{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Dasatinib : Questions médicales les plus fréquentes",
"headline": "Dasatinib : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Dasatinib : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-02-06",
"dateModified": "2025-05-01",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Dasatinib"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Pyrimidines",
"url": "https://questionsmedicales.fr/mesh/D011743",
"about": {
"@type": "MedicalCondition",
"name": "Pyrimidines",
"code": {
"@type": "MedicalCode",
"code": "D011743",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D03.383.742"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Dasatinib",
"alternateName": "Dasatinib",
"code": {
"@type": "MedicalCode",
"code": "D000069439",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Mohammad Raish",
"url": "https://questionsmedicales.fr/author/Mohammad%20Raish",
"affiliation": {
"@type": "Organization",
"name": "Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia."
}
},
{
"@type": "Person",
"name": "Kirk N Campbell",
"url": "https://questionsmedicales.fr/author/Kirk%20N%20Campbell",
"affiliation": {
"@type": "Organization",
"name": "Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York."
}
},
{
"@type": "Person",
"name": "Edgar A Jaimes",
"url": "https://questionsmedicales.fr/author/Edgar%20A%20Jaimes",
"affiliation": {
"@type": "Organization",
"name": "Renal Service, Memorial Sloan Kettering Cancer Center, New York, New York."
}
},
{
"@type": "Person",
"name": "Evren U Azeloglu",
"url": "https://questionsmedicales.fr/author/Evren%20U%20Azeloglu",
"affiliation": {
"@type": "Organization",
"name": "Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York."
}
},
{
"@type": "Person",
"name": "Ajaz Ahmad",
"url": "https://questionsmedicales.fr/author/Ajaz%20Ahmad",
"affiliation": {
"@type": "Organization",
"name": "Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Mapping recurrent mosaic copy number variation in human neurons.",
"datePublished": "2024-05-17",
"url": "https://questionsmedicales.fr/article/38760338",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1038/s41467-024-48392-0"
}
},
{
"@type": "ScholarlyArticle",
"name": "A pan-cancer landscape of pathogenic somatic copy number variations.",
"datePublished": "2023-10-18",
"url": "https://questionsmedicales.fr/article/37858853",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.jbi.2023.104529"
}
},
{
"@type": "ScholarlyArticle",
"name": "Copy number variations in SPAST and ATL1 are rare among Brazilians.",
"datePublished": "2023-01-15",
"url": "https://questionsmedicales.fr/article/36537231",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1111/cge.14280"
}
},
{
"@type": "ScholarlyArticle",
"name": "Copy number variation alters local and global mutational tolerance.",
"datePublished": "2023-08-31",
"url": "https://questionsmedicales.fr/article/37652668",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1101/gr.277625.122"
}
},
{
"@type": "ScholarlyArticle",
"name": "Contribution of copy number variations to the risk of severe eating disorders.",
"datePublished": "2022-06-20",
"url": "https://questionsmedicales.fr/article/35611833",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1111/pcn.13430"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Composés hétérocycliques",
"item": "https://questionsmedicales.fr/mesh/D006571"
},
{
"@type": "ListItem",
"position": 3,
"name": "Composés hétéromonocycliques",
"item": "https://questionsmedicales.fr/mesh/D006573"
},
{
"@type": "ListItem",
"position": 4,
"name": "Pyrimidines",
"item": "https://questionsmedicales.fr/mesh/D011743"
},
{
"@type": "ListItem",
"position": 5,
"name": "Dasatinib",
"item": "https://questionsmedicales.fr/mesh/D000069439"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Dasatinib - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Dasatinib",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-11",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Dasatinib",
"description": "Comment le Dasatinib est-il utilisé dans le diagnostic ?\nQuels tests sont nécessaires avant de commencer le Dasatinib ?\nLe Dasatinib est-il efficace pour tous les types de leucémie ?\nComment confirmer une réponse au traitement par Dasatinib ?\nLe Dasatinib nécessite-t-il un suivi régulier ?",
