Tyler Laszewski

Affiliations

Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Publications (7)

Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments.

Nature cell biology

Avec: Michalina Janiszewska , Doris P Tabassum , Zafira Castaño , Simona Cristea , Kimiyo N Yamamoto , Natalie L Kingston , Katherine C Murphy , Shaokun Shu , Nicholas W Harper , Carlos Gil Del Alcazar , Maša Alečković , Muhammad B Ekram , Ofir Cohen , Minsuk Kwak , Yuanbo Qin , Tyler Laszewski , Adrienne Luoma , Andriy Marusyk , Kai W Wucherpfennig , Nikhil Wagle , Rong Fan , Franziska Michor , Sandra S McAllister , Kornelia Polyak

Targeting the IL1β Pathway for Cancer Immunotherapy Remodels the Tumor Microenvironment and Enhances Antitumor Immune Responses.

Cancer immunology research

Avec: Rohan Diwanji , Neil A O'Brien , Jiyoung E Choi , Beverly Nguyen , Tyler Laszewski , Angelo L Grauel , Zheng Yan , Xin Xu , Jincheng Wu , David A Ruddy , Michelle Piquet , Marc R Pelletier , Alexander Savchenko , LaSalette Charette , Vanessa Rodrik-Outmezguine , Jason Baum , John M Millholland , Connie C Wong , Anne-Marie Martin , Glenn Dranoff , Iulian Pruteanu-Malinici , Viviana Cremasco , Catherine Sabatos-Peyton , Pushpa Jayaraman

TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts.

Nature communications

Avec: Angelo L Grauel , Beverly Nguyen , David Ruddy , Tyler Laszewski , Stephanie Schwartz , Jonathan Chang , Julie Chen , Michelle Piquet , Marc Pelletier , Zheng Yan , Nathaniel D Kirkpatrick , Jincheng Wu , Antoine deWeck , Markus Riester , Matt Hims , Felipe Correa Geyer , Joel Wagner , Kenzie MacIsaac , James Deeds , Rohan Diwanji , Pushpa Jayaraman , Yenyen Yu , Quincey Simmons , Shaobu Weng , Alina Raza , Brian Minie , Mirek Dostalek , Pavitra Chikkegowda , Vera Ruda , Oleg Iartchouk , Naiyan Chen , Raphael Thierry , Joseph Zhou , Iulian Pruteanu-Malinici , Claire Fabre , Jeffrey A Engelman , Glenn Dranoff , Viviana Cremasco

Dynamic evolution of fibroblasts revealed by single cell RNA sequencing of human pancreatic cancer.

Cancer research communications

Avec: Slavica Dimitrieva , Jon M Harrison , Jonathan Chang , Michelle Piquet , Mari Mino-Kenudson , Millicent Gabriel , Vivek Sagar , Heiko Horn , Kasper Lage , Julie Kim , Gang Li , Shaobu Weng , Cynthia Harris , Anupriya S Kulkarni , David T Ting , Motaz Qadan , Peter J Fagenholz , Cristina R Ferrone , Angelo L Grauel , Tyler Laszewski , Alina Raza , Markus Riester , Tim Somerville , Joel P Wagner , Glenn Dranoff , Jeffrey A Engelman , Audrey Kauffmann , Rebecca Leary , Andrew L Warshaw , Keith D Lillemoe , Carlos Fernandez-Del Castillo , David A Ruddy , Andrew S Liss , Viviana Cremasco

Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing.

PLoS biology

Avec: Guadalupe J Jasso , Alok Jaiswal , Mukund Varma , Tyler Laszewski , Angelo Grauel , Abdifatah Omar , Nilsa Silva , Glenn Dranoff , Jeffrey A Porter , Keith Mansfield , Viviana Cremasco , Aviv Regev , Ramnik J Xavier , Daniel B Graham

Interferon Signaling Is Diminished with Age and Is Associated with Immune Checkpoint Blockade Efficacy in Triple-Negative Breast Cancer.

