T Menzen

Affiliations

Coriolis Pharma Research, Fraunhoferstr. 18 b, 82152 Martinsried, Germany.

Publications (39)

Oil-Immersion Flow Imaging Microscopy for Quantification and Morphological Characterization of Submicron Particles in Biopharmaceuticals.

The AAPS journal

Avec: Nils Krause , Sebastian Kuhn , Erik Frotscher , Felix Nikels , Andrea Hawe , Patrick Garidel , Tim Menzen

Exploring Chemical Space for New Substances to Stabilize a Therapeutic Monoclonal Antibody.

Journal of pharmaceutical sciences

Avec: Andreas Tosstorff , Tim Menzen , Gerhard Winter

Novel High-Throughput Assay for Polysorbate Quantification in Biopharmaceutical Products by Using the Fluorescent Dye DiI.

Journal of pharmaceutical sciences

Avec: Ariadna Martos , Michelle Berger , Wendelin Kranz , Anna Spanopoulou , Tim Menzen , Wolfgang Friess , Klaus Wuchner , Andrea Hawe

Systematic Studies on Stabilization of AAV Vector Formulations by Lyophilization.

Journal of pharmaceutical sciences

Avec: Ruth Rieser , Tim Menzen , Martin Biel , Stylianos Michalakis , Gerhard Winter

Imaging Flow Cytometry for Sizing and Counting of Subvisible Particles in Biotherapeutics.

Journal of pharmaceutical sciences

Avec: C Helbig , T Menzen , K Wuchner , A Hawe

Backgrounded Membrane Imaging (BMI) for High-Throughput Characterization of Subvisible Particles During Biopharmaceutical Drug Product Development.

Journal of pharmaceutical sciences

Avec: Constanze Helbig , Gregor Ammann , Tim Menzen , Wolfgang Friess , Klaus Wuchner , Andrea Hawe

Particulate impurities in cell-based medicinal products traced by flow imaging microscopy combined with deep learning for image analysis.

Cytotherapy

Avec: A D Grabarek , E Senel , T Menzen , K H Hoogendoorn , K Pike-Overzet , A Hawe , W Jiskoot

Ongoing Challenges to Develop High Concentration Monoclonal Antibody-based Formulations for Subcutaneous Administration: Quo Vadis?

Journal of pharmaceutical sciences

Avec: W Jiskoot , Andrea Hawe , Tim Menzen , David B Volkin , Daan J A Crommelin

Calorimetric Investigation of the Relaxation Phenomena in Amorphous Lyophilized Solids.

Pharmaceutics

Avec: Sebastian Groёl , Tim Menzen , Gerhard Winter

SV-AUC as a stability-indicating method for the characterization of mRNA-LNPs.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: Anian Thaller , Lukas Schmauder , Wolfgang Frieß , Gerhard Winter , Tim Menzen , Andrea Hawe , Klaus Richter

Three-Dimensional Homodyne Light Detection (3D-HLD) for High-Throughput Submicron Particle Analysis in (Highly Concentrated) Protein Biopharmaceuticals, Viral Vectors, and LNPs.

Journal of pharmaceutical sciences

Avec: Dominik Brandstetter , Constanze Helbig , Kentaro Osawa , Hiroyuki Minemura , Yumiko Anzai , Tetsuo Torisu , Susumu Uchiyama , Tim Menzen , Wolfgang Friess , Andrea Hawe

Modulated Scanning Fluorimetry Can Quickly Assess Thermal Protein Unfolding Reversibility in Microvolume Samples.

Molecular pharmaceutics

Avec: Hristo L Svilenov , Tim Menzen , Klaus Richter , Gerhard Winter

Stress Factors in mAb Drug Substance Production Processes: Critical Assessment of Impact on Product Quality and Control Strategy.

Journal of pharmaceutical sciences

Avec: Tapan K Das , Linda O Narhi , Alavattam Sreedhara , Tim Menzen , Christoph Grapentin , Danny K Chou , Valentyn Antochshuk , Vasco Filipe

Minimizing Oxidation of Freeze-Dried Monoclonal Antibodies in Polymeric Vials Using a Smart Packaging Approach.

Pharmaceutics

Avec: Nicole Härdter , Tim Menzen , Gerhard Winter

Combining Machine Learning and Backgrounded Membrane Imaging: A Case Study in Comparing and Classifying Different Types of Biopharmaceutically Relevant Particles.

