Scott B Rothbart

Affiliations

Center for Epigenetics, Van Andel Institute, Grand Rapids, MI, United States.

Publications (32)

A Degenerate Peptide Library Approach to Reveal Sequence Determinants of Methyllysine-Driven Protein Interactions.

Frontiers in cell and developmental biology

Avec: Ariana Kupai , Robert M Vaughan , Bradley M Dickson , Scott B Rothbart

Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Matt L Harlow , Maggie H Chasse , Elissa A Boguslawski , Katie M Sorensen , Jenna M Gedminas , Susan M Kitchen-Goosen , Scott B Rothbart , Cenny Taslim , Stephen L Lessnick , Anderson S Peck , Zachary B Madaj , Megan J Bowman , Patrick J Grohar

Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis.

Cell reports

Avec: Huihui Fan , Huda I Atiya , Yeh Wang , Thomas R Pisanic , Tza-Huei Wang , Ie-Ming Shih , Kelly K Foy , Leonard Frisbie , Ronald J Buckanovich , Alison A Chomiak , Rochelle L Tiedemann , Scott B Rothbart , Chelsea Chandler , Hui Shen , Lan G Coffman

Single-genome analysis reveals heterogeneous association of the Herpes Simplex Virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts.

bioRxiv : the preprint server for biology

Avec: Alison K Francois , Ali Rohani , Matt Loftus , Sara Dochnal , Joel Hrit , Steven McFarlane , Abigail Whitford , Anna Lewis , Patryk Krakowiak , Chris Boutell , Scott B Rothbart , David Kashatus , Anna R Cliffe

LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation.

Molecular cell

Avec: Shelby E Compton , Susan M Kitchen-Goosen , Lisa M DeCamp , Kin H Lau , Batsirai Mabvakure , Matthew Vos , Kelsey S Williams , Kwok-Kin Wong , Xiaobing Shi , Scott B Rothbart , Connie M Krawczyk , Russell G Jones

Single-genome analysis reveals a heterogeneous association of the herpes simplex virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts.

mBio

Epigenetic Therapy for Epithelioid Sarcoma.

Cell

Avec: Scott B Rothbart , Stephen B Baylin

Analysis of histone antibody specificity directly in sequencing data using siQ-ChIP.

bioRxiv : the preprint server for biology

Avec: Ariana Kupai , Robert M Vaughan , Scott B Rothbart , Bradley M Dickson

The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells.

Epigenetics & chromatin

Avec: Robert M Vaughan , Ariana Kupai , Caroline A Foley , Cari A Sagum , Bailey M Tibben , Hope E Eden , Rochelle L Tiedemann , Christine A Berryhill , Varun Patel , Kevin M Shaw , Krzysztof Krajewski , Brian D Strahl , Mark T Bedford , Stephen V Frye , Bradley M Dickson , Scott B Rothbart

ARID1A-dependent maintenance of H3.3 is required for repressive CHD4-ZMYND8 chromatin interactions at super-enhancers.

BMC biology

Avec: Jake J Reske , Mike R Wilson , Brooke Armistead , Shannon Harkins , Cristina Perez , Joel Hrit , Marie Adams , Scott B Rothbart , Stacey A Missmer , Asgerally T Fazleabas , Ronald L Chandler

Streamlined quantitative analysis of histone modification abundance at nucleosome-scale resolution with siQ-ChIP version 2.0.

Scientific reports

Avec: Bradley M Dickson , Ariana Kupai , Robert M Vaughan , Scott B Rothbart

The UHRF1 protein is a key regulator of retrotransposable elements and innate immune response to viral RNA in human cells.

Epigenetics

Avec: R E Irwin , C Scullion , S J Thursby , M Sun , A Thakur , L Hilman , B Callaghan , P D Thompson , D J McKenna , S B Rothbart , Guoliang Xu , C P Walsh

UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation.

bioRxiv : the preprint server for biology

Avec: Rochelle L Tiedemann , Joel Hrit , Qian Du , Ashley K Wiseman , Hope E Eden , Bradley M Dickson , Xiangqian Kong , Alison A Chomiak , Robert M Vaughan , Jakob M Hebert , Yael David , Wanding Zhou , Stephen B Baylin , Peter A Jones , Susan J Clark , Scott B Rothbart

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.

