Siddharth Sunilkumar

Affiliations

Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033.

Publications (21)

The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation.

The Journal of biological chemistry

Avec: William P Miller , Siddharth Sunilkumar , Joseph F Giordano , Allyson L Toro , Alistair J Barber , Michael D Dennis

Retinol-binding protein 4 mRNA translation in hepatocytes is enhanced by activation of mTORC1.

American journal of physiology. Endocrinology and metabolism

Avec: Jaclyn E Welles , Allyson L Toro , Siddharth Sunilkumar , Shaunaci A Stevens , Carson J Purnell , Scot R Kimball , Michael D Dennis

Glucagon transiently stimulates mTORC1 by activation of an EPAC/Rap1 signaling axis.

Cellular signalling

Avec: Siddharth Sunilkumar , Scot R Kimball , Michael D Dennis

REDD1 is a Promising Therapeutic Target to Combat the Development of Diabetic Complications: A Report on Research Supported by Pathway to Stop Diabetes.

Diabetes

Avec: Siddharth Sunilkumar , Michael D Dennis

Podocyte-Specific Expression of the Stress Response Protein REDD1 is Necessary for Diabetes-induced Podocytopenia.

Diabetes

Avec: Siddharth Sunilkumar , Esma I Yerlikaya , Allyson L Toro , Han Chen , Yandong Zhou , Donald L Gill , Scot R Kimball , Michael D Dennis

Elevated glucose concentration in culture media decreases membrane trafficking of SGLT2 in LLC-PK

American journal of physiology. Cell physiology

Avec: Siddharth Sunilkumar , Sue M Ford

Acetoacetate enhances oxidative metabolism and response to toxicants of cultured kidney cells.

Toxicology letters

Avec: Trudi Denoon , Siddharth Sunilkumar , Sue M Ford

The stress response protein REDD1 as a causal factor for oxidative stress in diabetic retinopathy.

Free radical biology & medicine

Avec: William P Miller , Siddharth Sunilkumar , Michael D Dennis

REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice.

Diabetes

Avec: Siddharth Sunilkumar , Esma I Yerlikaya , Allyson L Toro , William P Miller , Han Chen , Kebin Hu , Scot R Kimball , Michael D Dennis

Spleen Tyrosine Kinase Contributes to Müller Glial Expression of Proangiogenic Cytokines in Diabetes.

Investigative ophthalmology & visual science

Avec: Esma I Yerlikaya , Allyson L Toro , Siddharth Sunilkumar , Ashley M VanCleave , Ming Leung , Yuka Imamura Kawasawa , Scot R Kimball , Michael D Dennis

REDD1-dependent GSK3β dephosphorylation promotes NF-κB activation and macrophage infiltration in the retina of diabetic mice.

The Journal of biological chemistry

Avec: Siddharth Sunilkumar , Ashley M VanCleave , Christopher M McCurry , Allyson L Toro , Shaunaci A Stevens , Scot R Kimball , Michael D Dennis

PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice.

American journal of physiology. Endocrinology and metabolism

Avec: Shaunaci A Stevens , Maria K Gonzalez Aguiar , Allyson L Toro , Esma I Yerlikaya , Siddharth Sunilkumar , Ashley M VanCleave , Jessica Pfleger , Elisa A Bradley , Scot R Kimball , Michael D Dennis

Activation of Disulfide Redox Switch in REDD1 Promotes Oxidative Stress Under Hyperglycemic Conditions.

Diabetes

Avec: William P Miller , Congzhou M Sha , Siddharth Sunilkumar , Allyson L Toro , Ashley M VanCleave , Scot R Kimball , Nikolay V Dokholyan , Michael D Dennis

Deletion of the stress response protein REDD1 prevents sodium iodate-induced RPE damage and photoreceptor loss.

GeroScience

Avec: Sandeep M Subrahmanian , Esma I Yerlikaya , Siddharth Sunilkumar , Allyson L Toro , Christopher M McCurry , Stephanie L Grillo , Alistair J Barber , Jeffrey M Sundstrom , Michael D Dennis

Chrysin Ameliorates Cyclosporine-A-Induced Renal Fibrosis by Inhibiting TGF-β

International journal of molecular sciences

Avec: Rohan Reddy Nagavally , Siddharth Sunilkumar , Mumtaz Akhtar , Louis D Trombetta , Sue M Ford

Stress response protein REDD1 promotes diabetes-induced retinal inflammation by sustaining canonical NF-κB signaling.

