Philip R Tedbury

Affiliations

Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.

Publications (28)

Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules.

Viruses

Avec: Sanjeev Kumar V Vernekar , Rajkumar Lalji Sahani , Mary C Casey , Jayakanth Kankanala , Lei Wang , Karen A Kirby , Haijuan Du , Huanchun Zhang , Philip R Tedbury , Jiashu Xie , Stefan G Sarafianos , Zhengqiang Wang

Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability.

Acta pharmaceutica Sinica. B

Avec: Lei Wang , Mary C Casey , Sanjeev Kumar V Vernekar , Rajkumar Lalji Sahani , Karen A Kirby , Haijuan Du , Huanchun Zhang , Philip R Tedbury , Jiashu Xie , Stefan G Sarafianos , Zhengqiang Wang

Drug Interactions in Lenacapavir-Based Long-Acting Antiviral Combinations.

Viruses

Avec: Maria E Cilento , Yee Tsuey Ong , Philip R Tedbury , Stefan G Sarafianos

Chemical profiling of HIV-1 capsid-targeting antiviral PF74.

European journal of medicinal chemistry

Avec: Lei Wang , Mary C Casey , Sanjeev Kumar V Vernekar , Ha T Do , Rajkumar Lalji Sahani , Karen A Kirby , Haijuan Du , Atsuko Hachiya , Huanchun Zhang , Philip R Tedbury , Jiashu Xie , Stefan G Sarafianos , Zhengqiang Wang

Novel HIV-1 capsid-targeting small molecules of the PF74 binding site.

European journal of medicinal chemistry

Avec: Lei Wang , Mary C Casey , Sanjeev Kumar V Vernekar , Rajkumar Lalji Sahani , Jayakanth Kankanala , Karen A Kirby , Haijuan Du , Atsuko Hachiya , Huanchun Zhang , Philip R Tedbury , Jiashu Xie , Stefan G Sarafianos , Zhengqiang Wang

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.

Nature communications

Avec: Ashwanth C Francis , Mariana Marin , Parmit K Singh , Vasudevan Achuthan , Mathew J Prellberg , Kristina Palermino-Rowland , Shuiyun Lan , Philip R Tedbury , Stefan G Sarafianos , Alan N Engelman , Gregory B Melikyan

Design, Synthesis and Characterization of HIV-1 CA-Targeting Small Molecules: Conformational Restriction of PF74.

Viruses

Avec: Rajkumar Lalji Sahani , Raquel Diana-Rivero , Sanjeev Kumar V Vernekar , Lei Wang , Haijuan Du , Huanchun Zhang , Andres Emanuelli Castaner , Mary C Casey , Karen A Kirby , Philip R Tedbury , Jiashu Xie , Stefan G Sarafianos , Zhengqiang Wang

Marine Natural Products as Leads against SARS-CoV-2 Infection.

Journal of natural products

Avec: Bhuwan Khatri Chhetri , Philip R Tedbury , Anne Marie Sweeney-Jones , Luke Mani , Katy Soapi , Candela Manfredi , Eric Sorscher , Stefan G Sarafianos , Julia Kubanek

Single-cell Multiplexed Fluorescence Imaging to Visualize Viral Nucleic Acids and Proteins and Monitor HIV, HTLV, HBV, HCV, Zika Virus, and Influenza Infection.

Journal of visualized experiments : JoVE

Avec: Raven Shah , Shuiyun Lan , Maritza N Puray-Chavez , Dandan Liu , Philip R Tedbury , Stefan G Sarafianos

Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.

Nature communications

Analysis of HIV-1 Matrix-Envelope Cytoplasmic Tail Interactions.

Journal of virology

Avec: Ayna Alfadhli , August O Staubus , Philip R Tedbury , Mariia Novikova , Eric O Freed , Eric Barklis

Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside.

Current research in pharmacology and drug discovery

Avec: Sijia Tao , Keivan Zandi , Leda Bassit , Yee Tsuey Ong , Kiran Verma , Peng Liu , Jessica A Downs-Bowen , Tamara McBrayer , Julia C LeCher , James J Kohler , Philip R Tedbury , Baek Kim , Franck Amblard , Stefan G Sarafianos , Raymond F Schinazi

SARS-CoV-2 Induces Epithelial-Enteric Neuronal Crosstalk Stimulating VIP Release.

