Patrick Trojer

Affiliations

Constellation Pharmaceuticals, Cambridge, MA, USA.

Publications (10)

Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis.

Nature cell biology

Avec: Donglim Esther Park , Jingwei Cheng , John P McGrath , Matthew Y Lim , Camille Cushman , Selene K Swanson , Michelle L Tillgren , Joao A Paulo , Prafulla C Gokhale , Laurence Florens , Michael P Washburn , Patrick Trojer , James A DeCaprio

BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer.

bioRxiv : the preprint server for biology

Avec: Shipra Shukla , Dan Li , Holly Nguyen , Jennifer Conner , Gabriella Bayshtok , Woo Hyun Cho , Mohini Pachai , Nicholas Teri , Eric Campeau , Sarah Attwell , Patrick Trojer , Irina Ostrovnaya , Anuradha Gopalan , Eva Corey , Ping Chi , Yu Chen

Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activity.

The Journal of biological chemistry

Avec: Jacob I Stuckey , Nico R Cantone , Alexandre Côté , Shilpi Arora , Valerie Vivat , Ashwin Ramakrishnan , Jennifer A Mertz , Avinash Khanna , Jehrod Brenneman , Victor S Gehling , Ludivine Moine , Robert J Sims , James E Audia , Patrick Trojer , Julian R Levell , Richard T Cummings

Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of ARID1A Mutant Cancers.

Cancer research

Avec: Patricia J Keller , Elizabeth J Adams , Rentian Wu , Alexandre Côté , Shilpi Arora , Nico Cantone , Rosana Meyer , Jennifer A Mertz , Victor Gehling , Jike Cui , Jacob I Stuckey , Avinash Khanna , Feng Zhao , Zehua Chen , Ziyang Yu , Richard Cummings , Mohammed Taimi , Nehal J Lakhani , Drew W Rasco , Martin Gutierrez , Linda Duska , Michael Devitt , Ronda Rippley , Julian Levell , Jennifer Truong , Jing Wang , Kaiming Sun , Patrick Trojer

Screening for Small-Molecule Inhibitors of Histone Methyltransferases.

Methods in molecular biology (Clifton, N.J.)

Avec: Nico Cantone , Richard T Cummings , Patrick Trojer

Author Correction: Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis.

Nature cell biology

Avec: Donglim Esther Park , Jingwei Cheng , John P McGrath , Matthew Y Lim , Camille Cushman , Selene K Swanson , Michelle L Tillgren , Joao A Paulo , Prafulla C Gokhale , Laurence Florens , Michael P Washburn , Patrick Trojer , James A DeCaprio

Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time.

ACS medicinal chemistry letters

Avec: Avinash Khanna , Alexandre Côté , Shilpi Arora , Ludivine Moine , Victor S Gehling , Jehrod Brenneman , Nico Cantone , Jacob I Stuckey , Shruti Apte , Ashwin Ramakrishnan , Kamil Bruderek , William D Bradley , James E Audia , Richard T Cummings , Robert J Sims , Patrick Trojer , Julian R Levell

Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors.

ACS medicinal chemistry letters

Avec: Victor S Gehling , John P McGrath , Martin Duplessis , Avinash Khanna , Francois Brucelle , Rishi G Vaswani , Alexandre Côté , Jacob Stuckey , Venita Watson , Richard T Cummings , Srividya Balasubramanian , Priyadarshini Iyer , Priyanka Sawant , Andrew C Good , Brian K Albrecht , Jean-Christophe Harmange , James E Audia , Steven F Bellon , Patrick Trojer , Julian R Levell

Small molecule targeting of chromatin writers in cancer.

Nature chemical biology

Avec: Andrew R Conery , Jennifer L Rocnik , Patrick Trojer

A Phase I Study of Pelabresib (CPI-0610), a Small-Molecule Inhibitor of BET Proteins, in Patients with Relapsed or Refractory Lymphoma.

