Sebastian Mathea

Affiliations

Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences (BMLS), Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.

Publications (28)

Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis.

Journal of medicinal chemistry

Avec: Marek Wanior , Franziska Preuss , Xiaomin Ni , Andreas Krämer , Sebastian Mathea , Tamara Göbel , David Heidenreich , Svenja Simonyi , Astrid S Kahnt , Andreas C Joerger , Stefan Knapp

Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4.

Structure (London, England : 1993)

Avec: Franziska Preuss , Deep Chatterjee , Sebastian Mathea , Safal Shrestha , Jonathan St-Germain , Manipa Saha , Natarajan Kannan , Brian Raught , Robert Rottapel , Stefan Knapp

Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization.

European journal of medicinal chemistry

Avec: Anthony Champiré , Rayan Berabez , Abdennour Braka , Aurélie Cosson , Justine Corret , Caroline Girardin , Amandine Serrano , Samia Aci-Sèche , Pascal Bonnet , Béatrice Josselin , Pierre Brindeau , Sandrine Ruchaud , Rémy Leguevel , Deep Chatterjee , Sebastian Mathea , Stefan Knapp , Régis Brion , Franck Verrecchia , Béatrice Vallée , Karen Plé , Hélène Bénédetti , Sylvain Routier

Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA.

Journal of medicinal chemistry

Avec: Reem K Fathalla , Wolfgang Fröhner , Chantal D Bader , Patrick D Fischer , Charlotte Dahlem , Deep Chatterjee , Sebastian Mathea , Alexandra K Kiemer , Haribabu Arthanari , Rolf Müller , Mohammad Abdel-Halim , Christian Ducho , Matthias Engel

Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics.

Frontiers in chemistry

Avec: Adán Pinto-Fernández , Simon Davis , Abigail B Schofield , Hannah C Scott , Ping Zhang , Eidarus Salah , Sebastian Mathea , Philip D Charles , Andreas Damianou , Gareth Bond , Roman Fischer , Benedikt M Kessler

Lessons from LIMK1 enzymology and their impact on inhibitor design.

The Biochemical journal

Avec: Eidarus Salah , Deep Chatterjee , Alessandra Beltrami , Anthony Tumber , Franziska Preuss , Peter Canning , Apirat Chaikuad , Petra Knaus , Stefan Knapp , Alex N Bullock , Sebastian Mathea

Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.

Journal of medicinal chemistry

Avec: David H Drewry , Joel K Annor-Gyamfi , Carrow I Wells , Julie E Pickett , Verena Dederer , Franziska Preuss , Sebastian Mathea , Alison D Axtman

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system.

Science advances

Avec: Olawale G Raimi , Hina Ojha , Kenneth Ehses , Verena Dederer , Sven M Lange , Cristian Polo Rivera , Tom D Deegan , Yinchen Chen , Melanie Wightman , Rachel Toth , Karim P M Labib , Sebastian Mathea , Neil Ranson , Rubén Fernández-Busnadiego , Miratul M K Muqit

Structure of LRRK2 in Parkinson's disease and model for microtubule interaction.

Nature

Avec: C K Deniston , J Salogiannis , S Mathea , D M Snead , I Lahiri , M Matyszewski , O Donosa , R Watanabe , J Böhning , A K Shiau , S Knapp , E Villa , S L Reck-Peterson , A E Leschziner

Trypsiligase-Catalyzed Labeling of Proteins on Living Cells.

Chembiochem : a European journal of chemical biology

Avec: Sandra Liebscher , Sebastian Mathea , Tobias Aumüller , Andreas Pech , Frank Bordusa

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.

The Biochemical journal

Avec: Asad U Malik , Athanasios Karapetsas , Raja S Nirujogi , Sebastian Mathea , Deep Chatterjee , Prosenjit Pal , Pawel Lis , Matthew Taylor , Elena Purlyte , Robert Gourlay , Mark Dorward , Simone Weidlich , Rachel Toth , Nicole K Polinski , Stefan Knapp , Francesca Tonelli , Dario R Alessi

Structural Aspects of LIMK Regulation and Pharmacology.