Journal of pharmaceutical sciences

Avec: Christopher P Calderon , Ana Krhač Levačić , Constanze Helbig , Klaus Wuchner , Tim Menzen

Understanding opalescence measurements of biologics - A comparison study of methods, standards, and molecules.

International journal of pharmaceutics

Avec: Patrick Kunz , Eva Stuckenberger , Kerstin Hausmann , Lorenzo Gentiluomo , Malene Neustrup , Stylianos Michalakis , Ruth Rieser , Stefan Romeijn , Christian Wichmann , Roland Windisch , Andrea Hawe , Wim Jiskoot , Tim Menzen

Prediction of Unwanted Crystallization of Freeze-Dried Protein Formulations Using α-Relaxation Measurements.

Pharmaceutics

Avec: Sebastian Groël , Tim Menzen , Gerhard Winter

Possibilities and limitations of α-relaxation data of amorphous freeze-dried cakes to predict long term IgG

International journal of pharmaceutics

Avec: Sebastian Groël , Tim Menzen , Gerhard Winter

Is lyophilization key for transportation and storage of biopharmaceutical drug products in space?

Journal of pharmaceutical sciences

Avec: Tim Menzen

Taking Subvisible Particle Quantitation to the Limit: Uncertainties and Statistical Challenges With Ophthalmic Products for Intravitreal Injection.

Journal of pharmaceutical sciences

Avec: Marina Gühlke , Johanna Hecht , Armin Böhrer , Andrea Hawe , Felix Nikels , Patrick Garidel , Tim Menzen

Utility of Three Flow Imaging Microscopy Instruments for Image Analysis in Evaluating four Types of Subvisible Particle in Biopharmaceuticals.

Journal of pharmaceutical sciences

Avec: Haruka Nishiumi , Natalie Deiringer , Nils Krause , Saki Yoneda , Tetsuo Torisu , Tim Menzen , Wolfgang Friess , Susumu Uchiyama

Genome length determination in adeno-associated virus vectors with mass photometry.

Molecular therapy. Methods & clinical development

Avec: Cornelia Hiemenz , Nadine Baumeister , Constanze Helbig , Andrea Hawe , Sabrina Babutzka , Stylianos Michalakis , Wolfgang Friess , Tim Menzen

Characterization of Virus Particles and Submicron-Sized Particulate Impurities in Recombinant Adeno-Associated Virus Drug Product.

Journal of pharmaceutical sciences

Avec: Cornelia Hiemenz , Anabel Pacios-Michelena , Constanze Helbig , Valerija Vezočnik , Michael Strebl , Felix Nikels , Andrea Hawe , Patrick Garidel , Tim Menzen

Purity and DNA content of AAV capsids assessed by analytical ultracentrifugation and orthogonal biophysical techniques.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: Klaus Richter , Christine Wurm , Kim Strasser , Jana Bauer , Maria Bakou , Ross VerHeul , Shawn Sternisha , Andrea Hawe , Michael Salomon , Tim Menzen , Akash Bhattacharya

A model-based optimization strategy to achieve fast and robust freeze-drying cycles.

International journal of pharmaceutics: X

Avec: Brecht Vanbillemont , Anna-Lena Greiner , Vanessa Ehrl , Tim Menzen , Wolfgang Friess , Andrea Hawe

Evaluating the chaos game representation of proteins for applications in machine learning models: prediction of antibody affinity and specificity as a case study.

Journal of molecular modeling

Avec: Andrea Arsiccio , Lorenzo Stratta , Tim Menzen

An Interlaboratory Study to Identify Potential Visible Protein-Like Particle Standards.

AAPS PharmSciTech

Avec: Srivalli N Telikepalli , Michael J Carrier , Dean C Ripple , Greg Barnett , Ashwinkumar Bhirde , Donna Bolton , George M Bou-Assaf , Erica Ferrari , Scott Leigh , Sophia Levitskaya-Seaman , Tim Menzen , Felix Nikels , Anna Riley , Miguel Saggu , Neha Sahni , Eric Vernooij , Klaus Wuchner

High throughput multidimensional liquid chromatography approach for online protein removal and characterization of polysorbates and poloxamer in monoclonal antibody formulations.

Journal of chromatography. A

Avec: Maksymilian M Zegota , Georg Schuster , Mauro De Pra , Tibor Müllner , Tim Menzen , Frank Steiner , Andrea Hawe

Micelle Driven Oxidation Mechansim and Novel Oxidation Markers for Different Grades of Polysorbate 20 and 80.