"url": "https://questionsmedicales.fr/mesh/D000069439?mesh_terms=DNA+Copy+Number+Variations&page=3#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Dasatinib",
"description": "Quels sont les effets secondaires courants du Dasatinib ?\nLe Dasatinib peut-il provoquer des symptômes respiratoires ?\nQuels symptômes indiquent une réaction allergique au Dasatinib ?\nLe Dasatinib peut-il affecter le système digestif ?\nQuels signes de toxicité doivent alerter lors du traitement ?",
"url": "https://questionsmedicales.fr/mesh/D000069439?mesh_terms=DNA+Copy+Number+Variations&page=3#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Dasatinib",
"description": "Peut-on prévenir les effets secondaires du Dasatinib ?\nY a-t-il des précautions à prendre avant de commencer le Dasatinib ?\nLe mode de vie influence-t-il l'efficacité du Dasatinib ?\nDes vaccinations sont-elles recommandées pendant le traitement ?\nComment gérer les interactions médicamenteuses avec le Dasatinib ?",
"url": "https://questionsmedicales.fr/mesh/D000069439?mesh_terms=DNA+Copy+Number+Variations&page=3#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Dasatinib",
"description": "Comment le Dasatinib est-il administré ?\nQuelle est la posologie standard du Dasatinib ?\nLe Dasatinib peut-il être combiné avec d'autres traitements ?\nQuels sont les objectifs du traitement par Dasatinib ?\nLe traitement par Dasatinib nécessite-t-il des ajustements ?",
"url": "https://questionsmedicales.fr/mesh/D000069439?mesh_terms=DNA+Copy+Number+Variations&page=3#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Dasatinib",
"description": "Quelles sont les complications possibles du traitement par Dasatinib ?\nLe Dasatinib peut-il causer des problèmes cardiaques ?\nComment surveiller les complications liées au Dasatinib ?\nLe Dasatinib peut-il affecter la fonction hépatique ?\nQuels signes doivent alerter sur une complication grave ?",
"url": "https://questionsmedicales.fr/mesh/D000069439?mesh_terms=DNA+Copy+Number+Variations&page=3#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Dasatinib",
"description": "Qui est à risque de complications avec le Dasatinib ?\nL'âge influence-t-il la tolérance au Dasatinib ?\nLes femmes enceintes peuvent-elles prendre du Dasatinib ?\nY a-t-il des interactions alimentaires avec le Dasatinib ?\nLes antécédents de leucémie augmentent-ils le risque de complications ?",
"url": "https://questionsmedicales.fr/mesh/D000069439?mesh_terms=DNA+Copy+Number+Variations&page=3#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment le Dasatinib est-il utilisé dans le diagnostic ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'est pas utilisé pour le diagnostic, mais pour traiter des leucémies diagnostiquées."
}
},
{
"@type": "Question",
"name": "Quels tests sont nécessaires avant de commencer le Dasatinib ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins pour évaluer la fonction hépatique et la numération des cellules sanguines."
}
},
{
"@type": "Question",
"name": "Le Dasatinib est-il efficace pour tous les types de leucémie ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, il est principalement efficace pour la leucémie myéloïde chronique et la LAL."
}
},
{
"@type": "Question",
"name": "Comment confirmer une réponse au traitement par Dasatinib ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Par des tests sanguins réguliers pour surveiller les niveaux de cellules sanguines."
}
},
{
"@type": "Question",
"name": "Le Dasatinib nécessite-t-il un suivi régulier ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un suivi régulier est essentiel pour ajuster le traitement et surveiller les effets."
}
},
{
"@type": "Question",
"name": "Quels sont les effets secondaires courants du Dasatinib ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fatigue, nausées, douleurs musculaires et éruptions cutanées sont fréquents."
}
},
{
"@type": "Question",
"name": "Le Dasatinib peut-il provoquer des symptômes respiratoires ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il peut causer des problèmes respiratoires comme la toux ou la dyspnée."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une réaction allergique au Dasatinib ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éruptions cutanées, démangeaisons, gonflement du visage ou des lèvres."
}
},
{
"@type": "Question",
"name": "Le Dasatinib peut-il affecter le système digestif ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des nausées, vomissements et diarrhées peuvent survenir."
