Rich Labotka

Affiliations

Takeda LLC, Cambridge, MA, USA.

Publications (24)

Ixazomib maintenance therapy in newly diagnosed multiple myeloma: An integrated analysis of four phase I/II studies.

European journal of haematology

Avec: Meletios A Dimopoulos , Jacob P Laubach , Maria Asunción Echeveste Gutierrez , Norbert Grzasko , Craig C Hofmeister , Jesus F San-Miguel , Shaji Kumar , Richard Labotka , Vickie Lu , Deborah Berg , Catriona Byrne , Zhaoyang Teng , Guohui Liu , Helgi van de Velde , Paul G Richardson

Adoption of triplet therapy and clinical outcomes in routine practice among newly diagnosed multiple myeloma patients not receiving frontline stem cell transplant in the USA.

Expert review of hematology

Avec: Parameswaran Hari , Marlo Blazer , Aditya Raju , Eileen Farrelly , Richard Labotka , Tomas Skacel , Dorothy Romanus

Joint AI-driven event prediction and longitudinal modeling in newly diagnosed and relapsed multiple myeloma.

NPJ digital medicine

Avec: Zeshan Hussain , Edward De Brouwer , Rebecca Boiarsky , Sama Setty , Neeraj Gupta , Guohui Liu , Cong Li , Jaydeep Srimani , Jacob Zhang , Rich Labotka , David Sontag

MRD dynamics during maintenance for improved prognostication of 1280 patients with myeloma in the TOURMALINE-MM3 and -MM4 trials.

Blood

Avec: Bruno Paiva , Irene Manrique , Meletios A Dimopoulos , Francesca Gay , Chang-Ki Min , Sonja Zweegman , Ivan Špička , Raphael Teipel , María-Victoria Mateos , Nicola Giuliani , Michele Cavo , Christine Rojas Hopkins , Weijun Fu , Kaveri Suryanarayan , Alexander Vorog , Cong Li , Bingxia Wang , Jose Estevam , Richard Labotka , Ajeeta B Dash

Deepening responses associated with improved progression-free survival with ixazomib versus placebo as posttransplant maintenance in multiple myeloma.

Leukemia

Avec: Hartmut Goldschmidt , Meletios A Dimopoulos , S Vincent Rajkumar , Katja C Weisel , Philippe Moreau , Wee-Joo Chng , Gábor Mikala , Michele Cavo , Karthik Ramasamy , Kaveri Suryanarayan , Zhaoyang Teng , Richard Labotka , Maria Victoria Mateos

Ixazomib as Postinduction Maintenance for Patients With Newly Diagnosed Multiple Myeloma Not Undergoing Autologous Stem Cell Transplantation: The Phase III TOURMALINE-MM4 Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Avec: Meletios A Dimopoulos , Ivan Špička , Hang Quach , Albert Oriol , Roman Hájek , Mamta Garg , Meral Beksac , Sara Bringhen , Eirini Katodritou , Wee-Joo Chng , Xavier Leleu , Shinsuke Iida , María-Victoria Mateos , Gareth Morgan , Alexander Vorog , Richard Labotka , Bingxia Wang , Antonio Palumbo , Sagar Lonial , Auteur inconnu

Late versus early response and depth of response are associated with improved outcomes in patients with newly diagnosed multiple myeloma enrolled in the TOURMALINE-MM2 trial.

EJHaem

Avec: Paul G Richardson , Thierry Facon , Christopher P Venner , Nizar J Bahlis , Fritz Offner , Darrell White , Lionel Karlin , Lotfi Benboubker , Eric Voog , Sung-Soo Yoon , Kenshi Suzuki , Hirohiko Shibayama , Xiaoquan Zhang , Miguel Villarreal , Philip Twumasi-Ankrah , Richard Labotka , Robert M Rifkin , Sagar Lonial , Shaji K Kumar , S Vincent Rajkumar , Philippe Moreau

Oral ixazomib maintenance following autologous stem cell transplantation (TOURMALINE-MM3): a double-blind, randomised, placebo-controlled phase 3 trial.

