Sebastian Frechen

Affiliations

Faculty of Medicine and University Hospital Cologne, Center for Pharmacology, Department I of Pharmacology, University of Cologne, Cologne, Germany.

Publications (19)

Sorafenib and everolimus in patients with advanced solid tumors and KRAS-mutated NSCLC: A phase I trial with early pharmacodynamic FDG-PET assessment.

Cancer medicine

Avec: Lucia Nogova , Christian Mattonet , Matthias Scheffler , Max Taubert , Masyar Gardizi , Martin L Sos , Sebastian Michels , Rieke N Fischer , Meike Limburg , Diana S Y Abdulla , Thorsten Persigehl , Carsten Kobe , Sabine Merkelbach-Bruse , Jeremy Franklin , Heiko Backes , Roland Schnell , Dirk Behringer , Britta Kaminsky , Martina Eichstaedt , Christoph Stelzer , Martina Kinzig , Fritz Sörgel , Yingying Tian , Lisa Junge , Ahmed A Suleiman , Sebastian Frechen , Dennis Rokitta , Dongsheng Ouyang , Uwe Fuhr , Reinhard Buettner , Jürgen Wolf

Physiologically-based pharmacokinetic modeling to predict CYP3A4-mediated drug-drug interactions of finerenone.

CPT: pharmacometrics & systems pharmacology

Avec: Thomas Wendl , Sebastian Frechen , Michael Gerisch , Roland Heinig , Thomas Eissing

Quality Assurance of PBPK Modeling Platforms and Guidance on Building, Evaluating, Verifying and Applying PBPK Models Prudently under the Umbrella of Qualification: Why, When, What, How and By Whom?

Pharmaceutical research

Avec: Sebastian Frechen , Amin Rostami-Hodjegan

Physiologically-based pharmacokinetic modeling of quinidine to establish a CYP3A4, P-gp, and CYP2D6 drug-drug-gene interaction network.

CPT: pharmacometrics & systems pharmacology

Avec: Denise Feick , Simeon Rüdesheim , Fatima Zahra Marok , Dominik Selzer , Helena Leonie Hanae Loer , Donato Teutonico , Sebastian Frechen , Maaike van der Lee , Dirk Jan A R Moes , Jesse J Swen , Matthias Schwab , Thorsten Lehr

Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug-Drug-Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole.

Clinical pharmacokinetics

Avec: Denise Türk , Nina Hanke , Sarah Wolf , Sebastian Frechen , Thomas Eissing , Thomas Wendl , Matthias Schwab , Thorsten Lehr

A generic framework for the physiologically-based pharmacokinetic platform qualification of PK-Sim and its application to predicting cytochrome P450 3A4-mediated drug-drug interactions.

CPT: pharmacometrics & systems pharmacology

Avec: Sebastian Frechen , Juri Solodenko , Thomas Wendl , André Dallmann , Ibrahim Ince , Thorsten Lehr , Jörg Lippert , Rolf Burghaus

Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: An InPharma commentary.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Christos Reppas , Martin Kuentz , Annette Bauer-Brandl , Sara Carlert , André Dallmann , Shirin Dietrich , Jennifer Dressman , Lotte Ejskjaer , Sebastian Frechen , Matteo Guidetti , René Holm , Florentin Lukas Holzem , Εva Karlsson , Edmund Kostewicz , Shaida Panbachi , Felix Paulus , Malte Bøgh Senniksen , Cordula Stillhart , David B Turner , Maria Vertzoni , Paul Vrenken , Laurin Zöller , Brendan T Griffin , Patrick J O'Dwyer

Population pharmacokinetic-pharmacodynamic model of elinzanetant based on integrated clinical phase I and II data.

CPT: pharmacometrics & systems pharmacology

Avec: Stefan Willmann , Adam Lloyd , Rupert Austin , Shiju Joseph , Alexander Solms , Yang Zhang , Annika R P Schneider , Sebastian Frechen , Marcus-Hillert Schultze-Mosgau

Predictive Pediatric Modeling and Simulation Using Ontogeny Information.

Journal of clinical pharmacology

Avec: Ibrahim Ince , Juri Solodenko , Sebastian Frechen , André Dallmann , Christoph Niederalt , Jan Schlender , Rolf Burghaus , Jörg Lippert , Stefan Willmann

In-Depth Analysis of the Selection of PBPK Modeling Tools: Bibliometric and Social Network Analysis of the Open Systems Pharmacology Community.