Biomolecules

Avec: Arun Balasubramaniam , Philip R Tedbury , Simon M Mwangi , Yunshan Liu , Ge Li , Didier Merlin , Adam D Gracz , Peijian He , Stefan G Sarafianos , Shanthi Srinivasan

HIV-1 Resistance to Islatravir/Tenofovir Combination Therapy in Wild-Type or NRTI-Resistant Strains of Diverse HIV-1 Subtypes.

Viruses

Avec: Maria E Cilento , Xin Wen , Aaron B Reeve , Obiaara B Ukah , Alexa A Snyder , Ciro M Carrillo , Cole P Smith , Kristin Edwards , Claudia C Wahoski , Deborah R Kitzler , Eiichi N Kodama , Hiroaki Mitsuya , Michael A Parniak , Philip R Tedbury , Stefan G Sarafianos

Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication.

Viruses

Avec: Maritza N Puray-Chavez , Mahmoud H Farghali , Vincent Yapo , Andrew D Huber , Dandan Liu , Tanyaradzwa P Ndongwe , Mary C Casey , Thomas G Laughlin , Mark Hannink , Philip R Tedbury , Stefan G Sarafianos

Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus.

Viruses

Avec: Dandan Liu , Philip R Tedbury , Shuiyun Lan , Andrew D Huber , Maritza N Puray-Chavez , Juan Ji , Eleftherios Michailidis , Mohsan Saeed , Tanyaradzwa P Ndongwe , Leda C Bassit , Raymond F Schinazi , Robert Ralston , Charles M Rice , Stefan G Sarafianos

Development of Human Immunodeficiency Virus Type 1 Resistance to 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine Starting with Wild-Type or Nucleoside Reverse Transcriptase Inhibitor-Resistant Strains.

Antimicrobial agents and chemotherapy

Avec: Maria E Cilento , Aaron B Reeve , Eleftherios Michailidis , Tatiana V Ilina , Eva Nagy , Hiroaki Mitsuya , Michael A Parniak , Philip R Tedbury , Stefan G Sarafianos

Discovery of New Small Molecule Hits as Hepatitis B Virus Capsid Assembly Modulators: Structure and Pharmacophore-Based Approaches.

Viruses

Avec: Sameera Senaweera , Haijuan Du , Huanchun Zhang , Karen A Kirby , Philip R Tedbury , Jiashu Xie , Stefan G Sarafianos , Zhengqiang Wang

Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus.

Viruses

Avec: Dandan Liu , Tanya P Ndongwe , Juan Ji , Andrew D Huber , Eleftherios Michailidis , Charles M Rice , Robert Ralston , Philip R Tedbury , Stefan G Sarafianos

Identification of clickable HIV-1 capsid-targeting probes for viral replication inhibition.

Cell chemical biology

Avec: William M McFadden , Mary C Casey-Moore , Grant A L Bare , Karen A Kirby , Xin Wen , Gencheng Li , Hua Wang , Ryan L Slack , Alexa A Snyder , Zachary C Lorson , Isabella L Kaufman , Maria E Cilento , Philip R Tedbury , Milan Gembicky , Arthur J Olson , Bruce E Torbett , K Barry Sharpless , Stefan G Sarafianos

HIV-2 inhibits HIV-1 gene expression via two independent mechanisms during cellular co-infection.

Journal of virology

Avec: Vincent Yapo , Kinjal Majumder , Philip R Tedbury , Xin Wen , Yee T Ong , Marc C Johnson , Stefan G Sarafianos

Effect of P-body component Mov10 on HCV virus production and infectivity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Dandan Liu , Tanyaradzwa P Ndongwe , Maritza Puray-Chavez , Mary C Casey , Taisuke Izumi , Vinay K Pathak , Philip R Tedbury , Stefan G Sarafianos

HIV-1 Matrix Trimerization-Impaired Mutants Are Rescued by Matrix Substitutions That Enhance Envelope Glycoprotein Incorporation.

Journal of virology

Avec: Philip R Tedbury , Mariia Novikova , Ayna Alfadhli , Yuta Hikichi , Ioannis Kagiampakis , Vineet N KewalRamani , Eric Barklis , Eric O Freed

Rotten to the core: antivirals targeting the HIV-1 capsid core.

Retrovirology

Avec: William M McFadden , Alexa A Snyder , Karen A Kirby , Philip R Tedbury , Monika Raj , Zhengqiang Wang , Stefan G Sarafianos

Elucidating the Basis for Permissivity of the MT-4 T-Cell Line to Replication of an HIV-1 Mutant Lacking the gp41 Cytoplasmic Tail.

