Pierre Raboisson

Affiliations

Janssen Pharmaceutica, N.V. , Turnhoutseweg 30 , 2340 Beerse , Belgium.

Publications (21)

Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region.

Journal of medicinal chemistry

Avec: David C McGowan , Wendy Balemans , Werner Embrechts , Magali Motte , Jeremy R Keown , Christophe Buyck , Jordi Corbera , Mario Funes , Laura Moreno , Ludwig Cooymans , Abdellah Tahri , Julien Eymard , Bart Stoops , Rudy Strijbos , Joke Van den Berg , Ervin Fodor , Jonathan M Grimes , Anil Koul , Tim H M Jonckers , Pierre Raboisson , Jérôme Guillemont

Early-stage Mycosis Fungoides: Epidemiology and Prognosis.

Acta dermato-venereologica

Avec: Andrew Maguire , Jorge Puelles , Patrick Raboisson , Rajeev Chavda , Sylvie Gabriel , Susan Thornton

A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.

Nature

Avec: Suzanne J F Kaptein , Olivia Goethals , Dominik Kiemel , Arnaud Marchand , Bart Kesteleyn , Jean-François Bonfanti , Dorothée Bardiot , Bart Stoops , Tim H M Jonckers , Kai Dallmeier , Peggy Geluykens , Kim Thys , Marjolein Crabbe , Laurent Chatel-Chaix , Max Münster , Gilles Querat , Franck Touret , Xavier de Lamballerie , Pierre Raboisson , Kenny Simmen , Patrick Chaltin , Ralf Bartenschlager , Marnix Van Loock , Johan Neyts

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor

mBio

Avec: Dirk Jochmans , Cheng Liu , Kim Donckers , Antitsa Stoycheva , Sandro Boland , Sarah K Stevens , Chloe De Vita , Bert Vanmechelen , Piet Maes , Bettina Trüeb , Nadine Ebert , Volker Thiel , Steven De Jonghe , Laura Vangeel , Dorothée Bardiot , Andreas Jekle , Lawrence M Blatt , Leonid Beigelman , Julian A Symons , Pierre Raboisson , Patrick Chaltin , Arnaud Marchand , Johan Neyts , Jerome Deval , Koen Vandyck

ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.

Biochemical and biophysical research communications

Avec: Koen Vandyck , Rana Abdelnabi , Kusum Gupta , Dirk Jochmans , Andreas Jekle , Jerome Deval , Dinah Misner , Dorothée Bardiot , Caroline S Foo , Cheng Liu , Suping Ren , Leonid Beigelman , Lawrence M Blatt , Sandro Boland , Laura Vangeel , Steven Dejonghe , Patrick Chaltin , Arnaud Marchand , Vladimir Serebryany , Antitsa Stoycheva , Sushmita Chanda , Julian A Symons , Pierre Raboisson , Johan Neyts

Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1

Journal of medicinal chemistry

Avec: Sandrine Vendeville , Abdellah Tahri , Lili Hu , Samuel Demin , Ludwig Cooymans , Ann Vos , Leen Kwanten , Joke Van den Berg , Michael B Battles , Jason S McLellan , Anil Koul , Pierre Raboisson , Dirk Roymans , Tim H M Jonckers

Discovery of

Journal of medicinal chemistry

Avec: Sandrine Grosse , Ludwig Cooymans , Werner Embrechts , David McGowan , Edgar Jacoby , Bart Stoops , Kusum Gupta , Mark Ackermann , Sarhad Alnajjar , Jerome Guillemont , Zhinan Jin , Bart Kesteleyn , Kiran Matcha , Pun Sriboonyapirat , Anh Truong , Joke Van Den Berg , Xiaodi Yu , Florence Herschke , Dirk Roymans , Pierre Raboisson , Peter Rigaux , Tim H M Jonckers

Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.

Journal of medicinal chemistry

Avec: Koen Vandyck , David C McGowan , Xuan G Luong , Sarah K Stevens , Andreas Jekle , Kusum Gupta , Dinah L Misner , Sushmita Chanda , Vladimir Serebryany , Michael Welch , Haiyang Hu , Zhidan Lv , Caroline Williams , Klaus Maskos , Alfred Lammens , Antitsa D Stoycheva , Tse-I Lin , Lawrence M Blatt , Leonid N Beigelman , Julian A Symons , Pierre Raboisson , Jerome Deval

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH).