Lancet (London, England)

Avec: Meletios A Dimopoulos , Francesca Gay , Fredrik Schjesvold , Meral Beksac , Roman Hajek , Katja Christina Weisel , Hartmut Goldschmidt , Vladimir Maisnar , Philippe Moreau , Chang Ki Min , Agnieszka Pluta , Wee-Joo Chng , Martin Kaiser , Sonja Zweegman , Maria-Victoria Mateos , Andrew Spencer , Shinsuke Iida , Gareth Morgan , Kaveri Suryanarayan , Zhaoyang Teng , Tomas Skacel , Antonio Palumbo , Ajeeta B Dash , Neeraj Gupta , Richard Labotka , S Vincent Rajkumar , Auteur inconnu

Population pharmacokinetic/pharmacodynamic joint modeling of ixazomib efficacy and safety using data from the pivotal phase III TOURMALINE-MM1 study in multiple myeloma patients.

CPT: pharmacometrics & systems pharmacology

Avec: Jaydeep K Srimani , Paul M Diderichsen , Michael J Hanley , Karthik Venkatakrishnan , Richard Labotka , Neeraj Gupta

Oral ixazomib-dexamethasone vs oral pomalidomide-dexamethasone for lenalidomide-refractory, proteasome inhibitor-exposed multiple myeloma: a randomized Phase 2 trial.

Blood cancer journal

Avec: Meletios A Dimopoulos , Fredrik Schjesvold , Vadim Doronin , Olga Vinogradova , Hang Quach , Xavier Leleu , Yolanda Gonzalez Montes , Karthik Ramasamy , Alessandra Pompa , Mark-David Levin , Cindy Lee , Ulf Henrik Mellqvist , Roland Fenk , Hélène Demarquette , Hamdi Sati , Alexander Vorog , Richard Labotka , Jichang Du , Mohamed Darif , Shaji Kumar

A pooled analysis of outcomes according to cytogenetic abnormalities in patients receiving ixazomib- vs placebo-based therapy for multiple myeloma.

Blood cancer journal

Avec: Wee-Joo Chng , Sagar Lonial , Gareth J Morgan , Shinsuke Iida , Philippe Moreau , Shaji K Kumar , Philip Twumasi-Ankrah , Miguel Villarreal , Ajeeta B Dash , Alexander Vorog , Xiaoquan Zhang , Kaveri Suryanarayan , Richard Labotka , Meletios A Dimopoulos , S Vincent Rajkumar

Dose Titration of Ixazomib Maintenance Therapy in Transplant-Ineligible Multiple Myeloma: Exposure-Response Analysis of the TOURMALINE-MM4 Study.

Clinical pharmacology and therapeutics

Avec: Jaydeep K Srimani , Paul M Diderichsen , Michael J Hanley , Richard Labotka , Neeraj Gupta

Model-Informed Drug Development for Ixazomib, an Oral Proteasome Inhibitor.

Clinical pharmacology and therapeutics

Avec: Neeraj Gupta , Michael J Hanley , Paul M Diderichsen , Huyuan Yang , Alice Ke , Zhaoyang Teng , Richard Labotka , Deborah Berg , Chirag Patel , Guohui Liu , Helgi van de Velde , Karthik Venkatakrishnan

Developments in continuous therapy and maintenance treatment approaches for patients with newly diagnosed multiple myeloma.

Blood cancer journal

Avec: Meletios A Dimopoulos , Andrzej J Jakubowiak , Philip L McCarthy , Robert Z Orlowski , Michel Attal , Joan Bladé , Hartmut Goldschmidt , Katja C Weisel , Karthik Ramasamy , Sonja Zweegman , Andrew Spencer , Jeffrey S Y Huang , Jin Lu , Kazutaka Sunami , Shinsuke Iida , Wee-Joo Chng , Sarah A Holstein , Alberto Rocci , Tomas Skacel , Richard Labotka , Antonio Palumbo , Kenneth C Anderson

Adjusting for subsequent therapies in the TOURMALINE-MM1 study shows clinically meaningful improvement in overall survival with addition of ixazomib to lenalidomide and dexamethasone.

Haematologica

Avec: Karthik Ramasamy , Nizar J Bahlis , Shaji K Kumar , Arun Kumar , Holly Cranmer , Bingxia Wang , Jonathan Dabora , Richard Labotka , Paul G Richardson , Philippe Moreau

Ixazomib plus daratumumab and dexamethasone: Final analysis of a phase 2 study among patients with relapsed/refractory multiple myeloma.