Nature communications

Avec: Yi Zhang , Younghoon Jang , Ji-Eun Lee , JaeWoo Ahn , Longxia Xu , Michael R Holden , Evan M Cornett , Krzysztof Krajewski , Brianna J Klein , Shu-Ping Wang , Yali Dou , Robert G Roeder , Brian D Strahl , Scott B Rothbart , Xiaobing Shi , Kai Ge , Tatiana G Kutateladze

The finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for the maintenance of DNA methylation.

The Journal of biological chemistry

Avec: Robert M Vaughan , Scott B Rothbart , Bradley M Dickson

Global lysine methylome profiling using systematically characterized affinity reagents.

Scientific reports

Avec: Christine A Berryhill , Jocelyne N Hanquier , Emma H Doud , Eric Cordeiro-Spinetti , Bradley M Dickson , Scott B Rothbart , Amber L Mosley , Evan M Cornett

Ketolysis drives CD8

Immunity

Avec: Katarzyna M Luda , Joseph Longo , Susan M Kitchen-Goosen , Lauren R Duimstra , Eric H Ma , McLane J Watson , Brandon M Oswald , Zhen Fu , Zachary Madaj , Ariana Kupai , Bradley M Dickson , Lisa M DeCamp , Michael S Dahabieh , Shelby E Compton , Robert Teis , Irem Kaymak , Kin H Lau , Daniel P Kelly , Patrycja Puchalska , Kelsey S Williams , Connie M Krawczyk , Dominique Lévesque , François-Michel Boisvert , Ryan D Sheldon , Scott B Rothbart , Peter A Crawford , Russell G Jones

Mitotic chromatin marking governs asymmetric segregation of DNA damage.

bioRxiv : the preprint server for biology

Avec: Juliette Ferrand , Juliette Dabin , Odile Chevallier , Ariana Kupai , Scott B Rothbart , Sophie E Polo

Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling.

Science advances

Avec: Alison A Chomiak , Rochelle L Tiedemann , Yanqing Liu , Xiangqian Kong , Ying Cui , Ashley K Wiseman , Kate E Thurlow , Evan M Cornett , Michael J Topper , Stephen B Baylin , Scott B Rothbart

A Read/Write Mechanism Connects p300 Bromodomain Function to H2A.Z Acetylation.

iScience

Avec: Yolanda Colino-Sanguino , Evan M Cornett , David Moulder , Grady C Smith , Joel Hrit , Eric Cordeiro-Spinetti , Robert M Vaughan , Krzysztof Krajewski , Scott B Rothbart , Susan J Clark , Fátima Valdés-Mora

Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties.

Cancer cell

Avec: Xiangqian Kong , Jie Chen , Wenbing Xie , Stephen M Brown , Yi Cai , Kaichun Wu , Daiming Fan , Yongzhan Nie , Srinivasan Yegnasubramanian , Rochelle L Tiedemann , Yong Tao , Ray-Whay Chiu Yen , Michael J Topper , Cynthia A Zahnow , Hariharan Easwaran , Scott B Rothbart , Limin Xia , Stephen B Baylin

Lysine Methylation Regulators Moonlighting outside the Epigenome.

Molecular cell

Avec: Evan M Cornett , Laure Ferry , Pierre-Antoine Defossez , Scott B Rothbart

Histone H3.3 phosphorylation amplifies stimulation-induced transcription.