Cancer discovery

Avec: Jaclyn Sceneay , Gregory J Goreczny , Kristin Wilson , Sara Morrow , Molly J DeCristo , Jessalyn M Ubellacker , Yuanbo Qin , Tyler Laszewski , Daniel G Stover , Victor Barrera , John N Hutchinson , Rachel A Freedman , Elizabeth A Mittendorf , Sandra S McAllister

SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms.

Scientific reports

Avec: Ye Wang , Morvarid Mohseni , Angelo Grauel , Javier Estrada Diez , Wei Guan , Simon Liang , Jiyoung Elizabeth Choi , Minying Pu , Dongshu Chen , Tyler Laszewski , Stephanie Schwartz , Jane Gu , Leandra Mansur , Tyler Burks , Lauren Brodeur , Roberto Velazquez , Steve Kovats , Bhavesh Pant , Giri Buruzula , Emily Deng , Julie T Chen , Farid Sari-Sarraf , Christina Dornelas , Malini Varadarajan , Haiyan Yu , Chen Liu , Joanne Lim , Huai-Xiang Hao , Xiaomo Jiang , Anthony Malamas , Matthew J LaMarche , Felipe Correa Geyer , Margaret McLaughlin , Carlotta Costa , Joel Wagner , David Ruddy , Pushpa Jayaraman , Nathaniel D Kirkpatrick , Pu Zhang , Oleg Iartchouk , Kimberly Aardalen , Viviana Cremasco , Glenn Dranoff , Jeffrey A Engelman , Serena Silver , Hongyun Wang , William D Hastings , Silvia Goldoni