American journal of hematology

Avec: Sosana Delimpasi , Meletios A Dimopoulos , Jan Straub , Argiris Symeonidis , Luděk Pour , Roman Hájek , Cyrille Touzeau , Viralkumar K Bhanderi , Jesus G Berdeja , Petr Pavlíček , Jeffrey V Matous , Pawel J Robak , Kaveri Suryanarayan , Alison Miller , Miguel Villarreal , Dasha Cherepanov , Jaydeep K Srimani , Huilan Yao , Richard Labotka , Robert Z Orlowski

Modeling serum M-protein response for early detection of biochemical relapse in myeloma patients treated with bortezomib, lenalidomide and dexamethasone.

CPT: pharmacometrics & systems pharmacology

Avec: Yuki Otani , Yunqi Zhao , Guanyu Wang , Richard Labotka , Mark Rogge , Neeraj Gupta , Majid Vakilynejad , Dean Bottino , Yusuke Tanigawara

Adverse event management in the TOURMALINE-MM3 study of post-transplant ixazomib maintenance in multiple myeloma.

Annals of hematology

Avec: Martin Kaiser , Meral Beksaç , Nina Gulbrandsen , Fredrik Schjesvold , Roman Hájek , Philippe Moreau , Felipe de Arriba de la Fuente , María-Victoria Mateos , Sharon West , Andrew Spencer , S Vincent Rajkumar , Kaveri Suryanarayan , Michael Czorniak , Cong Li , Zhaoyang Teng , Richard Labotka , Meletios A Dimopoulos

Clinical Pharmacology of Ixazomib: The First Oral Proteasome Inhibitor.

Clinical pharmacokinetics

Avec: Neeraj Gupta , Michael J Hanley , Cindy Xia , Richard Labotka , R Donald Harvey , Karthik Venkatakrishnan

Phase 2 study of all-oral ixazomib, cyclophosphamide and low-dose dexamethasone for relapsed/refractory multiple myeloma.

British journal of haematology

Avec: Shaji K Kumar , Norbert Grzasko , Sosana Delimpasi , Wieslaw W Jedrzejczak , Sebastian Grosicki , Marie-Christine Kyrtsonis , Andrew Spencer , Neeraj Gupta , Zhaoyang Teng , Catriona Byrne , Richard Labotka , Meletios A Dimopoulos

All-oral ixazomib, cyclophosphamide, and dexamethasone for transplant-ineligible patients with newly diagnosed multiple myeloma.

European journal of cancer (Oxford, England : 1990)

Avec: Meletios A Dimopoulos , Sebastian Grosicki , Wiesław W Jędrzejczak , Hareth Nahi , Astrid Gruber , Markus Hansson , Neeraj Gupta , Catriona Byrne , Richard Labotka , Zhaoyang Teng , Huyuan Yang , Norbert Grzasko , Shaji Kumar

Final Overall Survival Analysis of the TOURMALINE-MM1 Phase III Trial of Ixazomib, Lenalidomide, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Avec: Paul G Richardson , Shaji K Kumar , Tamás Masszi , Norbert Grzasko , Nizar J Bahlis , Markus Hansson , Luděk Pour , Irwindeep Sandhu , Peter Ganly , Bartrum W Baker , Sharon R Jackson , Anne-Marie Stoppa , Peter Gimsing , Laurent Garderet , Cyrille Touzeau , Francis K Buadi , Jacob P Laubach , Michele Cavo , Mohamed Darif , Richard Labotka , Deborah Berg , Philippe Moreau

Quality of life and symptoms among patients with relapsed/refractory AL amyloidosis treated with ixazomib-dexamethasone versus physician's choice.

American journal of hematology

Avec: Vaishali Sanchorawala , Ashutosh D Wechalekar , Kihyun Kim , Stefan O Schönland , Heather J Landau , Fiona Kwok , Kenshi Suzuki , Angela Dispenzieri , Giampaolo Merlini , Raymond L Comenzo , Dasha Cherepanov , Vanessa C Hayden , Arun Kumar , Richard Labotka , Douglas V Faller , Efstathios Kastritis

Impact of ixazomib-lenalidomide-dexamethasone therapy on overall survival in multiple myeloma patients: Analysis of the emerging-markets subgroup of the TOURMALINE-MM1 trial.

