Tim Donselaar

Affiliations

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584CL, Utrecht, the Netherlands.

Publications (5)

Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors.

Antiviral research

Avec: Roberto Manganaro , Birgit Zonsics , Lisa Bauer , Moira Lorenzo Lopez , Tim Donselaar , Marleen Zwaagstra , Fabiana Saporito , Salvatore Ferla , Jeroen R P M Strating , Bruno Coutard , Daniel L Hurdiss , Frank J M van Kuppeveld , Andrea Brancale

Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C.

PLoS biology

Avec: Lisa Bauer , Roberto Manganaro , Birgit Zonsics , Daniel L Hurdiss , Marleen Zwaagstra , Tim Donselaar , Naemi G E Welter , Regina G D M van Kleef , Moira Lorenzo Lopez , Federica Bevilacqua , Thamidur Raman , Salvatore Ferla , Marcella Bassetto , Johan Neyts , Jeroen R P M Strating , Remco H S Westerink , Andrea Brancale , Frank J M van Kuppeveld

A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Vito Thijssen , Daniel L Hurdiss , Oliver J Debski-Antoniak , Matthew A Spence , Charlotte Franck , Alexander Norman , Anupriya Aggarwal , Nadia J Mokiem , David A A van Dongen , Stein W Vermeir , Minglong Liu , Wentao Li , Marianthi Chatziandreou , Tim Donselaar , Wenjuan Du , Ieva Drulyte , Berend-Jan Bosch , Joost Snijder , Stuart G Turville , Richard J Payne , Colin J Jackson , Frank J M van Kuppeveld , Seino A K Jongkees

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.

Science advances

Avec: Daniel L Hurdiss , Priscila El Kazzi , Lisa Bauer , Nicolas Papageorgiou , François P Ferron , Tim Donselaar , Arno L W van Vliet , Tatiana M Shamorkina , Joost Snijder , Bruno Canard , Etienne Decroly , Andrea Brancale , Tzviya Zeev-Ben-Mordehai , Friedrich Förster , Frank J M van Kuppeveld , Bruno Coutard

SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b.

PLoS pathogens

Avec: Chiara Aloise , Jelle G Schipper , Arno van Vliet , Judith Oymans , Tim Donselaar , Daniel L Hurdiss , Raoul J de Groot , Frank J M van Kuppeveld

Réseau de co-auteurs

Daniel L Hurdiss 5 collaborations

Frank J M van Kuppeveld 5 collaborations

Lisa Bauer 3 collaborations

Andrea Brancale 3 collaborations

Roberto Manganaro 2 collaborations

Birgit Zonsics 2 collaborations

Moira Lorenzo Lopez 2 collaborations

Marleen Zwaagstra 2 collaborations

Salvatore Ferla 2 collaborations

Jeroen R P M Strating 2 collaborations

Bruno Coutard 2 collaborations

Joost Snijder 2 collaborations

Fabiana Saporito 1 collaboration

Naemi G E Welter 1 collaboration

Regina G D M van Kleef 1 collaboration

Federica Bevilacqua 1 collaboration

Thamidur Raman 1 collaboration

Marcella Bassetto 1 collaboration

Johan Neyts 1 collaboration

Remco H S Westerink 1 collaboration

Vito Thijssen 1 collaboration

Oliver J Debski-Antoniak 1 collaboration

Matthew A Spence 1 collaboration

Charlotte Franck 1 collaboration

Alexander Norman 1 collaboration

Anupriya Aggarwal 1 collaboration

Nadia J Mokiem 1 collaboration

David A A van Dongen 1 collaboration

Stein W Vermeir 1 collaboration

Minglong Liu 1 collaboration

Wentao Li 1 collaboration

Marianthi Chatziandreou 1 collaboration

Wenjuan Du 1 collaboration

Ieva Drulyte 1 collaboration

Berend-Jan Bosch 1 collaboration

Stuart G Turville 1 collaboration

Richard J Payne 1 collaboration

Colin J Jackson 1 collaboration

Seino A K Jongkees 1 collaboration

Priscila El Kazzi 1 collaboration

Nicolas Papageorgiou 1 collaboration

François P Ferron 1 collaboration

Arno L W van Vliet 1 collaboration

Tatiana M Shamorkina 1 collaboration

Bruno Canard 1 collaboration

Etienne Decroly 1 collaboration

Tzviya Zeev-Ben-Mordehai 1 collaboration

Friedrich Förster 1 collaboration

Chiara Aloise 1 collaboration

Jelle G Schipper 1 collaboration

Arno van Vliet 1 collaboration

Judith Oymans 1 collaboration

Raoul J de Groot 1 collaboration