Journal of clinical pharmacology

Avec: André Dallmann , Donato Teutonico , Stephan Schaller , Rolf Burghaus , Sebastian Frechen

Physiologically based pharmacokinetic modeling of tacrolimus for food-drug and CYP3A drug-drug-gene interaction predictions.

CPT: pharmacometrics & systems pharmacology

Avec: Helena Leonie Hanae Loer , Denise Feick , Simeon Rüdesheim , Dominik Selzer , Matthias Schwab , Donato Teutonico , Sebastian Frechen , Maaike van der Lee , Dirk Jan A R Moes , Jesse J Swen , Thorsten Lehr

PBPK modeling: What is the role of CYP3A4 expression in the gastrointestinal tract to accurately predict first-pass metabolism?

CPT: pharmacometrics & systems pharmacology

Avec: Justine Henriot , André Dallmann , François Dupuis , Jérémy Perrier , Sebastian Frechen

Effectiveness of Thymepearls After Vocal Loading in Professional Voice Users: A Randomized Placebo-Controlled Double-Blind Clinical Trial.

Journal of voice : official journal of the Voice Foundation

Avec: Sarah Frechen , Ewa V Latoszek

Applied physiologically-based pharmacokinetic modeling to assess uridine diphosphate-glucuronosyltransferase-mediated drug-drug interactions for Vericiguat.

CPT: pharmacometrics & systems pharmacology

Avec: Sebastian Frechen , Ibrahim Ince , André Dallmann , Michael Gerisch , Natalia A Jungmann , Corina Becker , Maximilian Lobmeyer , Maria E Trujillo , Shiyao Xu , Rolf Burghaus , Michaela Meyer

A Novel Study Design Using Continuous Intravenous and Intraduodenal Infusions of Midazolam and Voriconazole for Mechanistic Quantitative Assessment of Hepatic and Intestinal CYP3A Inhibition.

Journal of clinical pharmacology

Avec: Xia Li , Lisa Junge , Max Taubert , Anabelle von Georg , Dominik Dahlinger , Chris Starke , Sebastian Frechen , Christoph Stelzer , Martina Kinzig , Fritz Sörgel , Ulrich Jaehde , Ulrich Töx , Tobias Goeser , Uwe Fuhr

A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug-Drug Interactions.

Clinical pharmacokinetics

Avec: Xia Li , Sebastian Frechen , Daniel Moj , Thorsten Lehr , Max Taubert , Chih-Hsuan Hsin , Gerd Mikus , Pertti J Neuvonen , Klaus T Olkkola , Teijo I Saari , Uwe Fuhr

Physiologically-Based Pharmacokinetic Models for CYP1A2 Drug-Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam.

CPT: pharmacometrics & systems pharmacology

Avec: Hannah Britz , Nina Hanke , Anke-Katrin Volz , Olav Spigset , Matthias Schwab , Thomas Eissing , Thomas Wendl , Sebastian Frechen , Thorsten Lehr

Predictive Performance of Physiology-Based Pharmacokinetic Dose Estimates for Pediatric Trials: Evaluation With 10 Bayer Small-Molecule Compounds in Children.

Journal of clinical pharmacology

Avec: Ibrahim Ince , André Dallmann , Sebastian Frechen , Katrin Coboeken , Christoph Niederalt , Thomas Wendl , Michael Block , Michaela Meyer , Thomas Eissing , Rolf Burghaus , Jörg Lippert , Stefan Willmann , Jan-Frederik Schlender

Assessment of the CYP3A4 Induction Potential by Carbamazepine: Insights from two Clinical DDI Studies and PBPK Modeling.

Clinical pharmacology and therapeutics

Avec: Friederike Kanefendt , André Dallmann , Huijun Chen , Klaus Francke , Tianxing Liu , Christine Brase , Sebastian Frechen , Marcus-Hillert Schultze-Mosgau