Journal of pharmaceutical sciences

Avec: Wendelin Kranz , Klaus Wuchner , Eleonora Corradini , Tim Menzen , Andrea Hawe

What Makes Polysorbate Functional? Impact of Polysorbate 80 Grade and Quality on IgG Stability During Mechanical Stress.

Journal of pharmaceutical sciences

Avec: Adam Dariusz Grabarek , Ula Bozic , Jannik Rousel , Tim Menzen , Wendelin Kranz , Klaus Wuchner , Wim Jiskoot , Andrea Hawe

Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of Adeno-Associated Virus Serotypes.

Journal of pharmaceutical sciences

Avec: Ruth Rieser , Magalie Penaud-Budloo , Mohammed Bouzelha , Axel Rossi , Tim Menzen , Martin Biel , Hildegard Büning , Eduard Ayuso , Gerhard Winter , Stylianos Michalakis

Particles in Biopharmaceutical Formulations, Part 2: An Update on Analytical Techniques and Applications for Therapeutic Proteins, Viruses, Vaccines and Cells.

Journal of pharmaceutical sciences

Avec: Alexandra Roesch , Sarah Zölls , Daniela Stadler , Constanze Helbig , Klaus Wuchner , Gideon Kersten , Andrea Hawe , Wim Jiskoot , Tim Menzen

Combining Unfolding Reversibility Studies and Molecular Dynamics Simulations to Select Aggregation-Resistant Antibodies.

Molecular pharmaceutics

Avec: Carolin Berner , Tim Menzen , Gerhard Winter , Hristo L Svilenov

Towards quantification and differentiation of protein aggregates and silicone oil droplets in the low micrometer and submicrometer size range by using oil-immersion flow imaging microscopy and convolutional neural networks.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: Muhammad Umar , Nils Krause , Andrea Hawe , Friedrich Simmel , Tim Menzen

Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors.

Pharmaceutics

Avec: Ruth Rieser , Johanna Koch , Greta Faccioli , Klaus Richter , Tim Menzen , Martin Biel , Gerhard Winter , Stylianos Michalakis

Forced degradation of cell-based medicinal products guided by flow imaging microscopy: Explorative studies with Jurkat cells.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: A D Grabarek , W Jiskoot , A Hawe , K Pike-Overzet , T Menzen

Comparison of Submicron Particle Counting Methods with a Heat Stressed Monoclonal Antibody: Effect of Electrolytes and Implications on Sample Preparation.

Journal of pharmaceutical sciences

Avec: Andreas Stelzl , Adam Grabarek , Stefan Schneid , Wim Jiskoot , Tim Menzen , Gerhard Winter

Osmotic properties of T cells determined by flow imaging microscopy in comparison to electrical sensing zone analysis.

Cryobiology

Avec: Alexandra Roesch , Roland Windisch , Christian Wichmann , Willem F Wolkers , Gideon Kersten , Tim Menzen

Challenges in the analysis of pharmaceutical lentiviral vector products by orthogonal and complementary physical (nano)particle characterization techniques.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: Daniela Stadler , Constanze Helbig , Klaus Wuchner , Jürgen Frank , Klaus Richter , Andrea Hawe , Tim Menzen