PloS one

Avec: Xuan G Luong , Sarah K Stevens , Andreas Jekle , Tse-I Lin , Kusum Gupta , Dinah Misner , Sushmita Chanda , Sucheta Mukherjee , Caroline Williams , Antitsa Stoycheva , Lawrence M Blatt , Leonid N Beigelman , Julian A Symons , Pierre Raboisson , David McGowan , Koen Vandyck , Jerome Deval

Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors.

Journal of medicinal chemistry

Avec: Bart Kesteleyn , Dorothée Bardiot , Jean-François Bonfanti , Benoît De Boeck , Olivia Goethals , Suzanne J F Kaptein , Bart Stoops , Erwin Coesemans , Jérôme Fortin , Philippe Muller , Frédéric Doublet , Gunter Carlens , Mohamed Koukni , Wim Smets , Pierre Raboisson , Patrick Chaltin , Kenny Simmen , Marnix Van Loock , Johan Neyts , Arnaud Marchand , Tim H M Jonckers

Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.

Hepatology (Baltimore, Md.)

Avec: Dieudonné Buh Kum , Hannah Vanrusselt , Abel Acosta Sanchez , Valerio Taverniti , Eloi R Verrier , Thomas F Baumert , Cheng Liu , Jerome Deval , Nikky Corthout , Sebastian Munck , Leonid Beigelman , Lawrence M Blatt , Julian A Symons , Pierre Raboisson , Andreas Jekle , Sandrine Vendeville , Yannick Debing

Novel non-HAP class A HBV capsid assembly modulators have distinct

Journal of virology

Avec: Hannah Vanrusselt , Dieudonné Buh Kum , Valerio Taverniti , Cheng Liu , Abel Acosta Sanchez , Nikky Corthout , Sebastian Munck , Thomas F Baumert , Leonid Beigelman , Lawrence M Blatt , Julian A Symons , Jerome Deval , Pierre Raboisson , Eloi R Verrier , Andreas Jekle , Sandrine Vendeville , Yannick Debing

Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.

Nature

Avec: Olivia Goethals , Suzanne J F Kaptein , Bart Kesteleyn , Jean-François Bonfanti , Liesbeth Van Wesenbeeck , Dorothée Bardiot , Ernst J Verschoor , Babs E Verstrepen , Zahra Fagrouch , J Robert Putnak , Dominik Kiemel , Oliver Ackaert , Roel Straetemans , Sophie Lachau-Durand , Peggy Geluykens , Marjolein Crabbe , Kim Thys , Bart Stoops , Oliver Lenz , Lotke Tambuyzer , Sandra De Meyer , Kai Dallmeier , Michael K McCracken , Gregory D Gromowski , Wiriya Rutvisuttinunt , Richard G Jarman , Nicos Karasavvas , Franck Touret , Gilles Querat , Xavier de Lamballerie , Laurent Chatel-Chaix , Gregg N Milligan , David W C Beasley , Nigel Bourne , Alan D T Barrett , Arnaud Marchand , Tim H M Jonckers , Pierre Raboisson , Kenny Simmen , Patrick Chaltin , Ralf Bartenschlager , Willy M Bogers , Johan Neyts , Marnix Van Loock

A small-molecule fusion inhibitor of influenza virus is orally active in mice.

Science (New York, N.Y.)

Avec: Maria J P van Dongen , Rameshwar U Kadam , Jarek Juraszek , Edward Lawson , Boerries Brandenburg , Frederike Schmitz , Wim B G Schepens , Bart Stoops , Harry A van Diepen , Mandy Jongeneelen , Chan Tang , Jan Vermond , Alida van Eijgen-Obregoso Real , Sven Blokland , Divita Garg , Wenli Yu , Wouter Goutier , Ellen Lanckacker , Jaco M Klap , Daniëlle C G Peeters , Jin Wu , Christophe Buyck , Tim H M Jonckers , Dirk Roymans , Peter Roevens , Ronald Vogels , Wouter Koudstaal , Robert H E Friesen , Pierre Raboisson , Dashyant Dhanak , Jaap Goudsmit , Ian A Wilson

Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry.

