Tim Harvey-Samuel

Affiliations

The Pirbright Institute Woking UK.

Publications (20)

Population-level multiplexing: A promising strategy to manage the evolution of resistance against gene drives targeting a neutral locus.

Evolutionary applications

Avec: Matthew P Edgington , Tim Harvey-Samuel , Luke Alphey

Toward a CRISPR-Cas9-Based Gene Drive in the Diamondback Moth

The CRISPR journal

Avec: Xuejiao Xu , Tim Harvey-Samuel , Hamid Anees Siddiqui , Joshua Xin De Ang , Michelle Ellis Anderson , Christine M Reitmayer , Erica Lovett , Philip T Leftwich , Minsheng You , Luke Alphey

Ommochrome pathway genes kynurenine 3-hydroxylase and cardinal participate in eye pigmentation in Plutella xylostella.

BMC molecular and cell biology

Avec: Xuejiao Xu , Tim Harvey-Samuel , Jie Yang , Luke Alphey , Minsheng You

Gene drive: a faster route to plant improvement.

Trends in plant science

Avec: Hamid Anees Siddiqui , Tim Harvey-Samuel , Shahid Mansoor

Transgenic expression of cif genes from Wolbachia strain wAlbB recapitulates cytoplasmic incompatibility in Aedes aegypti.

Nature communications

Avec: Cameron J McNamara , Thomas H Ant , Tim Harvey-Samuel , Helen White-Cooper , Julien Martinez , Luke Alphey , Steven P Sinkins

Manipulating Insect Sex Determination Pathways for Genetic Pest Management: Opportunities and Challenges.

Frontiers in bioengineering and biotechnology

Avec: Alex Siddall , Tim Harvey-Samuel , Tracey Chapman , Philip T Leftwich

Silencing RNAs expressed from W-linked

Proceedings of the National Academy of Sciences of the United States of America

Avec: Tim Harvey-Samuel , Xuejiao Xu , Michelle A E Anderson , Leonela Z Carabajal Paladino , Deepak Purusothaman , Victoria C Norman , Christine M Reitmayer , Minsheng You , Luke Alphey

Identification and characterization of a Masculinizer homologue in the diamondback moth, Plutella xylostella.

Insect molecular biology

Avec: T Harvey-Samuel , V C Norman , R Carter , E Lovett , L Alphey

Expanding the CRISPR Toolbox in Culicine Mosquitoes:

ACS synthetic biology

Avec: Michelle A E Anderson , Jessica Purcell , Sebald A N Verkuijl , Victoria C Norman , Philip T Leftwich , Tim Harvey-Samuel , Luke S Alphey

Engineered expression of the invertebrate-specific scorpion toxin AaHIT reduces adult longevity and female fecundity in the diamondback moth Plutella xylostella.

Pest management science

Avec: Tim Harvey-Samuel , Xuejiao Xu , Erica Lovett , Tarig Dafa'alla , Adam Walker , Victoria C Norman , Ruth Carter , Joss Teal , Luxziyah Akilan , Philip T Leftwich , Christine M Reitmayer , Hamid A Siddiqui , Luke Alphey

CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus.

Nature communications

Avec: Tim Harvey-Samuel , Xuechun Feng , Emily M Okamoto , Deepak-Kumar Purusothaman , Philip T Leftwich , Luke Alphey , Valentino M Gantz

Closing the gap to effective gene drive in Aedes aegypti by exploiting germline regulatory elements.

Nature communications

Avec: Michelle A E Anderson , Estela Gonzalez , Joshua X D Ang , Lewis Shackleford , Katherine Nevard , Sebald A N Verkuijl , Matthew P Edgington , Tim Harvey-Samuel , Luke Alphey

Engineered action at a distance: Blood-meal-inducible paralysis in Aedes aegypti.

PLoS neglected tropical diseases

Avec: Roya Elaine Haghighat-Khah , Tim Harvey-Samuel , Sanjay Basu , Oliver StJohn , Sarah Scaife , Sebald Verkuijl , Erica Lovett , Luke Alphey

Identification and characterization of the vasa gene in the diamondback moth, Plutella xylostella.

Insect biochemistry and molecular biology

Avec: Xuejiao Xu , Jie Yang , Tim Harvey-Samuel , Yuping Huang , Muhammad Asad , Wei Chen , Weiyi He , Guang Yang , Luke Alphey , Minsheng You

Genetic Biocontrol for Invasive Species.

Frontiers in bioengineering and biotechnology

Avec: John L Teem , Luke Alphey , Sarah Descamps , Matt P Edgington , Owain Edwards , Neil Gemmell , Tim Harvey-Samuel , Rachel L Melnick , Kevin P Oh , Antoinette J Piaggio , J Royden Saah , Dan Schill , Paul Thomas , Trevor Smith , Andrew Roberts

Split drive killer-rescue provides a novel threshold-dependent gene drive.