Réseau de co-auteurs

André Dallmann 8 collaborations

Thorsten Lehr 6 collaborations

Thomas Wendl 5 collaborations

Rolf Burghaus 5 collaborations

Thomas Eissing 4 collaborations

Matthias Schwab 4 collaborations

Ibrahim Ince 4 collaborations

Max Taubert 3 collaborations

Uwe Fuhr 3 collaborations

Donato Teutonico 3 collaborations

Jörg Lippert 3 collaborations

Stefan Willmann 3 collaborations

Christoph Stelzer 2 collaborations

Martina Kinzig 2 collaborations

Fritz Sörgel 2 collaborations

Lisa Junge 2 collaborations

Michael Gerisch 2 collaborations

Denise Feick 2 collaborations

Simeon Rüdesheim 2 collaborations

Dominik Selzer 2 collaborations

Helena Leonie Hanae Loer 2 collaborations

Maaike van der Lee 2 collaborations

Dirk Jan A R Moes 2 collaborations

Jesse J Swen 2 collaborations

Nina Hanke 2 collaborations

Juri Solodenko 2 collaborations

Marcus-Hillert Schultze-Mosgau 2 collaborations

Christoph Niederalt 2 collaborations

Michaela Meyer 2 collaborations

Xia Li 2 collaborations

Lucia Nogova 1 collaboration

Christian Mattonet 1 collaboration

Matthias Scheffler 1 collaboration

Masyar Gardizi 1 collaboration

Martin L Sos 1 collaboration

Sebastian Michels 1 collaboration

Rieke N Fischer 1 collaboration

Meike Limburg 1 collaboration

Diana S Y Abdulla 1 collaboration

Thorsten Persigehl 1 collaboration

Carsten Kobe 1 collaboration

Sabine Merkelbach-Bruse 1 collaboration

Jeremy Franklin 1 collaboration

Heiko Backes 1 collaboration

Roland Schnell 1 collaboration

Dirk Behringer 1 collaboration

Britta Kaminsky 1 collaboration

Martina Eichstaedt 1 collaboration

Yingying Tian 1 collaboration

Ahmed A Suleiman 1 collaboration

Dennis Rokitta 1 collaboration

Dongsheng Ouyang 1 collaboration

Reinhard Buettner 1 collaboration

Jürgen Wolf 1 collaboration

Roland Heinig 1 collaboration

Amin Rostami-Hodjegan 1 collaboration

Fatima Zahra Marok 1 collaboration

Denise Türk 1 collaboration

Sarah Wolf 1 collaboration

Christos Reppas 1 collaboration

Martin Kuentz 1 collaboration

Annette Bauer-Brandl 1 collaboration

Sara Carlert 1 collaboration

Shirin Dietrich 1 collaboration

Jennifer Dressman 1 collaboration

Lotte Ejskjaer 1 collaboration

Matteo Guidetti 1 collaboration

René Holm 1 collaboration

Florentin Lukas Holzem 1 collaboration

Εva Karlsson 1 collaboration

Edmund Kostewicz 1 collaboration

Shaida Panbachi 1 collaboration

Felix Paulus 1 collaboration

Malte Bøgh Senniksen 1 collaboration

Cordula Stillhart 1 collaboration

David B Turner 1 collaboration

Maria Vertzoni 1 collaboration

Paul Vrenken 1 collaboration

Laurin Zöller 1 collaboration

Brendan T Griffin 1 collaboration

Patrick J O'Dwyer 1 collaboration

Adam Lloyd 1 collaboration

Rupert Austin 1 collaboration

Shiju Joseph 1 collaboration

Alexander Solms 1 collaboration

Yang Zhang 1 collaboration

Annika R P Schneider 1 collaboration

Jan Schlender 1 collaboration

Stephan Schaller 1 collaboration

Justine Henriot 1 collaboration

François Dupuis 1 collaboration

Jérémy Perrier 1 collaboration

Sarah Frechen 1 collaboration

Ewa V Latoszek 1 collaboration

Natalia A Jungmann 1 collaboration

Corina Becker 1 collaboration

Maximilian Lobmeyer 1 collaboration

Maria E Trujillo 1 collaboration

Shiyao Xu 1 collaboration

Anabelle von Georg 1 collaboration

Dominik Dahlinger 1 collaboration

Chris Starke 1 collaboration

Ulrich Jaehde 1 collaboration

Ulrich Töx 1 collaboration

Tobias Goeser 1 collaboration

Daniel Moj 1 collaboration

Chih-Hsuan Hsin 1 collaboration

Gerd Mikus 1 collaboration

Pertti J Neuvonen 1 collaboration

Klaus T Olkkola 1 collaboration

Teijo I Saari 1 collaboration

Hannah Britz 1 collaboration

Anke-Katrin Volz 1 collaboration

Olav Spigset 1 collaboration

Katrin Coboeken 1 collaboration

Michael Block 1 collaboration

Jan-Frederik Schlender 1 collaboration

Friederike Kanefendt 1 collaboration

Huijun Chen 1 collaboration

Klaus Francke 1 collaboration

Tianxing Liu 1 collaboration

Christine Brase 1 collaboration