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"description": "Comment le Dasatinib est-il utilisé dans le diagnostic ?\nQuels tests sont nécessaires avant de commencer le Dasatinib ?\nLe Dasatinib est-il efficace pour tous les types de leucémie ?\nComment confirmer une réponse au traitement par Dasatinib ?\nLe Dasatinib nécessite-t-il un suivi régulier ?",
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"@type": "Question",
"name": "Comment le Dasatinib est-il utilisé dans le diagnostic ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'est pas utilisé pour le diagnostic, mais pour traiter des leucémies diagnostiquées."
}
},
{
"@type": "Question",
"name": "Quels tests sont nécessaires avant de commencer le Dasatinib ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins pour évaluer la fonction hépatique et la numération des cellules sanguines."
}
},
{
"@type": "Question",
"name": "Le Dasatinib est-il efficace pour tous les types de leucémie ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, il est principalement efficace pour la leucémie myéloïde chronique et la LAL."
}
},
{
"@type": "Question",
"name": "Comment confirmer une réponse au traitement par Dasatinib ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Par des tests sanguins réguliers pour surveiller les niveaux de cellules sanguines."
}
},
{
"@type": "Question",
"name": "Le Dasatinib nécessite-t-il un suivi régulier ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un suivi régulier est essentiel pour ajuster le traitement et surveiller les effets."
}
},
{
"@type": "Question",
"name": "Quels sont les effets secondaires courants du Dasatinib ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fatigue, nausées, douleurs musculaires et éruptions cutanées sont fréquents."
}
},
{
"@type": "Question",
"name": "Le Dasatinib peut-il provoquer des symptômes respiratoires ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il peut causer des problèmes respiratoires comme la toux ou la dyspnée."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une réaction allergique au Dasatinib ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éruptions cutanées, démangeaisons, gonflement du visage ou des lèvres."
}
},
{
"@type": "Question",
"name": "Le Dasatinib peut-il affecter le système digestif ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des nausées, vomissements et diarrhées peuvent survenir."
}
},
{
"@type": "Question",
"name": "Quels signes de toxicité doivent alerter lors du traitement ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Saignements inhabituels, fièvre persistante ou signes d'infection."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les effets secondaires du Dasatinib ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines mesures comme une bonne hydratation et une alimentation équilibrée peuvent aider."
}
},
{
"@type": "Question",
"name": "Y a-t-il des précautions à prendre avant de commencer le Dasatinib ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, informer le médecin de toutes les allergies et médicaments en cours est crucial."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il l'efficacité du Dasatinib ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain peut améliorer la tolérance et l'efficacité du traitement."
}
},
{
"@type": "Question",
"name": "Des vaccinations sont-elles recommandées pendant le traitement ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines vaccinations peuvent être nécessaires pour prévenir les infections."
}
},
{
"@type": "Question",
"name": "Comment gérer les interactions médicamenteuses avec le Dasatinib ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Consulter un médecin avant d'ajouter tout nouveau médicament pour éviter les interactions."
}
},
{
"@type": "Question",
"name": "Comment le Dasatinib est-il administré ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il est généralement pris par voie orale sous forme de comprimés."
}
},
{
"@type": "Question",
"name": "Quelle est la posologie standard du Dasatinib ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "La posologie varie, mais elle est souvent de 100 mg par jour pour la LMC."
}
},
{
"@type": "Question",
"name": "Le Dasatinib peut-il être combiné avec d'autres traitements ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il peut être utilisé en association avec d'autres thérapies ciblées."
}
},
{
"@type": "Question",
"name": "Quels sont les objectifs du traitement par Dasatinib ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Contrôler la maladie, réduire les symptômes et améliorer la qualité de vie."
}
},
{
"@type": "Question",
"name": "Le traitement par Dasatinib nécessite-t-il des ajustements ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des ajustements peuvent être nécessaires en fonction des effets secondaires."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles du traitement par Dasatinib ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des infections, des saignements et des problèmes cardiaques."
}
},
{
"@type": "Question",
"name": "Le Dasatinib peut-il causer des problèmes cardiaques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il peut augmenter le risque de complications cardiaques chez certains patients."
