Rob M F Wolthuis

Affiliations

Amsterdam UMC, Vrije Universiteit Amsterdam, Clinical Genetics, section Oncogenetics, Cancer Center Amsterdam, Amsterdam, The Netherlands.

ORCID: http://orcid.org/0000-0002-3109-1588

Publications (16)

Chemopreventive targeted treatment of head and neck precancer by Wee1 inhibition.

Scientific reports

Avec: Anne M van Harten , D Vicky de Boer , Sanne R Martens-de Kemp , Marijke Buijze , Sonja H Ganzevles , Keith D Hunter , C René Leemans , Victor W van Beusechem , Rob M F Wolthuis , Renée X de Menezes , Ruud H Brakenhoff

Effective CRISPR/Cas9-mediated correction of a Fanconi anemia defect by error-prone end joining or templated repair.

Scientific reports

Avec: Henri J van de Vrugt , Tim Harmsen , Joey Riepsaame , Georgina Alexantya , Saskia E van Mil , Yne de Vries , Rahmen Bin Ali , Ivo J Huijbers , Josephine C Dorsman , Rob M F Wolthuis , Hein Te Riele

ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients.

The Journal of experimental medicine

Avec: Katja Apelt , Susan M White , Hyun Suk Kim , Jung-Eun Yeo , Angela Kragten , Annelotte P Wondergem , Martin A Rooimans , Román González-Prieto , Wouter W Wiegant , Sebastian Lunke , Daniel Flanagan , Sarah Pantaleo , Catherine Quinlan , Winita Hardikar , Haico van Attikum , Alfred C O Vertegaal , Brian T Wilson , Rob M F Wolthuis , Orlando D Schärer , Martijn S Luijsterburg

Keeping ribosomal DNA intact: a repeating challenge.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology

Avec: Daniël O Warmerdam , Rob M F Wolthuis

WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion.

Developmental cell

Avec: Bente Benedict , Janne J M van Schie , Anneke B Oostra , Jesper A Balk , Rob M F Wolthuis , Hein Te Riele , Job de Lange

The CRISPR journal

Avec: Kavish A V Kohabir , Lars O Nooi , Arjen Brink , Ruud H Brakenhoff , Erik A Sistermans , Rob M F Wolthuis

[Pneumothorax as an early indication for a genetic disorder].

Nederlands tijdschrift voor geneeskunde

Avec: Lore van Riel , Irma van de Beek , Rob M F Wolthuis , Bart G Boerrigter , R J A van Moorselaar , Arjan C Houweling

Non-redundant roles in sister chromatid cohesion of the DNA helicase DDX11 and the SMC3 acetyl transferases ESCO1 and ESCO2.

PloS one

Avec: Atiq Faramarz , Jesper A Balk , Janne J M van Schie , Anneke B Oostra , Cherien A Ghandour , Martin A Rooimans , Rob M F Wolthuis , Job de Lange

Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion.

Nature communications

Avec: Janne J M van Schie , Atiq Faramarz , Jesper A Balk , Grant S Stewart , Erika Cantelli , Anneke B Oostra , Martin A Rooimans , Joanna L Parish , Cynthia de Almeida Estéves , Katja Dumic , Ingeborg Barisic , Karin E M Diderich , Marjon A van Slegtenhorst , Mohammad Mahtab , Francesca M Pisani , Hein Te Riele , Najim Ameziane , Rob M F Wolthuis , Job de Lange

Biallelic

Science advances

Avec: Sara Carvalhal , Ingrid Bader , Martin A Rooimans , Anneke B Oostra , Jesper A Balk , René G Feichtinger , Christine Beichler , Michael R Speicher , Johanna M van Hagen , Quinten Waisfisz , Mieke van Haelst , Martijn Bruijn , Alexandra Tavares , Johannes A Mayr , Rob M F Wolthuis , Raquel A Oliveira , Job de Lange

Combined germline pathogenic variants in FLCN and TP53 are associated with early onset renal cell carcinoma and brain tumors.