EJHaem

Avec: Andrew Spencer , Olga Samoilova , Wee-Joo Chng , Richard Labotka , Cong Li , Kwang-Wei Wu , Nakul Saxena , Xu Yan , Jae Hoon Lee , Meral Beksac

Réseau de co-auteurs

Richard Labotka 23 collaborations

Meletios A Dimopoulos 12 collaborations

Neeraj Gupta 9 collaborations

Zhaoyang Teng 7 collaborations

Philippe Moreau 7 collaborations

Kaveri Suryanarayan 6 collaborations

Wee-Joo Chng 6 collaborations

S Vincent Rajkumar 5 collaborations

Shaji K Kumar 5 collaborations

Andrew Spencer 5 collaborations

Norbert Grzasko 4 collaborations

Paul G Richardson 4 collaborations

Cong Li 4 collaborations

Alexander Vorog 4 collaborations

Karthik Ramasamy 4 collaborations

Shinsuke Iida 4 collaborations

Michael J Hanley 4 collaborations

Shaji Kumar 3 collaborations

Deborah Berg 3 collaborations

Catriona Byrne 3 collaborations

Guohui Liu 3 collaborations

Tomas Skacel 3 collaborations

Sonja Zweegman 3 collaborations

María-Victoria Mateos 3 collaborations

Michele Cavo 3 collaborations

Bingxia Wang 3 collaborations

Ajeeta B Dash 3 collaborations

Hartmut Goldschmidt 3 collaborations

Roman Hájek 3 collaborations

Meral Beksac 3 collaborations

Antonio Palumbo 3 collaborations

Sagar Lonial 3 collaborations

Nizar J Bahlis 3 collaborations

Miguel Villarreal 3 collaborations

Fredrik Schjesvold 3 collaborations

Jaydeep K Srimani 3 collaborations

Paul M Diderichsen 3 collaborations

Karthik Venkatakrishnan 3 collaborations

Jacob P Laubach 2 collaborations

Helgi van de Velde 2 collaborations

Francesca Gay 2 collaborations

Ivan Špička 2 collaborations

Katja C Weisel 2 collaborations

Hang Quach 2 collaborations

Xavier Leleu 2 collaborations

Gareth Morgan 2 collaborations

None None 2 collaborations

Kenshi Suzuki 2 collaborations

Xiaoquan Zhang 2 collaborations

Philip Twumasi-Ankrah 2 collaborations

Martin Kaiser 2 collaborations

Mohamed Darif 2 collaborations

Huyuan Yang 2 collaborations

Robert Z Orlowski 2 collaborations

Arun Kumar 2 collaborations

Sosana Delimpasi 2 collaborations

Luděk Pour 2 collaborations

Cyrille Touzeau 2 collaborations

Dasha Cherepanov 2 collaborations

Sebastian Grosicki 2 collaborations

Markus Hansson 2 collaborations

Maria Asunción Echeveste Gutierrez 1 collaboration

Craig C Hofmeister 1 collaboration

Jesus F San-Miguel 1 collaboration

Vickie Lu 1 collaboration

Parameswaran Hari 1 collaboration

Marlo Blazer 1 collaboration

Aditya Raju 1 collaboration

Eileen Farrelly 1 collaboration

Dorothy Romanus 1 collaboration

Zeshan Hussain 1 collaboration

Edward De Brouwer 1 collaboration

Rebecca Boiarsky 1 collaboration

Sama Setty 1 collaboration

Jaydeep Srimani 1 collaboration

Jacob Zhang 1 collaboration

David Sontag 1 collaboration

Bruno Paiva 1 collaboration

Irene Manrique 1 collaboration

Chang-Ki Min 1 collaboration

Raphael Teipel 1 collaboration

Nicola Giuliani 1 collaboration

Christine Rojas Hopkins 1 collaboration

Weijun Fu 1 collaboration

Jose Estevam 1 collaboration

Gábor Mikala 1 collaboration

Maria Victoria Mateos 1 collaboration

Albert Oriol 1 collaboration

Mamta Garg 1 collaboration

Sara Bringhen 1 collaboration

