Institute of Resource Biology and Biotechnology, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, No.1037 Luoyu Road, Wuhan 430074, PR China; Key Laboratory of Molecular Biophysics Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, No.1037 Luoyu Road, Wuhan 430074, PR China; Hubei Food and medicine Resources Engineering Research Center, College of Life Science and Technology, Huazhong University of Science and Technology, No.1037 Luoyu Road, Wuhan 430074, PR China.