Molecular genetics & genomic medicine

Avec: Irma van de Beek , Iris E Glykofridis , Anja Wagner , Dorine T den Toom , Ernie M H F Bongers , Geert J L H van Leenders , Paul C Johannesma , Hanne E J Meijers-Heijboer , Rob M F Wolthuis , Maurice A M van Steensel , Hendrikus J Dubbink , Arjan C Houweling

CRISPR screens in sister chromatid cohesion defective cells reveal PAXIP1-PAGR1 as regulator of chromatin association of cohesin.

Nucleic acids research

Avec: Janne J M van Schie , Klaas de Lint , Thom M Molenaar , Macarena Moronta Gines , Jesper A Balk , Martin A Rooimans , Khashayar Roohollahi , Govind M Pai , Lauri Borghuis , Anisha R Ramadhin , Francesco Corazza , Josephine C Dorsman , Kerstin S Wendt , Rob M F Wolthuis , Job de Lange

PRDM10 directs FLCN expression in a novel disorder overlapping with Birt-Hogg-Dubé syndrome and familial lipomatosis.

Human molecular genetics

Avec: Irma van de Beek , Iris E Glykofridis , Jan C Oosterwijk , Peter C van den Akker , Gilles F H Diercks , Maria C Bolling , Quinten Waisfisz , Arjen R Mensenkamp , Jesper A Balk , Rob Zwart , Alex V Postma , Hanne E J Meijers-Heijboer , R Jeroen A van Moorselaar , Rob M F Wolthuis , Arjan C Houweling

STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair.

bioRxiv : the preprint server for biology

Avec: Diana van den Heuvel , Marta Rodríguez-Martínez , Paula J van der Meer , Nicolas Nieto Moreno , Jiyoung Park , Hyun-Suk Kim , Janne J M van Schie , Annelotte P Wondergem , Areetha D'Souza , George Yakoub , Anna E Herlihy , Krushanka Kashyap , Thierry Boissière , Jane Walker , Richard Mitter , Katja Apelt , Klaas de Lint , Idil Kirdök , Mats Ljungman , Rob M F Wolthuis , Patrick Cramer , Orlando D Schärer , Goran Kokic , Jesper Q Svejstrup , Martijn S Luijsterburg

[Genetic therapy by CRISPR-Cas: paving the way to clinical practice].

Nederlands tijdschrift voor geneeskunde

Avec: Philip R Jansen , Mieke van Haelst , Rob M F Wolthuis

Point-of-care CRISPR/Cas nucleic acid detection: Recent advances, challenges and opportunities.

Biosensors & bioelectronics

Avec: Jeanne E van Dongen , Johanna T W Berendsen , Renske D M Steenbergen , Rob M F Wolthuis , Jan C T Eijkel , Loes I Segerink