Cells

Avec: Deep Chatterjee , Franziska Preuss , Verena Dederer , Stefan Knapp , Sebastian Mathea

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Sven H Schmidt , Jui-Hung Weng , Phillip C Aoto , Daniela Boassa , Sebastian Mathea , Steve Silletti , Junru Hu , Maximilian Wallbott , Elizabeth A Komives , Stefan Knapp , Friedrich W Herberg , Susan S Taylor

A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins.

Frontiers in cell and developmental biology

Avec: Martin P Schwalm , Lena M Berger , Maximilian N Meuter , James D Vasta , Cesear R Corona , Sandra Röhm , Benedict-Tilman Berger , Frederic Farges , Sebastian M Beinert , Franziska Preuss , Viktoria Morasch , Vladimir V Rogov , Sebastian Mathea , Krishna Saxena , Matthew B Robers , Susanne Müller , Stefan Knapp

Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes.

Journal of medicinal chemistry

Avec: Thomas Hanke , Sebastian Mathea , Julia Woortman , Eidarus Salah , Benedict-Tilman Berger , Anthony Tumber , Risa Kashima , Akiko Hata , Bernhard Kuster , Susanne Müller , Stefan Knapp

High-Throughput Purification of Protein Kinases from Escherichia coli and Insect Cells.

Methods in molecular biology (Clifton, N.J.)

Avec: Sebastian Mathea , Eidarus Salah , Stefan Knapp

Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery.

Frontiers in molecular neuroscience

Avec: Susan S Taylor , Pallavi Kaila-Sharma , Jui-Hung Weng , Phillip Aoto , Sven H Schmidt , Stefan Knapp , Sebastian Mathea , Friedrich W Herberg

Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors.

Cell chemical biology

Avec: André Richters , Shelby K Doyle , David B Freeman , Christina Lee , Becky S Leifer , Sajjeev Jagannathan , Florian Kabinger , Jošt Vrabič Koren , Nicholas B Struntz , Julie Urgiles , Ryan A Stagg , Brice H Curtin , Deep Chatterjee , Sebastian Mathea , Peter J Mikochik , Tamara D Hopkins , Hua Gao , Jonathan R Branch , Hong Xin , Lori Westover , Gilles C Bignan , Brent A Rupnow , Kristen L Karlin , Calla M Olson , Thomas F Westbrook , Joseph Vacca , Chris M Wilfong , B Wesley Trotter , Douglas C Saffran , Norbert Bischofberger , Stefan Knapp , Joshua W Russo , Ian Hickson , James R Bischoff , Marco M Gottardis , Steven P Balk , Charles Y Lin , Marius S Pop , Angela N Koehler

Enabling pseudokinases as potential drug targets.

Methods in enzymology

Avec: Franziska Preuss , Deep Chatterjee , Verena Dederer , Stefan Knapp , Sebastian Mathea

Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-

Journal of medicinal chemistry

Avec: Christian G Kurz , Franziska Preuss , Amelie Tjaden , Martin Cusack , Jennifer Alisa Amrhein , Deep Chatterjee , Sebastian Mathea , Lena Marie Berger , Benedict-Tilman Berger , Andreas Krämer , Michael Weller , Tobias Weiss , Susanne Müller , Stefan Knapp , Thomas Hanke

Structure of LRRK1 and mechanisms of autoinhibition and activation.

Nature structural & molecular biology

Avec: Janice M Reimer , Andrea M Dickey , Yu Xuan Lin , Robert G Abrisch , Sebastian Mathea , Deep Chatterjee , Elizabeth J Fay , Stefan Knapp , Matthew D Daugherty , Samara L Reck-Peterson , Andres E Leschziner

A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2.