Cancer research communications

Avec: Kristie A Blum , Jeffrey G Supko , Michael B Maris , Ian W Flinn , Andre Goy , Anas Younes , Suresh Bobba , Adrian M Senderowicz , Sergey Efuni , Ronda Rippley , Gozde Colak , Patrick Trojer , Jeremy S Abramson

Réseau de co-auteurs

Alexandre Côté 4 collaborations

Avinash Khanna 4 collaborations

Richard T Cummings 4 collaborations

John P McGrath 3 collaborations

Jacob I Stuckey 3 collaborations

Shilpi Arora 3 collaborations

Victor S Gehling 3 collaborations

James E Audia 3 collaborations

Julian R Levell 3 collaborations

Nico Cantone 3 collaborations

Donglim Esther Park 2 collaborations

Jingwei Cheng 2 collaborations

Matthew Y Lim 2 collaborations

Camille Cushman 2 collaborations

Selene K Swanson 2 collaborations

Michelle L Tillgren 2 collaborations

Joao A Paulo 2 collaborations

Prafulla C Gokhale 2 collaborations

Laurence Florens 2 collaborations

Michael P Washburn 2 collaborations

James A DeCaprio 2 collaborations

Ashwin Ramakrishnan 2 collaborations

Jennifer A Mertz 2 collaborations

Jehrod Brenneman 2 collaborations

Ludivine Moine 2 collaborations

Robert J Sims 2 collaborations

Ronda Rippley 2 collaborations

Shipra Shukla 1 collaboration

Dan Li 1 collaboration

Holly Nguyen 1 collaboration

Jennifer Conner 1 collaboration

Gabriella Bayshtok 1 collaboration

Woo Hyun Cho 1 collaboration

Mohini Pachai 1 collaboration

Nicholas Teri 1 collaboration

Eric Campeau 1 collaboration

Sarah Attwell 1 collaboration

Irina Ostrovnaya 1 collaboration

Anuradha Gopalan 1 collaboration

Eva Corey 1 collaboration

Ping Chi 1 collaboration

Yu Chen 1 collaboration

Nico R Cantone 1 collaboration

Valerie Vivat 1 collaboration

Patricia J Keller 1 collaboration

Elizabeth J Adams 1 collaboration

Rentian Wu 1 collaboration

Rosana Meyer 1 collaboration

Victor Gehling 1 collaboration

Jike Cui 1 collaboration

Feng Zhao 1 collaboration

Zehua Chen 1 collaboration

Ziyang Yu 1 collaboration

Richard Cummings 1 collaboration

Mohammed Taimi 1 collaboration

Nehal J Lakhani 1 collaboration

Drew W Rasco 1 collaboration

Martin Gutierrez 1 collaboration

Linda Duska 1 collaboration

Michael Devitt 1 collaboration

Julian Levell 1 collaboration

Jennifer Truong 1 collaboration

Jing Wang 1 collaboration

Kaiming Sun 1 collaboration

Shruti Apte 1 collaboration

Kamil Bruderek 1 collaboration

William D Bradley 1 collaboration

Martin Duplessis 1 collaboration

Francois Brucelle 1 collaboration

Rishi G Vaswani 1 collaboration

Jacob Stuckey 1 collaboration

Venita Watson 1 collaboration

Srividya Balasubramanian 1 collaboration

Priyadarshini Iyer 1 collaboration

Priyanka Sawant 1 collaboration

Andrew C Good 1 collaboration

Brian K Albrecht 1 collaboration

Jean-Christophe Harmange 1 collaboration

Steven F Bellon 1 collaboration

Andrew R Conery 1 collaboration

Jennifer L Rocnik 1 collaboration

Kristie A Blum 1 collaboration

Jeffrey G Supko 1 collaboration

Michael B Maris 1 collaboration

Ian W Flinn 1 collaboration

Andre Goy 1 collaboration

Anas Younes 1 collaboration

Suresh Bobba 1 collaboration

Adrian M Senderowicz 1 collaboration

Sergey Efuni 1 collaboration

Gozde Colak 1 collaboration

Jeremy S Abramson 1 collaboration