Nature

Avec: Anja Armache , Shuang Yang , Alexia Martínez de Paz , Lexi E Robbins , Ceyda Durmaz , Jin Q Cheong , Arjun Ravishankar , Andrew W Daman , Dughan J Ahimovic , Thaís Klevorn , Yuan Yue , Tanja Arslan , Shu Lin , Tanya Panchenko , Joel Hrit , Miao Wang , Samuel Thudium , Benjamin A Garcia , Erica Korb , Karim-Jean Armache , Scott B Rothbart , Sandra B Hake , C David Allis , Haitao Li , Steven Z Josefowicz

A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer.

Genes & development

Avec: Marc A J Morgan , Irina K Popova , Anup Vaidya , Jonathan M Burg , Matthew R Marunde , Emily J Rendleman , Zachary J Dumar , Rachel Watson , Matthew J Meiners , Sarah A Howard , Natalia Khalatyan , Robert M Vaughan , Scott B Rothbart , Michael-C Keogh , Ali Shilatifard

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

PLoS biology

Avec: Jennifer L Franks , Raquel C Martinez-Chacin , Xianxi Wang , Rochelle L Tiedemann , Thomas Bonacci , Rajarshi Choudhury , Derek L Bolhuis , Taylor P Enrico , Ryan D Mouery , Jeffrey S Damrauer , Feng Yan , Joseph S Harrison , M Ben Major , Katherine A Hoadley , Aussie Suzuki , Scott B Rothbart , Nicholas G Brown , Michael J Emanuele

Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications.

Trends in biochemical sciences

Avec: Robert M Vaughan , Ariana Kupai , Scott B Rothbart

HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies.

Cell reports

Avec: Mariesa J Slaughter , Erin K Shanle , Abid Khan , Katrin F Chua , Tao Hong , Lisa D Boxer , C David Allis , Steven Z Josefowicz , Benjamin A Garcia , Scott B Rothbart , Brian D Strahl , Ian J Davis

Distinguishing Active Versus Passive DNA Demethylation Using Illumina MethylationEPIC BeadChip Microarrays.

Methods in molecular biology (Clifton, N.J.)

Avec: Rochelle L Tiedemann , Hope E Eden , Zhijun Huang , Keith D Robertson , Scott B Rothbart

A physical basis for quantitative ChIP-sequencing.

The Journal of biological chemistry

Avec: Bradley M Dickson , Rochelle L Tiedemann , Alison A Chomiak , Evan M Cornett , Robert M Vaughan , Scott B Rothbart

Binding specificity and function of the SWI/SNF subunit SMARCA4 bromodomain interaction with acetylated histone H3K14.

The Journal of biological chemistry

Avec: Paul Enríquez , Krzysztof Krajewski , Brian D Strahl , Scott B Rothbart , Robert H Dowen , Robert B Rose

Mechanisms of DNA methylation regulatory function and crosstalk with histone lysine methylation.

Journal of molecular biology

Avec: Bailey M Tibben , Scott B Rothbart

Lysine methylation signaling in skeletal muscle biology: from myogenesis to clinical insights.