Antiviral research

Avec: Zachary A Gurard-Levin , Cheng Liu , Andreas Jekle , Ruchika Jaisinghani , Suping Ren , Koen Vandyck , Dirk Jochmans , Pieter Leyssen , Johan Neyts , Lawrence M Blatt , Leonid Beigelman , Julian A Symons , Pierre Raboisson , Michael D Scholle , Jerome Deval

Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development.

Antiviral research

Avec: Cheng Liu , Sandro Boland , Michael D Scholle , Dorothee Bardiot , Arnaud Marchand , Patrick Chaltin , Lawrence M Blatt , Leonid Beigelman , Julian A Symons , Pierre Raboisson , Zachary A Gurard-Levin , Koen Vandyck , Jerome Deval

The formalin test does not probe inflammatory pain but excitotoxicity in rodent skin.

Physiological reports

Avec: Tal Hoffmann , Florian Klemm , Tatjana I Kichko , Susanne K Sauer , Katrin Kistner , Bernhard Riedl , Patrick Raboisson , Lei Luo , Alexandru Babes , Laurence Kocher , Giancarlo Carli , Michael J M Fischer , Peter W Reeh

Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor.

Journal of medicinal chemistry

Avec: Bart Kesteleyn , Jean-François Bonfanti , Dorothée Bardiot , Benoît De Boeck , Olivia Goethals , Suzanne J F Kaptein , Bart Stoops , Erwin Coesemans , Jérôme Fortin , Philippe Muller , Frédéric Doublet , Gunter Carlens , Mohamed Koukni , Wim Smets , Pierre Raboisson , Patrick Chaltin , Kenny Simmen , Marnix Van Loock , Johan Neyts , Arnaud Marchand , Tim H M Jonckers

Antiviral Properties and Mechanism of Action Studies of the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379.

Antimicrobial agents and chemotherapy

Avec: Jan Martin Berke , Pascale Dehertogh , Karen Vergauwen , Wendy Mostmans , Koen Vandyck , Pierre Raboisson , Frederik Pauwels

An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients.

Antiviral research

Avec: Yannick Debing , Hannah Vanrusselt , Lars Degrauwe , Daniel Apolônio Silva de Oliveira , Christopher Kinyanjui Kariuki , Ebanja Joseph Ebwanga , Shahbaz Bashir , Wouter Merckx , Santhosh Kumar Thatikonda , Vivek Rajwanshi , Vikrant Gohil , Jin Hong , Dieudonné Buh Kum , Abel Acosta Sanchez , Sushmita Chanda , Lawrence M Blatt , Andreas Jekle , Julian A Symons , David B Smith , Pierre Raboisson , Tse-I Lin , Leonid Beigelman , Jan Paeshuyse

From Oxetane to Thietane: Extending the Antiviral Spectrum of 2'-Spirocyclic Uridines by Substituting Oxygen with Sulfur.

ACS medicinal chemistry letters

Avec: Sandrine Grosse , Abdellah Tahri , Pierre Raboisson , Yannis Houpis , Bart Stoops , Edgar Jacoby , Jean-Marc Neefs , Marnix Van Loock , Olivia Goethals , Peggy Geluykens , Jean-François Bonfanti , Tim H M Jonckers

