Rubin Lubomirov

Affiliations

PharmaMar S.A., Clinical Development, Colmenar Viejo (Madrid), Spain.

ORCID: 0000-0003-0550-8228

Publications (12)

Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC-MS/MS.

PloS one

Avec: Nicholas King , Soledad Garcia-Martinez , Eider Alcaraz , Alba Grisalena , Rubin Lubomirov , Raquel Altares , Carlos Fernandez-Teruel , Andrés M Francesch , Pablo M Avilés , Salvador Fudio

Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization.

medRxiv : the preprint server for health sciences

Avec: José F Varona , Pedro Landete , Jose A Lopez-Martin , Vicente Estrada , Roger Paredes , Pablo Guisado-Vasco , Lucía Fernández de Orueta , Miguel Torralba , Jesús Fortún , Roberto Vates , José Barberán , Bonaventura Clotet , Julio Ancochea , Daniel Carnevali , Noemí Cabello , Lourdes Porras , Paloma Gijón , Alfonso Monereo , Daniel Abad , Sonia Zúñiga , Isabel Sola , Jordi Rodon , Nuria Izquierdo-Useros , Salvador Fudio , María José Pontes , Beatriz de Rivas , Patricia Girón de Velasco , Belén Sopesén , Antonio Nieto , Javier Gómez , Pablo Avilés , Rubin Lubomirov , Kris M White , Romel Rosales , Soner Yildiz , Ann-Kathrin Reuschl , Lucy G Thorne , Clare Jolly , Greg J Towers , Lorena Zuliani-Alvarez , Mehdi Bouhaddou , Kirsten Obernier , Luis Enjuanes , Jose M Fernández-Sousa , Auteur inconnu , Nevan J Krogan , José M Jimeno , Adolfo García-Sastre

Impact of a Moderate CYP3A4 Inducer (Bosentan) on Lurbinectedin Pharmacokinetics and Safety in Patients with Advanced Solid Tumors: An Open-Label, Two-Way, Crossover, Phase Ib Drug-Drug Interaction Study.

Pharmaceuticals (Basel, Switzerland)

Avec: Irene Moreno , Tatiana Hernández , Emiliano Calvo , Salvador Fudio , Carmen Kahatt , Cristian Fernández , Jorge Luis Iglesias , Gema Corral , Laura Pérez-Ramos , Lola Montilla , Ali Zeaiter , Rubin Lubomirov

Population-Pharmacokinetic and Covariate Analysis of Lurbinectedin (PM01183), a New RNA Polymerase II Inhibitor, in Pooled Phase I/II Trials in Patients with Cancer.

Clinical pharmacokinetics

Avec: Carlos Fernandez-Teruel , Ignacio Gonzalez , Iñaki F Trocóniz , Rubin Lubomirov , Arturo Soto , Salvador Fudio

Integrated exposure-response analysis of efficacy and safety of lurbinectedin to support the dose regimen in small-cell lung cancer.

Cancer chemotherapy and pharmacology

Avec: Carlos Fernández-Teruel , Salvador Fudio , Rubin Lubomirov

A model-based head-to-head comparison of single-agent lurbinectedin in the pivotal ATLANTIS Study.

Frontiers in oncology

Avec: Salvador Fudio , Laura Pérez-Ramos , Eduardo Asín-Prieto , Ali Zeaiter , Rubin Lubomirov

Pharmacokinetics and Safety of Lurbinectedin Administrated with Itraconazole in Cancer Patients: A Drug-Drug Interaction Study.

Marine drugs

Avec: Irene Moreno , Tatiana Hernández , Emiliano Calvo , Salvador Fudio , Carmen Kahatt , Sara Martínez , Jorge Luis Iglesias , Román Octavio Calafati , Laura Pérez-Ramos , Lola Montilla , Ali Zeaiter , Rubin Lubomirov

Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19.