The Journal of biological chemistry

Avec: Verena Dederer , Marta Sanz Murillo , Eva P Karasmanis , Kathryn S Hatch , Deep Chatterjee , Franziska Preuss , Kamal R Abdul Azeez , Landon Vu Nguyen , Christian Galicia , Birgit Dreier , Andreas Plückthun , Wim Versees , Sebastian Mathea , Andres E Leschziner , Samara L Reck-Peterson , Stefan Knapp

Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.

Molecular cell

Avec: Joshua B Sheetz , Sebastian Mathea , Hanna Karvonen , Ketan Malhotra , Deep Chatterjee , Wilhelmiina Niininen , Robert Perttilä , Franziska Preuss , Krishna Suresh , Steven E Stayrook , Yuko Tsutsui , Ravi Radhakrishnan , Daniela Ungureanu , Stefan Knapp , Mark A Lemmon

Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.

Journal of medicinal chemistry

Avec: Sandra Röhm , Benedict-Tilman Berger , Martin Schröder , Deep Chatterjee , Sebastian Mathea , Andreas C Joerger , Daniel M Pinkas , Joshua C Bufton , Amelie Tjaden , Lohitesh Kovooru , Mark Kudolo , Christian Pohl , Alex N Bullock , Susanne Müller , Stefan Laufer , Stefan Knapp

Conformational plasticity of the ULK3 kinase domain.

The Biochemical journal

Avec: Sebastian Mathea , Eidarus Salah , Cynthia Tallant , Deep Chatterjee , Benedict-Tilman Berger , Rebecca Konietzny , Susanne Müller , Benedikt M Kessler , Stefan Knapp

LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.

PLoS biology

Avec: Jui-Hung Weng , Phillip C Aoto , Robin Lorenz , Jian Wu , Sven H Schmidt , Jascha T Manschwetus , Pallavi Kaila-Sharma , Steve Silletti , Sebastian Mathea , Deep Chatterjee , Stefan Knapp , Friedrich W Herberg , Susan S Taylor

Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.

Science advances

Avec: Marta Sanz Murillo , Amalia Villagran Suarez , Verena Dederer , Deep Chatterjee , Jaime Alegrio Louro , Stefan Knapp , Sebastian Mathea , Andres E Leschziner

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.

The Biochemical journal

Avec: Asad U Malik , Athanasios Karapetsas , Raja S Nirujogi , Deep Chatterjee , Toan K Phung , Melanie Wightman , Robert Gourlay , Nick Morrice , Sebastian Mathea , Stefan Knapp , Dario R Alessi

