kågedal , Francois Mercier , Kenta Yoshida , Jérémie Guedj , Chunze Li , Ulrich Beyer , Jin Y Jin

Tumor growth and overall survival modeling to support decision making in phase Ib/II trials: A comparison of the joint and two-stage approaches.

CPT: pharmacometrics & systems pharmacology

Avec: Mathilde Marchand , Antonio Gonçalves , François Mercier , Pascal Chanu , Jin Y Jin , Jérémie Guedj , René Bruno

Réseau de co-auteurs

Chunze Li 7 collaborations

Sandhya Girish 5 collaborations

Kenta Yoshida 4 collaborations

Jin Y Jin 4 collaborations

Mathilde Marchand 4 collaborations

Dan Lu 3 collaborations

Tong Lu 3 collaborations

Leonid Gibiansky 3 collaborations

Priya Agarwal 3 collaborations

Colby S Shemesh 3 collaborations

Rong Shi 3 collaborations

Jamie Hirata 3 collaborations

Dale Miles 3 collaborations

Jin Yan Jin 3 collaborations

Bei Wang 3 collaborations

René Bruno 3 collaborations

Rene Bruno 2 collaborations

Justin Wilkins 2 collaborations

Janet R Wade 2 collaborations

Naoki Kotani 2 collaborations

Rucha Sane 2 collaborations

Xiaobin Li 2 collaborations

Randall C Dere 2 collaborations

Jin Jin 2 collaborations

None None 2 collaborations

Chi-Chung Li 2 collaborations

Brendan Bender 2 collaborations

Feifei Li 2 collaborations

David C Turner 2 collaborations

Rong Deng 2 collaborations

Shweta Vadhavkar 2 collaborations

Shen Yin 2 collaborations

Phyllis Chan 2 collaborations

Wei Zou 2 collaborations

Francois Mercier 2 collaborations

Jérémie Guedj 2 collaborations

Xiang Gao 1 collaboration

Laurent Claret 1 collaboration

Lutz Harnisch 1 collaboration

Julia Winkler 1 collaboration

Nina Wang 1 collaboration

Franz Schaefer 1 collaboration

Bradley A Warady 1 collaboration

Claus Peter Schmitt 1 collaboration

Bruno Reigner 1 collaboration

Gabriel Schnetzler 1 collaboration

Sylvie Meyer Reigner 1 collaboration

Mark Eisner 1 collaboration

Arlette Weichert 1 collaboration

Nicolas Frey 1 collaboration

Kris Jamsen 1 collaboration

Russ Wada 1 collaboration

Gianluca Rossato 1 collaboration

Francis Donaldson 1 collaboration

Amit Garg 1 collaboration

Helen Winter 1 collaboration

Jane Ruppel 1 collaboration

Xin Wang 1 collaboration

Uzor Ogbu 1 collaboration

Rui Zhu 1 collaboration

Bianca Vora 1 collaboration

Sujatha Menon 1 collaboration

Islam Younis 1 collaboration

Gaurav Dwivedi 1 collaboration

Zhaoling Meng 1 collaboration

Amita Datta-Mannan 1 collaboration

Pooja Manchandani 1 collaboration

Satyaprakash Nayak 1 collaboration

Brinda K Tammara 1 collaboration

Parag Garhyan 1 collaboration

Shahed Iqbal 1 collaboration

Simon Dagenais 1 collaboration

Arnab Mukherjee 1 collaboration

Cyrus Ghobadi 1 collaboration

Samira Jamalian 1 collaboration

Michael Dolton 1 collaboration

Vidya Ramakrishnan 1 collaboration

Yesenia Franco 1 collaboration

Kristin Wildsmith 1 collaboration

Paul Manser 1 collaboration

Edmond Teng 1 collaboration

Angelica Quartino 1 collaboration

Joy C Hsu 1 collaboration

Zao Li 1 collaboration

Antonia Kwan 1 collaboration

Huang Huang 1 collaboration

Kun Peng 1 collaboration

Elicia Penuel 1 collaboration

Ling-Yuh Huw 1 collaboration

Michael C Wei 1 collaboration

Enriqueta Felip 1 collaboration

Mauricio Burotto 1 collaboration

Zanete Zvirbule 1 collaboration

Luis A Herraez-Baranda 1 collaboration

Smita Kshirsagar 1 collaboration

Vidya Maiya 1 collaboration

Emanuela Pozzi 1 collaboration

Marion Monchalin 1 collaboration

Kunihiko Tanaka 1 collaboration

Nadia Tosti 1 collaboration

Eleonora Restuccia 1 collaboration

Cristina Julian 1 collaboration

Robson J M Machado 1 collaboration

Dominik Heinzmann 1 collaboration

Chris Harbron 1 collaboration

Anda Gershon 1 collaboration

Shannon M Pfeiffer 1 collaboration

Valerie Quarmby 1 collaboration

Qing Zhang 1 collaboration

Yachi Chen 1 collaboration

James Lu 1 collaboration

Michael Wei 1 collaboration

Justin J Wilkins 1 collaboration

Steve Dang 1 collaboration

Dhruvitkumar S Sutaria 1 collaboration

Sameer Sundrani 1 collaboration

Hao Ding 1 collaboration

Josep Garcia 1 collaboration

Heather Hinton 1 collaboration

Haocheng Li 1 collaboration

Benjamin Wu 1 collaboration

Anthony Lee 1 collaboration

Michael L Maitland 1 collaboration

Martin Reck 1 collaboration

Mark A Socinski 1 collaboration

Matts Kågedal 1 collaboration

Ulrich Beyer 1 collaboration

Antonio Gonçalves 1 collaboration

François Mercier 1 collaboration