Réseau de co-auteurs

Jesper A Balk 6 collaborations

Martin A Rooimans 5 collaborations

Janne J M van Schie 5 collaborations

Job de Lange 5 collaborations

Anneke B Oostra 4 collaborations

Hein Te Riele 3 collaborations

Irma van de Beek 3 collaborations

Arjan C Houweling 3 collaborations

Ruud H Brakenhoff 2 collaborations

Josephine C Dorsman 2 collaborations

Katja Apelt 2 collaborations

Annelotte P Wondergem 2 collaborations

Orlando D Schärer 2 collaborations

Martijn S Luijsterburg 2 collaborations

Atiq Faramarz 2 collaborations

Quinten Waisfisz 2 collaborations

Mieke van Haelst 2 collaborations

Iris E Glykofridis 2 collaborations

Hanne E J Meijers-Heijboer 2 collaborations

Klaas de Lint 2 collaborations

Anne M van Harten 1 collaboration

D Vicky de Boer 1 collaboration

Sanne R Martens-de Kemp 1 collaboration

Marijke Buijze 1 collaboration

Sonja H Ganzevles 1 collaboration

Keith D Hunter 1 collaboration

C René Leemans 1 collaboration

Victor W van Beusechem 1 collaboration

Renée X de Menezes 1 collaboration

Henri J van de Vrugt 1 collaboration

Tim Harmsen 1 collaboration

Joey Riepsaame 1 collaboration

Georgina Alexantya 1 collaboration

Saskia E van Mil 1 collaboration

Yne de Vries 1 collaboration

Rahmen Bin Ali 1 collaboration

Ivo J Huijbers 1 collaboration

Susan M White 1 collaboration

Hyun Suk Kim 1 collaboration

Jung-Eun Yeo 1 collaboration

Angela Kragten 1 collaboration

Román González-Prieto 1 collaboration

Wouter W Wiegant 1 collaboration

Sebastian Lunke 1 collaboration

Daniel Flanagan 1 collaboration

Sarah Pantaleo 1 collaboration

Catherine Quinlan 1 collaboration

Winita Hardikar 1 collaboration

Haico van Attikum 1 collaboration

Alfred C O Vertegaal 1 collaboration

Brian T Wilson 1 collaboration

Daniël O Warmerdam 1 collaboration

Bente Benedict 1 collaboration

Kavish A V Kohabir 1 collaboration

Lars O Nooi 1 collaboration

Arjen Brink 1 collaboration

Erik A Sistermans 1 collaboration

Lore van Riel 1 collaboration

Bart G Boerrigter 1 collaboration

R J A van Moorselaar 1 collaboration

Cherien A Ghandour 1 collaboration

Grant S Stewart 1 collaboration

Erika Cantelli 1 collaboration

Joanna L Parish 1 collaboration

Cynthia de Almeida Estéves 1 collaboration

Katja Dumic 1 collaboration

Ingeborg Barisic 1 collaboration

Karin E M Diderich 1 collaboration

Marjon A van Slegtenhorst 1 collaboration

Mohammad Mahtab 1 collaboration

Francesca M Pisani 1 collaboration

Najim Ameziane 1 collaboration

Sara Carvalhal 1 collaboration

Ingrid Bader 1 collaboration

René G Feichtinger 1 collaboration

Christine Beichler 1 collaboration

Michael R Speicher 1 collaboration

Johanna M van Hagen 1 collaboration

Martijn Bruijn 1 collaboration

Alexandra Tavares 1 collaboration

Johannes A Mayr 1 collaboration

Raquel A Oliveira 1 collaboration

Anja Wagner 1 collaboration

Dorine T den Toom 1 collaboration

Ernie M H F Bongers 1 collaboration

Geert J L H van Leenders 1 collaboration

Paul C Johannesma 1 collaboration

Maurice A M van Steensel 1 collaboration

Hendrikus J Dubbink 1 collaboration

Thom M Molenaar 1 collaboration

Macarena Moronta Gines 1 collaboration

Khashayar Roohollahi 1 collaboration

Govind M Pai 1 collaboration

Lauri Borghuis 1 collaboration

Anisha R Ramadhin 1 collaboration

Francesco Corazza 1 collaboration

Kerstin S Wendt 1 collaboration

Jan C Oosterwijk 1 collaboration

Peter C van den Akker 1 collaboration

Gilles F H Diercks 1 collaboration

Maria C Bolling 1 collaboration

Arjen R Mensenkamp 1 collaboration

Rob Zwart 1 collaboration

Alex V Postma 1 collaboration

R Jeroen A van Moorselaar 1 collaboration

Diana van den Heuvel 1 collaboration

Marta Rodríguez-Martínez 1 collaboration

Paula J van der Meer 1 collaboration

Nicolas Nieto Moreno 1 collaboration

Jiyoung Park 1 collaboration

Hyun-Suk Kim 1 collaboration

Areetha D'Souza 1 collaboration

George Yakoub 1 collaboration

Anna E Herlihy 1 collaboration

Krushanka Kashyap 1 collaboration

Thierry Boissière 1 collaboration

Jane Walker 1 collaboration

Richard Mitter 1 collaboration

Idil Kirdök 1 collaboration

Mats Ljungman 1 collaboration

Patrick Cramer 1 collaboration

Goran Kokic 1 collaboration

Jesper Q Svejstrup 1 collaboration

Philip R Jansen 1 collaboration

Jeanne E van Dongen 1 collaboration

Johanna T W Berendsen 1 collaboration

Renske D M Steenbergen 1 collaboration

Jan C T Eijkel 1 collaboration

Loes I Segerink 1 collaboration