Réseau de co-auteurs

Tim H M Jonckers 9 collaborations

Lawrence M Blatt 9 collaborations

Julian A Symons 9 collaborations

Bart Stoops 8 collaborations

Andreas Jekle 8 collaborations

Jerome Deval 8 collaborations

Arnaud Marchand 7 collaborations

Patrick Chaltin 7 collaborations

Johan Neyts 7 collaborations

Leonid Beigelman 7 collaborations

Koen Vandyck 7 collaborations

Dorothée Bardiot 6 collaborations

Cheng Liu 6 collaborations

Olivia Goethals 5 collaborations

Bart Kesteleyn 5 collaborations

Jean-François Bonfanti 5 collaborations

Marnix Van Loock 5 collaborations

Suzanne J F Kaptein 4 collaborations

Kenny Simmen 4 collaborations

Kusum Gupta 4 collaborations

Sushmita Chanda 4 collaborations

Ludwig Cooymans 3 collaborations

Abdellah Tahri 3 collaborations

Peggy Geluykens 3 collaborations

Dirk Jochmans 3 collaborations

Antitsa Stoycheva 3 collaborations

Sandro Boland 3 collaborations

Sarah K Stevens 3 collaborations

Sandrine Vendeville 3 collaborations

Dirk Roymans 3 collaborations

Tse-I Lin 3 collaborations

Dieudonné Buh Kum 3 collaborations

Hannah Vanrusselt 3 collaborations

Abel Acosta Sanchez 3 collaborations

Yannick Debing 3 collaborations

David C McGowan 2 collaborations

Werner Embrechts 2 collaborations

Christophe Buyck 2 collaborations

Joke Van den Berg 2 collaborations

Anil Koul 2 collaborations

Patrick Raboisson 2 collaborations

Dominik Kiemel 2 collaborations

Kai Dallmeier 2 collaborations

Kim Thys 2 collaborations

Marjolein Crabbe 2 collaborations

Laurent Chatel-Chaix 2 collaborations

Gilles Querat 2 collaborations

Franck Touret 2 collaborations

Xavier de Lamballerie 2 collaborations

Ralf Bartenschlager 2 collaborations

Laura Vangeel 2 collaborations

Dinah Misner 2 collaborations

Suping Ren 2 collaborations

Vladimir Serebryany 2 collaborations

Sandrine Grosse 2 collaborations

David McGowan 2 collaborations

Edgar Jacoby 2 collaborations

Xuan G Luong 2 collaborations

Caroline Williams 2 collaborations

Leonid N Beigelman 2 collaborations

Benoît De Boeck 2 collaborations

Erwin Coesemans 2 collaborations

Jérôme Fortin 2 collaborations

Philippe Muller 2 collaborations

Frédéric Doublet 2 collaborations

Gunter Carlens 2 collaborations

Mohamed Koukni 2 collaborations

Wim Smets 2 collaborations

Valerio Taverniti 2 collaborations

Eloi R Verrier 2 collaborations

Thomas F Baumert 2 collaborations

Nikky Corthout 2 collaborations

Sebastian Munck 2 collaborations

Zachary A Gurard-Levin 2 collaborations

Michael D Scholle 2 collaborations

Wendy Balemans 1 collaboration

Magali Motte 1 collaboration

Jeremy R Keown 1 collaboration

Jordi Corbera 1 collaboration

Mario Funes 1 collaboration

Laura Moreno 1 collaboration

Julien Eymard 1 collaboration

Rudy Strijbos 1 collaboration

Ervin Fodor 1 collaboration

Jonathan M Grimes 1 collaboration

Jérôme Guillemont 1 collaboration

Andrew Maguire 1 collaboration

Jorge Puelles 1 collaboration

Rajeev Chavda 1 collaboration

Sylvie Gabriel 1 collaboration

Susan Thornton 1 collaboration

Max Münster 1 collaboration

Kim Donckers 1 collaboration

Chloe De Vita 1 collaboration

Bert Vanmechelen 1 collaboration

Piet Maes 1 collaboration

Bettina Trüeb 1 collaboration

Nadine Ebert 1 collaboration

Volker Thiel 1 collaboration

Steven De Jonghe 1 collaboration

Rana Abdelnabi 1 collaboration

Caroline S Foo 1 collaboration

Steven Dejonghe 1 collaboration

Lili Hu 1 collaboration

Samuel Demin 1 collaboration