Réseau de co-auteurs

Stefan Knapp 22 collaborations

Deep Chatterjee 17 collaborations

Franziska Preuss 10 collaborations

Verena Dederer 6 collaborations

Eidarus Salah 5 collaborations

Benedict-Tilman Berger 5 collaborations

Susanne Müller 5 collaborations

Sven H Schmidt 3 collaborations

Jui-Hung Weng 3 collaborations

Friedrich W Herberg 3 collaborations

Susan S Taylor 3 collaborations

Andres E Leschziner 3 collaborations

Andreas Krämer 2 collaborations

Andreas C Joerger 2 collaborations

Benedikt M Kessler 2 collaborations

Anthony Tumber 2 collaborations

Alex N Bullock 2 collaborations

Melanie Wightman 2 collaborations

Rachel Toth 2 collaborations

Asad U Malik 2 collaborations

Athanasios Karapetsas 2 collaborations

Raja S Nirujogi 2 collaborations

Robert Gourlay 2 collaborations

Dario R Alessi 2 collaborations

Phillip C Aoto 2 collaborations

Steve Silletti 2 collaborations

Sandra Röhm 2 collaborations

Thomas Hanke 2 collaborations

Pallavi Kaila-Sharma 2 collaborations

Amelie Tjaden 2 collaborations

Samara L Reck-Peterson 2 collaborations

Marta Sanz Murillo 2 collaborations

Marek Wanior 1 collaboration

Xiaomin Ni 1 collaboration

Tamara Göbel 1 collaboration

David Heidenreich 1 collaboration

Svenja Simonyi 1 collaboration

Astrid S Kahnt 1 collaboration

Safal Shrestha 1 collaboration

Jonathan St-Germain 1 collaboration

Manipa Saha 1 collaboration

Natarajan Kannan 1 collaboration

Brian Raught 1 collaboration

Robert Rottapel 1 collaboration

Anthony Champiré 1 collaboration

Rayan Berabez 1 collaboration

Abdennour Braka 1 collaboration

Aurélie Cosson 1 collaboration

Justine Corret 1 collaboration

Caroline Girardin 1 collaboration

Amandine Serrano 1 collaboration

Samia Aci-Sèche 1 collaboration

Pascal Bonnet 1 collaboration

Béatrice Josselin 1 collaboration

Pierre Brindeau 1 collaboration

Sandrine Ruchaud 1 collaboration

Rémy Leguevel 1 collaboration

Régis Brion 1 collaboration

Franck Verrecchia 1 collaboration

Béatrice Vallée 1 collaboration

Karen Plé 1 collaboration

Hélène Bénédetti 1 collaboration

Sylvain Routier 1 collaboration

Reem K Fathalla 1 collaboration

Wolfgang Fröhner 1 collaboration

Chantal D Bader 1 collaboration

Patrick D Fischer 1 collaboration

Charlotte Dahlem 1 collaboration

Alexandra K Kiemer 1 collaboration

Haribabu Arthanari 1 collaboration

Rolf Müller 1 collaboration

Mohammad Abdel-Halim 1 collaboration

Christian Ducho 1 collaboration

Matthias Engel 1 collaboration

Adán Pinto-Fernández 1 collaboration

Simon Davis 1 collaboration

Abigail B Schofield 1 collaboration

Hannah C Scott 1 collaboration

Ping Zhang 1 collaboration

Philip D Charles 1 collaboration

Andreas Damianou 1 collaboration

Gareth Bond 1 collaboration

Roman Fischer 1 collaboration

Alessandra Beltrami 1 collaboration

Peter Canning 1 collaboration

Apirat Chaikuad 1 collaboration

Petra Knaus 1 collaboration

David H Drewry 1 collaboration

Joel K Annor-Gyamfi 1 collaboration

Carrow I Wells 1 collaboration

Julie E Pickett 1 collaboration

Alison D Axtman 1 collaboration

Olawale G Raimi 1 collaboration

Hina Ojha 1 collaboration

Kenneth Ehses 1 collaboration

Sven M Lange 1 collaboration

Cristian Polo Rivera 1 collaboration

Tom D Deegan 1 collaboration

Yinchen Chen 1 collaboration

Karim P M Labib 1 collaboration

Neil Ranson 1 collaboration

Rubén Fernández-Busnadiego 1 collaboration

Miratul M K Muqit 1 collaboration

C K Deniston 1 collaboration

J Salogiannis 1 collaboration

S Mathea 1 collaboration

D M Snead 1 collaboration

I Lahiri 1 collaboration

M Matyszewski 1 collaboration

O Donosa 1 collaboration

R Watanabe 1 collaboration

J Böhning 1 collaboration

A K Shiau 1 collaboration

S Knapp 1 collaboration

E Villa 1 collaboration

S L Reck-Peterson 1 collaboration