The Journal of biological chemistry

Avec: Siddharth Sunilkumar , Allyson L Toro , Christopher M McCurry , Ashley M VanCleave , Shaunaci A Stevens , William P Miller , Scot R Kimball , Michael D Dennis

Cranberry Proanthocyanidins Mitigate Reflux-Induced Transporter Dysregulation in an Esophageal Adenocarcinoma Model.

Pharmaceuticals (Basel, Switzerland)

Avec: Yun Zhang , Katherine M Weh , Bridget A Tripp , Jennifer L Clarke , Connor L Howard , Shruthi Sunilkumar , Amy B Howell , Laura A Kresty

NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires REDD1-Dependent Activation of GSK3β.

Investigative ophthalmology & visual science

Avec: Christopher M McCurry , Siddharth Sunilkumar , Sandeep M Subrahmanian , Esma I Yerlikaya , Allyson L Toro , Ashley M VanCleave , Shaunaci A Stevens , Alistair J Barber , Jeffery M Sundstrom , Michael D Dennis

Diabetes enhances translation of

The Journal of biological chemistry

Avec: Sadie K Dierschke , Allyson L Toro , William P Miller , Siddharth Sunilkumar , Michael D Dennis

Müller Glial Expression of REDD1 Is Required for Retinal Neurodegeneration and Visual Dysfunction in Diabetic Mice.

Diabetes

Avec: William P Miller , Allyson L Toro , Siddharth Sunilkumar , Shaunaci A Stevens , Ashley M VanCleave , David L Williamson , Alistair J Barber , Michael D Dennis

REDD1 Deletion Suppresses NF-κB Signaling in Cardiomyocytes and Prevents Deficits in Cardiac Function in Diabetic Mice.

International journal of molecular sciences

Avec: Shaunaci A Stevens , Siddharth Sunilkumar , Sandeep M Subrahmanian , Allyson L Toro , Omer Cavus , Efosa V Omorogbe , Elisa A Bradley , Michael D Dennis

Réseau de co-auteurs

Michael D Dennis 17 collaborations

Allyson L Toro 14 collaborations

Scot R Kimball 9 collaborations

William P Miller 7 collaborations

Shaunaci A Stevens 7 collaborations

Ashley M VanCleave 7 collaborations

Esma I Yerlikaya 6 collaborations

Alistair J Barber 4 collaborations

Christopher M McCurry 4 collaborations

Sue M Ford 3 collaborations

Sandeep M Subrahmanian 3 collaborations

Han Chen 2 collaborations

Elisa A Bradley 2 collaborations

Joseph F Giordano 1 collaboration

Jaclyn E Welles 1 collaboration

Carson J Purnell 1 collaboration

Yandong Zhou 1 collaboration

Donald L Gill 1 collaboration

Trudi Denoon 1 collaboration

Kebin Hu 1 collaboration

Ming Leung 1 collaboration

Yuka Imamura Kawasawa 1 collaboration

Maria K Gonzalez Aguiar 1 collaboration

Jessica Pfleger 1 collaboration

Congzhou M Sha 1 collaboration

Nikolay V Dokholyan 1 collaboration

Stephanie L Grillo 1 collaboration

Jeffrey M Sundstrom 1 collaboration

Rohan Reddy Nagavally 1 collaboration

Mumtaz Akhtar 1 collaboration

Louis D Trombetta 1 collaboration

Yun Zhang 1 collaboration

Katherine M Weh 1 collaboration

Bridget A Tripp 1 collaboration

Jennifer L Clarke 1 collaboration

Connor L Howard 1 collaboration

Shruthi Sunilkumar 1 collaboration

Amy B Howell 1 collaboration

Laura A Kresty 1 collaboration

Jeffery M Sundstrom 1 collaboration

Sadie K Dierschke 1 collaboration

David L Williamson 1 collaboration

Omer Cavus 1 collaboration

Efosa V Omorogbe 1 collaboration