}
},
{
"@type": "Question",
"name": "Comment surveiller les complications liées au Dasatinib ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des examens réguliers et des tests sanguins sont nécessaires pour détecter les complications."
}
},
{
"@type": "Question",
"name": "Le Dasatinib peut-il affecter la fonction hépatique ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il peut entraîner des anomalies des tests hépatiques chez certains patients."
}
},
{
"@type": "Question",
"name": "Quels signes doivent alerter sur une complication grave ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Saignements excessifs, douleurs thoraciques ou signes d'infection sévère."
}
},
{
"@type": "Question",
"name": "Qui est à risque de complications avec le Dasatinib ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les patients avec des antécédents cardiaques ou des problèmes hépatiques sont à risque."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il la tolérance au Dasatinib ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes âgées peuvent avoir une tolérance réduite et des effets secondaires accrus."
}
},
{
"@type": "Question",
"name": "Les femmes enceintes peuvent-elles prendre du Dasatinib ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, le Dasatinib est contre-indiqué pendant la grossesse en raison de risques pour le fœtus."
}
},
{
"@type": "Question",
"name": "Y a-t-il des interactions alimentaires avec le Dasatinib ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains aliments peuvent affecter l'absorption du Dasatinib, comme le pamplemousse."
}
},
{
"@type": "Question",
"name": "Les antécédents de leucémie augmentent-ils le risque de complications ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients ayant des antécédents de leucémie peuvent avoir un risque accru."
}
}
]
}
]
}
Adverse childhood experiences (ACEs) are associated with poor oral health. Using a life course theoretical framework, this study explored the associations of specific and cumulative ACEs with caries a...
Participants were adolescents (n = 6351) age 13-17 years from The Young-HUNT4 Survey. Clinical data were retrieved from dental health records. Oral health outcomes were toothbrushing frequency, dentin...
Adolescents exposed to physical abuse by others, sexual abuse by peers, parental separation/divorce, bullying, or who had witnessed violence, were more likely to report non-daily toothbrushing compare...
Several specific ACEs were associated with non-daily toothbrushing and a higher caries experience among Norwegian adolescents in the Young-HUNT4 Survey....
This study aims to evaluate three types of manual toothbrushes [Cross action (CA), Flat trim (FT), and orthodontic type (OT)] in terms of efficacy in plaque removal in patients undergoing fixed orthod...
Manual toothbrushes are an essential part of oral hygiene for primary prevention. Plaque control, however, can be influenced by a number of individual and material-related factors. Individual factors ...
The experiment followed the Consolidated Standards of Reporting Trials (CONSORT) guidelines. This was a three treatment, three-period crossover clinical trial with a single brushing exercise. Thirty s...
Of the thirty-four subjects enrolled in the study, thirty of the subjects met the inclusion criteria and completed all three periods of the study. The mean age was 19.5 ± 1.52 years, with a range of 1...
Plaque was significantly removed by the conventional FT toothbrush after a single brushing compared to the OT and CA types....
Toothbrushes require flexibility to access all dental surfaces and remove plaque effectively, but they should also aim to prevent or limit overbrushing and consequent damage to teeth and gums. In two ...
In Study 1, a universal testing machine (Instron E 10,000) with a specially designed setup was used to test the deflection behaviour of toothbrush head and neck. Untufted toothbrushes were fixed in a ...
Study 1 showed that the flexible-neck toothbrush deflected 2 to 2.5 times more than the rigid-neck reference toothbrush when same force was applied to the toothbrush head. Study 2 revealed that all fi...
The addition of a flexible-neck component to the toothbrush designs helped to reduce stiffness and may allow more effective cleaning compared to rigid designs with controlled force distribution on the...
This in-vitro study aimed to investigate the cleaning efficacy of 18 different manual children's toothbrushes applying horizontal, vertical, and rotational movements, as well as to evaluate the roundi...
Models equipped with artificial teeth (coated with titanium dioxide) were brushed using a brushing machine with clamped manual children's toothbrushes. The machine carried out horizontal, vertical, an...