Ann Vos 1 collaboration

Leen Kwanten 1 collaboration

Michael B Battles 1 collaboration

Jason S McLellan 1 collaboration

Mark Ackermann 1 collaboration

Sarhad Alnajjar 1 collaboration

Jerome Guillemont 1 collaboration

Zhinan Jin 1 collaboration

Kiran Matcha 1 collaboration

Pun Sriboonyapirat 1 collaboration

Anh Truong 1 collaboration

Joke Van Den Berg 1 collaboration

Xiaodi Yu 1 collaboration

Florence Herschke 1 collaboration

Peter Rigaux 1 collaboration

Dinah L Misner 1 collaboration

Michael Welch 1 collaboration

Haiyang Hu 1 collaboration

Zhidan Lv 1 collaboration

Klaus Maskos 1 collaboration

Alfred Lammens 1 collaboration

Antitsa D Stoycheva 1 collaboration

Sucheta Mukherjee 1 collaboration

Liesbeth Van Wesenbeeck 1 collaboration

Ernst J Verschoor 1 collaboration

Babs E Verstrepen 1 collaboration

Zahra Fagrouch 1 collaboration

J Robert Putnak 1 collaboration

Oliver Ackaert 1 collaboration

Roel Straetemans 1 collaboration

Sophie Lachau-Durand 1 collaboration

Oliver Lenz 1 collaboration

Lotke Tambuyzer 1 collaboration

Sandra De Meyer 1 collaboration

Michael K McCracken 1 collaboration

Gregory D Gromowski 1 collaboration

Wiriya Rutvisuttinunt 1 collaboration

Richard G Jarman 1 collaboration

Nicos Karasavvas 1 collaboration

Gregg N Milligan 1 collaboration

David W C Beasley 1 collaboration

Nigel Bourne 1 collaboration

Alan D T Barrett 1 collaboration

Willy M Bogers 1 collaboration

Maria J P van Dongen 1 collaboration

Rameshwar U Kadam 1 collaboration

Jarek Juraszek 1 collaboration

Edward Lawson 1 collaboration

Boerries Brandenburg 1 collaboration

Frederike Schmitz 1 collaboration

Wim B G Schepens 1 collaboration

Harry A van Diepen 1 collaboration

Mandy Jongeneelen 1 collaboration

Chan Tang 1 collaboration

Jan Vermond 1 collaboration

Alida van Eijgen-Obregoso Real 1 collaboration

Sven Blokland 1 collaboration

Divita Garg 1 collaboration

Wenli Yu 1 collaboration

Wouter Goutier 1 collaboration

Ellen Lanckacker 1 collaboration

Jaco M Klap 1 collaboration

Daniëlle C G Peeters 1 collaboration

Jin Wu 1 collaboration

Peter Roevens 1 collaboration

Ronald Vogels 1 collaboration

Wouter Koudstaal 1 collaboration

Robert H E Friesen 1 collaboration

Dashyant Dhanak 1 collaboration

Jaap Goudsmit 1 collaboration

Ian A Wilson 1 collaboration

Ruchika Jaisinghani 1 collaboration

Pieter Leyssen 1 collaboration

Dorothee Bardiot 1 collaboration

Tal Hoffmann 1 collaboration

Florian Klemm 1 collaboration

Tatjana I Kichko 1 collaboration

Susanne K Sauer 1 collaboration

Katrin Kistner 1 collaboration

Bernhard Riedl 1 collaboration

Lei Luo 1 collaboration

Alexandru Babes 1 collaboration

Laurence Kocher 1 collaboration

Giancarlo Carli 1 collaboration

Michael J M Fischer 1 collaboration

Peter W Reeh 1 collaboration

Jan Martin Berke 1 collaboration

Pascale Dehertogh 1 collaboration

Karen Vergauwen 1 collaboration

Wendy Mostmans 1 collaboration

Frederik Pauwels 1 collaboration

Lars Degrauwe 1 collaboration

Daniel Apolônio Silva de Oliveira 1 collaboration

Christopher Kinyanjui Kariuki 1 collaboration

Ebanja Joseph Ebwanga 1 collaboration

Shahbaz Bashir 1 collaboration

Wouter Merckx 1 collaboration

Santhosh Kumar Thatikonda 1 collaboration

Vivek Rajwanshi 1 collaboration

Vikrant Gohil 1 collaboration

Jin Hong 1 collaboration

David B Smith 1 collaboration

Jan Paeshuyse 1 collaboration

Yannis Houpis 1 collaboration

Jean-Marc Neefs 1 collaboration