Journal of virology

Avec: Melissa V Fernandez , Huxley K Hoffman , Nairi Pezeshkian , Philip R Tedbury , Schuyler B van Engelenburg , Eric O Freed

Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Philip R Tedbury , Candela Manfredi , Frauke Degenhardt , Joseph Conway , Michael C Horwath , Courtney McCracken , Adam J Sorscher , Sandy Moreau , Christine Wright , Carolina Edwards , Jo Brewer , Jeannette Guarner , Emmie de Wit , Brandi N Williamson , Mehul S Suthar , Yee T Ong , John D Roback , David N Alter , Jan C Holter , Tom H Karlsen , Nicoletta Sacchi , Manuel Romero-Gómez , Pietro Invernizzi , Javier Fernández , Maria Buti , Agustin Albillos , Antonio Julià , Luca Valenti , Rosanna Asselta , Jesus M Banales , Luis Bujanda , Rafael de Cid , André Franke , Auteur inconnu , Stefan G Sarafianos , Jeong S Hong , Eric J Sorscher , Annette Ehrhardt

Activation of HIV-1 proviruses increases downstream chromatin accessibility.

iScience

Avec: Raven Shah , Christian M Gallardo , Yoonhee H Jung , Ben Clock , Jesse R Dixon , William M McFadden , Kinjal Majumder , David J Pintel , Victor G Corces , Bruce E Torbett , Philip R Tedbury , Stefan G Sarafianos

Nirmatrelvir Resistance in SARS-CoV-2 Omicron_BA.1 and WA1 Replicons and Escape Strategies.

bioRxiv : the preprint server for biology

Avec: Shuiyun Lan , Grace Neilsen , Ryan L Slack , William A Cantara , Andres Emanuelli Castaner , Zachary C Lorson , Nicole Lulkin , Huanchun Zhang , Jasper Lee , Maria E Cilento , Philip R Tedbury , Stefan G Sarafianos