Réseau de co-auteurs

Tim Menzen 36 collaborations

Andrea Hawe 18 collaborations

Gerhard Winter 12 collaborations

Klaus Wuchner 8 collaborations

Constanze Helbig 7 collaborations

Wolfgang Friess 6 collaborations

Stylianos Michalakis 5 collaborations

Klaus Richter 5 collaborations

Felix Nikels 4 collaborations

Ruth Rieser 4 collaborations

Wim Jiskoot 4 collaborations

Nils Krause 3 collaborations

Patrick Garidel 3 collaborations

Wendelin Kranz 3 collaborations

Martin Biel 3 collaborations

A Hawe 3 collaborations

W Jiskoot 3 collaborations

A D Grabarek 2 collaborations

K Pike-Overzet 2 collaborations

Tetsuo Torisu 2 collaborations

Susumu Uchiyama 2 collaborations

Hristo L Svilenov 2 collaborations

Christian Wichmann 2 collaborations

Roland Windisch 2 collaborations

Sebastian Groël 2 collaborations

Cornelia Hiemenz 2 collaborations

Alexandra Roesch 2 collaborations

Daniela Stadler 2 collaborations

Gideon Kersten 2 collaborations

Sebastian Kuhn 1 collaboration

Erik Frotscher 1 collaboration

Andreas Tosstorff 1 collaboration

Ariadna Martos 1 collaboration

Michelle Berger 1 collaboration

Anna Spanopoulou 1 collaboration

C Helbig 1 collaboration

K Wuchner 1 collaboration

Gregor Ammann 1 collaboration

E Senel 1 collaboration

K H Hoogendoorn 1 collaboration

David B Volkin 1 collaboration

Daan J A Crommelin 1 collaboration

Sebastian Groёl 1 collaboration

Anian Thaller 1 collaboration

Lukas Schmauder 1 collaboration

Wolfgang Frieß 1 collaboration

Dominik Brandstetter 1 collaboration

Kentaro Osawa 1 collaboration

Hiroyuki Minemura 1 collaboration

Yumiko Anzai 1 collaboration

Tapan K Das 1 collaboration

Linda O Narhi 1 collaboration

Alavattam Sreedhara 1 collaboration

Christoph Grapentin 1 collaboration

Danny K Chou 1 collaboration

Valentyn Antochshuk 1 collaboration

Vasco Filipe 1 collaboration

Nicole Härdter 1 collaboration

Christopher P Calderon 1 collaboration

Ana Krhač Levačić 1 collaboration

Patrick Kunz 1 collaboration

Eva Stuckenberger 1 collaboration

Kerstin Hausmann 1 collaboration

Lorenzo Gentiluomo 1 collaboration

Malene Neustrup 1 collaboration

Stefan Romeijn 1 collaboration

Marina Gühlke 1 collaboration

Johanna Hecht 1 collaboration

Armin Böhrer 1 collaboration

Haruka Nishiumi 1 collaboration

Natalie Deiringer 1 collaboration

Saki Yoneda 1 collaboration

Nadine Baumeister 1 collaboration

Sabrina Babutzka 1 collaboration

Anabel Pacios-Michelena 1 collaboration

Valerija Vezočnik 1 collaboration

Michael Strebl 1 collaboration

Christine Wurm 1 collaboration

Kim Strasser 1 collaboration

Jana Bauer 1 collaboration

Maria Bakou 1 collaboration

Ross VerHeul 1 collaboration

Shawn Sternisha 1 collaboration

Michael Salomon 1 collaboration

Akash Bhattacharya 1 collaboration

Brecht Vanbillemont 1 collaboration

Anna-Lena Greiner 1 collaboration

Vanessa Ehrl 1 collaboration

Andrea Arsiccio 1 collaboration

Lorenzo Stratta 1 collaboration

Srivalli N Telikepalli 1 collaboration

Michael J Carrier 1 collaboration

Dean C Ripple 1 collaboration

Greg Barnett 1 collaboration

Ashwinkumar Bhirde 1 collaboration

Donna Bolton 1 collaboration

George M Bou-Assaf 1 collaboration

Erica Ferrari 1 collaboration

Scott Leigh 1 collaboration

Sophia Levitskaya-Seaman 1 collaboration

Anna Riley 1 collaboration

Miguel Saggu 1 collaboration

Neha Sahni 1 collaboration

Eric Vernooij 1 collaboration

Maksymilian M Zegota 1 collaboration

Georg Schuster 1 collaboration

Mauro De Pra 1 collaboration

Tibor Müllner 1 collaboration

Frank Steiner 1 collaboration

Eleonora Corradini 1 collaboration

Adam Dariusz Grabarek 1 collaboration

Ula Bozic 1 collaboration

Jannik Rousel 1 collaboration

Magalie Penaud-Budloo 1 collaboration

Mohammed Bouzelha 1 collaboration

Axel Rossi 1 collaboration

Hildegard Büning 1 collaboration

Eduard Ayuso 1 collaboration

Sarah Zölls 1 collaboration

Carolin Berner 1 collaboration

Muhammad Umar 1 collaboration

Friedrich Simmel 1 collaboration

Johanna Koch 1 collaboration

Greta Faccioli 1 collaboration

Andreas Stelzl 1 collaboration

Adam Grabarek 1 collaboration

Stefan Schneid 1 collaboration

Willem F Wolkers 1 collaboration

Jürgen Frank 1 collaboration