Réseau de co-auteurs

Glenn Dranoff 5 collaborations

Viviana Cremasco 5 collaborations

Angelo L Grauel 3 collaborations

Michelle Piquet 3 collaborations

Pushpa Jayaraman 3 collaborations

Jeffrey A Engelman 3 collaborations

Yuanbo Qin 2 collaborations

Sandra S McAllister 2 collaborations

Rohan Diwanji 2 collaborations

Beverly Nguyen 2 collaborations

Zheng Yan 2 collaborations

Jincheng Wu 2 collaborations

David A Ruddy 2 collaborations

Iulian Pruteanu-Malinici 2 collaborations

David Ruddy 2 collaborations

Stephanie Schwartz 2 collaborations

Jonathan Chang 2 collaborations

Nathaniel D Kirkpatrick 2 collaborations

Markus Riester 2 collaborations

Felipe Correa Geyer 2 collaborations

Joel Wagner 2 collaborations

Shaobu Weng 2 collaborations

Alina Raza 2 collaborations

Oleg Iartchouk 2 collaborations

Angelo Grauel 2 collaborations

Michalina Janiszewska 1 collaboration

Doris P Tabassum 1 collaboration

Zafira Castaño 1 collaboration

Simona Cristea 1 collaboration

Kimiyo N Yamamoto 1 collaboration

Natalie L Kingston 1 collaboration

Katherine C Murphy 1 collaboration

Shaokun Shu 1 collaboration

Nicholas W Harper 1 collaboration

Carlos Gil Del Alcazar 1 collaboration

Maša Alečković 1 collaboration

Muhammad B Ekram 1 collaboration

Ofir Cohen 1 collaboration

Minsuk Kwak 1 collaboration

Adrienne Luoma 1 collaboration

Andriy Marusyk 1 collaboration

Kai W Wucherpfennig 1 collaboration

Nikhil Wagle 1 collaboration

Rong Fan 1 collaboration

Franziska Michor 1 collaboration

Kornelia Polyak 1 collaboration

Neil A O'Brien 1 collaboration

Jiyoung E Choi 1 collaboration

Xin Xu 1 collaboration

Marc R Pelletier 1 collaboration

Alexander Savchenko 1 collaboration

LaSalette Charette 1 collaboration

Vanessa Rodrik-Outmezguine 1 collaboration

Jason Baum 1 collaboration

John M Millholland 1 collaboration

Connie C Wong 1 collaboration

Anne-Marie Martin 1 collaboration

Catherine Sabatos-Peyton 1 collaboration

Julie Chen 1 collaboration

Marc Pelletier 1 collaboration

Antoine deWeck 1 collaboration

Matt Hims 1 collaboration

Kenzie MacIsaac 1 collaboration

James Deeds 1 collaboration

Yenyen Yu 1 collaboration

Quincey Simmons 1 collaboration

Brian Minie 1 collaboration

Mirek Dostalek 1 collaboration

Pavitra Chikkegowda 1 collaboration

Vera Ruda 1 collaboration

Naiyan Chen 1 collaboration

Raphael Thierry 1 collaboration

Joseph Zhou 1 collaboration

Claire Fabre 1 collaboration

Slavica Dimitrieva 1 collaboration

Jon M Harrison 1 collaboration

Mari Mino-Kenudson 1 collaboration

Millicent Gabriel 1 collaboration

Vivek Sagar 1 collaboration

Heiko Horn 1 collaboration

Kasper Lage 1 collaboration

Julie Kim 1 collaboration

Gang Li 1 collaboration

Cynthia Harris 1 collaboration

Anupriya S Kulkarni 1 collaboration

David T Ting 1 collaboration

Motaz Qadan 1 collaboration

Peter J Fagenholz 1 collaboration

Cristina R Ferrone 1 collaboration

Tim Somerville 1 collaboration

Joel P Wagner 1 collaboration

Audrey Kauffmann 1 collaboration

Rebecca Leary 1 collaboration

Andrew L Warshaw 1 collaboration

Keith D Lillemoe 1 collaboration

Carlos Fernandez-Del Castillo 1 collaboration

Andrew S Liss 1 collaboration

Guadalupe J Jasso 1 collaboration

Alok Jaiswal 1 collaboration

Mukund Varma 1 collaboration

Abdifatah Omar 1 collaboration

Nilsa Silva 1 collaboration

Jeffrey A Porter 1 collaboration

Keith Mansfield 1 collaboration

Aviv Regev 1 collaboration

Ramnik J Xavier 1 collaboration

Daniel B Graham 1 collaboration

Jaclyn Sceneay 1 collaboration

Gregory J Goreczny 1 collaboration

Kristin Wilson 1 collaboration

Sara Morrow 1 collaboration

Molly J DeCristo 1 collaboration

Jessalyn M Ubellacker 1 collaboration

Daniel G Stover 1 collaboration

Victor Barrera 1 collaboration

John N Hutchinson 1 collaboration

Rachel A Freedman 1 collaboration

Elizabeth A Mittendorf 1 collaboration

Ye Wang 1 collaboration

Morvarid Mohseni 1 collaboration

Javier Estrada Diez 1 collaboration

Wei Guan 1 collaboration

Simon Liang 1 collaboration

Jiyoung Elizabeth Choi 1 collaboration

Minying Pu 1 collaboration

Dongshu Chen 1 collaboration

Jane Gu 1 collaboration

Leandra Mansur 1 collaboration

Tyler Burks 1 collaboration

Lauren Brodeur 1 collaboration

Roberto Velazquez 1 collaboration

Steve Kovats 1 collaboration

Bhavesh Pant 1 collaboration

Giri Buruzula 1 collaboration

Emily Deng 1 collaboration

Julie T Chen 1 collaboration

Farid Sari-Sarraf 1 collaboration

Christina Dornelas 1 collaboration

Malini Varadarajan 1 collaboration

Haiyan Yu 1 collaboration

Chen Liu 1 collaboration

Joanne Lim 1 collaboration

Huai-Xiang Hao 1 collaboration

Xiaomo Jiang 1 collaboration

Anthony Malamas 1 collaboration

Matthew J LaMarche 1 collaboration

Margaret McLaughlin 1 collaboration

Carlotta Costa 1 collaboration

Pu Zhang 1 collaboration

Kimberly Aardalen 1 collaboration

Serena Silver 1 collaboration

Hongyun Wang 1 collaboration

William D Hastings 1 collaboration

Silvia Goldoni 1 collaboration