Réseau de co-auteurs

Stefan G Sarafianos 25 collaborations

Karen A Kirby 8 collaborations

Mary C Casey 7 collaborations

Huanchun Zhang 7 collaborations

Zhengqiang Wang 7 collaborations

Haijuan Du 6 collaborations

Jiashu Xie 6 collaborations

Sanjeev Kumar V Vernekar 5 collaborations

Rajkumar Lalji Sahani 5 collaborations

Lei Wang 5 collaborations

Maria E Cilento 5 collaborations

Shuiyun Lan 5 collaborations

Dandan Liu 5 collaborations

Maritza N Puray-Chavez 3 collaborations

Eric O Freed 3 collaborations

Xin Wen 3 collaborations

Alexa A Snyder 3 collaborations

Andrew D Huber 3 collaborations

Tanyaradzwa P Ndongwe 3 collaborations

Eleftherios Michailidis 3 collaborations

William M McFadden 3 collaborations

Jayakanth Kankanala 2 collaborations

Yee Tsuey Ong 2 collaborations

Atsuko Hachiya 2 collaborations

Ashwanth C Francis 2 collaborations

Mariana Marin 2 collaborations

Parmit K Singh 2 collaborations

Vasudevan Achuthan 2 collaborations

Mathew J Prellberg 2 collaborations

Kristina Palermino-Rowland 2 collaborations

Alan N Engelman 2 collaborations

Gregory B Melikyan 2 collaborations

Andres Emanuelli Castaner 2 collaborations

Candela Manfredi 2 collaborations

Raven Shah 2 collaborations

Ayna Alfadhli 2 collaborations

Mariia Novikova 2 collaborations

Eric Barklis 2 collaborations

Raymond F Schinazi 2 collaborations

Aaron B Reeve 2 collaborations

Hiroaki Mitsuya 2 collaborations

Michael A Parniak 2 collaborations

Vincent Yapo 2 collaborations

Juan Ji 2 collaborations

Robert Ralston 2 collaborations

Charles M Rice 2 collaborations

Ryan L Slack 2 collaborations

Zachary C Lorson 2 collaborations

Bruce E Torbett 2 collaborations

Kinjal Majumder 2 collaborations

Yee T Ong 2 collaborations

Ha T Do 1 collaboration

Raquel Diana-Rivero 1 collaboration

Bhuwan Khatri Chhetri 1 collaboration

Anne Marie Sweeney-Jones 1 collaboration

Luke Mani 1 collaboration

Katy Soapi 1 collaboration

Eric Sorscher 1 collaboration

Julia Kubanek 1 collaboration

August O Staubus 1 collaboration

Sijia Tao 1 collaboration

Keivan Zandi 1 collaboration

Leda Bassit 1 collaboration

Kiran Verma 1 collaboration

Peng Liu 1 collaboration

Jessica A Downs-Bowen 1 collaboration

Tamara McBrayer 1 collaboration

Julia C LeCher 1 collaboration

James J Kohler 1 collaboration

Baek Kim 1 collaboration

Franck Amblard 1 collaboration

Arun Balasubramaniam 1 collaboration

Simon M Mwangi 1 collaboration

Yunshan Liu 1 collaboration

Ge Li 1 collaboration

Didier Merlin 1 collaboration

Adam D Gracz 1 collaboration

Peijian He 1 collaboration

Shanthi Srinivasan 1 collaboration

Obiaara B Ukah 1 collaboration

Ciro M Carrillo 1 collaboration

Cole P Smith 1 collaboration

Kristin Edwards 1 collaboration

Claudia C Wahoski 1 collaboration

Deborah R Kitzler 1 collaboration

Eiichi N Kodama 1 collaboration

Mahmoud H Farghali 1 collaboration

Thomas G Laughlin 1 collaboration

Mark Hannink 1 collaboration

Mohsan Saeed 1 collaboration

Leda C Bassit 1 collaboration

Tatiana V Ilina 1 collaboration

Eva Nagy 1 collaboration

Sameera Senaweera 1 collaboration

Tanya P Ndongwe 1 collaboration

Mary C Casey-Moore 1 collaboration

Grant A L Bare 1 collaboration

Gencheng Li 1 collaboration

Hua Wang 1 collaboration

Isabella L Kaufman 1 collaboration

Milan Gembicky 1 collaboration

Arthur J Olson 1 collaboration

K Barry Sharpless 1 collaboration

Marc C Johnson 1 collaboration

Maritza Puray-Chavez 1 collaboration

Taisuke Izumi 1 collaboration

Vinay K Pathak 1 collaboration

Yuta Hikichi 1 collaboration

Ioannis Kagiampakis 1 collaboration

Vineet N KewalRamani 1 collaboration

Monika Raj 1 collaboration

Melissa V Fernandez 1 collaboration

Huxley K Hoffman 1 collaboration

Nairi Pezeshkian 1 collaboration

Schuyler B van Engelenburg 1 collaboration

Frauke Degenhardt 1 collaboration

Joseph Conway 1 collaboration

Michael C Horwath 1 collaboration

Courtney McCracken 1 collaboration

Adam J Sorscher 1 collaboration

Sandy Moreau 1 collaboration

Christine Wright 1 collaboration

Carolina Edwards 1 collaboration

Jo Brewer 1 collaboration

Jeannette Guarner 1 collaboration

Emmie de Wit 1 collaboration

Brandi N Williamson 1 collaboration

Mehul S Suthar 1 collaboration

John D Roback 1 collaboration

David N Alter 1 collaboration

Jan C Holter 1 collaboration

Tom H Karlsen 1 collaboration

Nicoletta Sacchi 1 collaboration

Manuel Romero-Gómez 1 collaboration

Pietro Invernizzi 1 collaboration

Javier Fernández 1 collaboration

Maria Buti 1 collaboration

Agustin Albillos 1 collaboration

Antonio Julià 1 collaboration

Luca Valenti 1 collaboration

Rosanna Asselta 1 collaboration

Jesus M Banales 1 collaboration

Luis Bujanda 1 collaboration

Rafael de Cid 1 collaboration

André Franke 1 collaboration

None None 1 collaboration

Jeong S Hong 1 collaboration

Eric J Sorscher 1 collaboration

Annette Ehrhardt 1 collaboration

Christian M Gallardo 1 collaboration

Yoonhee H Jung 1 collaboration

Ben Clock 1 collaboration

Jesse R Dixon 1 collaboration

David J Pintel 1 collaboration

Victor G Corces 1 collaboration

Grace Neilsen 1 collaboration

William A Cantara 1 collaboration

Nicole Lulkin 1 collaboration

Jasper Lee 1 collaboration