The Biochemical journal

Avec: Eric Cordeiro-Spinetti , Scott B Rothbart

Réseau de co-auteurs

Robert M Vaughan 10 collaborations

Bradley M Dickson 9 collaborations

Rochelle L Tiedemann 8 collaborations

Ariana Kupai 7 collaborations

Joel Hrit 6 collaborations

Evan M Cornett 6 collaborations

Alison A Chomiak 4 collaborations

Stephen B Baylin 4 collaborations

Krzysztof Krajewski 4 collaborations

Brian D Strahl 4 collaborations

Susan M Kitchen-Goosen 3 collaborations

Hope E Eden 3 collaborations

Xiangqian Kong 3 collaborations

Eric Cordeiro-Spinetti 3 collaborations

Alison K Francois 2 collaborations

Ali Rohani 2 collaborations

Matt Loftus 2 collaborations

Sara Dochnal 2 collaborations

Steven McFarlane 2 collaborations

Abigail Whitford 2 collaborations

Anna Lewis 2 collaborations

Patryk Krakowiak 2 collaborations

Chris Boutell 2 collaborations

David Kashatus 2 collaborations

Anna R Cliffe 2 collaborations

Shelby E Compton 2 collaborations

Lisa M DeCamp 2 collaborations

Kin H Lau 2 collaborations

Kelsey S Williams 2 collaborations

Xiaobing Shi 2 collaborations

Connie M Krawczyk 2 collaborations

Russell G Jones 2 collaborations

Bailey M Tibben 2 collaborations

Christine A Berryhill 2 collaborations

Ashley K Wiseman 2 collaborations

Susan J Clark 2 collaborations

Michael J Topper 2 collaborations

Benjamin A Garcia 2 collaborations

C David Allis 2 collaborations

Steven Z Josefowicz 2 collaborations

Matt L Harlow 1 collaboration

Maggie H Chasse 1 collaboration

Elissa A Boguslawski 1 collaboration

Katie M Sorensen 1 collaboration

Jenna M Gedminas 1 collaboration

Cenny Taslim 1 collaboration

Stephen L Lessnick 1 collaboration

Anderson S Peck 1 collaboration

Zachary B Madaj 1 collaboration

Megan J Bowman 1 collaboration

Patrick J Grohar 1 collaboration

Huihui Fan 1 collaboration

Huda I Atiya 1 collaboration

Yeh Wang 1 collaboration

Thomas R Pisanic 1 collaboration

Tza-Huei Wang 1 collaboration

Ie-Ming Shih 1 collaboration

Kelly K Foy 1 collaboration

Leonard Frisbie 1 collaboration

Ronald J Buckanovich 1 collaboration

Chelsea Chandler 1 collaboration

Hui Shen 1 collaboration

Lan G Coffman 1 collaboration

Batsirai Mabvakure 1 collaboration

Matthew Vos 1 collaboration

Kwok-Kin Wong 1 collaboration

Caroline A Foley 1 collaboration

Cari A Sagum 1 collaboration

Varun Patel 1 collaboration

Kevin M Shaw 1 collaboration

Mark T Bedford 1 collaboration

Stephen V Frye 1 collaboration

Jake J Reske 1 collaboration

Mike R Wilson 1 collaboration

Brooke Armistead 1 collaboration

Shannon Harkins 1 collaboration

Cristina Perez 1 collaboration

Marie Adams 1 collaboration

Stacey A Missmer 1 collaboration

Asgerally T Fazleabas 1 collaboration

Ronald L Chandler 1 collaboration

R E Irwin 1 collaboration

C Scullion 1 collaboration

S J Thursby 1 collaboration

M Sun 1 collaboration

A Thakur 1 collaboration

L Hilman 1 collaboration

B Callaghan 1 collaboration

P D Thompson 1 collaboration

D J McKenna 1 collaboration

S B Rothbart 1 collaboration

Guoliang Xu 1 collaboration

C P Walsh 1 collaboration

Qian Du 1 collaboration

Jakob M Hebert 1 collaboration

Yael David 1 collaboration

Wanding Zhou 1 collaboration

Peter A Jones 1 collaboration

Yi Zhang 1 collaboration

Younghoon Jang 1 collaboration

Ji-Eun Lee 1 collaboration

JaeWoo Ahn 1 collaboration

Longxia Xu 1 collaboration

Michael R Holden 1 collaboration

Brianna J Klein 1 collaboration

Shu-Ping Wang 1 collaboration

Yali Dou 1 collaboration