A E Leschziner 1 collaboration

Sandra Liebscher 1 collaboration

Tobias Aumüller 1 collaboration

Andreas Pech 1 collaboration

Frank Bordusa 1 collaboration

Prosenjit Pal 1 collaboration

Pawel Lis 1 collaboration

Matthew Taylor 1 collaboration

Elena Purlyte 1 collaboration

Mark Dorward 1 collaboration

Simone Weidlich 1 collaboration

Nicole K Polinski 1 collaboration

Francesca Tonelli 1 collaboration

Daniela Boassa 1 collaboration

Junru Hu 1 collaboration

Maximilian Wallbott 1 collaboration

Elizabeth A Komives 1 collaboration

Martin P Schwalm 1 collaboration

Lena M Berger 1 collaboration

Maximilian N Meuter 1 collaboration

James D Vasta 1 collaboration

Cesear R Corona 1 collaboration

Frederic Farges 1 collaboration

Sebastian M Beinert 1 collaboration

Viktoria Morasch 1 collaboration

Vladimir V Rogov 1 collaboration

Krishna Saxena 1 collaboration

Matthew B Robers 1 collaboration

Julia Woortman 1 collaboration

Risa Kashima 1 collaboration

Akiko Hata 1 collaboration

Bernhard Kuster 1 collaboration

Phillip Aoto 1 collaboration

André Richters 1 collaboration

Shelby K Doyle 1 collaboration

David B Freeman 1 collaboration

Christina Lee 1 collaboration

Becky S Leifer 1 collaboration

Sajjeev Jagannathan 1 collaboration

Florian Kabinger 1 collaboration

Jošt Vrabič Koren 1 collaboration

Nicholas B Struntz 1 collaboration

Julie Urgiles 1 collaboration

Ryan A Stagg 1 collaboration

Brice H Curtin 1 collaboration

Peter J Mikochik 1 collaboration

Tamara D Hopkins 1 collaboration

Hua Gao 1 collaboration

Jonathan R Branch 1 collaboration

Hong Xin 1 collaboration

Lori Westover 1 collaboration

Gilles C Bignan 1 collaboration

Brent A Rupnow 1 collaboration

Kristen L Karlin 1 collaboration

Calla M Olson 1 collaboration

Thomas F Westbrook 1 collaboration

Joseph Vacca 1 collaboration

Chris M Wilfong 1 collaboration

B Wesley Trotter 1 collaboration

Douglas C Saffran 1 collaboration

Norbert Bischofberger 1 collaboration

Joshua W Russo 1 collaboration

Ian Hickson 1 collaboration

James R Bischoff 1 collaboration

Marco M Gottardis 1 collaboration

Steven P Balk 1 collaboration

Charles Y Lin 1 collaboration

Marius S Pop 1 collaboration

Angela N Koehler 1 collaboration

Christian G Kurz 1 collaboration

Martin Cusack 1 collaboration

Jennifer Alisa Amrhein 1 collaboration

Lena Marie Berger 1 collaboration

Michael Weller 1 collaboration

Tobias Weiss 1 collaboration

Janice M Reimer 1 collaboration

Andrea M Dickey 1 collaboration

Yu Xuan Lin 1 collaboration

Robert G Abrisch 1 collaboration

Elizabeth J Fay 1 collaboration

Matthew D Daugherty 1 collaboration

Eva P Karasmanis 1 collaboration

Kathryn S Hatch 1 collaboration

Kamal R Abdul Azeez 1 collaboration

Landon Vu Nguyen 1 collaboration

Christian Galicia 1 collaboration

Birgit Dreier 1 collaboration

Andreas Plückthun 1 collaboration

Wim Versees 1 collaboration

Joshua B Sheetz 1 collaboration

Hanna Karvonen 1 collaboration

Ketan Malhotra 1 collaboration

Wilhelmiina Niininen 1 collaboration

Robert Perttilä 1 collaboration

Krishna Suresh 1 collaboration

Steven E Stayrook 1 collaboration

Yuko Tsutsui 1 collaboration

Ravi Radhakrishnan 1 collaboration

Daniela Ungureanu 1 collaboration

Mark A Lemmon 1 collaboration

Martin Schröder 1 collaboration

Daniel M Pinkas 1 collaboration

Joshua C Bufton 1 collaboration

Lohitesh Kovooru 1 collaboration

Mark Kudolo 1 collaboration

Christian Pohl 1 collaboration

Stefan Laufer 1 collaboration

Cynthia Tallant 1 collaboration

Rebecca Konietzny 1 collaboration

Robin Lorenz 1 collaboration

Jian Wu 1 collaboration

Jascha T Manschwetus 1 collaboration

Amalia Villagran Suarez 1 collaboration

Jaime Alegrio Louro 1 collaboration

Toan K Phung 1 collaboration

Nick Morrice 1 collaboration