Life science alliance

Avec: Jose F Varona , Pedro Landete , Jose A Lopez-Martin , Vicente Estrada , Roger Paredes , Pablo Guisado-Vasco , Lucia Fernandez de Orueta , Miguel Torralba , Jesus Fortun , Roberto Vates , Jose Barberan , Bonaventura Clotet , Julio Ancochea , Daniel Carnevali , Noemi Cabello , Lourdes Porras , Paloma Gijon , Alfonso Monereo , Daniel Abad , Sonia Zuñiga , Isabel Sola , Jordi Rodon , Julia Vergara-Alert , Nuria Izquierdo-Useros , Salvador Fudio , Maria Jose Pontes , Beatriz de Rivas , Patricia Giron de Velasco , Antonio Nieto , Javier Gomez , Pablo Aviles , Rubin Lubomirov , Alvaro Belgrano , Belen Sopesen , Kris M White , Romel Rosales , Soner Yildiz , Ann-Kathrin Reuschl , Lucy G Thorne , Clare Jolly , Greg J Towers , Lorena Zuliani-Alvarez , Mehdi Bouhaddou , Kirsten Obernier , Briana L McGovern , M Luis Rodriguez , Luis Enjuanes , Jose M Fernandez-Sousa , Nevan J Krogan , Jose M Jimeno , Adolfo Garcia-Sastre

Metabolic Disposition of Lurbinectedin, a Potent Selective Inhibitor of Active Transcription of Protein-Coding Genes, in Nonclinical Species and Patients.

Drug metabolism and disposition: the biological fate of chemicals

Avec: P Aviles , R Altares , L van Andel , R Lubomirov , S Fudio , H Rosing , F M Márquez Del Pino , M M Tibben , G Benedit , L Nan-Offeringa , X E Luepke Estefan , A Francesch , A Zeaiter , C Cuevas , J H M Schellens , J H Beijnen

Population Pharmacokinetic-Pharmacodynamic Modeling and Covariate Analyses of Neutropenia and Thrombocytopenia in Patients With Solid Tumors Treated With Lurbinectedin.

Journal of clinical pharmacology

Avec: Carlos Fernández-Teruel , Rubin Lubomirov , Salvador Fudio

Effect of lurbinectedin on the QTc interval in patients with advanced solid tumors: an exposure-response analysis.

Cancer chemotherapy and pharmacology

Avec: Salvador Fudio , Josep Tabernero , Vivek Subbiah , Sant P Chawla , Victor Moreno , Federico Longo , Rafael Lopez , Antonio Anton , Jose Manuel Trigo , Geoffrey Shapiro , Woondong Jeong , Victor Manuel Villalobos , Rubin Lubomirov , Carlos Fernandez-Teruel , Vicente Alfaro , Valentina Boni

Anti-cancer drug combinations approved by US FDA from 2011 to 2021: main design features of clinical trials and role of pharmacokinetics.

Cancer chemotherapy and pharmacology

Avec: Salvador Fudio , Alvaro Sellers , Laura Pérez Ramos , Beatriz Gil-Alberdi , Ali Zeaiter , Mikel Urroz , Antonio Carcas , Rubin Lubomirov