Scientific reports

Avec: Matthew P Edgington , Tim Harvey-Samuel , Luke Alphey

Genetic pest management and the background genetics of release strains.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Avec: Philip T Leftwich , Lewis G Spurgin , Tim Harvey-Samuel , Callum J E Thomas , Leonela Carabajal Paladino , Matthew P Edgington , Luke Alphey

CRISPR/Cas9-based functional characterization of the pigmentation gene ebony in Plutella xylostella.

Insect molecular biology

Avec: X Xu , T Harvey-Samuel , J Yang , M You , L Alphey

CRISPR/Cas-9 mediated knock-in by homology dependent repair in the West Nile Virus vector Culex quinquefasciatus Say.

Scientific reports

Avec: Deepak-Kumar Purusothaman , Lewis Shackleford , Michelle A E Anderson , Tim Harvey-Samuel , Luke Alphey

A multiplexed, confinable CRISPR/Cas9 gene drive can propagate in caged Aedes aegypti populations.

Nature communications

Avec: Michelle A E Anderson , Estela Gonzalez , Matthew P Edgington , Joshua X D Ang , Deepak-Kumar Purusothaman , Lewis Shackleford , Katherine Nevard , Sebald A N Verkuijl , Timothy Harvey-Samuel , Philip T Leftwich , Kevin Esvelt , Luke Alphey

Réseau de co-auteurs

Luke Alphey 15 collaborations

Philip T Leftwich 7 collaborations

Matthew P Edgington 5 collaborations

Xuejiao Xu 5 collaborations

Michelle A E Anderson 5 collaborations

Minsheng You 4 collaborations

Christine M Reitmayer 3 collaborations

Erica Lovett 3 collaborations

Victoria C Norman 3 collaborations

Sebald A N Verkuijl 3 collaborations

Deepak-Kumar Purusothaman 3 collaborations

Lewis Shackleford 3 collaborations

Hamid Anees Siddiqui 2 collaborations

Jie Yang 2 collaborations

T Harvey-Samuel 2 collaborations

L Alphey 2 collaborations

Estela Gonzalez 2 collaborations

Joshua X D Ang 2 collaborations

Katherine Nevard 2 collaborations

Joshua Xin De Ang 1 collaboration

Michelle Ellis Anderson 1 collaboration

Shahid Mansoor 1 collaboration

Cameron J McNamara 1 collaboration

Thomas H Ant 1 collaboration

Helen White-Cooper 1 collaboration

Julien Martinez 1 collaboration

Steven P Sinkins 1 collaboration

Alex Siddall 1 collaboration

Tracey Chapman 1 collaboration

Leonela Z Carabajal Paladino 1 collaboration

Deepak Purusothaman 1 collaboration

V C Norman 1 collaboration

R Carter 1 collaboration

E Lovett 1 collaboration

Jessica Purcell 1 collaboration

Luke S Alphey 1 collaboration

Tarig Dafa'alla 1 collaboration

Adam Walker 1 collaboration

Ruth Carter 1 collaboration

Joss Teal 1 collaboration

Luxziyah Akilan 1 collaboration

Hamid A Siddiqui 1 collaboration

Xuechun Feng 1 collaboration

Emily M Okamoto 1 collaboration

Valentino M Gantz 1 collaboration

Roya Elaine Haghighat-Khah 1 collaboration

Sanjay Basu 1 collaboration

Oliver StJohn 1 collaboration

Sarah Scaife 1 collaboration

Sebald Verkuijl 1 collaboration

Yuping Huang 1 collaboration

Muhammad Asad 1 collaboration

Wei Chen 1 collaboration

Weiyi He 1 collaboration

Guang Yang 1 collaboration

John L Teem 1 collaboration

Sarah Descamps 1 collaboration

Matt P Edgington 1 collaboration

Owain Edwards 1 collaboration

Neil Gemmell 1 collaboration

Rachel L Melnick 1 collaboration

Kevin P Oh 1 collaboration

Antoinette J Piaggio 1 collaboration

J Royden Saah 1 collaboration

Dan Schill 1 collaboration

Paul Thomas 1 collaboration

Trevor Smith 1 collaboration

Andrew Roberts 1 collaboration

Lewis G Spurgin 1 collaboration

Callum J E Thomas 1 collaboration

Leonela Carabajal Paladino 1 collaboration

X Xu 1 collaboration

J Yang 1 collaboration

M You 1 collaboration

Timothy Harvey-Samuel 1 collaboration

Kevin Esvelt 1 collaboration