Robert G Roeder 1 collaboration

Kai Ge 1 collaboration

Tatiana G Kutateladze 1 collaboration

Jocelyne N Hanquier 1 collaboration

Emma H Doud 1 collaboration

Amber L Mosley 1 collaboration

Katarzyna M Luda 1 collaboration

Joseph Longo 1 collaboration

Lauren R Duimstra 1 collaboration

Eric H Ma 1 collaboration

McLane J Watson 1 collaboration

Brandon M Oswald 1 collaboration

Zhen Fu 1 collaboration

Zachary Madaj 1 collaboration

Michael S Dahabieh 1 collaboration

Robert Teis 1 collaboration

Irem Kaymak 1 collaboration

Daniel P Kelly 1 collaboration

Patrycja Puchalska 1 collaboration

Dominique Lévesque 1 collaboration

François-Michel Boisvert 1 collaboration

Ryan D Sheldon 1 collaboration

Peter A Crawford 1 collaboration

Juliette Ferrand 1 collaboration

Juliette Dabin 1 collaboration

Odile Chevallier 1 collaboration

Sophie E Polo 1 collaboration

Yanqing Liu 1 collaboration

Ying Cui 1 collaboration

Kate E Thurlow 1 collaboration

Yolanda Colino-Sanguino 1 collaboration

David Moulder 1 collaboration

Grady C Smith 1 collaboration

Fátima Valdés-Mora 1 collaboration

Jie Chen 1 collaboration

Wenbing Xie 1 collaboration

Stephen M Brown 1 collaboration

Yi Cai 1 collaboration

Kaichun Wu 1 collaboration

Daiming Fan 1 collaboration

Yongzhan Nie 1 collaboration

Srinivasan Yegnasubramanian 1 collaboration

Yong Tao 1 collaboration

Ray-Whay Chiu Yen 1 collaboration

Cynthia A Zahnow 1 collaboration

Hariharan Easwaran 1 collaboration

Limin Xia 1 collaboration

Laure Ferry 1 collaboration

Pierre-Antoine Defossez 1 collaboration

Anja Armache 1 collaboration

Shuang Yang 1 collaboration

Alexia Martínez de Paz 1 collaboration

Lexi E Robbins 1 collaboration

Ceyda Durmaz 1 collaboration

Jin Q Cheong 1 collaboration

Arjun Ravishankar 1 collaboration

Andrew W Daman 1 collaboration

Dughan J Ahimovic 1 collaboration

Thaís Klevorn 1 collaboration

Yuan Yue 1 collaboration

Tanja Arslan 1 collaboration

Shu Lin 1 collaboration

Tanya Panchenko 1 collaboration

Miao Wang 1 collaboration

Samuel Thudium 1 collaboration

Erica Korb 1 collaboration

Karim-Jean Armache 1 collaboration

Sandra B Hake 1 collaboration

Haitao Li 1 collaboration

Marc A J Morgan 1 collaboration

Irina K Popova 1 collaboration

Anup Vaidya 1 collaboration

Jonathan M Burg 1 collaboration

Matthew R Marunde 1 collaboration

Emily J Rendleman 1 collaboration

Zachary J Dumar 1 collaboration

Rachel Watson 1 collaboration

Matthew J Meiners 1 collaboration

Sarah A Howard 1 collaboration

Natalia Khalatyan 1 collaboration

Michael-C Keogh 1 collaboration

Ali Shilatifard 1 collaboration

Jennifer L Franks 1 collaboration

Raquel C Martinez-Chacin 1 collaboration

Xianxi Wang 1 collaboration

Thomas Bonacci 1 collaboration

Rajarshi Choudhury 1 collaboration

Derek L Bolhuis 1 collaboration

Taylor P Enrico 1 collaboration

Ryan D Mouery 1 collaboration

Jeffrey S Damrauer 1 collaboration

Feng Yan 1 collaboration

Joseph S Harrison 1 collaboration

M Ben Major 1 collaboration

Katherine A Hoadley 1 collaboration

Aussie Suzuki 1 collaboration

Nicholas G Brown 1 collaboration

Michael J Emanuele 1 collaboration

Mariesa J Slaughter 1 collaboration

Erin K Shanle 1 collaboration

Abid Khan 1 collaboration

Katrin F Chua 1 collaboration

Tao Hong 1 collaboration

Lisa D Boxer 1 collaboration

Ian J Davis 1 collaboration

Zhijun Huang 1 collaboration

Keith D Robertson 1 collaboration

Paul Enríquez 1 collaboration

Robert H Dowen 1 collaboration

Robert B Rose 1 collaboration