The rotational and the vertical movements achieved the best cleaning efficacy with all tested toothbrushes. The vast majority of the tested toothbrushes had their poorest cleaning efficacy in the hori...
Based on the present results, it could be concluded that the cleaning efficacy of different manual children's toothbrushes varied considerably. The best cleaning efficacy was almost always observed fo...
Proper toothbrush care and maintenance play an important role in oral health. This study aimed to investigate the knowledge, attitude and practice of medical and dental students regarding the maintena...
This cross-sectional descriptive study examined 824 medical and dental students of Babol University of Medical Sciences, Babol, Iran. Data were collected using a researcher-made questionnaire and anal...
Nearly 63.7% of the students had a good level of knowledge regarding toothbrush maintenance, 62.2% had a positive attitude toward toothbrush care, and 53.7% had a good practice. The mean scores of kno...
This study indicated the moderate level of knowledge, attitude, and practice of medical and dental students in maintaining and disinfecting their toothbrushes. The students' oral health habits were al...
The study assessed the association of country-level income inequalities with the percentage of schoolchildren toothbrushing-at-least-twice-daily; and the mediating effect of country-level unemployment...
This was an ecological study. The dependent variable was country-level toothbrushing-at-least-twice-daily among 11-15-year-old schoolchildren. Data for the period 2009 to 2019 were extracted from two ...
Data were available for 127 countries. The mean (SD) percentage of children who brushed-at-least-twice-daily was 67.3 (16.1), the mean (SD) GC = 41.4 (8.2), unemployment rate = 7.5 (4.7) and EH&E = 8....
Unemployment and EH&E mediated the association between income inequality and toothbrushing. Country-level factors may indirectly impact toothbrushing....
To systematically review the literature about the antiplaque and antigingivitis efficacy of new and worn manual toothbrushes....
Five databases were searched to identify randomized controlled trials, involving adults, comparing the clinical efficacy of new and worn manual toothbrushes. Experimental groups need to have different...
Eight studies were included, totalling 344 individuals. In studies with a single-use design, no statistically difference was found between new and worn toothbrushes for antiplaque efficacy (SMD:-0.39;...
New and worn toothbrushes presented similar antiplaque and antigingivitis efficacy. However, further randomized controlled trials, with a lower risk of bias, are needed to enhance the certainty of thi...
To compare the effectiveness of three oral hygiene groups: a novel sonic-flosser toothbrush with a compact brush head, a novel sonic-flosser toothbrush with a full size brush head and manual toothbrus...
One hundred and five (n = 105) healthy adults were enrolled in this randomized, examiner-blind, three-group, parallel clinical trial. Subjects were assigned to one of three groups: sonic-flosser tooth...
All subjects completed the study. All three groups demonstrated a significant reduction in BOP, MGI and RMNPI from baseline to 4-weeks for all areas recorded (p < 0.001), except gingival margin plaque...
The sonic-flosser toothbrush with a full size or compact brush head was statistically and clinically more effective at improving gingival health and reducing plaque than manual toothbrush and dental f...
This study evaluated surface roughness, color stability, whitening index, and opacity of different types of modeling liquids for resin composite coating after exposure to staining and toothbrushing. D...
The aim of the study is to evaluate the effectiveness of different toothbrushes in reducing gingival inflammation and dental biofilm removal in gingivitis patients with fixed orthodontic appliances....
Following baseline clinical assessments, including the Turesky modification of the Quigley-Hein plaque index (TQHI), gingival index (GI), bleeding on probing (BOP), and probing pocket depth (PPD), all...
Thirty-six patients with a mean age of 23.14 ± 3.86 (18-32 years) participated in the study. All groups with twelve patients each demonstrated significant improvements in clinical parameters compared ...
The ST-TB was shown to be more effective in reducing gingival inflammation over three months, while it demonstrated similar efficacy to the O-TB in dental biofilm removal. Further research is necessar...
This study was registered with the National Library of Medicine Clinical Trials Registry Platform on 19/07/2024 as NCT06510179....