}
},
{
"@type": "Question",
"name": "Quels signes de toxicité doivent alerter lors du traitement ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Saignements inhabituels, fièvre persistante ou signes d'infection."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les effets secondaires du Dasatinib ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines mesures comme une bonne hydratation et une alimentation équilibrée peuvent aider."
}
},
{
"@type": "Question",
"name": "Y a-t-il des précautions à prendre avant de commencer le Dasatinib ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, informer le médecin de toutes les allergies et médicaments en cours est crucial."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il l'efficacité du Dasatinib ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain peut améliorer la tolérance et l'efficacité du traitement."
}
},
{
"@type": "Question",
"name": "Des vaccinations sont-elles recommandées pendant le traitement ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines vaccinations peuvent être nécessaires pour prévenir les infections."
}
},
{
"@type": "Question",
"name": "Comment gérer les interactions médicamenteuses avec le Dasatinib ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Consulter un médecin avant d'ajouter tout nouveau médicament pour éviter les interactions."
}
},
{
"@type": "Question",
"name": "Comment le Dasatinib est-il administré ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il est généralement pris par voie orale sous forme de comprimés."
}
},
{
"@type": "Question",
"name": "Quelle est la posologie standard du Dasatinib ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "La posologie varie, mais elle est souvent de 100 mg par jour pour la LMC."
}
},
{
"@type": "Question",
"name": "Le Dasatinib peut-il être combiné avec d'autres traitements ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il peut être utilisé en association avec d'autres thérapies ciblées."
}
},
{
"@type": "Question",
"name": "Quels sont les objectifs du traitement par Dasatinib ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Contrôler la maladie, réduire les symptômes et améliorer la qualité de vie."
}
},
{
"@type": "Question",
"name": "Le traitement par Dasatinib nécessite-t-il des ajustements ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des ajustements peuvent être nécessaires en fonction des effets secondaires."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles du traitement par Dasatinib ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des infections, des saignements et des problèmes cardiaques."
}
},
{
"@type": "Question",
"name": "Le Dasatinib peut-il causer des problèmes cardiaques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il peut augmenter le risque de complications cardiaques chez certains patients."
}
},
{
"@type": "Question",
"name": "Comment surveiller les complications liées au Dasatinib ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des examens réguliers et des tests sanguins sont nécessaires pour détecter les complications."
}
},
{
"@type": "Question",
"name": "Le Dasatinib peut-il affecter la fonction hépatique ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il peut entraîner des anomalies des tests hépatiques chez certains patients."
}
},
{
"@type": "Question",
"name": "Quels signes doivent alerter sur une complication grave ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Saignements excessifs, douleurs thoraciques ou signes d'infection sévère."
}
},
{
"@type": "Question",
"name": "Qui est à risque de complications avec le Dasatinib ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les patients avec des antécédents cardiaques ou des problèmes hépatiques sont à risque."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il la tolérance au Dasatinib ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes âgées peuvent avoir une tolérance réduite et des effets secondaires accrus."
}
},
{
"@type": "Question",
"name": "Les femmes enceintes peuvent-elles prendre du Dasatinib ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, le Dasatinib est contre-indiqué pendant la grossesse en raison de risques pour le fœtus."
}
},
{
"@type": "Question",
"name": "Y a-t-il des interactions alimentaires avec le Dasatinib ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains aliments peuvent affecter l'absorption du Dasatinib, comme le pamplemousse."
}
},
{
"@type": "Question",
"name": "Les antécédents de leucémie augmentent-ils le risque de complications ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients ayant des antécédents de leucémie peuvent avoir un risque accru."
}
}
]
}
]
}
When somatic cells acquire complex karyotypes, they often are removed by the immune system. Mutant somatic cells that evade immune surveillance can lead to cancer. Neurons with complex karyotypes aris...
Copy number variations (CNVs) play crucial roles in physiological and pathological processes, including cancer. However, the functional implications of somatic CNVs in tumor progression and evolution ...
Starting from 7352 copy number profiles across 33 different cancer types, we infer the pathogenicity of each CNV and perform both intra- and inter-tumor analyses to predict the functional impact of di...
Our analysis uncovered large heterogeneity among different tumors suggesting in many cases distinct genetic drivers of tumorigenesis. Recurrent genomic alterations frequently coincide with dysfunction...