Réseau de co-auteurs

Salvador Fudio 11 collaborations

Ali Zeaiter 4 collaborations

Carlos Fernandez-Teruel 3 collaborations

Laura Pérez-Ramos 3 collaborations

Pedro Landete 2 collaborations

Jose A Lopez-Martin 2 collaborations

Vicente Estrada 2 collaborations

Roger Paredes 2 collaborations

Pablo Guisado-Vasco 2 collaborations

Miguel Torralba 2 collaborations

Roberto Vates 2 collaborations

Bonaventura Clotet 2 collaborations

Julio Ancochea 2 collaborations

Daniel Carnevali 2 collaborations

Lourdes Porras 2 collaborations

Alfonso Monereo 2 collaborations

Daniel Abad 2 collaborations

Isabel Sola 2 collaborations

Jordi Rodon 2 collaborations

Nuria Izquierdo-Useros 2 collaborations

Beatriz de Rivas 2 collaborations

Antonio Nieto 2 collaborations

Kris M White 2 collaborations

Romel Rosales 2 collaborations

Soner Yildiz 2 collaborations

Ann-Kathrin Reuschl 2 collaborations

Lucy G Thorne 2 collaborations

Clare Jolly 2 collaborations

Greg J Towers 2 collaborations

Lorena Zuliani-Alvarez 2 collaborations

Mehdi Bouhaddou 2 collaborations

Kirsten Obernier 2 collaborations

Luis Enjuanes 2 collaborations

Nevan J Krogan 2 collaborations

Irene Moreno 2 collaborations

Tatiana Hernández 2 collaborations

Emiliano Calvo 2 collaborations

Carmen Kahatt 2 collaborations

Jorge Luis Iglesias 2 collaborations

Lola Montilla 2 collaborations

Carlos Fernández-Teruel 2 collaborations

Nicholas King 1 collaboration

Soledad Garcia-Martinez 1 collaboration

Eider Alcaraz 1 collaboration

Alba Grisalena 1 collaboration

Raquel Altares 1 collaboration

Andrés M Francesch 1 collaboration

Pablo M Avilés 1 collaboration

José F Varona 1 collaboration

Lucía Fernández de Orueta 1 collaboration

Jesús Fortún 1 collaboration

José Barberán 1 collaboration

Noemí Cabello 1 collaboration

Paloma Gijón 1 collaboration

Sonia Zúñiga 1 collaboration

María José Pontes 1 collaboration

Patricia Girón de Velasco 1 collaboration

Belén Sopesén 1 collaboration

Javier Gómez 1 collaboration

Pablo Avilés 1 collaboration

Jose M Fernández-Sousa 1 collaboration

None None 1 collaboration

José M Jimeno 1 collaboration

Adolfo García-Sastre 1 collaboration

Cristian Fernández 1 collaboration

Gema Corral 1 collaboration

Ignacio Gonzalez 1 collaboration

Iñaki F Trocóniz 1 collaboration

Arturo Soto 1 collaboration

Eduardo Asín-Prieto 1 collaboration

Sara Martínez 1 collaboration

Román Octavio Calafati 1 collaboration

Jose F Varona 1 collaboration

Lucia Fernandez de Orueta 1 collaboration

Jesus Fortun 1 collaboration

Jose Barberan 1 collaboration

Noemi Cabello 1 collaboration

Paloma Gijon 1 collaboration

Sonia Zuñiga 1 collaboration

Julia Vergara-Alert 1 collaboration

Maria Jose Pontes 1 collaboration

Patricia Giron de Velasco 1 collaboration

Javier Gomez 1 collaboration

Pablo Aviles 1 collaboration

Alvaro Belgrano 1 collaboration

Belen Sopesen 1 collaboration

Briana L McGovern 1 collaboration

M Luis Rodriguez 1 collaboration

Jose M Fernandez-Sousa 1 collaboration

Jose M Jimeno 1 collaboration

Adolfo Garcia-Sastre 1 collaboration

P Aviles 1 collaboration

R Altares 1 collaboration

L van Andel 1 collaboration

R Lubomirov 1 collaboration

S Fudio 1 collaboration

H Rosing 1 collaboration

F M Márquez Del Pino 1 collaboration

M M Tibben 1 collaboration

G Benedit 1 collaboration

L Nan-Offeringa 1 collaboration

X E Luepke Estefan 1 collaboration

A Francesch 1 collaboration

A Zeaiter 1 collaboration

C Cuevas 1 collaboration

J H M Schellens 1 collaboration

J H Beijnen 1 collaboration

Josep Tabernero 1 collaboration

Vivek Subbiah 1 collaboration

Sant P Chawla 1 collaboration

Victor Moreno 1 collaboration

Federico Longo 1 collaboration

Rafael Lopez 1 collaboration

Antonio Anton 1 collaboration

Jose Manuel Trigo 1 collaboration

Geoffrey Shapiro 1 collaboration

Woondong Jeong 1 collaboration

Victor Manuel Villalobos 1 collaboration

Vicente Alfaro 1 collaboration

Valentina Boni 1 collaboration

Alvaro Sellers 1 collaboration

Laura Pérez Ramos 1 collaboration

Beatriz Gil-Alberdi 1 collaboration

Mikel Urroz 1 collaboration

Antonio Carcas 1 collaboration