Pius Loetscher

Affiliations

Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

Publications (7)

Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an

ACS medicinal chemistry letters

Avec: Claudia Betschart , Michael Faller , Florence Zink , René Hemmig , Jutta Blank , Eric Vangrevelinghe , Marjorie Bourrel , Ralf Glatthar , Dirk Behnke , Kerstin Barker , Andreas Heizmann , Daniela Angst , Pierre Nimsgern , Sébastien Jacquier , Tobias Junt , Géraldine Zipfel , Giulia Ruzzante , Pius Loetscher , Sarah Limonta , Stuart Hawtin , Cedric Bernard Andre , Thomas Boulay , Roland Feifel , Thomas Knoepfel

Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A

Journal of medicinal chemistry

Avec: Christian Markert , Gebhard Thoma , Honnappa Srinivas , Birgit Bollbuck , Rainer M Lüönd , Wolfgang Miltz , Rudolf Wälchli , Romain Wolf , Jürgen Hinrichs , Christian Bergsdorf , Kamal Azzaoui , Carlos A Penno , Kai Klein , Nathalie Wack , Petra Jäger , Franziska Hasler , Christian Beerli , Pius Loetscher , Janet Dawson , Grazyna Wieczorek , Shin Numao , Amanda Littlewood-Evans , Till A Röhn

Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants.

JCI insight

Avec: Thomas Hoyler , Bettina Bannert , Cédric André , Damian Beck , Thomas Boulay , David Buffet , Nadja Caesar , Thomas Calzascia , Janet Dawson , Diego Kyburz , Robert Hennze , Christine Huppertz , Amanda Littlewood-Evans , Pius Loetscher , Kirsten D Mertz , Satoru Niwa , Gautier Robert , James S Rush , Giulia Ruzzante , Sophie Sarret , Thomas Stein , Ismahane Touil , Grazyna Wieczorek , Geraldine Zipfel , Stuart Hawtin , Tobias Junt

Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy.

Cell reports. Medicine

Avec: Stuart Hawtin , Cédric André , Géraldine Collignon-Zipfel , Simone Appenzeller , Bettina Bannert , Lea Baumgartner , Damian Beck , Claudia Betschart , Thomas Boulay , Hermine I Brunner , Melanie Ceci , Jonathan Deane , Roland Feifel , Enrico Ferrero , Diego Kyburz , Frederique Lafossas , Pius Loetscher , Christina Merz-Stoeckle , Pierre Michellys , Barbara Nuesslein-Hildesheim , Friedrich Raulf , James S Rush , Giulia Ruzzante , Thomas Stein , Samantha Zaharevitz , Grazyna Wieczorek , Richard Siegel , Peter Gergely , Tamas Shisha , Tobias Junt

The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells.

iScience

Avec: Elizabeth A Krewson , Edward J Sanderlin , Mona A Marie , Shayan Nik Akhtar , Juraj Velcicky , Pius Loetscher , Li V Yang

Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.

Journal of medicinal chemistry

Avec: Thomas Knoepfel , Pierre Nimsgern , Sébastien Jacquier , Marjorie Bourrel , Eric Vangrevelinghe , Ralf Glatthar , Dirk Behnke , Phil B Alper , Pierre-Yves Michellys , Jonathan Deane , Tobias Junt , Géraldine Zipfel , Sarah Limonta , Stuart Hawtin , Cedric Andre , Thomas Boulay , Pius Loetscher , Michael Faller , Jutta Blank , Roland Feifel , Claudia Betschart

Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model.

European journal of pharmacology

Avec: Edward J Sanderlin , Mona Marie , Juraj Velcicky , Pius Loetscher , Li V Yang

Réseau de co-auteurs

Tobias Junt 4 collaborations

Stuart Hawtin 4 collaborations

Thomas Boulay 4 collaborations

Claudia Betschart 3 collaborations

Giulia Ruzzante 3 collaborations

Roland Feifel 3 collaborations

Grazyna Wieczorek 3 collaborations

Michael Faller 2 collaborations

Jutta Blank 2 collaborations

Eric Vangrevelinghe 2 collaborations

Marjorie Bourrel 2 collaborations

Ralf Glatthar 2 collaborations

Dirk Behnke 2 collaborations

Pierre Nimsgern 2 collaborations

Sébastien Jacquier 2 collaborations

Géraldine Zipfel 2 collaborations

Sarah Limonta 2 collaborations

Thomas Knoepfel 2 collaborations

Janet Dawson 2 collaborations

Amanda Littlewood-Evans 2 collaborations

Bettina Bannert 2 collaborations

Cédric André 2 collaborations

Damian Beck 2 collaborations

Diego Kyburz 2 collaborations

James S Rush 2 collaborations

Thomas Stein 2 collaborations

Jonathan Deane 2 collaborations

Edward J Sanderlin 2 collaborations

Juraj Velcicky 2 collaborations

Li V Yang 2 collaborations

Florence Zink 1 collaboration

René Hemmig 1 collaboration

Kerstin Barker 1 collaboration

Andreas Heizmann 1 collaboration

Daniela Angst 1 collaboration

Cedric Bernard Andre 1 collaboration

Christian Markert 1 collaboration

Gebhard Thoma 1 collaboration

Honnappa Srinivas 1 collaboration

Birgit Bollbuck 1 collaboration

Rainer M Lüönd 1 collaboration

Wolfgang Miltz 1 collaboration

Rudolf Wälchli 1 collaboration

Romain Wolf 1 collaboration

Jürgen Hinrichs 1 collaboration

Christian Bergsdorf 1 collaboration

Kamal Azzaoui 1 collaboration

Carlos A Penno 1 collaboration

Kai Klein 1 collaboration

Nathalie Wack 1 collaboration

Petra Jäger 1 collaboration

Franziska Hasler 1 collaboration

Christian Beerli 1 collaboration

Shin Numao 1 collaboration

Till A Röhn 1 collaboration

Thomas Hoyler 1 collaboration

David Buffet 1 collaboration

Nadja Caesar 1 collaboration

Thomas Calzascia 1 collaboration

Robert Hennze 1 collaboration

Christine Huppertz 1 collaboration

Kirsten D Mertz 1 collaboration

Satoru Niwa 1 collaboration

Gautier Robert 1 collaboration

Sophie Sarret 1 collaboration

Ismahane Touil 1 collaboration

Geraldine Zipfel 1 collaboration

Géraldine Collignon-Zipfel 1 collaboration

Simone Appenzeller 1 collaboration

Lea Baumgartner 1 collaboration

Hermine I Brunner 1 collaboration

Melanie Ceci 1 collaboration

Enrico Ferrero 1 collaboration

Frederique Lafossas 1 collaboration

Christina Merz-Stoeckle 1 collaboration

Pierre Michellys 1 collaboration

Barbara Nuesslein-Hildesheim 1 collaboration

Friedrich Raulf 1 collaboration

Samantha Zaharevitz 1 collaboration

Richard Siegel 1 collaboration

Peter Gergely 1 collaboration

Tamas Shisha 1 collaboration

Elizabeth A Krewson 1 collaboration

Mona A Marie 1 collaboration

Shayan Nik Akhtar 1 collaboration

Phil B Alper 1 collaboration

Pierre-Yves Michellys 1 collaboration

Cedric Andre 1 collaboration

Mona Marie 1 collaboration