This study contributes to elucidate the functional impact of pathogenic CNVs in tumor progression and sheds light on their potential as prognostic markers in specific cancer types....
Copy number variations (CNV) may represent a significant proportion of SPG4 and SPG3A diagnosis, the most frequent autosomal dominant subtypes of hereditary spastic paraplegias (HSP). We aimed to asse...
Copy number variants (CNVs), duplications and deletions of genomic sequences, contribute to evolutionary adaptation but can also confer deleterious effects and cause disease. Whereas the effects of am...
Eating disorders (EDs) are complex, multifactorial psychiatric conditions. Previous studies identified pathogenic copy number variations associated with NDDs (NDD-CNVs) in ED patients. However, no sta...
Using array comparative genomic hybridization (aCGH), we conducted a high-resolution CNV analysis of 71 severe female ED patients and 1045 female controls. According to the American College of Medical...
Of the samples analyzed with aCGH, 70 severe ED patients (98.6%) and 1036 controls (99.1%) passed our quality control filtering. We obtained 189 and 2539 rare CNVs from patients and controls, respecti...
Our study provides the first preliminary evidence that NDD-CNVs may confer risk for severe EDs. The pathophysiology may involve synaptic dysfunction....
Circulating cell-free DNA (cfDNA) is a noninvasive substitute to liver biopsy for hepatocellular carcinoma (HCC) molecular profiling. This study aimed to use cfDNA to investigate copy number variation...
Real-Time Polymerase Chain Reaction was used to determine the CNV and cfDNA integrity index in 100 HCC patients....
CNV gain in BCL9 and RPS6KB1 genes was detected in 14% and 24% of patients, respectively. Gain in CNV of BCL9 associated with risk of HCC in alcohol drinkers and hepatitis C seropositivity. In patient...
cfDNA was used to detect BCL9 and RPS6KB1 CNVs, which influence prognosis and can be used as independent predictors of HCC patient survival....
Venous thromboembolism (VTE) is a common disease with high heritability. However, only a small portion of the genetic variance of VTE can be explained by known genetic risk factors. Neutrophil extrace...
Mitochondrial DNA (mtDNA) copy number is associated with tumor activity and carcinogenesis. This study was undertaken to investigate mtDNA copy number in papillary thyroid cancer (PTC) tissues and to ...
DNA was extracted from 105 PTC tissues and 67 control thyroid tissues, and mtDNA copy number mtDNA oxidative damage were determined using qPCR techniques....
Overall, the relative mtDNA copy number was significantly higher in PTC patients (p < 0.001). The risk of developing PTC increased significantly across the tertiles of mtDNA copy number (p trend < 0.0...
Our results indicated that the augmentation of mtDNA content plays a significant role during the initiation of thyroid cancer, and it might represent a potential biomarker for predicting the risk of P...
Considering the essential roles that genetic factors play in azoospermia and oligospermia, this study aims to identify abnormal chromosomes using karyotyping and CNVs and elucidate the associated gene...
A total of 1157 azoospermia and oligospermia patients were recruited, of whom, 769 and 674 underwent next-generation sequencing (NGS) to identify CNVs and routine G-band karyotyping, respectively....
First, 286 patients were co-analyzed using CNV sequencing (CNV-seq) and karyotyping. Of the 725 and 432 patients with azoospermia and oligospermia, 33.8% and 48.9% had abnormal karyotypes and CNVs, re...
Sex chromosome and autosomal CNV loci, such as Xp22.31 and 2p24.3, as well as the associated genes, such as VCX and NACAP9, could be candidate spermatogenesis genes. The high-frequency abnormal karyot...
Copy number variation (CNV) is a type of structural variation, which is a gain or loss event with abnormal changes in copy number. Methods to predict the pathogenicity of CNVs are required to realize ...
From single nucleotide polymorphism (SNP), gene and region dimensions, we collected 79 informative features that quantitatively describe the characteristics of CNV, such as CNV length, the number of p...
The performance of the dbCNV suggest that functional deleteriousness-based model of CNV is a promising approach to support the classification prediction and to further understand the pathogenic mechan...