Eirini Katodritou 1 collaboration

Thierry Facon 1 collaboration

Christopher P Venner 1 collaboration

Fritz Offner 1 collaboration

Darrell White 1 collaboration

Lionel Karlin 1 collaboration

Lotfi Benboubker 1 collaboration

Eric Voog 1 collaboration

Sung-Soo Yoon 1 collaboration

Hirohiko Shibayama 1 collaboration

Robert M Rifkin 1 collaboration

Roman Hajek 1 collaboration

Katja Christina Weisel 1 collaboration

Vladimir Maisnar 1 collaboration

Chang Ki Min 1 collaboration

Agnieszka Pluta 1 collaboration

Maria-Victoria Mateos 1 collaboration

Vadim Doronin 1 collaboration

Olga Vinogradova 1 collaboration

Yolanda Gonzalez Montes 1 collaboration

Alessandra Pompa 1 collaboration

Mark-David Levin 1 collaboration

Cindy Lee 1 collaboration

Ulf Henrik Mellqvist 1 collaboration

Roland Fenk 1 collaboration

Hélène Demarquette 1 collaboration

Hamdi Sati 1 collaboration

Jichang Du 1 collaboration

Gareth J Morgan 1 collaboration

Alice Ke 1 collaboration

Chirag Patel 1 collaboration

Andrzej J Jakubowiak 1 collaboration

Philip L McCarthy 1 collaboration

Michel Attal 1 collaboration

Joan Bladé 1 collaboration

Jeffrey S Y Huang 1 collaboration

Jin Lu 1 collaboration

Kazutaka Sunami 1 collaboration

Sarah A Holstein 1 collaboration

Alberto Rocci 1 collaboration

Kenneth C Anderson 1 collaboration

Holly Cranmer 1 collaboration

Jonathan Dabora 1 collaboration

Jan Straub 1 collaboration

Argiris Symeonidis 1 collaboration

Viralkumar K Bhanderi 1 collaboration

Jesus G Berdeja 1 collaboration

Petr Pavlíček 1 collaboration

Jeffrey V Matous 1 collaboration

Pawel J Robak 1 collaboration

Alison Miller 1 collaboration

Huilan Yao 1 collaboration

Yuki Otani 1 collaboration

Yunqi Zhao 1 collaboration

Guanyu Wang 1 collaboration

Mark Rogge 1 collaboration

Majid Vakilynejad 1 collaboration

Dean Bottino 1 collaboration

Yusuke Tanigawara 1 collaboration

Meral Beksaç 1 collaboration

Nina Gulbrandsen 1 collaboration

Felipe de Arriba de la Fuente 1 collaboration

Sharon West 1 collaboration

Michael Czorniak 1 collaboration

Cindy Xia 1 collaboration

R Donald Harvey 1 collaboration

Wieslaw W Jedrzejczak 1 collaboration

Marie-Christine Kyrtsonis 1 collaboration

Wiesław W Jędrzejczak 1 collaboration

Hareth Nahi 1 collaboration

Astrid Gruber 1 collaboration

Tamás Masszi 1 collaboration

Irwindeep Sandhu 1 collaboration

Peter Ganly 1 collaboration

Bartrum W Baker 1 collaboration

Sharon R Jackson 1 collaboration

Anne-Marie Stoppa 1 collaboration

Peter Gimsing 1 collaboration

Laurent Garderet 1 collaboration

Francis K Buadi 1 collaboration

Vaishali Sanchorawala 1 collaboration

Ashutosh D Wechalekar 1 collaboration

Kihyun Kim 1 collaboration

Stefan O Schönland 1 collaboration

Heather J Landau 1 collaboration

Fiona Kwok 1 collaboration

Angela Dispenzieri 1 collaboration

Giampaolo Merlini 1 collaboration

Raymond L Comenzo 1 collaboration

Vanessa C Hayden 1 collaboration

Douglas V Faller 1 collaboration

Efstathios Kastritis 1 collaboration

Olga Samoilova 1 collaboration

Kwang-Wei Wu 1 collaboration

Nakul Saxena 1 collaboration

Xu Yan 1 collaboration

Jae Hoon Lee 1 collaboration